메뉴 건너뛰기




Volumn 1830, Issue 2, 2013, Pages 2345-2353

DNA double-strand break response in stem cells: Mechanisms to maintain genomic integrity

Author keywords

DNA damage; Double strand break repair; Embryonic stem cell; Induced pluripotent stem cell

Indexed keywords

ATM PROTEIN; BRCA1 PROTEIN; CHECKPOINT KINASE 2; HISTONE H2AX; KRUPPEL LIKE FACTOR 4; MEDIATOR OF DNA DAMAGE CHECKPOINT PROTEIN 1; MEIOTIC RECOMBINASE 11; MYC PROTEIN; NIBRIN; NUCLEAR PROTEIN; PROTEIN P53; REACTIVE OXYGEN METABOLITE; RECOMBINASE; REPLICATION FACTOR A; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG; XRCC4 PROTEIN;

EID: 84872495141     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2012.09.001     Document Type: Review
Times cited : (65)

References (127)
  • 1
    • 39149086121 scopus 로고    scopus 로고
    • Stems cells and the pathways to aging and cancer
    • D.J. Rossi, C.H. Jamieson, and I.L. Weissman Stems cells and the pathways to aging and cancer Cell 132 2008 681 696
    • (2008) Cell , vol.132 , pp. 681-696
    • Rossi, D.J.1    Jamieson, C.H.2    Weissman, I.L.3
  • 3
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • K.K. Khanna, and S.P. Jackson DNA double-strand breaks: signaling, repair and the cancer connection Nat. Genet. 27 2001 247 254
    • (2001) Nat. Genet. , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 4
    • 36749022214 scopus 로고    scopus 로고
    • The DNA damage response: Ten years after
    • J.W. Harper, and S.J. Elledge The DNA damage response: ten years after Mol. Cell 28 2007 739 745
    • (2007) Mol. Cell , vol.28 , pp. 739-745
    • Harper, J.W.1    Elledge, S.J.2
  • 5
    • 0029892791 scopus 로고    scopus 로고
    • DNA repair in eukaryotes
    • R.D. Wood DNA repair in eukaryotes Annu. Rev. Biochem. 65 1996 135 167
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 135-167
    • Wood, R.D.1
  • 6
    • 0033815382 scopus 로고    scopus 로고
    • Review of mammalian DNA repair and translational implications
    • W.K. Hansen, and M.R. Kelley Review of mammalian DNA repair and translational implications J. Pharmacol. Exp. Ther. 295 2000 1 9
    • (2000) J. Pharmacol. Exp. Ther. , vol.295 , pp. 1-9
    • Hansen, W.K.1    Kelley, M.R.2
  • 7
    • 39449085063 scopus 로고    scopus 로고
    • DNA-damage repair; The good, the bad, and the ugly
    • R. Hakem DNA-damage repair; the good, the bad, and the ugly EMBO J. 27 2008 589 605
    • (2008) EMBO J. , vol.27 , pp. 589-605
    • Hakem, R.1
  • 8
    • 0033520969 scopus 로고    scopus 로고
    • Quality control by DNA repair
    • T. Lindahl, and R.D. Wood Quality control by DNA repair Science 286 1999 1897 1905
    • (1999) Science , vol.286 , pp. 1897-1905
    • Lindahl, T.1    Wood, R.D.2
  • 9
    • 38049024575 scopus 로고    scopus 로고
    • The role of DNA damage repair in aging of adult stem cells
    • J. Kenyon, and S.L. Gerson The role of DNA damage repair in aging of adult stem cells Nucleic Acids Res. 35 2007 7557 7565
    • (2007) Nucleic Acids Res. , vol.35 , pp. 7557-7565
    • Kenyon, J.1    Gerson, S.L.2
  • 10
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 11
    • 80052488381 scopus 로고    scopus 로고
    • Mechanisms maintaining genomic integrity in embryonic stem cells and induced pluripotent stem cells
    • E.D. Tichy Mechanisms maintaining genomic integrity in embryonic stem cells and induced pluripotent stem cells Exp. Biol. Med. (Maywood) 236 2011 987 996
    • (2011) Exp. Biol. Med. (Maywood) , vol.236 , pp. 987-996
    • Tichy, E.D.1
  • 13
    • 30444461346 scopus 로고    scopus 로고
    • Cell cycle control of embryonic stem cells
    • J. White, and S. Dalton Cell cycle control of embryonic stem cells Stem Cell Rev. 1 2005 131 138
    • (2005) Stem Cell Rev. , vol.1 , pp. 131-138
    • White, J.1    Dalton, S.2
  • 14
    • 19944426528 scopus 로고    scopus 로고
    • Karyotypic stability, genotyping, differentiation, feeder-free maintenance, and gene expression sampling in three human embryonic stem cell lines derived prior to August 9, 2001
    • S.N. Brimble, X. Zeng, D.A. Weiler, Y. Luo, Y. Liu, I.G. Lyons, W.J. Freed, A.J. Robins, M.S. Rao, and T.C. Schulz Karyotypic stability, genotyping, differentiation, feeder-free maintenance, and gene expression sampling in three human embryonic stem cell lines derived prior to August 9, 2001 Stem Cells Dev. 13 2004 585 597
