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Volumn 114, Issue , 2013, Pages 251-276

Free fatty acid receptor GPR120 and pathogenesis of obesity and type 2 diabetes mellitus

Author keywords

Free fatty acids; GPR120; Keywords; Obesity

Indexed keywords


EID: 84872379068     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-386933-3.00007-8     Document Type: Chapter
Times cited : (26)

References (89)
  • 1
    • 84856487711 scopus 로고    scopus 로고
    • Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010
    • K.M. Flegal, M.D. Carroll, B.K. Kit, and C.L. Ogden Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010 JAMA 307 2012 491 497
    • (2012) JAMA , vol.307 , pp. 491-497
    • Flegal, K.M.1    Carroll, M.D.2    Kit, B.K.3    Ogden, C.L.4
  • 3
    • 0142093526 scopus 로고    scopus 로고
    • Fatty acid metabolism and insulin secretion in pancreatic beta cells
    • G.C. Yaney, and B.E. Corkey Fatty acid metabolism and insulin secretion in pancreatic beta cells Diabetologia 46 2003 1297 1312
    • (2003) Diabetologia , vol.46 , pp. 1297-1312
    • Yaney, G.C.1    Corkey, B.E.2
  • 4
    • 39749122734 scopus 로고    scopus 로고
    • The opposing effects of n-3 and n-6 fatty acids
    • G. Schmitz, and J. Ecker The opposing effects of n-3 and n-6 fatty acids Prog Lipid Res 47 2008 147 155
    • (2008) Prog Lipid Res , vol.47 , pp. 147-155
    • Schmitz, G.1    Ecker, J.2
  • 5
    • 0035976638 scopus 로고    scopus 로고
    • Nuclear receptors and lipid physiology: Opening the X-files
    • A. Chawla, J.J. Repa, R.M. Evans, and D.J. Mangelsdorf Nuclear receptors and lipid physiology: opening the X-files Science 294 2001 1866 1870
    • (2001) Science , vol.294 , pp. 1866-1870
    • Chawla, A.1    Repa, J.J.2    Evans, R.M.3    Mangelsdorf, D.J.4
  • 6
    • 0034665566 scopus 로고    scopus 로고
    • Mechanism for the antitumor and anticachectic effects of n-3 fatty acids
    • L.A. Sauer, R.T. Dauchy, and D.E. Blask Mechanism for the antitumor and anticachectic effects of n-3 fatty acids Cancer Res 60 2000 5289 5295
    • (2000) Cancer Res , vol.60 , pp. 5289-5295
    • Sauer, L.A.1    Dauchy, R.T.2    Blask, D.E.3
  • 7
    • 0035865496 scopus 로고    scopus 로고
    • Long-chain fatty acids regulate liver carnitine palmitoyltransferase i gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor α (PPARα)-independent pathway
    • J.F. Louet, F. Chatelain, J.F. Decaux, E.A. Park, C. Kohl, and T. Pineau Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor α (PPARα)-independent pathway Biochem J 354 2001 189 197
    • (2001) Biochem J , vol.354 , pp. 189-197
    • Louet, J.F.1    Chatelain, F.2    Decaux, J.F.3    Park, E.A.4    Kohl, C.5    Pineau, T.6
  • 8
    • 0242710648 scopus 로고    scopus 로고
    • Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives
    • R. Fredriksson, P.J. Hoglund, D.E.I. Gloriam, M.C. Lagerstrom, and H.B. Schioth Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives FEBS Lett 554 2003 381 388
    • (2003) FEBS Lett , vol.554 , pp. 381-388
    • Fredriksson, R.1    Hoglund, P.J.2    Gloriam, D.E.I.3    Lagerstrom, M.C.4    Schioth, H.B.5
  • 10
    • 75749092632 scopus 로고    scopus 로고
    • New frontiers in gut nutrient sensor research: Free fatty acid sensing in the gastrointestinal tract
    • S. Miyauchi, A. Hirasawa, A. Ichimura, T. Hara, and G. Tsujimoto New frontiers in gut nutrient sensor research: free fatty acid sensing in the gastrointestinal tract J Pharmacol Sci 112 2010 19 24
    • (2010) J Pharmacol Sci , vol.112 , pp. 19-24
    • Miyauchi, S.1    Hirasawa, A.2    Ichimura, A.3    Hara, T.4    Tsujimoto, G.5
  • 11
    • 80052021813 scopus 로고    scopus 로고
    • Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases
