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Volumn 70, Issue 1, 2013, Pages 71-88

Genetic determinants of neuronal vulnerability to apoptosis

Author keywords

Apoptosis; Genetic; Neurodegeneration; Neuron; p53; Polymorphism

Indexed keywords

ARGININE; BIM PROTEIN; BIOLOGICAL MARKER; CASPASE 3; CASPASE 8; CASPASE 9; FAS ANTIGEN; FAS LIGAND; PROLINE; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN MDM2; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA;

EID: 84872323075     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1029-y     Document Type: Review
Times cited : (16)

References (218)
  • 1
    • 0013982846 scopus 로고
    • The nerve growth factor: Its mode of action on sensory and sympathetic nerve cells
    • 5338067 1:CAS:528:DyaF28XkvVCgtbg%3D
    • Levi-Montalcini R (1966) The nerve growth factor: its mode of action on sensory and sympathetic nerve cells. Harvey Lect 60:217-259
    • (1966) Harvey Lect , vol.60 , pp. 217-259
    • Levi-Montalcini, R.1
  • 2
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • 4561027 1:STN:280:DyaE3s%2FgsFSksw%3D%3D
    • Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 3
    • 0034641936 scopus 로고    scopus 로고
    • Apoptosis in the nervous system
    • 11048732 1:CAS:528:DC%2BD3cXnsFWrsbY%3D
    • Yuan J, Yankner BA (2000) Apoptosis in the nervous system. Nature 407:802-809
    • (2000) Nature , vol.407 , pp. 802-809
    • Yuan, J.1    Yankner, B.A.2
  • 4
    • 33750292972 scopus 로고    scopus 로고
    • Cell death in the nervous system
    • 17051206 1:CAS:528:DC%2BD28XhtVyktbbP
    • Bredesen DE, Rao RV, Mehlen P (2006) Cell death in the nervous system. Nature 443:796-802
    • (2006) Nature , vol.443 , pp. 796-802
    • Bredesen, D.E.1    Rao, R.V.2    Mehlen, P.3
  • 6
    • 79955978036 scopus 로고    scopus 로고
    • Matter of life and death: The pharmacological approaches targeting apoptosis in brain diseases
    • 21348825 1:CAS:528:DC%2BC3MXltVSnsrs%3D
    • Cavallucci V, D'Amelio M (2011) Matter of life and death: the pharmacological approaches targeting apoptosis in brain diseases. Curr Pharm Des 17:215-229
    • (2011) Curr Pharm des , vol.17 , pp. 215-229
    • Cavallucci, V.1    D'Amelio, M.2
  • 7
    • 33749572210 scopus 로고    scopus 로고
    • Carcinogenesis and apoptosis: Paradigms and paradoxes
    • 16606631 1:CAS:528:DC%2BD28XhtVOmu77F
    • Zhivotovsky B, Orrenius S (2006) Carcinogenesis and apoptosis: paradigms and paradoxes. Carcinogenesis 27:1939-1945
    • (2006) Carcinogenesis , vol.27 , pp. 1939-1945
    • Zhivotovsky, B.1    Orrenius, S.2
  • 8
    • 63249087082 scopus 로고    scopus 로고
    • Gene polymorphisms, apoptotic capacity and cancer risk
    • 19214578
    • Imyanitov EN (2009) Gene polymorphisms, apoptotic capacity and cancer risk. Hum Genet 125:239-246
    • (2009) Hum Genet , vol.125 , pp. 239-246
    • Imyanitov, E.N.1
  • 10
    • 33845480311 scopus 로고    scopus 로고
    • Caspase substrates
    • 17082814 1:CAS:528:DC%2BD28XhtlSqur%2FE
    • Timmer JC, Salvesen GS (2007) Caspase substrates. Cell Death Differ 14:66-72
    • (2007) Cell Death Differ , vol.14 , pp. 66-72
    • Timmer, J.C.1    Salvesen, G.S.2
  • 11
    • 79953719964 scopus 로고    scopus 로고
    • Role of Bcl-2 family proteins and caspases in the regulation of apoptosis
    • 21210296 1:CAS:528:DC%2BC3MXjvFejtLk%3D
    • Ola MS, Nawaz M, Ahsan H (2011) Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Mol Cell Biochem 351:41-58
    • (2011) Mol Cell Biochem , vol.351 , pp. 41-58
    • Ola, M.S.1    Nawaz, M.2    Ahsan, H.3
  • 12
    • 0037204948 scopus 로고    scopus 로고
    • TNF-R1 signaling: A beautiful pathway
