Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice

Cell and Tissue Research

Volumn 338, Issue 2, 2009, Pages 257-269

  Ito, Junko ^a   Ito, Masahiko ^a   Nambu, Hirohide ^a   Fujikawa, Toru ^a   Tanaka, Kenichi ^a   Iwaasa, Hisashi ^a   Tokita, Shigeru ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Expression profile; Gastrointestinal tract; Mouse (C57BL 6, male); Orphan G protein coupled receptor; Quantitative real time PCR

Indexed keywords

CHOLECYSTOKININ A RECEPTOR; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 106; G PROTEIN COUPLED RECEPTOR 112; G PROTEIN COUPLED RECEPTOR 120; G PROTEIN COUPLED RECEPTOR 37; G PROTEIN COUPLED RECEPTOR 5A; G PROTEIN COUPLED RECEPTOR 85; G PROTEIN COUPLED RECEPTOR C5B; MESSENGER RNA; NERVE PROTEIN; PROTEIN BAI1; PROTEIN BAI2; PROTEIN BAI3; PROTEIN TAAR1; PROTEIN TAAR2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GASTROINTESTINAL TRACT; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; UNINDEXED SEQUENCE;

ANIMALS; GASTROINTESTINAL TRACT; GENE EXPRESSION; MICE; MICE, INBRED C57BL; MUCOUS MEMBRANE; ORGAN SPECIFICITY; RECEPTORS, CHOLECYSTOKININ; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

MUS;

EID: 70350610662     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00441-009-0859-x     Document Type: Article

References (48)