    • S. Talukdar, J.M. Olefsky, and O. Osborn Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases Trends Pharmacol Sci 32 2011 543 550
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 543-550
    • Talukdar, S.1    Olefsky, J.M.2    Osborn, O.3
  • 13
    • 13444263540 scopus 로고    scopus 로고
    • Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
    • A. Hirasawa, K. Tsumaya, T. Awaji, S. Katsuma, T. Adachi, and M. Yamada Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 Nat Med 11 2005 90 94
    • (2005) Nat Med , vol.11 , pp. 90-94
    • Hirasawa, A.1    Tsumaya, K.2    Awaji, T.3    Katsuma, S.4    Adachi, T.5    Yamada, M.6
  • 14
    • 72649095986 scopus 로고    scopus 로고
    • Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: Comparison with human GPR120 splice variants
    • K. Moore, Q. Zhang, N. Murgolo, T. Hosted, and R. Duffy Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: comparison with human GPR120 splice variants Comp Biochem Physiol B Biochem Mol Biol 154 2009 419 426
    • (2009) Comp Biochem Physiol B Biochem Mol Biol , vol.154 , pp. 419-426
    • Moore, K.1    Zhang, Q.2    Murgolo, N.3    Hosted, T.4    Duffy, R.5
  • 15
    • 45849153782 scopus 로고    scopus 로고
    • Cloning and characterization of the rat free fatty acid receptor GPR120: In vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells
    • T. Tanaka, T. Yano, T. Adachi, T.A. Koshimizu, A. Hirasawa, and G. Tsujimoto Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells Naunyn Schmiedebergs Arch Pharmacol 377 2008 515 522
    • (2008) Naunyn Schmiedebergs Arch Pharmacol , vol.377 , pp. 515-522
    • Tanaka, T.1    Yano, T.2    Adachi, T.3    Koshimizu, T.A.4    Hirasawa, A.5    Tsujimoto, G.6
  • 16
    • 33646162635 scopus 로고    scopus 로고
    • GRKs and beta-arrestins: Roles in receptor silencing, trafficking and signaling
    • E. Reiter, and R.J. Lefkowitz GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling Trends Endocrinol Metab 17 2006 159 165
    • (2006) Trends Endocrinol Metab , vol.17 , pp. 159-165
    • Reiter, E.1    Lefkowitz, R.J.2
  • 17
    • 47849101639 scopus 로고    scopus 로고
    • Location, location, location ... site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling
    • A.B. Tobin, A.J. Butcher, and K.C. Kong Location, location, location... site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling Trends Pharmacol Sci 29 2008 413 420
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 413-420
    • Tobin, A.B.1    Butcher, A.J.2    Kong, K.C.3
  • 18
    • 52649145895 scopus 로고    scopus 로고
    • GPS 2.0, a tool to predict kinase-specific phosphorylation sites in hierarchy
    • Y. Xue, J. Ren, X.J. Gao, C.J. Jin, L.P. Wen, and X.B. Yao GPS 2.0, a tool to predict kinase-specific phosphorylation sites in hierarchy Mol Cell Proteomics 7 2008 1598 1608
    • (2008) Mol Cell Proteomics , vol.7 , pp. 1598-1608
    • Xue, Y.1    Ren, J.2    Gao, X.J.3    Jin, C.J.4    Wen, L.P.5    Yao, X.B.6
  • 19
    • 77953287113 scopus 로고    scopus 로고
    • Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor
    • R.N. Burns, and N.H. Moniri Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor Biochem Biophys Res Commun 396 2010 1030 1035
    • (2010) Biochem Biophys Res Commun , vol.396 , pp. 1030-1035
    • Burns, R.N.1    Moniri, N.H.2
  • 21
    • 70350610662 scopus 로고    scopus 로고
    • Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice
    • J. Ito, M. Ito, H. Nambu, T. Fujikawa, K. Tanaka, and H. Iwaasa Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice Cell Tissue Res 338 2009 257 269
    • (2009) Cell Tissue Res , vol.338 , pp. 257-269
    • Ito, J.1    Ito, M.2    Nambu, H.3    Fujikawa, T.4    Tanaka, K.5    Iwaasa, H.6
  • 23
    • 58149464981 scopus 로고    scopus 로고
    • Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells
    • H.E. Parker, A.M. Habib, G.J. Rogers, F.M. Gribble, and F. Reimann Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells Diabetologia 52 2009 289 298
    • (2009) Diabetologia , vol.52 , pp. 289-298
    • Parker, H.E.1    Habib, A.M.2    Rogers, G.J.3    Gribble, F.M.4    Reimann, F.5
  • 24
    • 84863084353 scopus 로고    scopus 로고
    • Sensing of fatty acids for octanoylation of ghrelin involves a gustatory g-protein
    • S. Janssen, J. Laermans, H. Iwakura, J. Tack, and I. Depoortere Sensing of fatty acids for octanoylation of ghrelin involves a gustatory g-protein PLoS One 7 2012 e40168
    • (2012) PLoS One , vol.7 , pp. 40168
    • Janssen, S.1    Laermans, J.2    Iwakura, H.3    Tack, J.4    Depoortere, I.5
  • 27
    • 77956165390 scopus 로고    scopus 로고
    • GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
    • D.Y. Oh, S. Talukdar, E.J. Bae, T. Imamura, H. Morinaga, and W.Q. Fan GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects Cell 142 2010 687 698
    • (2010) Cell , vol.142 , pp. 687-698
    • Oh, D.Y.1    Talukdar, S.2    Bae, E.J.3    Imamura, T.4    Morinaga, H.5    Fan, W.Q.6
  • 29
    • 70349988797 scopus 로고    scopus 로고
    • G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell
    • N.G. Morgan, and S. Dhayal G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell Biochem Pharmacol 78 2009 1419 1427
    • (2009) Biochem Pharmacol , vol.78 , pp. 1419-1427
    • Morgan, N.G.1    Dhayal, S.2
  • 30
    • 80555157690 scopus 로고    scopus 로고
    • Processing of proglucagon to GLP-1 in pancreatic alpha-cells: Is this a paracrine mechanism enabling GLP-1 to act on beta-cells?
    • N.M. Whalley, L.E. Pritchard, D.M. Smith, and A. White Processing of proglucagon to GLP-1 in pancreatic alpha-cells: is this a paracrine mechanism enabling GLP-1 to act on beta-cells? J Endocrinol 211 2011 99 106
    • (2011) J Endocrinol , vol.211 , pp. 99-106
    • Whalley, N.M.1    Pritchard, L.E.2    Smith, D.M.3    White, A.4
  • 31
    • 83755225879 scopus 로고    scopus 로고
    • Diet-induced obesity up-regulates the abundance of GPR43 and GPR120 in a tissue specific manner
    • L.M. Cornall, M.L. Mathai, D.H. Hryciw, and A.J. McAinch Diet-induced obesity up-regulates the abundance of GPR43 and GPR120 in a tissue specific manner Cell Physiol Biochem 28 2011 949 958
    • (2011) Cell Physiol Biochem , vol.28 , pp. 949-958
    • Cornall, L.M.1    Mathai, M.L.2    Hryciw, D.H.3    McAinch, A.J.4
  • 32
    • 53649083414 scopus 로고    scopus 로고
    • Oleic acid induces ERK1/2 activation and AP-1 DNA binding activity through a mechanism involving Src kinase and EGFR transactivation in breast cancer cells
    • A. Soto-Guzman, T. Robledo, M. Lopez-Perez, and E.P. Salazar Oleic acid induces ERK1/2 activation and AP-1 DNA binding activity through a mechanism involving Src kinase and EGFR transactivation in breast cancer cells Mol Cell Endocrinol 294 2008 81 91
    • (2008) Mol Cell Endocrinol , vol.294 , pp. 81-91
    • Soto-Guzman, A.1    Robledo, T.2    Lopez-Perez, M.3    Salazar, E.P.4
  • 33
    • 84872413987 scopus 로고    scopus 로고
    • The role of cholecystokinin receptors in the short-term control of food intake
    • A.I. Sayegh The role of cholecystokinin receptors in the short-term control of food intake Prog Mol Biol Trans Sci 114 2012 1 40
    • (2012) Prog Mol Biol Trans Sci , vol.114 , pp. 1-40
    • Sayegh, A.I.1
  • 36
    • 83455250388 scopus 로고    scopus 로고
    • TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1
    • B.P. Shah, P. Liu, T. Yu, D.R. Hansen, and T.A. Gilbertson TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1 Am J Physiol Cell Physiol 302 2012 C210 C219
    • (2012) Am J Physiol Cell Physiol , vol.302
