Urokinase potentiates PDGF-induced chemotaxis of human airway smooth muscle cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 284, Issue 6 28-6, 2003, Pages

  Carlin, Stephen M ^a,b   Roth, Michael ^a,b   Black, Judith L ^a  

^a University of Sydney   (Australia)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Airway remodeling; Asthma; Cell migration; Urokinase type plasminogen activator

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; BUDESONIDE; COLLAGEN; FORMOTEROL; MITOGEN ACTIVATED PROTEIN KINASE; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR AA; PLATELET DERIVED GROWTH FACTOR AB; PLATELET DERIVED GROWTH FACTOR BB; PROSTAGLANDIN E2; UROKINASE;

ARTICLE; ASTHMA; BRONCHUS MUSCLE; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; WESTERN BLOTTING;

EID: 0038511363     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00092.2002     Document Type: Article

References (37)

1. Bornfeldt KE, Campbell JS, Koyama H, Argast GM, Leslie CC, Raines EW, Krebs EG, and Ross R. The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets. J Clin Invest 100: 875-885, 1997.
2. Carroll N, Elliot J, Morton A, and James A. The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis 147: 405-410, 1993.
3. Chung CY, Funamoto S, and Firtel RA. Signaling pathways controlling cell polarity and chemotaxis. Trends Biochem Sci 26: 557-566, 2001.
4. Clowes AW, Clowes MM, Au YP, Reidy MA, and Belin D. Smooth muscle cells express urokinase during mitogenesis and tissue-type plasminogen activator during migration in injured rat carotid artery. Circ Res 67: 61-67, 1990.
5. Degryse B, Orlando S, Resnati M, Rabbani SA, and Blasi F. Urokinase/urokinase receptor and vitronectin/alpha(v)beta(3) integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways. Oncogene 20: 2032-2043, 2001.
6. Degryse B, Resnati M, Rabbani SA, Villa A, Fazioli F, and Blasi F. Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells. Blood 94: 649-662, 1999.
7. Dumler I, Weis A, Mayboroda OA, Maasch C, Jerke U, Haller H, and Gulba DC. The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells. J Biol Chem 273: 315-321, 1998.
8. Eda R, Sugiyama H, Hopp RJ, Okada C, Bewtra AK, and Townley RG. Inhibitory effects of formoterol on platelet-activating factor induced eosinophil chemotaxis and degranulation. Int Arch Allergy Immunol 102: 391-398, 1993.
9. Eikelberg O, Roth M, Lorx R, Bruce V, Rudiger J, Johnson M, and Block LH. Ligand-independent activation of the glucocorticoid receptor by beta-2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells. J Biol Chem 274: 1005-1010, 1999.
10. Fazioli F, Resnati M, Sidenius N, Higashimoto Y, Appella E, and Blasi F. A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity. EMBO J 16: 7279-7286, 1997.
11. Ferns GA, Sprugel KH, Seifert RA, Bowen-Pope DF, Kelly JD, and Murray M. Relative platelet-derived growth factor receptor subunit expression determines cell migration to different dimeric forms of PDGF. Growth Factors 3: 315-324, 1990.
12. Garcia JG, Wang P, Liu F, Hershenson MB, Borbiev T, and Verin AD. Pertussis toxin directly activates endothelial cell p42/p44 MAP kinases via a novel signaling pathway. Am J Physiol Cell Physiol 280: C1233-C1241, 2001.
13. Gizycki MJ, Adelroth E, Rogers AV, Obyrne PM, and Jeffery PK. Myofibroblast involvement in the allergen-induced late response in mild atopic asthma. Am J Respir Cell Mol Biol 16: 664-673, 1997.
14. Glading A, Uberall F, Keyse SM, Lauffenburger DA, and Wells A. Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling. J Biol Chem 276: 23341-23348, 2001.
15. Graves LM, Bornfeldt KE, Sidhu JS, Argast GM, Raines EW, Ross R, Leslie CC, and Krebs EG. Platelet-derived growth factor stimulates protein kinase A through a mitogen-activated protein kinase-dependent pathway in human arterial smooth muscle cells. J Biol Chem 271: 505-511, 1996.
16. Grotendorst GR, Seppa HE, Kleinman HK, and Martin GR. Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor. Proc Natl Acad Sci USA 78: 3669-3672, 1981.
17. Guo NH, Zabrenetzky VS, Chandrasekaran L, Sipes JM, Lawler J, Krutzsch HC, and Roberts DD. Differential roles of protein kinase C and pertussis toxin-sensitive G-binding proteins in modulation of melanoma cell proliferation and motility by thrombospondin 1. Cancer Res 58: 3154-3162, 1998.
