Conopeptide p-tia defines a new allosteric site on the extracellular surface of the α1b-adrenoceptor

Journal of Biological Chemistry

Volumn 288, Issue 3, 2013, Pages 1814-1827

  Ragnarsson, Lotten ^a   Wang, Ching I Anderson ^a   Andersson, Asa ^a   Fajarningsih, Dewi ^a   Monks, Thea ^a   Brust, Andreas ^a   Rosengren, K Johan ^a   Lewis, Richard J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTORS; ALLOSTERIC INHIBITOR; ALLOSTERIC MODULATION; ALLOSTERIC MODULATORS; ALLOSTERIC SITE; CLASS A; CONOPEPTIDES; DOUBLE MUTANTS; DRUG TARGETS; EXTRACELLULAR; EXTRACELLULAR LOOPS; EXTRACELLULAR STIMULI; G-PROTEIN COUPLED RECEPTORS; MEMBRANE RECEPTORS; MOLECULAR DOCKING SIMULATIONS; PEPTIDE BINDING; PHARMACOPHORES; POSITIVELY CHARGED; RADIOLIGAND BINDING; SALT BRIDGES; STRUCTURAL CONSTRAINTS; SURFACE RESIDUES; TRANSMEMBRANE HELICES;

DESIGN; ENZYME INHIBITION; HYDROGEN BONDS; PHARMACODYNAMICS; SUGARS;

ENZYME ACTIVITY;

ALPHA 1B ADRENERGIC RECEPTOR; ARGININE; ASPARAGINE; ASPARTIC ACID; BETA 1 ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUTAMINE; INOSITOL PHOSPHATE; MEMBRANE PROTEIN; PHENYLALANINE; PRAZOSIN; PROTEIN RHO TIA; SERINE; TRYPTOPHAN; UNCLASSIFIED DRUG; VALINE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; AMINO ACID; PEPTIDE; RECOMBINANT PROTEIN;

ALLOSTERISM; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; CRYSTAL STRUCTURE; EXTRACELLULAR SURFACE; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR INTERACTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; GENETICS; HAMSTER; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEAR MAGNETIC RESONANCE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; RAT; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION; TURKEY (BIRD);

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ALLOSTERIC SITE; AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; COMPUTER SIMULATION; CRICETINAE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TURKEYS;

MLCS; MLOWN;

EID: 84872689496     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.430785     Document Type: Article

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