    • Shah, B.P.1    Liu, P.2    Yu, T.3    Hansen, D.R.4    Gilbertson, T.A.5
  • 38
    • 84863112820 scopus 로고    scopus 로고
    • Increased oral detection, but decreased intestinal signaling for fats in mice lacking gut microbiota
    • F.A. Duca, T.D. Swartz, Y. Sakar, and M. Covasa Increased oral detection, but decreased intestinal signaling for fats in mice lacking gut microbiota PLoS One 7 2012 e39748
    • (2012) PLoS One , vol.7 , pp. 39748
    • Duca, F.A.1    Swartz, T.D.2    Sakar, Y.3    Covasa, M.4
  • 39
    • 34047177401 scopus 로고    scopus 로고
    • GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo
    • M.G. Latour, T. Alquier, E. Oseid, C. Tremblay, T.L. Jetton, and J. Luo GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo Diabetes 56 2007 1087 1094
    • (2007) Diabetes , vol.56 , pp. 1087-1094
    • Latour, M.G.1    Alquier, T.2    Oseid, E.3    Tremblay, C.4    Jetton, T.L.5    Luo, J.6
  • 40
    • 0037434991 scopus 로고    scopus 로고
    • Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40
    • Y. Itoh, Y. Kawamata, M. Harada, M. Kobayashi, R. Fujii, and S. Fukusumi Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40 Nature 422 2003 173 176
    • (2003) Nature , vol.422 , pp. 173-176
    • Itoh, Y.1    Kawamata, Y.2    Harada, M.3    Kobayashi, M.4    Fujii, R.5    Fukusumi, S.6
  • 42
    • 84863516095 scopus 로고    scopus 로고
    • A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets
    • J. Taneera, S. Lang, A. Sharma, J. Fadista, Y. Zhou, and E. Ahlqvist A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets Cell Metab 16 2012 122 134
    • (2012) Cell Metab , vol.16 , pp. 122-134
    • Taneera, J.1    Lang, S.2    Sharma, A.3    Fadista, J.4    Zhou, Y.5    Ahlqvist, E.6
  • 43
    • 0030927581 scopus 로고    scopus 로고
    • Fat perception is related to PROP taster status
    • B.J. Tepper, and R.J. Nurse Fat perception is related to PROP taster status Physiol Behav 61 1997 949 954
    • (1997) Physiol Behav , vol.61 , pp. 949-954
    • Tepper, B.J.1    Nurse, R.J.2
  • 44
    • 0027731470 scopus 로고
    • Role of olfaction in starch and oil preference
    • I. Ramirez Role of olfaction in starch and oil preference Am J Physiol 265 1993 R1404 R1409
    • (1993) Am J Physiol , vol.265
    • Ramirez, I.1
  • 45
    • 0029805363 scopus 로고    scopus 로고
    • The controls of fat intake
    • D. Greenberg, and G.P. Smith The controls of fat intake Psychosom Med 58 1996 559 569
    • (1996) Psychosom Med , vol.58 , pp. 559-569
    • Greenberg, D.1    Smith, G.P.2
  • 46
    • 0038356470 scopus 로고    scopus 로고
    • Role of gustation in the recognition of oleate and triolein in anosmic rats
    • T. Fukuwatari, K. Shibata, K. Iguchi, T. Saeki, A. Iwata, and K. Tani Role of gustation in the recognition of oleate and triolein in anosmic rats Physiol Behav 78 2003 579 583
    • (2003) Physiol Behav , vol.78 , pp. 579-583
    • Fukuwatari, T.1    Shibata, K.2    Iguchi, K.3    Saeki, T.4    Iwata, A.5    Tani, K.6
  • 47
    • 0041881949 scopus 로고    scopus 로고
    • Effects of oral stimulation with fats on the cephalic phase of pancreatic enzyme secretion in esophagostomized rats
    • T. Hiraoka, T. Fukuwatari, M. Imaizumi, and T. Fushiki Effects of oral stimulation with fats on the cephalic phase of pancreatic enzyme secretion in esophagostomized rats Physiol Behav 79 2003 713 717
    • (2003) Physiol Behav , vol.79 , pp. 713-717
    • Hiraoka, T.1    Fukuwatari, T.2    Imaizumi, M.3    Fushiki, T.4
  • 48
    • 27644533906 scopus 로고    scopus 로고
    • CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions
    • F. Laugerette, P. Passilly-Degrace, B. Patris, I. Niot, M. Febbraio, and J.P. Montmayeur CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions J Clin Invest 115 2005 3177 3184
