Processing of proglucagon to GLP-1 in pancreatic α-cells: Is this a paracrine mechanism enabling GLP-1 to act on β-cells?

Journal of Endocrinology

Volumn 211, Issue 1, 2011, Pages 99-106

  Whalley, N M ^a,b   Pritchard, L E ^a   Smith, D M ^b   White, A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR 120; G PROTEIN COUPLED RECEPTOR KINASE 5; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; PROGLUCAGON; STREPTOZOCIN; PROPROTEIN CONVERTASE 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL LINE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; GLUCAGON RELEASE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PARACRINE SIGNALING; PRIORITY JOURNAL; RAT; ANIMAL; ANIMAL MODEL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; METABOLISM; MOUSE; PANCREAS ISLET; PHYSIOLOGY; SECRETION; WISTAR RAT;

ANIMALS; CELL LINE; CELLS, CULTURED; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-SECRETING CELLS; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MODELS, ANIMAL; PARACRINE COMMUNICATION; PROGLUCAGON; PROPROTEIN CONVERTASE 1; RATS; RATS, WISTAR;

EID: 80555157690     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-11-0094     Document Type: Article

References (35)

1. Bloomquist BT, Eipper BA & Mains RE 1991 Prohormone-converting enzymes: regulation and evaluation of function using antisense RNA. Molecular Endocrinology 5 2014-2024. (doi:10.1210/mend-5-12-2014)
2. Buchanan CM, Malik AS & Cooper GJ 2007 Direct visualisation of peptide hormones in cultured pancreatic islet alpha- and beta-cells by intact-cell mass spectrometry. Rapid Communications in Mass Spectrometry 21 3452-3458. (doi:10.1002/rcm.3253)
3. Buteau J, El-Assaad W, Rhodes CJ, Rosenberg L, Joly E & Prentki M 2004 Glucagon-like peptide-1 prevents beta cell glucolipotoxicity. Diabetologia 47 806-815. (doi:10.1007/s00125-004-1379-6)
4. Chu ZL, Jones RM, He H, Carroll C, Gutierrez V, Lucman A, Moloney M, Gao H, Mondala H, Bagnol D et al. 2007 A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucosedependent insulin release. Endocrinology 148 2601-2609. (doi:10.1210/en.2006-1608)
5. De Leon DD, Crutchlow MF, Ham JY & Stoffers DA 2006 Role of glucagonlike peptide-1 in the pathogenesis and treatment of diabetes mellitus. International Journal of Biochemistry & Cell Biology 38 845-859. (doi:10.1016/j.biocel.2005.07.011)
6. Dhanvantari S, Izzo A, Jansen E & Brubaker PL 2001 Coregulation of glucagon-like peptide-1 synthesis with proglucagon and prohormone convertase 1 gene expression in enteroendocrine GLUTag cells. Endocrinology 142 37-42.
7. Ding J, Gao Y, Zhao J, Yan H, Guo S, Zhang Q, Li L & Gao X 2009 Pax6 haploinsufficiency causes abnormal metabolic homeostasis by downregulating glucagon-like peptide 1 in mice. Endocrinology 150 2136-2144. (doi:10.1210/en.2008-1006)
8. Edwards CM, Todd JF, Mahmoudi M, Wang Z, Wang RM, Ghatei MA & Bloom SR 1999 Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39. Diabetes 48 86-93. (doi:10.2337/diabetes.48.1.86)
9. Hansen L, Deacon CF, Orskov C & Holst JJ 1999 Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. Endocrinology 140 5356-5363. (doi:10.1210/en.140.11.5356)
10. Harb G, Toreson J, Dufour J & Korbutt G 2007 Acute exposure to streptozotocin but not human proinflammatory cytokines impairs neonatal porcine islet insulin secretion in vitro but not in vivo. Xenotransplantation 14 580-590. (doi:10.1111/j.1399-3089.2007.00427.x)
11. Heller RS & Aponte GW 1995 Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(7-36) amide. American Journal of Physiology 269 G852-G860.
12. Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, Sugimoto Y, Miyazaki S & Tsujimoto G 2005 Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nature Medicine 11 90-94. (doi:10.1038/nm1168)
13. Ionut V, Liberty IF, Hucking K, Lottati M, StefanovskiD, ZhengD&Bergman RN 2006 Exogenously imposed postprandial-like rises in systemic glucose and GLP-1 do not produce an incretin effect, suggesting an indirect mechanism of GLP-1 action. American Journal of Physiology. Endocrinology and Metabolism 291 E779-E785. (doi:10.1152/ajpendo.00106.2005)
14. Irwin DM 2001 Molecular evolution of proglucagon. Regulatory Peptides 98 1-12. (doi:10.1016/S0167-0115(00)00232-9)