1. TK Bjarnadottir DE Gloriam SH Hellstrand H Kristiansson R Fredriksson HB Schioth 2006 Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse Genomics 88 263 273 10.1016/j.ygeno.2006.04.001 16753280 (Pubitemid 44278529)
2. TK Bjarnadottir R Fredriksson HB Schioth 2007 The adhesion GPCRs: a unique family of G protein-coupled receptors with important roles in both central and peripheral tissues Cell Mol Life Sci 64 2104 2119 10.1007/s00018-007-7067-1 17502995 (Pubitemid 350092419)
3. J Bockaert JP Pin 1999 Molecular tinkering of G protein-coupled receptors: an evolutionary success EMBO J 18 1723 1729 10.1093/emboj/18.7.1723 10202136
4. G Burdyga G de Lartigue HE Raybould R Morris R Dimaline A Varro DG Thompson GJ Dockray 2008 Cholecystokinin regulates expression of Y2 receptors in vagal afferent neurons serving the stomach J Neurosci 28 11583 11592 10.1523/JNEUROSCI.2493-08.2008 18987194
5. YJ Cheng R Lotan 1998 Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor J Biol Chem 273 35008 35015 10.1074/jbc.273.52.35008 9857033 (Pubitemid 29028200)
6. HM Cox 2007 Neuropeptide Y receptors; antisecretory control of intestinal epithelial function Auton Neurosci 133 76 85 10.1016/j.autneu.2006.10.005 17140858 (Pubitemid 46483258)
7. DE Cummings J Overduin 2007 Gastrointestinal regulation of food intake J Clin Invest 117 13 23 10.1172/JCI30227 17200702 (Pubitemid 46048445)
8. DJ Drucker 2007 The role of gut hormones in glucose homeostasis J Clin Invest 117 24 32 10.1172/JCI30076 17200703 (Pubitemid 46048446)
9. MS Engelstoft KL Egerod B Holst TW Schwartz 2008 A gut feeling for obesity: 7TM sensors on enteroendocrine cells Cell Metab 8 447 449 10.1016/j.cmet.2008.11.004 19041758
10. R Fredriksson HB Schioth 2005 The repertoire of G-protein-coupled receptors in fully sequenced genomes Mol Pharmacol 67 1414 1425 10.1124/mol.104.009001 15687224 (Pubitemid 40594140)
11. R Fredriksson MC Lagerstrom LG Lundin HB Schioth 2003 The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints Mol Pharmacol 63 1256 1272 10.1124/mol.63.6.1256 12761335 (Pubitemid 36627220)
12. G Gabella 1985 Structure of the musculature of the chicken small-intestine Anat Embryol (Berl) 171 139 149 10.1007/BF00341408 (Pubitemid 15168464)
13. RD Giorgio G Barbara JB Furness M Tonini 2007 Novel therapeutic targets for enteric nervous system disorders Trends Pharmacol Sci 28 473 481 10.1016/j.tips.2007.08.003 17764756 (Pubitemid 47368703)
14. KJ Gross C Pothoulakis 2007 Role of neuropeptides in inflammatory bowel disease Inflamm Bowel Dis 13 918 932 10.1002/ibd.20129 17343284 (Pubitemid 47203871)
15. MB Hansen AB Witte 2008 The role of serotonin in intestinal luminal sensing and secretion Acta Physiol 193 311 323 10.1111/j.1748-1716.2008.01870.x
16. Higashi H, Kohyama A, Hirabayashi Y (2007) Development of the drugs for metabolic diseases such as diabetes using RAIG2 and RAIG3 G-protein-coupled sugar receptors as targets. Riken, Tokio
17. A Hirasawa K Tsumaya T Awaji S Katsuma T Adachi M Yamada Y Sugimoto S Miyazaki G Tsujimoto 2005 Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 Nat Med 11 90 94 10.1038/nm1168 15619630 (Pubitemid 40215843)
18. M Kidd IM Modlin BI Gustafsson I Drozdov O Hauso R Pfragner 2008 Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants Am J Physiol Gastrointest Liver Physiol 295 G260 G272 10.1152/ajpgi.00056.2008 18556422
19. YB Kim OD Peroni WG Aschenbach Y Minokoshi K Kotani A Zisman CR Kahn LJ Goodyear BB Kahn 2005 Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism Mol Cell Biol 25 9713 9723 10.1128/MCB.25.21.9713-9723.2005 16227617 (Pubitemid 41507867)
20. S Koda Y Date N Murakami T Shimbara T Hanada K Toshinai A Niijima M Furuya N Inomata K Osuye M Nakazato 2005 The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats Endocrinology 146 2369 2375 10.1210/en.2004-1266 15718279 (Pubitemid 40577525)
21. JT Koh ZH Lee KY Ahn JK Kim CS Bae HH Kim HJ Kee KK Kim 2001 Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein Mol Brain Res 87 223 237 10.1016/S0169-328X(01)00004-3 11245925 (Pubitemid 32195474)
22. JT Koh H Kook HJ Kee YW Seo BC Jeong JH Lee MY Kim KC Yoon S Jung KK Kim 2004 Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alpha(v)beta(5) integrin Exp Cell Res 294 172 184 10.1016/j.yexcr.2003.11.008 14980512 (Pubitemid 38232664)
23. MC Lagerstrom HB Schioth 2008 Structural diversity of G protein-coupled receptors and significance for drug discovery Nat Rev Drug Discov 7 339 357 10.1038/nrd2518 18382464
24. J Lattin DA Zidar K Schroder S Kellie DA Hume MJ Sweet 2007 G-protein-coupled receptor expression, function, and signaling in macrophages J Leukoc Biol 82 16 32 10.1189/jlb.0107051 17456803 (Pubitemid 47026413)
25. J Leja A Essaghir M Essand K Wester K Oberg TH Totterman R Lloyd G Vasmatzis JB Demoulin V Giandomenico 2009 Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas Eur J Clin Invest 39 17