18. Hawker KM, Johnson PRA, Hughes JM, and Black JL. Interleukin-4 inhibits mitogen-induced proliferation of human airway smooth muscle cells in culture. Am J Physiol Lung Cell Mol Physiol 275: L469-L477, 1998.
19. Hedges JC, Dechert MA, Yamboliev IA, Martin JL, Hickey E, Weber LA, and Gerthoffer WT. A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration. J Biol Chem 274: 24211-24219, 1999.
20. Hosang M and Rouge M. Human vascular smooth muscle cells have at least two distinct PDGF receptors and can secrete PDGF-AA. J Cardiovasc Pharmacol 14, Suppl 6: S22-S26, 1989.
21. Irani C, Goncharova EA, Hunter DS, Walker CL, Panettieri RA, and Krymskaya VP. Phosphatidylinositol 3-kinase but not tuberin is required for PDGF-induced cell migration. Am J Physiol Lung Cell Mol Physiol 282: L854-L862, 2002.
22. 2 inhibit DNA synthesis in human airway smooth muscle cells in culture. Am J Physiol Lung Cell Mol Physiol 269: L514-L519, 1995.
23. Kantele JM, Kurk S, and Jutila MA. Effects of continuous exposure to stromal cell-derived factor-1 alpha on T cell rolling and tight adhesion to monolayers of activated endothelial cells. J Immunol 164: 5035-5040, 2000.
24. 2 inhibits fibroblast chemotaxis. Am J Physiol Lung Cell Mol Physiol 281: L1257-L1263, 2001.
25. Maghazachi AA. Intracellular signaling events at the leading edge of migrating cells. Int J Biochem Cell Biol 32: 931-943, 2000.
26. Miyazaki K, Yano T, Schmidt DJ, Tokui T, Shibata M, Lifshitz LM, Kimura S, Tuft RA, and Ikebe M. Rho-dependent agonist-induced spatio-temporal change in myosin phosphorylation in smooth muscle cells. J Biol Chem 277: 725-734, 2002.
27. Mukhina S, Stepanova V, Traktouev D, Poliakov A, Bea-bealashvilly R, Gursky Y, Minashkin M, Shevelev A, and Tkachuk V. The chemotactic action of urokinase on smooth muscle cells is dependent on its kringle domain. Characterization of interactions and contribution to chemotaxis. J Biol Chem 275: 16450-16458, 2000.
28. Nguyen DHD, Catling AD, Webb DJ, Sankovic M, Walker LA, Somlyo AV, Weber MJ, and Gonias SL. Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner. J Cell Biol 146: 149-164, 1999.
29. Okada SS, Grobmyer SR, and Barnathan ES. Contrasting effects of plasminogen activators, urokinase receptor, and LDL receptor-related protein on smooth muscle cell migration and invasion. Arterioscler Thromb Vasc Biol 16: 1269-1276, 1996.
30. Reiske HR, Kao SC, Cary LA, Guan JL, Lai JF, and Chen HC. Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration. J Biol Chem 274: 12361-12366, 1999.
31. Richter A, Puddicombe SM, Lordan JL, Bucchieri F, Wilson SJ, Djukanovic R, Dent G, Holgate ST, and Davies DE. The contribution of interleukin (IL)-4 and IL-13 to the epithelilal-mesenchymal trophic unit in asthma. Am J Respir Cell Mol Biol 25: 385-391, 2001.
32. Roche WR, Beasley R, Williams JH, and Holgate ST. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1: 520-524, 1989.
33. Ronnstrand L and Heldin CH. Mechanisms of platelet-derived growth factor-induced chemotaxis. Int J Cancer 91: 757-762, 2001.
34. Skinner MP, Raines EW, and Ross R. Dynamic expression of alpha-1-beta-1 and alpha-2-beta-1 integrin receptors by human vascular smooth muscle cells: alpha-2-beta-1 integrin is required for chemotaxis across type I collagen-coated membranes. Am J Pathol 145: 1070-1081, 1994.
35. Stepanova V, Bobik A, Bibilashvily R, Belogurov A, Rybalkin I, Domogatsky S, Little PJ, Goncharova E, and Tkachuk V. Urokinase plasminogen activator induces smooth muscle cell migration: key role of growth factor-like domain. FEBS Lett 414: 471-474, 1997.
36. Stepanova V, Mukhina S, Kohler E, Resink TJ, Erne P, and Tkachuk VA. Urokinase plasminogen activator induces human smooth muscle cell migration and proliferation via distinct receptor-dependent and proteolysis-dependent mechanisms. Mol Cell Biochem 195: 199-206, 1999.
37. Wang XQ, Lindberg FP, and Frazier WA. Integrin-associated protein stimulates alpha 2 beta 1-dependent chemotaxis via Gi-mediated inhibition of adenylate cyclase and extracellular-regulated kinases. J Cell Biol 147: 389-399, 1999.