    • (2004) Stem Cells Dev. , vol.13 , pp. 585-597
    • Brimble, S.N.1    Zeng, X.2    Weiler, D.A.3    Luo, Y.4    Liu, Y.5    Lyons, I.G.6    Freed, W.J.7    Robins, A.J.8    Rao, M.S.9    Schulz, T.C.10
  • 16
    • 23844444042 scopus 로고    scopus 로고
    • Characterization and culture of human embryonic stem cells
    • L.M. Hoffman, and M.K. Carpenter Characterization and culture of human embryonic stem cells Nat. Biotechnol. 23 2005 699 708
    • (2005) Nat. Biotechnol. , vol.23 , pp. 699-708
    • Hoffman, L.M.1    Carpenter, M.K.2
  • 21
    • 0031239635 scopus 로고    scopus 로고
    • The chromosome make-up of mouse embryonic stem cells is predictive of somatic and germ cell chimaerism
    • L. Longo, A. Bygrave, F.G. Grosveld, and P.P. Pandolfi The chromosome make-up of mouse embryonic stem cells is predictive of somatic and germ cell chimaerism Transgenic Res. 6 1997 321 328
    • (1997) Transgenic Res. , vol.6 , pp. 321-328
    • Longo, L.1    Bygrave, A.2    Grosveld, F.G.3    Pandolfi, P.P.4
  • 25
    • 74849135201 scopus 로고    scopus 로고
    • The tumorigenicity of diploid and aneuploid human pluripotent stem cells
    • B. Blum, and N. Benvenisty The tumorigenicity of diploid and aneuploid human pluripotent stem cells Cell Cycle 8 2009 3822 3830
    • (2009) Cell Cycle , vol.8 , pp. 3822-3830
    • Blum, B.1    Benvenisty, N.2
  • 26
    • 79960274488 scopus 로고    scopus 로고
    • Human induced pluripotent cells resemble embryonic stem cells demonstrating enhanced levels of DNA repair and efficacy of nonhomologous end-joining
    • J. Fan, C. Robert, Y.Y. Jang, H. Liu, S. Sharkis, S.B. Baylin, and F.V. Rassool Human induced pluripotent cells resemble embryonic stem cells demonstrating enhanced levels of DNA repair and efficacy of nonhomologous end-joining Mutat. Res. 713 2011 8 17
    • (2011) Mutat. Res. , vol.713 , pp. 8-17
    • Fan, J.1    Robert, C.2    Jang, Y.Y.3    Liu, H.4    Sharkis, S.5    Baylin, S.B.6    Rassool, F.V.7
  • 27
    • 79959688280 scopus 로고    scopus 로고
    • Cell cycle adaptations and maintenance of genomic integrity in embryonic stem cells and induced pluripotent stem cells
    • O. Momcilovic, C. Navara, and G. Schatten Cell cycle adaptations and maintenance of genomic integrity in embryonic stem cells and induced pluripotent stem cells Results Probl. Cell Differ. 53 2011 415 458
    • (2011) Results Probl. Cell Differ. , vol.53 , pp. 415-458
    • Momcilovic, O.1    Navara, C.2    Schatten, G.3
  • 30
    • 78650134111 scopus 로고    scopus 로고
    • Genetic instability in human induced pluripotent stem cells: Classification of causes and possible safeguards
    • U. Ben-David, N. Benvenisty, and Y. Mayshar Genetic instability in human induced pluripotent stem cells: classification of causes and possible safeguards Cell Cycle 9 2010 4603 4604
    • (2010) Cell Cycle , vol.9 , pp. 4603-4604
    • Ben-David, U.1    Benvenisty, N.2    Mayshar, Y.3
  • 32
    • 84859503582 scopus 로고    scopus 로고
    • High prevalence of evolutionarily-conserved and species-specific genomic aberrations in mouse pluripotent stem cells
    • U. Ben-David, and N. Benvenisty High prevalence of evolutionarily- conserved and species-specific genomic aberrations in mouse pluripotent stem cells Stem Cells 30 2012 612 622
    • (2012) Stem Cells , vol.30 , pp. 612-622
    • Ben-David, U.1    Benvenisty, N.2
  • 33
    • 56749184298 scopus 로고    scopus 로고
    • Reflecting on 25 years with MYC
    • N. Meyer, and L.Z. Penn Reflecting on 25 years with MYC Nat. Rev. Cancer 8 2008 976 990
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 976-990
    • Meyer, N.1    Penn, L.Z.2
  • 34
    • 30144440248 scopus 로고    scopus 로고
    • The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene
    • B.D. Rowland, R. Bernards, and D.S. Peeper The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene Nat. Cell Biol. 7 2005 1074 1082
    • (2005) Nat. Cell Biol. , vol.7 , pp. 1074-1082
    • Rowland, B.D.1    Bernards, R.2    Peeper, D.S.3
  • 36
    • 0027756119 scopus 로고
    • Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits
    • B. Fischer, and B.D. Bavister Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits J. Reprod. Fertil. 99 1993 673 679
    • (1993) J. Reprod. Fertil. , vol.99 , pp. 673-679
    • Fischer, B.1    Bavister, B.D.2
