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Volumn 116, Issue 5, 2006, Pages 1400-1409

Airway smooth muscle prostaglandin-EP1 receptors directly modulate β2-adrenergic receptors within a unique heterodimeric complex

Author keywords

[No Author keywords available]

Indexed keywords

7 TRANSMEMBRANE SPANNING RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; FORSKOLIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HETERODIMER; MEMBRANE PROTEIN; PROSTAGLANDIN E1; PROSTAGLANDIN E2; PROSTANOID RECEPTOR; UNCLASSIFIED DRUG;

EID: 33646386694     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI25840     Document Type: Article
Times cited : (113)

References (48)
  • 1
    • 0002729049 scopus 로고    scopus 로고
    • G protein coupled receptor signalling in the lung
    • S. Liggett and D. Meyers, editors. Marcel Dekker Inc. New York, New York, USA
    • Green, S.A., and Liggett, S.B. 1996. G protein coupled receptor signalling in the lung. In The genetics of asthma. S. Liggett and D. Meyers, editors. Marcel Dekker Inc. New York, New York, USA. 67-90.
    • (1996) The Genetics of Asthma , pp. 67-90
    • Green, S.A.1    Liggett, S.B.2
  • 2
    • 36949043882 scopus 로고
    • Effects of prostaglandins on human bronchial muscle
    • Sweatman, W.J., and Collier, H.O. 1968. Effects of prostaglandins on human bronchial muscle. Nature. 217:69.
    • (1968) Nature , vol.217 , pp. 69
    • Sweatman, W.J.1    Collier, H.O.2
  • 3
    • 0031743176 scopus 로고    scopus 로고
    • Role of cyclo-oxygenase-2 induction in interleukin-1beta induced attenuation of cultured human airway smooth muscle cell cyclic AMP generation in response to isoprenaline
    • Pang, L., Holland, E., and Knox, A.J. 1998. Role of cyclo-oxygenase-2 induction in interleukin-1beta induced attenuation of cultured human airway smooth muscle cell cyclic AMP generation in response to isoprenaline. Br. J. Pharmacol. 125:1320-1328.
    • (1998) Br. J. Pharmacol. , vol.125 , pp. 1320-1328
    • Pang, L.1    Holland, E.2    Knox, A.J.3
  • 4
    • 0028175594 scopus 로고
    • Production of PGE2 by bovine cultured airway smooth muscle cells and its inhibition by cyclo-oxygenase inhibitors
    • Delamere, F., et al. 1994. Production of PGE2 by bovine cultured airway smooth muscle cells and its inhibition by cyclo-oxygenase inhibitors. Br. J. Pharmacol. 111:983-988.
    • (1994) Br. J. Pharmacol. , vol.111 , pp. 983-988
    • Delamere, F.1
  • 5
    • 0024416172 scopus 로고
    • Cyclooxygenase metabolism of endogenous arachidonic acid by cultured human tracheal epithelial cells
    • Churchill, L., et al. 1989. Cyclooxygenase metabolism of endogenous arachidonic acid by cultured human tracheal epithelial cells. Am. Rev. Respir. Dis. 140:449-459.
    • (1989) Am. Rev. Respir. Dis. , vol.140 , pp. 449-459
    • Churchill, L.1
  • 6
    • 0023188941 scopus 로고
    • Cyclooxygenase metabolites are compartmentalized in the human lower respiratory tract
    • Ozaki, T., Rennard, S.I., and Crystal, R.G. 1987. Cyclooxygenase metabolites are compartmentalized in the human lower respiratory tract. J. Appl. Physiol. 62:219-222.
    • (1987) J. Appl. Physiol. , vol.62 , pp. 219-222
    • Ozaki, T.1    Rennard, S.I.2    Crystal, R.G.3
  • 8
    • 0025097975 scopus 로고
    • Distribution of beta 1- and beta 2-adrenoceptors in mouse trachea and lung: A quantitative autoradiographic study
    • Henry, P.J., Rigby, P.J., and Goldie, R.G. 1990. Distribution of beta 1- and beta 2-adrenoceptors in mouse trachea and lung: a quantitative autoradiographic study. Br. J. Pharmacol. 99:136-144.
    • (1990) Br. J. Pharmacol. , vol.99 , pp. 136-144
    • Henry, P.J.1    Rigby, P.J.2    Goldie, R.G.3
  • 9
    • 0030613761 scopus 로고    scopus 로고
    • 2-adrenergic receptor to different G proteins by protein kinase A
    • 2-adrenergic receptor to different G proteins by protein kinase A. Nature. 390:88-91.