    • 12040173 1:CAS:528:DC%2BD38XktlChtrg%3D
    • Chen G, Goeddel DV (2002) TNF-R1 signaling: a beautiful pathway. Science 296:1634-1635
    • (2002) Science , vol.296 , pp. 1634-1635
    • Chen, G.1    Goeddel, D.V.2
  • 13
    • 0037204952 scopus 로고    scopus 로고
    • The Fas signaling pathway: More than a paradigm
    • 12040174 1:CAS:528:DC%2BD38XktlChtrk%3D
    • Wajant H (2002) The Fas signaling pathway: more than a paradigm. Science 296:1635-1636
    • (2002) Science , vol.296 , pp. 1635-1636
    • Wajant, H.1
  • 14
    • 0037276437 scopus 로고    scopus 로고
    • The CD95(APO-1/Fas) DISC and beyond
    • 12655293 1:CAS:528:DC%2BD3sXit12mu70%3D
    • Peter ME, Krammer PH (2003) The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ 10:26-35
    • (2003) Cell Death Differ , vol.10 , pp. 26-35
    • Peter, M.E.1    Krammer, P.H.2
  • 15
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • 9727492 1:CAS:528:DyaK1cXlslOrsbY%3D
    • Li H, Zhu H, Xu CJ, Yuan J (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94:491-501
    • (1998) Cell , vol.94 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.J.3    Yuan, J.4
  • 16
    • 68149103141 scopus 로고    scopus 로고
    • Bid: A Bax-like BH3 protein
    • 19641510 1:CAS:528:DC%2BD1MXpt1Wgs7s%3D
    • Billen LP, Shamas-Din A, Andrews DW (2008) Bid: a Bax-like BH3 protein. Oncogene 27(Suppl 1):S93-104
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1 , pp. 93-104
    • Billen, L.P.1    Shamas-Din, A.2    Andrews, D.W.3
  • 17
    • 71549170836 scopus 로고    scopus 로고
    • Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: Therapeutic implications
    • 19716390 1:CAS:528:DC%2BD1MXhsVWmu7nL
    • Bolanos JP, Moro MA, Lizasoain I, Almeida A (2009) Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: therapeutic implications. Adv Drug Deliv Rev 61:1299-1315
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 1299-1315
    • Bolanos, J.P.1    Moro, M.A.2    Lizasoain, I.3    Almeida, A.4
  • 18
    • 77956095537 scopus 로고    scopus 로고
    • Mitochondria and cell death: Outer membrane permeabilization and beyond
    • 20683470 1:CAS:528:DC%2BC3cXps1egt7w%3D
    • Tait SW, Green DR (2010) Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol 11:621-632
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 621-632
    • Tait, S.W.1    Green, D.R.2
  • 20
    • 79960230433 scopus 로고    scopus 로고
    • Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics
    • 21763611 1:CAS:528:DC%2BC3MXptVSqsrw%3D
    • Martinou JC, Youle RJ (2011) Mitochondria in apoptosis: bcl-2 family members and mitochondrial dynamics. Dev Cell 21:92-101
    • (2011) Dev Cell , vol.21 , pp. 92-101
    • Martinou, J.C.1    Youle, R.J.2
  • 21
  • 23
    • 1542465184 scopus 로고    scopus 로고
    • Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis
    • 14522999 1:CAS:528:DC%2BD3sXptlGku70%3D
    • Yethon JA, Epand RF, Leber B, Epand RM, Andrews DW (2003) Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis. J Biol Chem 278:48935-48941
    • (2003) J Biol Chem , vol.278 , pp. 48935-48941
    • Yethon, J.A.1    Epand, R.F.2    Leber, B.3    Epand, R.M.4    Andrews, D.W.5
  • 24
    • 57149135309 scopus 로고    scopus 로고
    • Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax
    • 19062087 1:CAS:528:DC%2BD1MXnslOq
    • Lovell JF, Billen LP, Bindner S, Shamas-Din A, Fradin C, Leber B, Andrews DW (2008) Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. Cell 135:1074-1084
    • (2008) Cell , vol.135 , pp. 1074-1084
    • Lovell, J.F.1    Billen, L.P.2    Bindner, S.3    Shamas-Din, A.4    Fradin, C.5    Leber, B.6    Andrews, D.W.7
  • 26
    • 45849085339 scopus 로고    scopus 로고
