Mechanism for the antitumor and anticachectic effects of n-3 fatty acids

Cancer Research

Volumn 60, Issue 18, 2000, Pages 5289-5295

  Saner, L A ^a   Dauchy, R T ^a   Blask, D E ^a  

^a BASSETT RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC AMP; ARACHIDONIC ACID; CORIOLIC ACID; FORSKOLIN; ICOSAPENTAENOIC ACID; LINOLEIC ACID; LINOLENIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PERTUSSIS TOXIN; THYMIDINE; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CACHEXIA; CANCER CELL CULTURE; CANCER PREVENTION; CONTROLLED STUDY; DIETARY INTAKE; FATTY ACID TRANSPORT; HEPATOMA CELL; IN VIVO STUDY; MALE; NONHUMAN; PERFUSION; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

5,8,11,14,17-EICOSAPENTAENOIC ACID; 8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ADIPOSE TISSUE; ALPHA-LINOLENIC ACID; ANIMAL; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; CACHEXIA; CYCLIC AMP; FATTY ACIDS; FORSKOLIN; GTP-BINDING PROTEINS; LINOLEIC ACIDS; LIVER NEOPLASMS, EXPERIMENTAL; MALE; NEOPLASM TRANSPLANTATION; RATS; RATS, INBRED BUF; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THYMIDINE;

EID: 0034665566     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Tar cancer in mice. II. The condition of the skin when modified by external treatment or diet, as a factor in influencing the cancerous reaction
2. The genesisgrowth of tumors. III. Effects of a high-fat diet
3. Relationships between dietary fat and experimental mammary tumorigenesis: A review and critique
4. Fat effects in experimental tumorigenesis
5. Requirement of essential fatty acid for mammary tumorigenesis in the rat
6. Induction of mammary tumors in female Sprague-Dawley rats by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and effect of dietary fat
7. Effect of dietary polyunsaturated fatty acids on growth of mammary adenacarcinomas in mice and rats
8. Dietary linoleic acid intake controls the arterial blood plasma concentration and the rates of growth and linoleic acid uptake and metabolism in hepatoma 7288CTC in Buffalo rats
9. Effects of diets containing different levels of linoleic acid on human breast cancer growth and lung metastasis in nude mice
10. Influence of dietary fat on growth of MDA-MB231 human breast carcinomas maintained in female athymic nude mice
11. Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethyl-hydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats
12. Effects of diets high in w-3 and w-6 fatty acids on initiation and postinitiation stages of colon carcinogenesis
13. Effect of w-3 fatty acids on growth of a rat mammary tumor
14. Kinetics of the inhibition of tumour growth in mice by eicosapentaenoic acid-reversal by linoleic acid
15. Effects of dietary ω-3 fatty acids on human breast cancer growth and metastasis in nude mice
16. Suppression of growth by dietary fish oil of human breast carcinomas maintained in three different strains of immune-deficient mice
17. 3H]thymidine incorporation in hepatoma 7288CTC perfused in situ
18. 13-Hydroxyoctadecadienoic acid is the mitogenic signal for linoleic acid-dependent growth in rat hepatoma 7288CTC in vivo
19. Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events
20. Fatty acids enter cells by simple diffusion
21. Protein-mediated facilitated uptake processes for fatty acids, bilirubin, and other amphipathic compounds
22. Amino acid, glucose, and lactic acid utilization in vivo by rat tumors
23. Stimulation of tumor growth in adult rats in vivo during an acute fast
24. Uptake of plasma lipids by tissue-isolated hepatomas 7288CTC and 7777 in vivo
25. 3H]thymidine incorporation in hepatoma 7288CTC perfused in situ
26. 14C] glucose
27. Cancer cachexia
28. Blood nutrient concentrations and tumor growth in vivo in rats: Relationships during the onset of an acute fast
29. Stimulation of tumor growth in adult rats in vivo during acute streptozotocin-induced diabetes
30. Melatonin madness
31. Melatonin agonists and antagonists: Pharmacological tools or therapeutic agents?
32. Effect of dietary fat on growth of MCF-7 and MDA-MB231 human breast carcinoma in athymic nude mice: Relationship between carcinoma growth and lipid peroxidation product levels
33. Effects of linoleic acid on the growth and metastasis of two human breast cancer cell lines in nude mice and the invasive capacity of these cell lines in vitro
34. Decreased growth of established human prostate LNCaP tumors in nude mice fed a low-fat diet
35. Decreased 13-S-hydroxyactadecadienoic acid levels and 15-1ipoxygenase-1 expression in human colon cancers
36. 13-Hydroxyactadecadienoic acid reverses the epidermal hyperproliferation via selective inhibition of protein kinase C-β activity
37. Plant and marine n-3 fatty acids inhibit experimental metastasis of rat mammary adenacarcinoma cells
38. Effect of high fat corn oil, olive oil and fish oil on phospholipid fatty acid composition in male F344 rats
39. Inhibition of tumour-induced lipolysis in vitro and cachexia and tumour growth in vivo by eicosapentaenoic acid
40. Mechanism of lipid mobilization associated with cancer cachexia: Interaction between the polyunsaturated fatty acid, eicosapentaenoic acid, and inhibitory guanine nucleotide-regulatory protein
41. Mechanism of inhibition of tumor-lipid mobilizing factor by eicosapentaenoic acid
42. Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity
43. Lipid-derived mediators in insulin action
44. Effect of varying proportions of dietary menhaden and corn oil on experimental rat mammary tumor promotion
45. Inhibitory effect of dietary perilla oil rich in the n-3 polyunsaturated fatty acid α-linolenic acid on colon carcinogenesis in rats
46. Expression cloning and characterization of a novel adipacyte long chain fatty acid transport protein
47. A family of fatty acid transporters conserved from Mycobacterium to man
48. Identification of the major intestinal fatty acid transport protein
49. Characterization of the murine fatty acid transport protein gene and its insulin response sequence
50. Regulation of the murine adipocyte fatty acid transporter gene by insulin
51. Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene
52. The fatty acid transport protein (FATP1) is a very long chain acyl-CoA synthetase