    • (1997) Nature , vol.390 , pp. 88-91
    • Daaka, Y.1    Luttrell, L.M.2    Lefkowitz, R.J.3
  • 10
    • 0022359727 scopus 로고
    • Agonist-induced redistribution of beta-adrenergic receptors on intact human mononuclear leukocytes: Redistributed receptors are nonfunctional
    • De Blasi, A., Lipartiti, M., Motulsky, H.J., Insel, P.A., and Fratelli, M. 1985. Agonist-induced redistribution of beta-adrenergic receptors on intact human mononuclear leukocytes: redistributed receptors are nonfunctional. J. Clin. Endocrinol. Metab. 61:1081-1088.
    • (1985) J. Clin. Endocrinol. Metab. , vol.61 , pp. 1081-1088
    • De Blasi, A.1    Lipartiti, M.2    Motulsky, H.J.3    Insel, P.A.4    Fratelli, M.5
  • 11
    • 0036174608 scopus 로고    scopus 로고
    • Dimerization: An emerging concept for G protein-coupled receptor ontogeny and function
    • Angers, S., Salahpour, A., and Bouvier, M. 2002. Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function. Annu. Rev. Pharmacol. Toxicol. 42:409-435.
    • (2002) Annu. Rev. Pharmacol. Toxicol. , vol.42 , pp. 409-435
    • Angers, S.1    Salahpour, A.2    Bouvier, M.3
  • 12
    • 14644387575 scopus 로고    scopus 로고
    • Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation
    • Bulenger, S., Marullo, S., and Bouvier, M. 2005. Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation. Trends Pharmacol. Sci. 26:131-137.
    • (2005) Trends Pharmacol. Sci. , vol.26 , pp. 131-137
    • Bulenger, S.1    Marullo, S.2    Bouvier, M.3
  • 13
    • 3142617997 scopus 로고    scopus 로고
    • Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties
    • Breit, A., Lagace, M., and Bouvier, M. 2004. Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties. J. Biol. Chem. 279:28756-28765.
    • (2004) J. Biol. Chem. , vol.279 , pp. 28756-28765
    • Breit, A.1    Lagace, M.2    Bouvier, M.3
  • 14
    • 0034724192 scopus 로고    scopus 로고
    • Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)
    • Angers, S., et al. 2000. Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). Proc. Natl. Acad. Sci. U. S. A. 97:3684-3689.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 3684-3689
    • Angers, S.1
  • 15
    • 0033947541 scopus 로고    scopus 로고
    • Functional significance of oligomerization of G-protein-coupled receptors
    • Salahpour, A., Angers, S., and Bouvier, M. 2000. Functional significance of oligomerization of G-protein-coupled receptors. Trends Endocrinol. Metab. 11:163-168.
    • (2000) Trends Endocrinol. Metab. , vol.11 , pp. 163-168
    • Salahpour, A.1    Angers, S.2    Bouvier, M.3
  • 16
    • 0035318509 scopus 로고    scopus 로고
    • Oligomerization of G-protein-coupled transmitter receptors
    • Bouvier, M. 2001. Oligomerization of G-protein-coupled transmitter receptors. Nat. Rev. Neurosci. 2:274-286.
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 274-286
    • Bouvier, M.1
  • 17
    • 0032823306 scopus 로고    scopus 로고
    • Prostanoid receptors: Structures, properties, and functions
    • Narumiya, S., Sugimoto, Y., and Ushikubi, F. 1999. Prostanoid receptors: structures, properties, and functions. Physiol. Rev. 79:1193-1226.
    • (1999) Physiol. Rev. , vol.79 , pp. 1193-1226
    • Narumiya, S.1    Sugimoto, Y.2    Ushikubi, F.3
  • 18
    • 0027370888 scopus 로고
    • Cloning and expression of a cDNA for the human prostaglandin e receptor EP1 subtype
    • Funk, C.D., et al. 1993. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J. Biol. Chem. 268:26767-26772.
    • (1993) J. Biol. Chem. , vol.268 , pp. 26767-26772
    • Funk, C.D.1
  • 19
    • 0029151040 scopus 로고
    • The mouse prostaglandin e receptor EP2 subtype: Cloning, expression, and northern blot analysis
    • Katsuyama, M., et al. 1995. The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and northern blot analysis. FEBS Lett. 372:151-156.