    • Cytochrome c: Functions beyond respiration
    • 18568041 1:CAS:528:DC%2BD1cXnsFGgu7k%3D
    • Ow YP, Green DR, Hao Z, Mak TW (2008) Cytochrome c: functions beyond respiration. Nat Rev Mol Cell Biol 9:532-542
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 532-542
    • Ow, Y.P.1    Green, D.R.2    Hao, Z.3    Mak, T.W.4
  • 27
    • 39749182234 scopus 로고    scopus 로고
    • Apoptosis: Controlled demolition at the cellular level
    • 18073771 1:CAS:528:DC%2BD1cXitlGnurs%3D
    • Taylor RC, Cullen SP, Martin SJ (2008) Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 9:231-241
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 231-241
    • Taylor, R.C.1    Cullen, S.P.2    Martin, S.J.3
  • 28
    • 34247345833 scopus 로고    scopus 로고
    • The apoptosome: Signalling platform of cell death
    • 17377525 1:CAS:528:DC%2BD2sXksFSjsr4%3D
    • Riedl SJ, Salvesen GS (2007) The apoptosome: signalling platform of cell death. Nat Rev Mol Cell Biol 8:405-413
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 405-413
    • Riedl, S.J.1    Salvesen, G.S.2
  • 29
    • 33749252583 scopus 로고    scopus 로고
    • Human inhibitor of apoptosis proteins: Why XIAP is the black sheep of the family
    • 17016456 1:CAS:528:DC%2BD28XhtVajtr7K
    • Eckelman BP, Salvesen GS, Scott FL (2006) Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep 7:988-994
    • (2006) EMBO Rep , vol.7 , pp. 988-994
    • Eckelman, B.P.1    Salvesen, G.S.2    Scott, F.L.3
  • 30
    • 79959354999 scopus 로고    scopus 로고
    • Mitochondria and the autophagy-inflammation-cell death axis in organismal aging
    • 21868666 1:CAS:528:DC%2BC3MXhtVGktrrN
    • Green DR, Galluzzi L, Kroemer G (2011) Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 333:1109-1112
    • (2011) Science , vol.333 , pp. 1109-1112
    • Green, D.R.1    Galluzzi, L.2    Kroemer, G.3
  • 32
    • 0033756901 scopus 로고    scopus 로고
    • Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease
    • 11031081 1:CAS:528:DC%2BD3cXnt1Wjsbo%3D
    • Tatton NA (2000) Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease. Exp Neurol 166:29-43
    • (2000) Exp Neurol , vol.166 , pp. 29-43
    • Tatton, N.A.1
  • 33
    • 0032747486 scopus 로고    scopus 로고
    • Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death
    • 10550301 1:CAS:528:DyaK1MXnvVKisrc%3D
    • Stadelmann C, Deckwerth TL, Srinivasan A, Bancher C, Bruck W, Jellinger K, Lassmann H (1999) Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death. Am J Pathol 155:1459-1466
    • (1999) Am J Pathol , vol.155 , pp. 1459-1466
    • Stadelmann, C.1    Deckwerth, T.L.2    Srinivasan, A.3    Bancher, C.4    Bruck, W.5    Jellinger, K.6    Lassmann, H.7
  • 34
    • 0036968953 scopus 로고    scopus 로고
    • Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain
    • 12505426 1:CAS:528:DC%2BD38Xps12rtLc%3D
    • Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW, Head E (2002) Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis 11:341-354
    • (2002) Neurobiol Dis , vol.11 , pp. 341-354
    • Rohn, T.T.1    Rissman, R.A.2    Davis, M.C.3    Kim, Y.E.4    Cotman, C.W.5    Head, E.6
  • 35
    • 77952553944 scopus 로고    scopus 로고
    • Ischemia induces endoplasmic reticulum stress and cell apoptosis in human brain
    • 20347937 1:CAS:528:DC%2BC3cXlsVyjsr4%3D
    • Duan SR, Wang JX, Wang J, Xu R, Zhao JK, Wang DS (2010) Ischemia induces endoplasmic reticulum stress and cell apoptosis in human brain. Neurosci Lett 475:132-135
    • (2010) Neurosci Lett , vol.475 , pp. 132-135
    • Duan, S.R.1    Wang, J.X.2    Wang, J.3    Xu, R.4    Zhao, J.K.5    Wang, D.S.6
  • 36
    • 69949145991 scopus 로고    scopus 로고
