Structural model of ligand-G protein-coupled receptor (GPCR) complex based on experimental double mutant cycle data: MT7 snake toxin bound to dimeric hM1 muscarinic receptor

Journal of Biological Chemistry

Volumn 286, Issue 36, 2011, Pages 31661-31675

  Marquer, Catherine ^b,d   Fruchart Gaillard, Carole ^b   Letellier, Guillaume ^a   Marcon, Elodie ^b   Mourier, Gilles ^b   Zinn Justin, Sophie ^a   Ménez, André ^c   Servent, Denis ^b   Gilquin, Bernard ^a,b  

^a CNRS   (France)

^b SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^c MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITIES; DIMER COMPLEXES; DOCKING CALCULATIONS; DOUBLE MUTANTS; EXPLICIT SOLVENTS; EXTRACELLULAR; EXTRACELLULAR LOOPS; FLEXIBLE DOCKING; G PROTEIN COUPLED RECEPTORS; HIGH AFFINITY; LIGAND-RECEPTOR; MUSCARINIC RECEPTOR; PROTEIN COUPLED RECEPTORS; STRUCTURAL MODELS; TRANSMEMBRANE HELICES;

BINDING ENERGY; CONFORMATIONS; DIMERS; LIGANDS; MODEL STRUCTURES;

TOXIC MATERIALS;

G PROTEIN COUPLED RECEPTOR; MUSCARINIC M1 RECEPTOR; SNAKE VENOM; SOLVENT;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; MATHEMATICAL COMPUTING; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING;

ANIMALS; COMPUTER SIMULATION; ELAPID VENOMS; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RECEPTOR, MUSCARINIC M1; RECEPTORS, G-PROTEIN-COUPLED;

EID: 80052415753     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.261404     Document Type: Article

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