χ-conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain

Journal of Medicinal Chemistry

Volumn 52, Issue 22, 2009, Pages 6991-7002

  Brust, Andreas ^a   Palant, Elka ^a   Croker, Daniel E ^a   Colless, Barbara ^a   Drinkwater, Roger ^a   Patterson, Brad ^a   Schroeder, Christina I ^b   Wilson, David ^a   Nielsen, Carsten K ^b   Smith, Maree T ^b   Alewood, Dianne ^a   Alewood, Paul F ^b   Lewis, Richard J ^a,b  

^a Xenome Ltd   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; LEUCINE; LYSINE; NORADRENALIN TRANSPORTER; NORADRENALIN UPTAKE INHIBITOR; TYROSINE; UNCLASSIFIED DRUG; XEN 2174;

ALLODYNIA; ALLOSTERISM; ANIMAL EXPERIMENT; ARTICLE; DRUG BINDING; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MARINE SNAIL; NEUROPATHIC PAIN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PHARMACOPHORE; RAT; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; CONOTOXINS; COS CELLS; DRUG DISCOVERY; DRUG STABILITY; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PAIN; PEPTIDES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 70949099866     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9003413     Document Type: Article

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