    • Neuronal caspase-3 and PARP-1 correlate differentially with apoptosis and necrosis in ischemic human stroke
    • 19529948 1:CAS:528:DC%2BD1MXhtVygsLzK
    • Sairanen T, Szepesi R, Karjalainen-Lindsberg ML, Saksi J, Paetau A, Lindsberg PJ (2009) Neuronal caspase-3 and PARP-1 correlate differentially with apoptosis and necrosis in ischemic human stroke. Acta Neuropathol 118:541-552
    • (2009) Acta Neuropathol , vol.118 , pp. 541-552
    • Sairanen, T.1    Szepesi, R.2    Karjalainen-Lindsberg, M.L.3    Saksi, J.4    Paetau, A.5    Lindsberg, P.J.6
  • 37
    • 0028853727 scopus 로고
    • Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity
    • 8593592 1:CAS:528:DyaK2MXptVehs78%3D
    • Satou T, Cummings BJ, Cotman CW (1995) Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity. Brain Res 697:35-43
    • (1995) Brain Res , vol.697 , pp. 35-43
    • Satou, T.1    Cummings, B.J.2    Cotman, C.W.3
  • 38
    • 0033976201 scopus 로고    scopus 로고
    • Developmental expression of Bcl-2 protein in human cortex
    • 10675772 1:CAS:528:DC%2BD3cXhtFamsro%3D
    • Jarskog LF, Gilmore JH (2000) Developmental expression of Bcl-2 protein in human cortex. Brain Res Dev Brain Res 119:225-230
    • (2000) Brain Res Dev Brain Res , vol.119 , pp. 225-230
    • Jarskog, L.F.1    Gilmore, J.H.2
  • 39
    • 62449129138 scopus 로고    scopus 로고
    • Cell death pathways in Parkinson's disease: Proximal triggers, distal effectors, and final steps
    • 19165601
    • Levy OA, Malagelada C, Greene LA (2009) Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps. Apoptosis 14:478-500
    • (2009) Apoptosis , vol.14 , pp. 478-500
    • Levy, O.A.1    Malagelada, C.2    Greene, L.A.3
  • 40
    • 1642575170 scopus 로고    scopus 로고
    • Fas ligand/Fas system in the brain: Regulator of immune and apoptotic responses
    • 14739003 1:CAS:528:DC%2BD2cXltVygug%3D%3D
    • Choi C, Benveniste EN (2004) Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses. Brain Res Brain Res Rev 44:65-81
    • (2004) Brain Res Brain Res Rev , vol.44 , pp. 65-81
    • Choi, C.1    Benveniste, E.N.2
  • 42
    • 0041831032 scopus 로고    scopus 로고
    • Fas ligand-mediated apoptosis in degenerative disorders of the brain
    • 15031631 1:CAS:528:DC%2BD2cXlsF2k
    • Ethell DW, Buhler LA (2003) Fas ligand-mediated apoptosis in degenerative disorders of the brain. J Clin Immunol 23:439-446
    • (2003) J Clin Immunol , vol.23 , pp. 439-446
    • Ethell, D.W.1    Buhler, L.A.2
  • 43
    • 50249100375 scopus 로고    scopus 로고
    • Death receptor Fas (CD95) signaling in the central nervous system: Tuning neuroplasticity?
    • 18676032 1:CAS:528:DC%2BD1cXhtVKnur3M
    • Reich A, Spering C, Schulz JB (2008) Death receptor Fas (CD95) signaling in the central nervous system: tuning neuroplasticity? Trends Neurosci 31:478-486
    • (2008) Trends Neurosci , vol.31 , pp. 478-486
    • Reich, A.1    Spering, C.2    Schulz, J.B.3
  • 45
    • 34547909939 scopus 로고    scopus 로고
    • CD95/Fas mediates cognitive improvement after traumatic brain injury
    • 17646846 1:CAS:528:DC%2BD2sXovFeqtr8%3D
    • Beier CP, Kolbl M, Beier D, Woertgen C, Bogdahn U, Brawanski A (2007) CD95/Fas mediates cognitive improvement after traumatic brain injury. Cell Res 17:732-734
    • (2007) Cell Res , vol.17 , pp. 732-734
    • Beier, C.P.1    Kolbl, M.2    Beier, D.3    Woertgen, C.4    Bogdahn, U.5    Brawanski, A.6
  • 46
    • 0033378856 scopus 로고    scopus 로고
    • Role of Fas-FasL interactions in the pathogenesis and regulation of autoimmune demyelinating disease
    • 10695714 1:CAS:528:DC%2BD3cXltVeitg%3D%3D