  • 37
    • 41149115123 scopus 로고    scopus 로고
    • The role of oxygen availability in embryonic development and stem cell function
    • M.C. Simon, and B. Keith The role of oxygen availability in embryonic development and stem cell function Nat. Rev. Mol. Cell Biol. 9 2008 285 296
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 285-296
    • Simon, M.C.1    Keith, B.2
  • 38
    • 16344380951 scopus 로고    scopus 로고
    • Low O2 tensions and the prevention of differentiation of hES cells
    • T. Ezashi, P. Das, and R.M. Roberts Low O2 tensions and the prevention of differentiation of hES cells Proc. Natl. Acad. Sci. U. S. A. 102 2005 4783 4788
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 4783-4788
    • Ezashi, T.1    Das, P.2    Roberts, R.M.3
  • 39
    • 8644232705 scopus 로고    scopus 로고
    • Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells
    • G. Saretzki, L. Armstrong, A. Leake, M. Lako, and T. von Zglinicki Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells Stem Cells 22 2004 962 971
    • (2004) Stem Cells , vol.22 , pp. 962-971
    • Saretzki, G.1    Armstrong, L.2    Leake, A.3    Lako, M.4    Von Zglinicki, T.5
  • 40
    • 27744563079 scopus 로고    scopus 로고
    • The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells
    • J.C. St John, J. Ramalho-Santos, H.L. Gray, P. Petrosko, V.Y. Rawe, C.S. Navara, C.R. Simerly, and G.P. Schatten The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells Cloning Stem Cells 7 2005 141 153
    • (2005) Cloning Stem Cells , vol.7 , pp. 141-153
    • St John, J.C.1    Ramalho-Santos, J.2    Gray, H.L.3    Petrosko, P.4    Rawe, V.Y.5    Navara, C.S.6    Simerly, C.R.7    Schatten, G.P.8
  • 41
    • 77951002352 scopus 로고    scopus 로고
    • The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells
    • A. Prigione, B. Fauler, R. Lurz, H. Lehrach, and J. Adjaye The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells Stem Cells 28 2010 721 733
    • (2010) Stem Cells , vol.28 , pp. 721-733
    • Prigione, A.1    Fauler, B.2    Lurz, R.3    Lehrach, H.4    Adjaye, J.5
  • 42
    • 78149408058 scopus 로고    scopus 로고
    • Empowering self-renewal and differentiation: The role of mitochondria in stem cells
    • J. Rehman Empowering self-renewal and differentiation: the role of mitochondria in stem cells J. Mol. Med. (Berl.) 88 2010 981 986
    • (2010) J. Mol. Med. (Berl.) , vol.88 , pp. 981-986
    • Rehman, J.1
  • 43
    • 79953000879 scopus 로고    scopus 로고
    • Mitochondrial function controls proliferation and early differentiation potential of embryonic stem cells
    • S. Mandal, A.G. Lindgren, A.S. Srivastava, A.T. Clark, and U. Banerjee Mitochondrial function controls proliferation and early differentiation potential of embryonic stem cells Stem Cells 29 2011 486 495
    • (2011) Stem Cells , vol.29 , pp. 486-495
    • Mandal, S.1    Lindgren, A.G.2    Srivastava, A.S.3    Clark, A.T.4    Banerjee, U.5
  • 44
    • 79952235291 scopus 로고    scopus 로고
    • Dynamics of DNA damage response proteins at DNA breaks: A focus on protein modifications
    • S.E. Polo, and S.P. Jackson Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications Genes Dev. 25 2011 409 433
    • (2011) Genes Dev. , vol.25 , pp. 409-433
    • Polo, S.E.1    Jackson, S.P.2
  • 45
    • 47749141560 scopus 로고    scopus 로고
    • ATR: An essential regulator of genome integrity
    • K.A. Cimprich, and D. Cortez ATR: an essential regulator of genome integrity Nat. Rev. Mol. Cell Biol. 9 2008 616 627
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 46
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    • J. Falck, J. Coates, and S.P. Jackson Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage Nature 434 2005 605 611
    • (2005) Nature , vol.434 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 48
    • 0033538496 scopus 로고    scopus 로고
    • The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage
    • Z. Dong, Q. Zhong, and P.L. Chen The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage J. Biol. Chem. 274 1999 19513 19516
    • (1999) J. Biol. Chem. , vol.274 , pp. 19513-19516
    • Dong, Z.1    Zhong, Q.2    Chen, P.L.3
  • 49
    • 38049059966 scopus 로고    scopus 로고
    • DNA damage, cellular senescence and organismal ageing: Causal or correlative?