    • (2005) J Clin Invest , vol.115 , pp. 3177-3184
    • Laugerette, F.1    Passilly-Degrace, P.2    Patris, B.3    Niot, I.4    Febbraio, M.5    Montmayeur, J.P.6
  • 50
    • 28444441946 scopus 로고    scopus 로고
    • Fatty acid responses in taste cells from obesity-prone and -resistant rats
    • T.A. Gilbertson, L. Liu, I. Kim, C.A. Burks, and D.R. Hansen Fatty acid responses in taste cells from obesity-prone and -resistant rats Physiol Behav 86 2005 681 690
    • (2005) Physiol Behav , vol.86 , pp. 681-690
    • Gilbertson, T.A.1    Liu, L.2    Kim, I.3    Burks, C.A.4    Hansen, D.R.5
  • 51
    • 0031559890 scopus 로고    scopus 로고
    • Expression of the putative membrane fatty acid transporter (FAT) in taste buds of the circumvallate papillae in rats
    • T. Fukuwatari, T. Kawada, M. Tsuruta, T. Hiraoka, T. Iwanaga, and E. Sugimoto Expression of the putative membrane fatty acid transporter (FAT) in taste buds of the circumvallate papillae in rats FEBS Lett 414 1997 461 464
    • (1997) FEBS Lett , vol.414 , pp. 461-464
    • Fukuwatari, T.1    Kawada, T.2    Tsuruta, M.3    Hiraoka, T.4    Iwanaga, T.5    Sugimoto, E.6
  • 52
    • 0033582645 scopus 로고    scopus 로고
    • Putative mammalian taste receptors: A class of taste-specific GPCRs with distinct topographic selectivity
    • M.A. Hoon, E. Adler, J. Lindemeier, J.F. Battey, N.J. Ryba, and C.S. Zuker Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity Cell 96 1999 541 551
    • (1999) Cell , vol.96 , pp. 541-551
    • Hoon, M.A.1    Adler, E.2    Lindemeier, J.3    Battey, J.F.4    Ryba, N.J.5    Zuker, C.S.6
  • 56
    • 0023624892 scopus 로고
    • Obesity and postmenopausal bone loss - The influence of obesity on vertebral density and bone turnover in postmenopausal women
    • C. Ribot, F. Tremollieres, J.M. Pouilles, M. Bonneu, F. Germain, and J.P. Louvet Obesity and postmenopausal bone loss - the influence of obesity on vertebral density and bone turnover in postmenopausal women Bone 8 1987 327 331
    • (1987) Bone , vol.8 , pp. 327-331
    • Ribot, C.1    Tremollieres, F.2    Pouilles, J.M.3    Bonneu, M.4    Germain, F.5    Louvet, J.P.6
  • 57
    • 0026775342 scopus 로고
    • Fat mass is an important determinant of whole-body bone-density in premenopausal women but not in men
    • I.R. Reid, L.D. Plank, and M.C. Evans Fat mass is an important determinant of whole-body bone-density in premenopausal women but not in men J Clin Endocrinol Metab 75 1992 779 782
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 779-782
    • Reid, I.R.1    Plank, L.D.2    Evans, M.C.3
  • 58
    • 0026642505 scopus 로고
    • Determinants of total-body and regional bone-mineral density in normal postmenopausal women - A key role for fat mass
    • I.R. Reid, R. Ames, M.C. Evans, S. Sharpe, G. Gamble, and J.T. France Determinants of total-body and regional bone-mineral density in normal postmenopausal women - a key role for fat mass J Clin Endocrinol Metab 75 1992 45 51
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 45-51
    • Reid, I.R.1    Ames, R.2    Evans, M.C.3    Sharpe, S.4    Gamble, G.5    France, J.T.6
  • 59
    • 0036861322 scopus 로고    scopus 로고
    • Relationships among body mass, its components, and bone
    • I.R. Reid Relationships among body mass, its components, and bone Bone 31 2002 547 555
    • (2002) Bone , vol.31 , pp. 547-555
    • Reid, I.R.1
  • 62
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • G.S. Hotamisligil Inflammation and metabolic disorders Nature 444 2006 860 867
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 63
  • 64
    • 19044393872 scopus 로고    scopus 로고
    • Adipose tissue, inflammation, and cardiovascular disease
    • A.H. Berg, and P.E. Scherer Adipose tissue, inflammation, and cardiovascular disease Circ Res 96 2005 939 949