    • Sabelko-Downes KA, Russell JH, Cross AH (1999) Role of Fas-FasL interactions in the pathogenesis and regulation of autoimmune demyelinating disease. J Neuroimmunol 100:42-52
    • (1999) J Neuroimmunol , vol.100 , pp. 42-52
    • Sabelko-Downes, K.A.1    Russell, J.H.2    Cross, A.H.3
  • 48
    • 0033562658 scopus 로고    scopus 로고
    • CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons
    • 10234013 1:CAS:528:DyaK1MXjtV2rtb8%3D
    • Martin-Villalba A, Herr I, Jeremias I, Hahne M, Brandt R, Vogel J, Schenkel J, Herdegen T, Debatin KM (1999) CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons. J Neurosci 19:3809-3817
    • (1999) J Neurosci , vol.19 , pp. 3809-3817
    • Martin-Villalba, A.1    Herr, I.2    Jeremias, I.3    Hahne, M.4    Brandt, R.5    Vogel, J.6    Schenkel, J.7    Herdegen, T.8    Debatin, K.M.9
  • 50
    • 33645822300 scopus 로고    scopus 로고
    • Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL
    • 16581901 1:CAS:528:DC%2BD28XktFaitbY%3D
    • Raoul C, Buhler E, Sadeghi C, Jacquier A, Aebischer P, Pettmann B, Henderson CE, Haase G (2006) Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL. Proc Natl Acad Sci USA 103:6007-6012
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 6007-6012
    • Raoul, C.1    Buhler, E.2    Sadeghi, C.3    Jacquier, A.4    Aebischer, P.5    Pettmann, B.6    Henderson, C.E.7    Haase, G.8
  • 51
    • 0038079348 scopus 로고    scopus 로고
    • Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death
    • 12742739 1:CAS:528:DC%2BD3sXjs1Wms78%3D
    • Su JH, Anderson AJ, Cribbs DH, Tu C, Tong L, Kesslack P, Cotman CW (2003) Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death. Neurobiol Dis 12:182-193
    • (2003) Neurobiol Dis , vol.12 , pp. 182-193
    • Su, J.H.1    Anderson, A.J.2    Cribbs, D.H.3    Tu, C.4    Tong, L.5    Kesslack, P.6    Cotman, C.W.7
  • 52
    • 21244435254 scopus 로고    scopus 로고
    • SOD-1 inhibits FAS expression in cortex of APP transgenic mice
    • 15909112 1:CAS:528:DC%2BD2MXktl2rsbo%3D
    • Chen Z, Duan RS, Lepecheur M, Paly E, London J, Zhu J (2005) SOD-1 inhibits FAS expression in cortex of APP transgenic mice. Apoptosis 10:499-502
    • (2005) Apoptosis , vol.10 , pp. 499-502
    • Chen, Z.1    Duan, R.S.2    Lepecheur, M.3    Paly, E.4    London, J.5    Zhu, J.6
  • 53
    • 0037154136 scopus 로고    scopus 로고
    • FADD: A link between TNF family receptors and caspases in Parkinson's disease
    • 11805265 1:CAS:528:DC%2BD38XhtVyksLo%3D
    • Hartmann A, Mouatt-Prigent A, Faucheux BA, Agid Y, Hirsch EC (2002) FADD: a link between TNF family receptors and caspases in Parkinson's disease. Neurology 58:308-310
    • (2002) Neurology , vol.58 , pp. 308-310
    • Hartmann, A.1    Mouatt-Prigent, A.2    Faucheux, B.A.3    Agid, Y.4    Hirsch, E.C.5
  • 55
    • 77954966128 scopus 로고    scopus 로고
    • NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy
    • 20530871 1:CAS:528:DC%2BC3cXovFartrg%3D
    • Gomez-Sintes R, Lucas JJ (2010) NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy. J Clin Invest 120:2432-2445
    • (2010) J Clin Invest , vol.120 , pp. 2432-2445
    • Gomez-Sintes, R.1    Lucas, J.J.2
  • 56
    • 33644938437 scopus 로고    scopus 로고
    • Nonparticipation of nuclear factor kappa B (NFkappaB) in the signaling cascade of c-Jun N-terminal kinase (JNK)- and p38 mitogen-activated protein kinase (p38MAPK)-dependent tumor necrosis factor alpha (TNFalpha) induction in lipopolysaccharide (LPS)-stimulated microglia
    • 16457791
    • Uesugi M, Nakajima K, Tohyama Y, Kohsaka S, Kurihara T (2006) Nonparticipation of nuclear factor kappa B (NFkappaB) in the signaling cascade of c-Jun N-terminal kinase (JNK)- and p38 mitogen-activated protein kinase (p38MAPK)-dependent tumor necrosis factor alpha (TNFalpha) induction in lipopolysaccharide (LPS)-stimulated microglia. Brain Res 1073-1074:48-59
