Human airway contraction and formoterol-induced relaxation is determined by Ca2+ oscillations and Ca2+ sensitivity

American Journal of Respiratory Cell and Molecular Biology

Volumn 43, Issue 2, 2010, Pages 179-191

  Ressmeyer, Anna Rebekka ^a   Bai, Yan ^a   Delmotte, Philippe ^a   Uy, Karl F ^b   Thistlethwaite, Patricia ^c   Fraire, Armando ^b   Sato, Osamu ^a   Ikebe, Mitsuo ^a   Sanderson, Michael J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UMASS MEMORIAL MEDICAL CENTER   (United States)

^c UCSD MEDICAL CENTER   (United States)

Author keywords

Histamine; Hyperresponsiveness; Lung slice; Smooth muscle cell; Two photon microscopy

Indexed keywords

CALCIUM ION; FORMOTEROL; HISTAMINE; RYANODINE RECEPTOR; BRONCHODILATING AGENT; CALCIUM; ETHANOLAMINE DERIVATIVE; INOSITOL 1,4,5 TRISPHOSPHATE;

AIRWAY CONTRACTION; AIRWAY RELAXATION; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; COMPETITIVE INHIBITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG INFLATION; LUNG PARENCHYMA; MUSCLE CONTRACTION; PHASE CONTRAST MICROSCOPY; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; RESPIRATORY FUNCTION; RESPIRATORY TRACT PARAMETERS; SENSITIVITY ANALYSIS; SMOOTH MUSCLE FIBER; ANIMAL; CHEMISTRY; CYTOLOGY; DRUG EFFECT; LUNG; METABOLISM; METHODOLOGY; OSCILLOMETRY; PATHOLOGY; SMOOTH MUSCLE;

ANIMALS; BRONCHODILATOR AGENTS; CALCIUM; CALCIUM SIGNALING; ETHANOLAMINES; HISTAMINE; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; LUNG; MICROSCOPY, PHASE-CONTRAST; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; OSCILLOMETRY; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL;

EID: 77955476124     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2009-0222OC     Document Type: Article

References (36)