    • (1995) FEBS Lett. , vol.372 , pp. 151-156
    • Katsuyama, M.1
  • 20
    • 0029866698 scopus 로고    scopus 로고
    • Cloning and expression of the rabbit prostaglandin EP4 receptor
    • Breyer, R.M., et al. 1996. Cloning and expression of the rabbit prostaglandin EP4 receptor. Am. J. Physiol. 270:F485-F493.
    • (1996) Am. J. Physiol. , vol.270
    • Breyer, R.M.1
  • 21
    • 0027998445 scopus 로고
    • Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype
    • Regan, J.W., et al. 1994. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Mol. Pharmacol. 46:213-220.
    • (1994) Mol. Pharmacol. , vol.46 , pp. 213-220
    • Regan, J.W.1
  • 22
    • 0027258001 scopus 로고
    • Alternative splicing of C-terminal tail of prostaglandin e receptor subtype EP3 determines G-protein specificity
    • Namba, T., et al. 1993. Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. Nature. 365:166-170.
    • (1993) Nature , vol.365 , pp. 166-170
    • Namba, T.1
  • 23
    • 0029181817 scopus 로고
    • Signal transductions of three isoforms of mouse prostaglandin e receptor EP3 subtype
    • Negishi, M., et al. 1995. Signal transductions of three isoforms of mouse prostaglandin E receptor EP3 subtype. Adv. Prostaglandin Thromboxane Leukot. Res. 23:255-257.
    • (1995) Adv. Prostaglandin Thromboxane Leukot. Res. , vol.23 , pp. 255-257
    • Negishi, M.1
  • 24
    • 17844368924 scopus 로고    scopus 로고
    • Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E2
    • Moore, B.B., et al. 2005. Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E2. J. Immunol. 174:5644-5649.
    • (2005) J. Immunol. , vol.174 , pp. 5644-5649
    • Moore, B.B.1
  • 25
    • 0034981863 scopus 로고    scopus 로고
    • Persistent wheezing in very young children is associated with lower respiratory inflammation
    • Krawiec, M.E., et al. 2001. Persistent wheezing in very young children is associated with lower respiratory inflammation. Am. J. Respir. Crit. Care Med. 163:1338-1343.
    • (2001) Am. J. Respir. Crit. Care Med. , vol.163 , pp. 1338-1343
    • Krawiec, M.E.1
  • 26
    • 0141956408 scopus 로고    scopus 로고
    • Increased prostaglandin E2 concentrations and cyclooxygenase-2 expression in asthmatic subjects with sputum eosinophilia
    • Profita, M., et al. 2003. Increased prostaglandin E2 concentrations and cyclooxygenase-2 expression in asthmatic subjects with sputum eosinophilia. J. Allergy Clin. Immunol. 112:709-716.
    • (2003) J. Allergy Clin. Immunol. , vol.112 , pp. 709-716
    • Profita, M.1
  • 27
    • 0035051851 scopus 로고    scopus 로고
    • Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment
    • Redington, A.E., et al. 2001. Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment. Thorax. 56:351-357.
    • (2001) Thorax , vol.56 , pp. 351-357
    • Redington, A.E.1
  • 28
    • 0034014278 scopus 로고    scopus 로고
    • Prostaglandin H synthase 2 expression in airway cells from patients with asthma and chronic obstructive pulmonary disease
    • Taha, R., et al. 2000. Prostaglandin H synthase 2 expression in airway cells from patients with asthma and chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 161:636-640.
    • (2000) Am. J. Respir. Crit. Care Med. , vol.161 , pp. 636-640
    • Taha, R.1
  • 29
    • 0037378249 scopus 로고    scopus 로고
    • Receptors and pathways mediating the effects of prostaglandin E2 on airway tone
    • Tilley, S.L., et al. 2003. Receptors and pathways mediating the effects of prostaglandin E2 on airway tone. Am. J. Physiol. Lung Cell. Mol. Physiol. 284:L599-L606.
    • (2003) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.284
    • Tilley, S.L.1
  • 30
    • 0016481764 scopus 로고
    • Effect of prostaglandins F2 alpha and E2 on airway conductance in healthy subjects and asthmatic patients
    • Mathe, A.A., and Hedqvist, P. 1975. Effect of prostaglandins F2 alpha and E2 on airway conductance in healthy subjects and asthmatic patients. Am. Rev. Respir. Dis. 111:313-320.