    • (2006) Brain Res , vol.1073-1074 , pp. 48-59
    • Uesugi, M.1    Nakajima, K.2    Tohyama, Y.3    Kohsaka, S.4    Kurihara, T.5
  • 57
    • 77952291438 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction
    • 20096353 1:CAS:528:DC%2BC3cXlt1Cksr8%3D
    • Park KM, Bowers WJ (2010) Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction. Cell Signal 22:977-983
    • (2010) Cell Signal , vol.22 , pp. 977-983
    • Park, K.M.1    Bowers, W.J.2
  • 58
    • 78650035858 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of excitotoxic neuronal death
    • 20213199 1:CAS:528:DC%2BC3cXhsVWqtr%2FJ
    • Wang Y, Qin ZH (2010) Molecular and cellular mechanisms of excitotoxic neuronal death. Apoptosis 15:1382-1402
    • (2010) Apoptosis , vol.15 , pp. 1382-1402
    • Wang, Y.1    Qin, Z.H.2
  • 62
    • 34447305483 scopus 로고    scopus 로고
    • Heritability of susceptibility to ionizing radiation-induced apoptosis of human lymphocyte subpopulations
    • 17637392 1:CAS:528:DC%2BD2sXnslWjsL4%3D
    • Schmitz A, Bayer J, Dechamps N, Goldin L, Thomas G (2007) Heritability of susceptibility to ionizing radiation-induced apoptosis of human lymphocyte subpopulations. Int J Radiat Oncol Biol Phys 68:1169-1177
    • (2007) Int J Radiat Oncol Biol Phys , vol.68 , pp. 1169-1177
    • Schmitz, A.1    Bayer, J.2    Dechamps, N.3    Goldin, L.4    Thomas, G.5
  • 63
    • 33747201603 scopus 로고    scopus 로고
    • Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins
    • 16819540 1:CAS:528:DC%2BD28XotV2rur8%3D
    • Camplejohn RS, Hodgson S, Carter N, Kato BS, Spector TD (2006) Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins. Br J Cancer 95:520-524
    • (2006) Br J Cancer , vol.95 , pp. 520-524
    • Camplejohn, R.S.1    Hodgson, S.2    Carter, N.3    Kato, B.S.4    Spector, T.D.5
  • 65
    • 77953556974 scopus 로고    scopus 로고
    • MicroRNAs in neurodegenerative disorders
    • 20404550 1:CAS:528:DC%2BC3cXht12itrrI
    • Junn E, Mouradian MM (2010) MicroRNAs in neurodegenerative disorders. Cell Cycle 9:1717-1721
    • (2010) Cell Cycle , vol.9 , pp. 1717-1721
    • Junn, E.1    Mouradian, M.M.2
  • 66
    • 77952584652 scopus 로고    scopus 로고
    • Dysregulated microRNAs in neurodegenerative disorders
    • 20080199 1:CAS:528:DC%2BC3cXhtVymurrJ
    • Lau P, de Strooper B (2010) Dysregulated microRNAs in neurodegenerative disorders. Semin Cell Dev Biol 21:768-773
    • (2010) Semin Cell Dev Biol , vol.21 , pp. 768-773
    • Lau, P.1    De Strooper, B.2
  • 68
    • 80052101257 scopus 로고    scopus 로고
    • MicroRNAs in Parkinson's disease
    • 21295133 1:CAS:528:DC%2BC3MXhtFShu77P
    • Harraz MM, Dawson TM, Dawson VL (2011) MicroRNAs in Parkinson's disease. J Chem Neuroanat 42:127-130
    • (2011) J Chem Neuroanat , vol.42 , pp. 127-130
    • Harraz, M.M.1    Dawson, T.M.2    Dawson, V.L.3
  • 69
    • 77953556974 scopus 로고    scopus 로고
    • MicroRNAs in neurodegenerative disorders
    • Junn E, Mouradian MM (2011) MicroRNAs in neurodegenerative disorders. Cell Cycle 9:1717-1721
    • (2011) Cell Cycle , vol.9 , pp. 1717-1721
    • Junn, E.1    Mouradian, M.M.2
  • 72
    • 0034633769 scopus 로고    scopus 로고
    • Apoptosis mediators fasL and TRAIL are upregulated in peripheral blood mononuclear cells in MS
    • 11061246 1:CAS:528:DC%2BD3cXnsF2gsbo%3D
    • Huang WX, Huang MP, Gomes MA, Hillert J (2000) Apoptosis mediators fasL and TRAIL are upregulated in peripheral blood mononuclear cells in MS. Neurology 55:928-934