    • J.H. Chen, C.N. Hales, and S.E. Ozanne DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res. 35 2007 7417 7428
    • (2007) Nucleic Acids Res. , vol.35 , pp. 7417-7428
    • Chen, J.H.1    Hales, C.N.2    Ozanne, S.E.3
  • 51
    • 70349438994 scopus 로고    scopus 로고
    • Tumour suppression by p53: A role for the DNA damage response?
    • D.W. Meek Tumour suppression by p53: a role for the DNA damage response? Nat. Rev. Cancer 9 2009 714 723
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 714-723
    • Meek, D.W.1
  • 54
    • 3042685445 scopus 로고    scopus 로고
    • Phosphorylation of histone H2B at DNA double-strand breaks
    • O. Fernandez-Capetillo, C.D. Allis, and A. Nussenzweig Phosphorylation of histone H2B at DNA double-strand breaks J. Exp. Med. 199 2004 1671 1677
    • (2004) J. Exp. Med. , vol.199 , pp. 1671-1677
    • Fernandez-Capetillo, O.1    Allis, C.D.2    Nussenzweig, A.3
  • 55
    • 20444391346 scopus 로고    scopus 로고
    • Chromatin in need of a fix: Phosphorylation of H2AX connects chromatin to DNA repair
    • C. Thiriet, and J.J. Hayes Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repair Mol. Cell 18 2005 617 622
    • (2005) Mol. Cell , vol.18 , pp. 617-622
    • Thiriet, C.1    Hayes, J.J.2
  • 56
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • E.P. Rogakou, C. Boon, C. Redon, and W.M. Bonner Megabase chromatin domains involved in DNA double-strand breaks in vivo J. Cell Biol. 146 1999 905 916
    • (1999) J. Cell Biol. , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 57
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • T.T. Paull, E.P. Rogakou, V. Yamazaki, C.U. Kirchgessner, M. Gellert, and W.M. Bonner A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage Curr. Biol. 10 2000 886 895
    • (2000) Curr. Biol. , vol.10 , pp. 886-895
    • Paull, T.T.1    Rogakou, E.P.2    Yamazaki, V.3    Kirchgessner, C.U.4    Gellert, M.5    Bonner, W.M.6
  • 59
    • 0038496703 scopus 로고    scopus 로고
    • Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control
    • Z. Lou, C.C. Chini, K. Minter-Dykhouse, and J. Chen Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control J. Biol. Chem. 278 2003 13599 13602
    • (2003) J. Biol. Chem. , vol.278 , pp. 13599-13602
    • Lou, Z.1    Chini, C.C.2    Minter-Dykhouse, K.3    Chen, J.4
  • 61
    • 78149468116 scopus 로고    scopus 로고
    • Targeting abnormal DNA double strand break repair in cancer
    • F.V. Rassool, and A.E. Tomkinson Targeting abnormal DNA double strand break repair in cancer Cell. Mol. Life Sci. 67 2010 3699 3710
    • (2010) Cell. Mol. Life Sci. , vol.67 , pp. 3699-3710
    • Rassool, F.V.1    Tomkinson, A.E.2
  • 62
    • 51849121635 scopus 로고    scopus 로고
    • DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells
    • Z. Mao, M. Bozzella, A. Seluanov, and V. Gorbunova DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells Cell Cycle 7 2008 2902 2906
    • (2008) Cell Cycle , vol.7 , pp. 2902-2906
    • Mao, Z.1    Bozzella, M.2    Seluanov, A.3    Gorbunova, V.4
  • 64
    • 77449086623 scopus 로고    scopus 로고
    • DNA resection in eukaryotes: Deciding how to fix the break
    • P. Huertas DNA resection in eukaryotes: deciding how to fix the break Nat. Struct. Mol. Biol. 17 2010 11 16
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 11-16
    • Huertas, P.1
  • 66
    • 33746189731 scopus 로고    scopus 로고
    • CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing
    • M.I. Petalcorin, J. Sandall, D.B. Wigley, and S.J. Boulton CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing J. Mol. Biol. 361 2006 231 242
    • (2006) J. Mol. Biol. , vol.361 , pp. 231-242
    • Petalcorin, M.I.1    Sandall, J.2    Wigley, D.B.3    Boulton, S.J.4
  • 68
    • 0037468267 scopus 로고    scopus 로고
    • BRCA2-dependent and independent formation of RAD51 nuclear foci
    • M. Tarsounas, D. Davies, and S.C. West BRCA2-dependent and independent formation of RAD51 nuclear foci Oncogene 22 2003 1115 1123
    • (2003) Oncogene , vol.22 , pp. 1115-1123
    • Tarsounas, M.1    Davies, D.2    West, S.C.3
  • 70
    • 14144253224 scopus 로고    scopus 로고
    • The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction
    • H. Yang, Q. Li, J. Fan, W.K. Holloman, and N.P. Pavletich The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction Nature 433 2005 653 657
    • (2005) Nature , vol.433 , pp. 653-657
    • Yang, H.1    Li, Q.2    Fan, J.3    Holloman, W.K.4    Pavletich, N.P.5
  • 71
    • 0027156140 scopus 로고
    • EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA
    • M. Falzon, J.W. Fewell, and E.L. Kuff EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA J. Biol. Chem. 268 1993 10546 10552
    • (1993) J. Biol. Chem. , vol.268 , pp. 10546-10552
    • Falzon, M.1    Fewell, J.W.2    Kuff, E.L.3
  • 72
    • 0027397867 scopus 로고
    • The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
    • T.M. Gottlieb, and S.P. Jackson The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen Cell 72 1993 131 142
    • (1993) Cell , vol.72 , pp. 131-142
    • Gottlieb, T.M.1    Jackson, S.P.2
  • 73
    • 0022827675 scopus 로고
    • Mechanism of interaction between Ku protein and DNA
    • T. Mimori, and J.A. Hardin Mechanism of interaction between Ku protein and DNA J. Biol. Chem. 261 1986 10375 10379
    • (1986) J. Biol. Chem. , vol.261 , pp. 10375-10379
    • Mimori, T.1    Hardin, J.A.2
  • 74
    • 0033583204 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA
    • P. Calsou, P. Frit, O. Humbert, C. Muller, D.J. Chen, and B. Salles The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA J. Biol. Chem. 274 1999 7848 7856
    • (1999) J. Biol. Chem. , vol.274 , pp. 7848-7856
    • Calsou, P.1    Frit, P.2    Humbert, O.3    Muller, C.4    Chen, D.J.5    Salles, B.6
  • 76
    • 0022256461 scopus 로고
    • Mechanisms of nonhomologous recombination in mammalian cells
    • D.B. Roth, T.N. Porter, and J.H. Wilson Mechanisms of nonhomologous recombination in mammalian cells Mol. Cell. Biol. 5 1985 2599 2607
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 2599-2607
    • Roth, D.B.1    Porter, T.N.2    Wilson, J.H.3
  • 77
    • 0022976432 scopus 로고
    • Nonhomologous recombination in mammalian cells: Role for short sequence homologies in the joining reaction
    • D.B. Roth, and J.H. Wilson Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction Mol. Cell. Biol. 6 1986 4295 4304
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 4295-4304
    • Roth, D.B.1    Wilson, J.H.2
  • 78
    • 35348821296 scopus 로고    scopus 로고
    • A backup DNA repair pathway moves to the forefront
    • A. Nussenzweig, and M.C. Nussenzweig A backup DNA repair pathway moves to the forefront Cell 131 2007 223 225
    • (2007) Cell , vol.131 , pp. 223-225
    • Nussenzweig, A.1    Nussenzweig, M.C.2
  • 79
    • 79956220705 scopus 로고    scopus 로고
    • Choosing the right path: Does DNA-PK help make the decision?