26. KJ Livak TD Schmittgen 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 402 408 10.1006/meth.2001.1262 11846609 (Pubitemid 34164012)
27. AE Lomax JB Furness 2000 Neurochemical classification of enteric neurons in the guinea-pig distal colon Cell Tissue Res 302 59 72 10.1007/s004410000260 11079716
28. K Lundstrom 2006 Latest development in drug discovery on G protein-coupled receptors Curr Protein Pept Sci 7 465 470 10.2174/ 138920306778559403 17073697 (Pubitemid 44524494)
29. YA Lysikov IA Morozov 1990 Ultrastructure of the juxtamural mucosal layer of the small-intestine Bull Exp Biol Med 110 1583 1587 10.1007/BF00841330
30. D Marazziti S Mandillo C Di Pietro E Golini R Matteoni GP Tocchini-Valentini 2007 GPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs Proc Natl Acad Sci USA 104 9846 9851 10.1073/pnas.0703368104 17519329 (Pubitemid 47175354)
31. M Matsumoto RE Straub S Marenco KK Nicodemus SI Matsumoto A Fujikawa S Miyoshi M Shobo S Takahashi J Yarimizu M Yuri M Hiramoto S Morita H Yokota T Sasayama K Terai M Yoshino A Miyake JH Callicott MF Egan A Meyer-Lindenberg L Kempf R Honea RK Vakkalanka J Takasaki M Kamohara T Soga H Hiyama H Ishii A Matsuo S Nishimura N Matsuoka M Kobori H Matsushime M Katoh K Furuichi DR Weinberger 2008 The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia Proc Natl Acad Sci USA 105 6133 6138 10.1073/pnas.0710717105 18413613 (Pubitemid 351758411)
32. Y Miyamoto M Miyamoto 2004 Immunohistochemical localizations of secretin, cholecystokinin, and somatostatin in the rat small intestine after acute cisplatin treatment Exp Mol Pathol 77 238 245 10.1016/j.yexmp.2004.05.007 15507242 (Pubitemid 39422625)
33. T Moore-Morris A Varrault ME Mangoni A Le Digarcher V Negre C Dantec L Journot J Nargeot B Couette 2009 Identification of potential pharmacological targets by analysis of the comprehensive G protein-coupled receptor repertoire in the four cardiac chambers Mol Pharmacol 75 1108 1116 10.1124/mol.108.054155 19229040
34. D Osei-Hyiaman J Liu L Zhou G Godlewski J Harvey-White WI Jeong S Batkai G Marsicano B Lutz C Buettner G Kunos 2008 Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice J Clin Invest 118 3160 3169 10.1172/JCI34827 18677409
35. LM Patterson HY Zheng HR Berthoud 2002 Vagal afferents innervating the gastrointestinal tract and CCKA-receptor immunoreactivity Anat Rec 266 10 20 10.1002/ar.10026 11748567 (Pubitemid 34027831)
36. KL Pierce RJ Lefkowitz 2001 Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors Nat Rev Neurosci 2 727 733 10.1038/35094577 11584310 (Pubitemid 33674818)
37. Z-D Qu M Thacker P Castelucci M Bagyanszki ML Epstein JB Furness 2008 Immunohistochemical analysis of neuron types in the mouse small intestine Cell Tissue Res 334 147 161 10.1007/s00441-008-0684-7 18855018
38. GV Rayasam VK Tulasi JA Davis VS Bansal 2007 Fatty acid receptors as new therapeutic targets for diabetes Expert Opin Ther Targets 11 661 671 10.1517/14728222.11.5.661 17465724 (Pubitemid 46758791)
39. JB Regard IT Sato SR Coughlin 2008 Anatomical profiling of G protein-coupled receptor expression Cell 135 561 571 10.1016/j.cell.2008.08.040 18984166
40. M Rettenbacher JC Reubi 2001 Localization and characterization of neuropeptide receptors in human colon Naunyn Schmiedebergs Arch Pharmacol 364 291 304 10.1007/s002100100454 11683516 (Pubitemid 32938335)
41. MJ Robbins KJ Charles DC Harrison MN Pangalos 2002 Localisation of the GPRC5B receptor in the rat brain and spinal cord Mol Brain Res 106 136 144 10.1016/S0169-328X(02)00420-5 12393273 (Pubitemid 35223286)
42. N Rozengurt SV Wu MC Chen C Huang C Sternini E Rozengurt 2006 Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon Am J Physiol Gastrointest Liver Physiol 291 G792 G802 10.1152/ajpgi.00074.2006 16728727 (Pubitemid 44772005)
43. GJ Sanger K Lee 2008 Hormones of the gut-brain axis as targets for the treatment of upper gastrointestinal disorders Nat Rev Drug Discov 7 241 254 10.1038/nrd2444 18309313 (Pubitemid 351321235)
44. R Spiller 2008 Serotonin and GI clinical disorders Neuropharmacology 55 1072 1080 10.1016/j.neuropharm.2008.07.016 18687345
45. TD Wolinsky CJ Swanson KE Smith H Zhong B Borowsky P Seeman T Branchek CP Gerald 2007 The trace amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia Genes Brain Behav 6 628 639 10.1111/j.1601-183X.2006. 00292.x 17212650 (Pubitemid 47476185)
46. S Yona HH Lin WO Siu S Gordon M Stacey 2008 Adhesion-GPCRs: emerging roles for novel receptors Trends Biochem Sci 33 491 500 10.1016/j.tibs.2008.07. 005 18789697
47. J Zhou M Hegsted KL McCutcheon MJ Keenan XC Xi AM Raggio RJ Martin 2006 Peptide YY and proglucagon mRNA expression patterns and regulation in the gut Obesity 14 683 689 10.1038/oby.2006.77 16741270
48. R Zucchi G Chiellini TS Scanlan DK Grandy 2006 Trace amine-associated receptors and their ligands Br J Pharmacol 149 967 978 10.1038/sj.bjp.0706948 17088868 (Pubitemid 44950800)