    • (2000) Neurology , vol.55 , pp. 928-934
    • Huang, W.X.1    Huang, M.P.2    Gomes, M.A.3    Hillert, J.4
  • 74
    • 0033757360 scopus 로고    scopus 로고
    • Apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease: Finding of a positive association for a polymorphism in the TNFRSF6 gene
    • 11129341 1:CAS:528:DC%2BD3cXotVelt78%3D
    • Feuk L, Prince JA, Breen G, Emahazion T, Carothers A, St Clair D, Brookes AJ (2000) Apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease: finding of a positive association for a polymorphism in the TNFRSF6 gene. Hum Genet 107:391-396
    • (2000) Hum Genet , vol.107 , pp. 391-396
    • Feuk, L.1    Prince, J.A.2    Breen, G.3    Emahazion, T.4    Carothers, A.5    St Clair, D.6    Brookes, A.J.7
  • 75
    • 0037224318 scopus 로고    scopus 로고
    • Further evidence for role of a promoter variant in the TNFRSF6 gene in Alzheimer disease
    • 12497631 1:CAS:528:DC%2BD3sXot1alsw%3D%3D
    • Feuk L, Prince JA, Blennow K, Brookes AJ (2003) Further evidence for role of a promoter variant in the TNFRSF6 gene in Alzheimer disease. Hum Mutat 21:53-60
    • (2003) Hum Mutat , vol.21 , pp. 53-60
    • Feuk, L.1    Prince, J.A.2    Blennow, K.3    Brookes, A.J.4
  • 79
    • 33645874766 scopus 로고    scopus 로고
    • The Fas gene A-670G polymorphism is not associated with sporadic Alzheimer disease in a Chinese Han population
    • 16703675 1:CAS:528:DC%2BD28XjtFaitr8%3D
    • He XM, Zhang ZX, Zhang JW, Zhou YT, Tang MN, Wu CB, Hong Z (2006) The Fas gene A-670G polymorphism is not associated with sporadic Alzheimer disease in a Chinese Han population. Brain Res 1082:192-195
    • (2006) Brain Res , vol.1082 , pp. 192-195
    • He, X.M.1    Zhang, Z.X.2    Zhang, J.W.3    Zhou, Y.T.4    Tang, M.N.5    Wu, C.B.6    Hong, Z.7
  • 82
    • 0344321151 scopus 로고    scopus 로고
    • An examination of the Apo-1/Fas promoter Mva i polymorphism in Japanese patients with multiple sclerosis
    • 12188927
    • Niino M, Kikuchi S, Fukazawa T, Miyagishi R, Yabe I, Tashiro K (2002) An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis. BMC Neurol 2:8
    • (2002) BMC Neurol , vol.2 , pp. 8
    • Niino, M.1    Kikuchi, S.2    Fukazawa, T.3    Miyagishi, R.4    Yabe, I.5    Tashiro, K.6
  • 84
    • 77949338415 scopus 로고    scopus 로고
    • The FAS gene, brain volume, and disease progression in Alzheimer's disease
    • 19766542 1:CAS:528:DC%2BC3cXlvFOntb8%3D
    • Erten-Lyons D, Jacobson A, Kramer P, Grupe A, Kaye J (2010) The FAS gene, brain volume, and disease progression in Alzheimer's disease. Alzheimers Dement 6:118-124
    • (2010) Alzheimers Dement , vol.6 , pp. 118-124
    • Erten-Lyons, D.1    Jacobson, A.2    Kramer, P.3    Grupe, A.4    Kaye, J.5
  • 85
    • 0029616220 scopus 로고
    • A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis
    • 8524870 1:CAS:528:DyaK2MXpvVOntLc%3D
    • Chu K, Niu X, Williams LT (1995) A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc Natl Acad Sci USA 92:11894-11898
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11894-11898
    • Chu, K.1    Niu, X.2    Williams, L.T.3
  • 86
  • 89
    • 69249211227 scopus 로고    scopus 로고
    • FAS-associated factor 1 (FAF1): Diverse functions and implications for oncogenesis
    • 19597341 1:CAS:528:DC%2BC3cXjsl2mu7Y%3D
    • Menges CW, Altomare DA, Testa JR (2009) FAS-associated factor 1 (FAF1): diverse functions and implications for oncogenesis. Cell Cycle 8:2528-2534
    • (2009) Cell Cycle , vol.8 , pp. 2528-2534
    • Menges, C.W.1    Altomare, D.A.2    Testa, J.R.3
  • 92
    • 79955548865 scopus 로고    scopus 로고
    • LRRK2 signaling pathways: The key to unlocking neurodegeneration?