    • (1975) Am. Rev. Respir. Dis. , vol.111 , pp. 313-320
    • Mathe, A.A.1    Hedqvist, P.2
  • 31
    • 14444273437 scopus 로고    scopus 로고
    • Cyclooxygenase-2 and synthesis of PGE2 in human bronchial smooth-muscle cells
    • Vigano, T., et al. 1997. Cyclooxygenase-2 and synthesis of PGE2 in human bronchial smooth-muscle cells. Am. J. Respir. Crit. Care Med. 155:864-868.
    • (1997) Am. J. Respir. Crit. Care Med. , vol.155 , pp. 864-868
    • Vigano, T.1
  • 32
    • 0031000946 scopus 로고    scopus 로고
    • Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: Novel inflammatory role of this cell type
    • Belvisi, M.G., et al. 1997. Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type. Br. J. Pharmacol. 120:910-916.
    • (1997) Br. J. Pharmacol. , vol.120 , pp. 910-916
    • Belvisi, M.G.1
  • 33
    • 0001760198 scopus 로고    scopus 로고
    • TGF-beta1 stimulates IL-8 release, COX-2 expression, and PGE(2) release in human airway smooth muscle cells
    • Fong, C.Y., Pang, L., Holland, E., and Knox, A.J. 2000. TGF-beta1 stimulates IL-8 release, COX-2 expression, and PGE(2) release in human airway smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 279:L201-L207.
    • (2000) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.279
    • Fong, C.Y.1    Pang, L.2    Holland, E.3    Knox, A.J.4
  • 34
    • 0030927344 scopus 로고    scopus 로고
    • Effect of interleukin-1 beta, tumour necrosis factor-alpha and interferon-gamma on the induction of cyclo-oxygenase-2 in cultured human airway smooth muscle cells
    • Pang, L., and Knox, A.J. 1997. Effect of interleukin-1 beta, tumour necrosis factor-alpha and interferon-gamma on the induction of cyclo-oxygenase-2 in cultured human airway smooth muscle cells. Br. J. Pharmacol. 121:579-587.
    • (1997) Br. J. Pharmacol. , vol.121 , pp. 579-587
    • Pang, L.1    Knox, A.J.2
  • 35
    • 3242741045 scopus 로고    scopus 로고
    • Beta(2)-Adrenergic receptor signaling complexes in cardiomyocyte caveolae/lipid rafts
    • Steinberg, S.F. 2004. beta(2)-Adrenergic receptor signaling complexes in cardiomyocyte caveolae/lipid rafts. J. Mol. Cell. Cardiol. 37:407-415.
    • (2004) J. Mol. Cell. Cardiol. , vol.37 , pp. 407-415
    • Steinberg, S.F.1
  • 36
    • 0031229651 scopus 로고    scopus 로고
    • EP1 receptor blockade attenuates both spontaneous tone and PGE2-elicited contraction in guinea pig trachealis
    • Ndukwu, I.M., White, S.R., Leff, A.R., and Mitchell, R.W. 1997. EP1 receptor blockade attenuates both spontaneous tone and PGE2-elicited contraction in guinea pig trachealis. Am. J. Physiol. 273:L626-L633.
    • (1997) Am. J. Physiol. , vol.273
    • Ndukwu, I.M.1    White, S.R.2    Leff, A.R.3    Mitchell, R.W.4
  • 37
    • 0035341213 scopus 로고    scopus 로고
    • Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function
    • Galvez, T., et al. 2001. Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function. EMBO J. 20:2152-2159.
    • (2001) EMBO J. , vol.20 , pp. 2152-2159
    • Galvez, T.1
  • 38
    • 0032929331 scopus 로고    scopus 로고
    • Role of heteromer formation in GABAB receptor function
    • Kuner, R., et al. 1999. Role of heteromer formation in GABAB receptor function. Science. 283:74-77.
    • (1999) Science , vol.283 , pp. 74-77
    • Kuner, R.1
  • 39
    • 2442597256 scopus 로고    scopus 로고
    • Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors
    • Hague, C., Uberti, M.A., Chen, Z., Hall, R.A., and Minneman, K.P. 2004. Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors. J. Biol. Chem. 279:15541-15549.
    • (2004) J. Biol. Chem. , vol.279 , pp. 15541-15549
    • Hague, C.1    Uberti, M.A.2    Chen, Z.3    Hall, R.A.4    Minneman, K.P.5
  • 40
    • 15744405558 scopus 로고    scopus 로고
    • Heterodimerization with beta2-adrenergic receptors promotes surface expression and functional activity of alpha1D-adrenergic receptors
    • Uberti, M.A., Hague, C., Oller, H., Minneman, K.P., and Hall, R.A. 2005. Heterodimerization with beta2-adrenergic receptors promotes surface expression and functional activity of alpha1D-adrenergic receptors. J. Pharmacol. Exp. Ther. 313:16-23.