    • (2005) Circ Res , vol.96 , pp. 939-949
    • Berg, A.H.1    Scherer, P.E.2
  • 65
    • 68749109536 scopus 로고    scopus 로고
    • A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    • B.Z. Qian, Y. Deng, J.H. Im, R.J. Muschel, Y.Y. Zou, and J.F. Li A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth PLoS One 4 2009 e6562
    • (2009) PLoS One , vol.4 , pp. 6562
    • Qian, B.Z.1    Deng, Y.2    Im, J.H.3    Muschel, R.J.4    Zou, Y.Y.5    Li, J.F.6
  • 69
    • 70349237729 scopus 로고    scopus 로고
    • Therapeutic potential of n-3 polyunsaturated fatty acids in disease
    • J.W. Fetterman, and M.M. Zdanowicz Therapeutic potential of n-3 polyunsaturated fatty acids in disease Am J Health Syst Pharm 66 2009 1169 1179
    • (2009) Am J Health Syst Pharm , vol.66 , pp. 1169-1179
    • Fetterman, J.W.1    Zdanowicz, M.M.2
  • 70
    • 84860575447 scopus 로고    scopus 로고
    • Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs
    • D.S. Im Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs Prog Lipid Res 51 2012 232 237
    • (2012) Prog Lipid Res , vol.51 , pp. 232-237
    • Im, D.S.1
  • 71
    • 84872419808 scopus 로고    scopus 로고
    • Low affinity GPCRs for metabolic intermediates: Challenges for pharmacologists
    • N.J. Smith Low affinity GPCRs for metabolic intermediates: challenges for pharmacologists Front Endocrinol (Lausanne) 3 2012 1
    • (2012) Front Endocrinol (Lausanne) , vol.3 , pp. 1
    • Smith, N.J.1
  • 73
    • 0026551309 scopus 로고
    • Fatty-acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor
    • M. Gottlicher, E. Widmark, Q. Li, and J.A. Gustafsson Fatty-acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor Proc Natl Acad Sci USA 89 1992 4653 4657
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4653-4657
    • Gottlicher, M.1    Widmark, E.2    Li, Q.3    Gustafsson, J.A.4
  • 74
    • 11844275233 scopus 로고    scopus 로고
    • A family of fatty acid binding receptors
    • A.J. Brown, S. Jupe, and C.P. Briscoe A family of fatty acid binding receptors DNA Cell Biol 24 2005 54 61
    • (2005) DNA Cell Biol , vol.24 , pp. 54-61
    • Brown, A.J.1    Jupe, S.2    Briscoe, C.P.3
  • 75
    • 33745607930 scopus 로고    scopus 로고
    • Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: Identification of agonist and antagonist small molecules
    • C.P. Briscoe, A.J. Peat, S.C. McKeown, D.F. Corbett, A.S. Goetz, and T.R. Littleton Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules Br J Pharmacol 148 2006 619 628
    • (2006) Br J Pharmacol , vol.148 , pp. 619-628
    • Briscoe, C.P.1    Peat, A.J.2    McKeown, S.C.3    Corbett, D.F.4    Goetz, A.S.5    Littleton, T.R.6
  • 76
    • 57349135245 scopus 로고    scopus 로고
    • Identification of G protein-coupled receptor 120-selective agonists derived from PPAR gamma agonists
    • T. Suzuki, S.I. Igari, A. Hirasawa, M. Hata, M. Ishiguro, and H. Fujieda Identification of G protein-coupled receptor 120-selective agonists derived from PPAR gamma agonists J Med Chem 51 2008 7640 7644
    • (2008) J Med Chem , vol.51 , pp. 7640-7644
    • Suzuki, T.1    Igari, S.I.2    Hirasawa, A.3    Hata, M.4    Ishiguro, M.5    Fujieda, H.6
  • 78
    • 77958142515 scopus 로고    scopus 로고
    • Structure-activity relationships of GPR120 agonists based on a docking simulation
    • Q. Sun, A. Hirasawa, T. Hara, I. Kimura, T. Adachi, and T. Awaji Structure-activity relationships of GPR120 agonists based on a docking simulation Mol Pharmacol 78 2010 804 810
    • (2010) Mol Pharmacol , vol.78 , pp. 804-810
    • Sun, Q.1    Hirasawa, A.2    Hara, T.3    Kimura, I.4    Adachi, T.5    Awaji, T.6
  • 79
    • 84859949278 scopus 로고    scopus 로고
    • Differential signaling by splice variants of the human free fatty acid receptor GPR120