    • J.A. Neal, and K. Meek Choosing the right path: does DNA-PK help make the decision? Mutat. Res. 711 2011 73 86
    • (2011) Mutat. Res. , vol.711 , pp. 73-86
    • Neal, J.A.1    Meek, K.2
  • 80
    • 0036864626 scopus 로고    scopus 로고
    • Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination
    • M. Frank-Vaillant, and S. Marcand Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination Mol. Cell 10 2002 1189 1199
    • (2002) Mol. Cell , vol.10 , pp. 1189-1199
    • Frank-Vaillant, M.1    Marcand, S.2
  • 81
    • 0037133699 scopus 로고    scopus 로고
    • DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination
    • C. Allen, A. Kurimasa, M.A. Brenneman, D.J. Chen, and J.A. Nickoloff DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination Proc. Natl. Acad. Sci. U. S. A. 99 2002 3758 3763
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 3758-3763
    • Allen, C.1    Kurimasa, A.2    Brenneman, M.A.3    Chen, D.J.4    Nickoloff, J.A.5
  • 82
    • 0035893363 scopus 로고    scopus 로고
    • Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
    • A.J. Pierce, P. Hu, M. Han, N. Ellis, and M. Jasin Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells Genes Dev. 15 2001 3237 3242
    • (2001) Genes Dev. , vol.15 , pp. 3237-3242
    • Pierce, A.J.1    Hu, P.2    Han, M.3    Ellis, N.4    Jasin, M.5
  • 83
    • 23744447715 scopus 로고    scopus 로고
    • Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells
    • J.S. Kim, T.B. Krasieva, H. Kurumizaka, D.J. Chen, A.M. Taylor, and K. Yokomori Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells J. Cell Biol. 170 2005 341 347
    • (2005) J. Cell Biol. , vol.170 , pp. 341-347
    • Kim, J.S.1    Krasieva, T.B.2    Kurumizaka, H.3    Chen, D.J.4    Taylor, A.M.5    Yokomori, K.6
  • 84
    • 0028577296 scopus 로고
    • Spontaneous and restriction enzyme-induced chromosomal recombination in mammalian cells
    • A.R. Godwin, R.J. Bollag, D.M. Christie, and R.M. Liskay Spontaneous and restriction enzyme-induced chromosomal recombination in mammalian cells Proc. Natl. Acad. Sci. U. S. A. 91 1994 12554 12558
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 12554-12558
    • Godwin, A.R.1    Bollag, R.J.2    Christie, D.M.3    Liskay, R.M.4
  • 85
    • 0028575712 scopus 로고
    • Repair of a specific double-strand break generated within a mammalian chromosome by yeast endonuclease I-SceI
    • T. Lukacsovich, D. Yang, and A.S. Waldman Repair of a specific double-strand break generated within a mammalian chromosome by yeast endonuclease I-SceI Nucleic Acids Res. 22 1994 5649 5657
    • (1994) Nucleic Acids Res. , vol.22 , pp. 5649-5657
    • Lukacsovich, T.1    Yang, D.2    Waldman, A.S.3
  • 86
    • 0032576768 scopus 로고    scopus 로고
    • ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage
    • M.I. Aladjem, B.T. Spike, L.W. Rodewald, T.J. Hope, M. Klemm, R. Jaenisch, and G.M. Wahl ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage Curr. Biol. 8 1998 145 155
    • (1998) Curr. Biol. , vol.8 , pp. 145-155
    • Aladjem, M.I.1    Spike, B.T.2    Rodewald, L.W.3    Hope, T.J.4    Klemm, M.5    Jaenisch, R.6    Wahl, G.M.7
  • 87
    • 13944273471 scopus 로고    scopus 로고
    • P53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression
    • T. Lin, C. Chao, S. Saito, S.J. Mazur, M.E. Murphy, E. Appella, and Y. Xu p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression Nat. Cell Biol. 7 2005 165 171
    • (2005) Nat. Cell Biol. , vol.7 , pp. 165-171
    • Lin, T.1    Chao, C.2    Saito, S.3    Mazur, S.J.4    Murphy, M.E.5    Appella, E.6    Xu, Y.7
  • 90
    • 5144231886 scopus 로고    scopus 로고
    • Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation
    • Y. Hong, and P.J. Stambrook Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation Proc. Natl. Acad. Sci. U. S. A. 101 2004 14443 14448
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 14443-14448
    • Hong, Y.1    Stambrook, P.J.2
  • 91
    • 73049105546 scopus 로고    scopus 로고
    • Modeling disease in human ESCs using an efficient BAC-based homologous recombination system
    • H. Song, S.K. Chung, and Y. Xu Modeling disease in human ESCs using an efficient BAC-based homologous recombination system Cell Stem Cell 6 2010 80 89
