Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists

Journal of Medicinal Chemistry

Volumn 51, Issue 23, 2008, Pages 7640-7644

  Suzuki, Takayoshi ^a   Igari, Sou Ichi ^a   Hirasawa, Akira ^b   Hata, Mie ^c   Ishiguro, Masaji ^d,e   Fujieda, Hiroki ^a   Itoh, Yukihiro ^a   Hirano, Tatsuya ^a   Nakagawa, Hidehiko ^a   Ogura, Michitaka ^d,e   Makishima, Makoto ^d,e   Tsujimoto, Gozoh ^b   Miyata, Naoki ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^e NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 [2 (PHENYL 2 PYRIDINYLAMINO)ETHOXY]PHENYL]BUTYRIC ACID; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 120; G PROTEIN COUPLED RECEPTOR 120 STIMULATING AGENT; G PROTEIN COUPLED RECEPTOR 40; LINOLENIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIRINIXIC ACID; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; REACTION ANALYSIS; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CARBOXYLIC ACIDS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PPAR GAMMA; RECEPTORS, G-PROTEIN-COUPLED; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 57349135245     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800970b     Document Type: Article

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