    • (2005) J. Pharmacol. Exp. Ther. , vol.313 , pp. 16-23
    • Uberti, M.A.1    Hague, C.2    Oller, H.3    Minneman, K.P.4    Hall, R.A.5
  • 41
    • 85047694597 scopus 로고    scopus 로고
    • Antithetic regulation by β-adrenergic receptors of Gq-receptor signaling via phospholipase-C underlies the airway β-agonist paradox
    • doi:10.1172/JCI200318193
    • McGraw, D.W., Almoosa, K.F., Paul, R.J., Kobilka, B.K., and Liggett, S.B. 2003. Antithetic regulation by β-adrenergic receptors of Gq-receptor signaling via phospholipase-C underlies the airway β-agonist paradox. J. Clin. Invest. 112:619-626. doi:10.1172/JCI200318193.
    • (2003) J. Clin. Invest. , vol.112 , pp. 619-626
    • McGraw, D.W.1    Almoosa, K.F.2    Paul, R.J.3    Kobilka, B.K.4    Liggett, S.B.5
  • 42
    • 0033527748 scopus 로고    scopus 로고
    • 2-adrenergic receptors in airway smooth muscle alters myocyte function and ablates bronchial hyperreactivity
    • 2-adrenergic receptors in airway smooth muscle alters myocyte function and ablates bronchial hyperreactivity. J. Biol. Chem. 274:32241-32247.
    • (1999) J. Biol. Chem. , vol.274 , pp. 32241-32247
    • McGraw, D.W.1
  • 43
    • 4444293419 scopus 로고    scopus 로고
    • Polymorphisms of the cardiac presynaptic α2Cadrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects
    • Small, K.M., et al. 2004. Polymorphisms of the cardiac presynaptic α2Cadrenergic receptors: diverse intragenic variability with haplotype-specific functional effects. Proc. Natl. Acad. Sci. U. S. A. 101:13020-13025.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 13020-13025
    • Small, K.M.1
  • 44
    • 4644252143 scopus 로고    scopus 로고
    • A primate-dominant third glycosylation site of the β2-adrenergic receptor routes receptors to degradation during agonist regulation
    • Mialet-Perez, J., Green, S.A., Miller, W.E., and Liggett, S.B. 2004. A primate-dominant third glycosylation site of the β2-adrenergic receptor routes receptors to degradation during agonist regulation. J. Biol. Chem. 279:38603-38607.
    • (2004) J. Biol. Chem. , vol.279 , pp. 38603-38607
    • Mialet-Perez, J.1    Green, S.A.2    Miller, W.E.3    Liggett, S.B.4
  • 45
    • 0027988520 scopus 로고
    • A proline-rich region of the third intracellular loop imparts phenotypic β1- versus β2-adrenergic receptor coupling and sequestration
    • Green, S., and Liggett, S.B. 1994. A proline-rich region of the third intracellular loop imparts phenotypic β1- versus β2-adrenergic receptor coupling and sequestration. J. Biol. Chem. 269:26215-26219.
    • (1994) J. Biol. Chem. , vol.269 , pp. 26215-26219
    • Green, S.1    Liggett, S.B.2
  • 46
    • 0034666151 scopus 로고    scopus 로고
    • 2C-adrenergic receptor third loop chimera show that agonist interaction with receptor-subtype backbone establishes G protein-coupled receptor kinase phosphorylation
    • 2C-adrenergic receptor third loop chimera show that agonist interaction with receptor-subtype backbone establishes G protein-coupled receptor kinase phosphorylation. J. Biol. Chem. 275:28989-28993.
    • (2000) J. Biol. Chem. , vol.275 , pp. 28989-28993
    • Jewell-Motz, E.A.1    Small, K.M.2    Liggett, S.B.3
  • 48
    • 0037305047 scopus 로고    scopus 로고
    • Principles: Extending the utility of [35S]GTP gamma S binding assays
    • Milligan, G. 2003. Principles: extending the utility of [35S]GTP gamma S binding assays. Trends Pharmacol. Sci. 24:87-90.
    • (2003) Trends Pharmacol. Sci. , vol.24 , pp. 87-90
    • Milligan, G.1


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