    • (2010) Cell Stem Cell , vol.6 , pp. 80-89
    • Song, H.1    Chung, S.K.2    Xu, Y.3
  • 93
    • 69249126660 scopus 로고    scopus 로고
    • Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells
    • O. Momcilovic, S. Choi, S. Varum, C. Bakkenist, G. Schatten, and C. Navara Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells Stem Cells 27 2009 1822 1835
    • (2009) Stem Cells , vol.27 , pp. 1822-1835
    • Momcilovic, O.1    Choi, S.2    Varum, S.3    Bakkenist, C.4    Schatten, G.5    Navara, C.6
  • 94
    • 77956327999 scopus 로고    scopus 로고
    • Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants
    • B.R. Adams, S.E. Golding, R.R. Rao, and K. Valerie Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants PLoS One 5 2010 e10001
    • (2010) PLoS One , vol.5 , pp. 10001
    • Adams, B.R.1    Golding, S.E.2    Rao, R.R.3    Valerie, K.4
  • 96
    • 51849165629 scopus 로고    scopus 로고
    • Activation of DNA damage response signaling in mouse embryonic stem cells
    • I.A. Chuykin, M.S. Lianguzova, T.V. Pospelova, and V.A. Pospelov Activation of DNA damage response signaling in mouse embryonic stem cells Cell Cycle 7 2008 2922 2928
    • (2008) Cell Cycle , vol.7 , pp. 2922-2928
    • Chuykin, I.A.1    Lianguzova, M.S.2    Pospelova, T.V.3    Pospelov, V.A.4
  • 97
    • 26444603774 scopus 로고    scopus 로고
    • Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells
    • L. Jirmanova, D.V. Bulavin, and A.J. Fornace Jr. Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells Cell Cycle 4 2005 1428 1434
    • (2005) Cell Cycle , vol.4 , pp. 1428-1434
    • Jirmanova, L.1    Bulavin, D.V.2    Fornace Jr., A.J.3
  • 99
    • 0029909565 scopus 로고    scopus 로고
    • A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53
    • D.S. Lim, and P. Hasty A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53 Mol. Cell. Biol. 16 1996 7133 7143
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 7133-7143
    • Lim, D.S.1    Hasty, P.2
  • 100
    • 0035936554 scopus 로고    scopus 로고
    • Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice
    • J. Zhu, S. Petersen, L. Tessarollo, and A. Nussenzweig Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice Curr. Biol. 11 2001 105 109
    • (2001) Curr. Biol. , vol.11 , pp. 105-109
    • Zhu, J.1    Petersen, S.2    Tessarollo, L.3    Nussenzweig, A.4
  • 101
    • 0030749867 scopus 로고    scopus 로고
    • Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
    • Y. Xiao, and D.T. Weaver Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells Nucleic Acids Res. 25 1997 2985 2991
    • (1997) Nucleic Acids Res. , vol.25 , pp. 2985-2991
    • Xiao, Y.1    Weaver, D.T.2
  • 102
    • 0033594904 scopus 로고    scopus 로고
    • Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
    • G. Luo, M.S. Yao, C.F. Bender, M. Mills, A.R. Bladl, A. Bradley, and J.H. Petrini Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation Proc. Natl. Acad. Sci. U. S. A. 96 1999 7376 7381
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 7376-7381
    • Luo, G.1    Yao, M.S.2    Bender, C.F.3    Mills, M.4    Bladl, A.R.5    Bradley, A.6    Petrini, J.H.7
  • 105
    • 78049381196 scopus 로고    scopus 로고
    • Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks
    • E.D. Tichy, R. Pillai, L. Deng, L. Liang, J. Tischfield, S.J. Schwemberger, G.F. Babcock, and P.J. Stambrook Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks Stem Cells Dev. 19 2010 1699 1711
    • (2010) Stem Cells Dev. , vol.19 , pp. 1699-1711
    • Tichy, E.D.1    Pillai, R.2    Deng, L.3    Liang, L.4    Tischfield, J.5    Schwemberger, S.J.6    Babcock, G.F.7    Stambrook, P.J.8
  • 106
    • 78951484462 scopus 로고    scopus 로고
    • Homologous recombination conserves DNA sequence integrity throughout the cell cycle in embryonic stem cells
    • L. Serrano, L. Liang, Y. Chang, L. Deng, C. Maulion, S. Nguyen, and J.A. Tischfield Homologous recombination conserves DNA sequence integrity throughout the cell cycle in embryonic stem cells Stem Cells Dev. 20 2011 363 374
    • (2011) Stem Cells Dev. , vol.20 , pp. 363-374
    • Serrano, L.1    Liang, L.2    Chang, Y.3    Deng, L.4    Maulion, C.5    Nguyen, S.6    Tischfield, J.A.7
  • 108
    • 79952114962 scopus 로고    scopus 로고
    • ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells
    • B.R. Adams, A.J. Hawkins, L.F. Povirk, and K. Valerie ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells Aging (Albany NY) 2 2010 582 596
    • (2010) Aging (Albany NY) , vol.2 , pp. 582-596
    • Adams, B.R.1    Hawkins, A.J.2    Povirk, L.F.3    Valerie, K.4
  • 109
    • 79953685437 scopus 로고    scopus 로고
    • Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells
    • T. Kinoshita, G. Nagamatsu, T. Kosaka, K. Takubo, A. Hotta, J. Ellis, and T. Suda Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells Biochem. Biophys. Res. Commun. 407 2011 321 326
    • (2011) Biochem. Biophys. Res. Commun. , vol.407 , pp. 321-326
    • Kinoshita, T.1    Nagamatsu, G.2    Kosaka, T.3    Takubo, K.4    Hotta, A.5    Ellis, J.6    Suda, T.7
  • 110
    • 78149445840 scopus 로고    scopus 로고
    • DNA damage responses in human induced pluripotent stem cells and embryonic stem cells
    • O. Momcilovic, L. Knobloch, J. Fornsaglio, S. Varum, C. Easley, and G. Schatten DNA damage responses in human induced pluripotent stem cells and embryonic stem cells PLoS One 5 2010 e13410
    • (2010) PLoS One , vol.5 , pp. 13410
    • Momcilovic, O.1    Knobloch, L.2    Fornsaglio, J.3    Varum, S.4    Easley, C.5    Schatten, G.6
  • 116
    • 34447338834 scopus 로고    scopus 로고
    • Hijacking the DNA damage response to enhance viral replication: Gamma-herpesvirus 68 orf36 phosphorylates histone H2AX
    • A. Xie, and R. Scully Hijacking the DNA damage response to enhance viral replication: gamma-herpesvirus 68 orf36 phosphorylates histone H2AX Mol. Cell 27 2007 178 179
    • (2007) Mol. Cell , vol.27 , pp. 178-179
    • Xie, A.1    Scully, R.2
  • 118
    • 0033551374 scopus 로고    scopus 로고
    • MYC oncogenes and human neoplastic disease
    • C.E. Nesbit, J.M. Tersak, and E.V. Prochownik MYC oncogenes and human neoplastic disease Oncogene 18 1999 3004 3016
    • (1999) Oncogene , vol.18 , pp. 3004-3016
    • Nesbit, C.E.1    Tersak, J.M.2    Prochownik, E.V.3
  • 119
    • 77957598016 scopus 로고    scopus 로고
    • IPSC lines that do not silence the expression of the ectopic reprogramming factors may display enhanced propensity to genomic instability
    • V. Ramos-Mejia, M. Munoz-Lopez, J.L. Garcia-Perez, and P. Menendez iPSC lines that do not silence the expression of the ectopic reprogramming factors may display enhanced propensity to genomic instability Cell Res. 20 2010 1092 1095
    • (2010) Cell Res. , vol.20 , pp. 1092-1095
    • Ramos-Mejia, V.1    Munoz-Lopez, M.2    Garcia-Perez, J.L.3    Menendez, P.4
  • 120
    • 84862858052 scopus 로고    scopus 로고
    • Human embryonic stem cells fail to activate CHK1 and commit to apoptosis in response to DNA replication stress
    • J.A. Desmarais, M.J. Hoffmann, G. Bingham, M.E. Gagou, M. Meuth, and P.W. Andrews Human embryonic stem cells fail to activate CHK1 and commit to apoptosis in response to DNA replication stress Stem Cells 30 2012 1385 1393
    • (2012) Stem Cells , vol.30 , pp. 1385-1393
    • Desmarais, J.A.1    Hoffmann, M.J.2    Bingham, G.3    Gagou, M.E.4    Meuth, M.5    Andrews, P.W.6
  • 121
    • 84861989101 scopus 로고    scopus 로고
    • Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis
    • R. Dumitru, V. Gama, B.M. Fagan, J.J. Bower, V. Swahari, L.H. Pevny, and M. Deshmukh Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis Mol. Cell 46 2012 573 583
    • (2012) Mol. Cell , vol.46 , pp. 573-583
    • Dumitru, R.1    Gama, V.2    Fagan, B.M.3    Bower, J.J.4    Swahari, V.5    Pevny, L.H.6    Deshmukh, M.7
  • 124
    • 70350088548 scopus 로고    scopus 로고
    • Mechanisms of double-strand break repair in somatic mammalian cells
    • A.J. Hartlerode, and R. Scully Mechanisms of double-strand break repair in somatic mammalian cells Biochem. J. 423 2009 157 168
    • (2009) Biochem. J. , vol.423 , pp. 157-168
    • Hartlerode, A.J.1    Scully, R.2
  • 126
    • 0036326014 scopus 로고    scopus 로고
    • Non-homologous DNA end joining in the mature rat brain
    • K. Ren, and S. Pena de Ortiz Non-homologous DNA end joining in the mature rat brain J. Neurochem. 80 2002 949 959
    • (2002) J. Neurochem. , vol.80 , pp. 949-959
    • Ren, K.1    Pena De Ortiz, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.