15. Jansen E, Ayoubi TA, Meulemans SM & Van de Ven WJ 1995 Neuroendocrine-specific expression of the human prohormone convertase 1 gene. Hormonal regulation of transcription through distinct cAMP response elements. Journal of Biological Chemistry 270 15391-15397. (doi:10.1074/jbc.270.19.11222)
16. Katsuma S, Hirasawa A & Tsujimoto G 2005 Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Biochemical and Biophysical Research Communications 329 386-390. (doi:10.1016/j.bbrc.2005.01.139)
17. Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y et al. 2003 A G protein-coupled receptor responsive to bile acids. Journal of Biological Chemistry 278 9435-9440. (doi:10.1074/jbc.M209706200)
18. Kilimnik G, Kim A, Steiner DF, Friedman TC & Hara M 2010 Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic a-cells in mouse models of b-cell regeneration. Islets 2 149-155. (doi:10.4161/isl.2.3.11396)
19. Larsen PJ & Holst JJ 2005 Glucagon-related peptide 1 (GLP-1): hormone and neurotransmitter. Regulatory Peptides 128 97-107. (doi:10.1016/j.regpep.2004.08.026)
20. Li QL, Jansen E, Brent GA & Friedman TC 2001 Regulation of prohormone convertase 1 (PC1) by thyroid hormone. American Journal of Physiology - Endocrinology and Metabolism 280 E160-E170.
21. Ligon B, Boyd AE III & Dunlap K 1998 Class A calcium channel variants in pancreatic islets and their role in insulin secretion. Journal of Biological Chemistry 273 13905-13911. (doi:10.1074/jbc.273.22.13905)
22. Martin SK, Carroll R, Benig M & Steiner DF 1994 Regulation by glucose of the biosynthesis of PC2, PC3 and proinsulin in (ob/ob) mouse islets of Langerhans. FEBS Letters 356 279-282. (doi:10.1016/0014-5793(94)01284-9)
23. Masur K, Tibaduiza EC, Chen C, Ligon B & BeinbornM2005 Basal receptor activation by locally produced glucagon-like peptide-1 contributes to maintaining beta-cell function. Molecular Endocrinology 19 1373-1382. (doi:10.1210/me.2004-0350)
24. McGirr R, Ejbick CE, Carter DE, Andrews JD, Nie Y, Friedman TC & Dhanvantari S 2005 Glucose dependence of the regulated secretory pathway in alphaTC1-6 cells. Endocrinology 146 4514-4523. (doi:10.1210/en.2005-0402)
25. McKinnon CM, Ravier MA & Rutter GA 2006 FoxO1 is required for the regulation of preproglucagon gene expression by insulin in pancreatic alphaTC1-9 cells. Journal of Biological Chemistry 281 39358-39369. (doi:10.1074/jbc.M605022200)
26. Mojsov S, Weir GC & Habener JF 1987 Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. Journal of Clinical Investigation 79 616-619. (doi:10.1172/JCI112855)
27. Nie Y, Nakashima M, Brubaker PL, Li QL, Perfetti R, Jansen E, Zambre Y, Pipeleers D & Friedman TC 2000 Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats. Journal of Clinical Investigation 105 955-965. (doi:10.1172/JCI7456)
28. Reimann F & Gribble FM 2002 Glucose-sensing in glucagon-like peptide-1-secreting cells. Diabetes 51 2757-2763. (doi:10.2337/diabetes.51.9.2757)
29. Rouille Y, Westermark G, Martin SK & Steiner DF 1994 Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells. PNAS 91 3242-3246. (doi:10.1073/pnas.91.8.3242)
30. Skelly RH, Schuppin GT, Ishihara H, Oka Y & Rhodes CJ 1996 Glucoseregulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line. Diabetes 45 37-43. (doi:10.2337/diabetes.45.1.37)
31. Thyssen S, Arany E & Hill DJ 2006 Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with streptozotocin. Endocrinology 147 2346-2356. (doi:10.1210/en.2005-0396)
32. Tucker JD, Dhanvantari S & Brubaker PL 1996 Proglucagon processing in islet and intestinal cell lines. Regulatory Peptides 62 29-35. (doi:10.1016/0167-0115(95)00167-0)
33. Unger RH & Orci L 2010 Paracrinology of islets and the paracrinopathy of diabetes. PNAS 107 16009-16012. (doi:10.1073/pnas.1006639107)
34. Wideman RD, Gray SL, Covey SD, Webb GC & Kieffer TJ 2009 Transplantation of PC1/3-expressing alpha-cells improves glucose handling and cold tolerance in leptin-resistant mice. Molecular Therapy 17 191-198. (doi:10.1038/mt.2008.219)
35. Xu G, Stoffers DA, Habener JF & Bonner-Weir S 1999 Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48 2270-2276. (doi:10.2337/diabetes.48.12.2270)