1. Martin JG, Duguet A, Eidelman DH. The contribution of airway smooth muscle to airway narrowing and airway hyperresponsiveness in disease. Eur Respir J 2000;16:349-354. (Pubitemid 30624956)
2. Kamm KE, Stull JT. The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. Annu Rev Pharmacol Toxicol 1985;25:593-620. (Pubitemid 15090995)
3. 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 2003;83:1325-1358.
4. Gunst SJ, Tang DD. The contractile apparatus and mechanical properties of airway smooth muscle. Eur Respir J 2000;15:600-616. (Pubitemid 30158203)
5. Perez JF, Sanderson MJ. The frequency of calcium oscillations induced by 5-HT, ACH, and KCl determine the contraction of smooth muscle cells of intrapulmonary bronchioles. J Gen Physiol 2005;125:535-553. (Pubitemid 40994114)
6. 2+ oscillations and contraction in airway smooth muscle cells of mouse lung slices. Am J Physiol Lung Cell Mol Physiol 2002;283:L1271-L1279.
7. Bergner A, Sanderson MJ. Acetylcholine-induced calcium signaling and contraction of airway smooth muscle cells in lung slices. J Gen Physiol 2002;119:187-198. (Pubitemid 34522235)
8. 2+ sensitization. Am J Physiol Lung Cell Mol Physiol 2007;293:L1000-L1011.
9. 2+ sensitivity to the regulation of airway smooth muscle contraction is different in rats and mice. Am J Physiol Lung Cell Mol Physiol 2009;296:L947-L958.
10. 2+ sensitivity of airway smooth muscle cells in murine lung slices. Am J Physiol Lung Cell Mol Physiol 2006;291:L208-L221.
11. Wohlsen A, Martin C, Vollmer E, Branscheid D, Magnussen H, Becker WM, Lepp U, Uhlig S. The early allergic response in small airways of human precision-cut lung slices. Eur Respir J 2003;21:1024-1032. (Pubitemid 36675621)
12. Ressmeyer AR, Larsson AK, Vollmer E, Dahlen SE, Uhlig S, Martin C. Characterisation of guinea pig precision-cut lung slices: comparison with human tissues. Eur Respir J 2006;28:603-611. (Pubitemid 44794677)
13. Cooper PR, Panettieri RA Jr. Steroids completely reverse albuterol-induced beta(2)-adrenergic receptor tolerance in human small airways. J Allergy Clin Immunol 2008;122:734-740.
14. Sturton RG, Trifilieff A, Nicholson AG, Barnes PJ. Pharmacological characterization of indacaterol, a novel once daily inhaled 2 adrenoceptor agonist, on small airways in human and rat precision-cut lung slices. J Pharmacol Exp Ther 2008;324:270-275. (Pubitemid 350294169)
15. 3 receptor. Respir Res 2006;7:34.
16. Leybaert L, Sanderson MJ. Intercellular calcium signaling and flash photolysis of caged compounds: a sensitive method to evaluate gap junctional coupling. Methods Mol Biol 2001;154:407-430.
17. Koga Y, Ikebe M. p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA. J Biol Chem 2005;280:4983-4991. (Pubitemid 40288674)
18. Gould JM, Cather R, Winget GD. Advantages of the use of Cerenkov counting for determination of P32 in photophosphorylation research. Anal Biochem 1972;50:540-548.
19. Pearson RB, Jakes R, John M, Kendrick-Jones J, Kemp BE. Phosphorylation site sequence of smooth muscle myosin light chain (Mr = 20 000). FEBS Lett 1984;168:108-112.
20. 2+ signaling of small airways in mouse lung slices. Am J Respir Cell Mol Biol 2008;38:524-531.
21. Cooper PR, McParland BE, Mitchell HW, Noble PB, Politi AZ, Ressmeyer AR, West AR. Airway mechanics and methods used to visualize smooth muscle dynamics in vitro. Pulm Pharmacol Ther 2009;22;398-406.
22. 2+ signaling and sensitivity. Proc Am Thorac Soc 2008;5:23-31.
23. Somlyo AP, Somlyo AV. Signal transduction and regulation in smooth muscle. Nature 1994;372:231-236. (Pubitemid 24352442)
24. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 2003;4:517-529.
25. Prakash YS, Kannan MS, Sieck GC. Regulation of intracellular calcium oscillations in porcine tracheal smooth muscle cells. Am J Physiol 1997;272:C966-C975. (Pubitemid 27146712)
26. Dai JM, Kuo KH, Leo JM, Pare PD, van Breemen C, Lee CH. Acetylcholine-induced asynchronous calcium waves in intact human bronchial muscle bundle. Am J Respir Cell Mol Biol 2007;36:600-608.
27. 2+ signaling of smooth muscle cells in different generations of mouse airways. Am J Respir Cell Mol Biol 2007;36:122-130.
28. Held HD, Martin C, Uhlig S. Characterization of airway and vascular responses in murine lungs. Br J Pharmacol 1999;126:1191-1199. (Pubitemid 29123755)
29. 2+ oscillations of porcine tracheal smooth muscle. Am J Physiol 1997;272:L659-L664.
30. 2+ signaling contributes to airway smooth muscle hyper-responsiveness. FASEB J 2003;17:452-454.
31. Deshpande DA, White TA, Dogan S, Walseth TF, Panettieri RA, Kannan MS. CD38/cyclic ADP-ribose signaling: role in the regulation of calcium homeostasis in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2005;288:L773-L788. (Pubitemid 40547901)
32. 2+ signaling of airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2009;297:L347-L361.
33. Derom EY, Pauwels RA. Time course of bronchodilating effect of inhaled formoterol, a potent and long acting sympathomimetic. Thorax 1992;47:30-33.
34. Kips JC, Pauwels RA. Long-acting inhaled beta(2)-agonist therapy in asthma. Am J Respir Crit Care Med 2001;164:923-932.
35. 2+ signaling of mouse airway smooth muscle cells. Am J Respir Cell Mol Biol 2010;42:373-381.
36. Wang I, Politi AZ, Tania N, Bai Y, Sanderson MJ, Sneyd J. A mathematical model of airway and pulmonary arteriole smooth muscle. Biophys J 2008;94:2053-2064.