    • S.J. Watson, A.J.H. Brown, and N.D. Holliday Differential signaling by splice variants of the human free fatty acid receptor GPR120 Mol Pharmacol 81 2012 631 642
    • (2012) Mol Pharmacol , vol.81 , pp. 631-642
    • Watson, S.J.1    Brown, A.J.H.2    Holliday, N.D.3
  • 80
    • 84872407744 scopus 로고    scopus 로고
    • Drug discovery opportunities and challenges at G protein-coupled receptors for long chain free fatty acids
    • N.D. Holliday, S.J. Watson, and A.J. Brown Drug discovery opportunities and challenges at G protein-coupled receptors for long chain free fatty acids Front Endocrinol (Lausanne) 2 2011 112
    • (2011) Front Endocrinol (Lausanne) , vol.2 , pp. 112
    • Holliday, N.D.1    Watson, S.J.2    Brown, A.J.3
  • 81
    • 4043093705 scopus 로고    scopus 로고
    • Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation
    • Y.X. Tao, and D.L. Segaloff Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation J Clin Endocrinol Metab 89 2004 3936 3942
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3936-3942
    • Tao, Y.X.1    Segaloff, D.L.2
  • 82
    • 33746527488 scopus 로고    scopus 로고
    • Inactivating mutations of G protein-coupled receptors and diseases: Structure-function insights and therapeutic implications
    • Y.X. Tao Inactivating mutations of G protein-coupled receptors and diseases: structure-function insights and therapeutic implications Pharmacol Ther 111 2006 949 973
    • (2006) Pharmacol Ther , vol.111 , pp. 949-973
    • Tao, Y.X.1
  • 83
    • 21244503501 scopus 로고    scopus 로고
    • Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1
    • S. Katsuma, N. Hatae, T. Yano, Y. Ruike, M. Kimura, and A. Hirasawa Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1 J Biol Chem 280 2005 19507 19515
    • (2005) J Biol Chem , vol.280 , pp. 19507-19515
    • Katsuma, S.1    Hatae, N.2    Yano, T.3    Ruike, Y.4    Kimura, M.5    Hirasawa, A.6
  • 84
    • 33847037154 scopus 로고    scopus 로고
    • Protein kinase C zeta is required for oleic acid-induced secretion of glucagon-like peptide-1 by intestinal endocrine L cells
    • R. Iakoubov, A. Izzo, A. Yeung, C.I. Whiteside, and P.L. Brubaker Protein kinase C zeta is required for oleic acid-induced secretion of glucagon-like peptide-1 by intestinal endocrine L cells Endocrinology 148 2007 1089 1098
    • (2007) Endocrinology , vol.148 , pp. 1089-1098
    • Iakoubov, R.1    Izzo, A.2    Yeung, A.3    Whiteside, C.I.4    Brubaker, P.L.5
  • 85
    • 84872369928 scopus 로고    scopus 로고
    • Altered expression of gustatory-signaling elements in gastric tissue of morbidly obese patients
    • P. Widmayer, M. Kuper, M. Kramer, A. Konigsrainer, and H. Breer Altered expression of gustatory-signaling elements in gastric tissue of morbidly obese patients Int J Obes (Lond) 36 2012 1353 1359 http://dx.doi.org/10.1038/ijo.2011. 216
    • (2012) Int J Obes (Lond) , vol.36 , pp. 1353-1359
    • Widmayer, P.1    Kuper, M.2    Kramer, M.3    Konigsrainer, A.4    Breer, H.5
  • 86
    • 34447633368 scopus 로고    scopus 로고
    • Conformational complexity of G-protein-coupled receptors
    • B.K. Kobilka, and X. Deupi Conformational complexity of G-protein-coupled receptors Trends Pharmacol Sci 28 2007 397 406
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 397-406
    • Kobilka, B.K.1    Deupi, X.2
  • 88
    • 34548758543 scopus 로고    scopus 로고
    • Splicing in disease: Disruption of the splicing code and the decoding machinery
    • G.S. Wang, and T.A. Cooper Splicing in disease: disruption of the splicing code and the decoding machinery Nat Rev Genet 8 2007 749 761
    • (2007) Nat Rev Genet , vol.8 , pp. 749-761
    • Wang, G.S.1    Cooper, T.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.