    • 21306901 1:CAS:528:DC%2BC3MXlvFWjs74%3D
    • Berwick DC, Harvey K (2011) LRRK2 signaling pathways: the key to unlocking neurodegeneration? Trends Cell Biol 21:257-265
    • (2011) Trends Cell Biol , vol.21 , pp. 257-265
    • Berwick, D.C.1    Harvey, K.2
  • 93
    • 59649089328 scopus 로고    scopus 로고
    • The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration
    • 19176810 1:CAS:528:DC%2BD1MXhs1KqsbY%3D
    • Ho CC, Rideout HJ, Ribe E, Troy CM, Dauer WT (2009) The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration. J Neurosci 29:1011-1016
    • (2009) J Neurosci , vol.29 , pp. 1011-1016
    • Ho, C.C.1    Rideout, H.J.2    Ribe, E.3    Troy, C.M.4    Dauer, W.T.5
  • 95
    • 80053152848 scopus 로고    scopus 로고
    • Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models
    • 21768216 1:CAS:528:DC%2BC3MXht1ajtbnL
    • Liu Z, Hamamichi S, Lee BD, Yang D, Ray A, Caldwell GA, Caldwell KA, Dawson TM, Smith WW, Dawson VL (2011) Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models. Hum Mol Genet 20:3933-3942
    • (2011) Hum Mol Genet , vol.20 , pp. 3933-3942
    • Liu, Z.1    Hamamichi, S.2    Lee, B.D.3    Yang, D.4    Ray, A.5    Caldwell, G.A.6    Caldwell, K.A.7    Dawson, T.M.8    Smith, W.W.9    Dawson, V.L.10
  • 99
    • 0032581020 scopus 로고    scopus 로고
    • Effects of tumor necrosis factor gene polymorphisms on patients with congestive heart failure. VEST Investigators for TNF Genotype Analysis. Vesnarinone Survival Trial
    • 9657468 1:CAS:528:DyaK1cXksVygsrc%3D
    • Kubota T, McNamara DM, Wang JJ, Trost M, McTiernan CF, Mann DL, Feldman AM (1998) Effects of tumor necrosis factor gene polymorphisms on patients with congestive heart failure. VEST Investigators for TNF Genotype Analysis. Vesnarinone Survival Trial. Circulation 97:2499-2501
    • (1998) Circulation , vol.97 , pp. 2499-2501
    • Kubota, T.1    McNamara, D.M.2    Wang, J.J.3    Trost, M.4    McTiernan, C.F.5    Mann, D.L.6    Feldman, A.M.7
  • 100
    • 4344579064 scopus 로고    scopus 로고
    • Is there a future for TNF promoter polymorphisms?
    • 14973548 1:CAS:528:DC%2BD2cXlvVals7o%3D
    • Bayley JP, Ottenhoff TH, Verweij CL (2004) Is there a future for TNF promoter polymorphisms? Genes Immun 5:315-329
    • (2004) Genes Immun , vol.5 , pp. 315-329
    • Bayley, J.P.1    Ottenhoff, T.H.2    Verweij, C.L.3
  • 101
    • 0031747683 scopus 로고    scopus 로고
    • Polymorphism of the 5′-flanking region of the human tumor necrosis factor (TNF)-alpha gene in Japanese
    • 9694352 1:CAS:528:DyaK1cXks12ks70%3D
    • Higuchi T, Seki N, Kamizono S, Yamada A, Kimura A, Kato H, Itoh K (1998) Polymorphism of the 5′-flanking region of the human tumor necrosis factor (TNF)-alpha gene in Japanese. Tissue Antigens 51:605-612
    • (1998) Tissue Antigens , vol.51 , pp. 605-612
    • Higuchi, T.1    Seki, N.2    Kamizono, S.3    Yamada, A.4    Kimura, A.5    Kato, H.6    Itoh, K.7
  • 102
    • 0032837736 scopus 로고    scopus 로고
    • A common functional polymorphism (C-A substitution at position -863) in the promoter region of the tumour necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alpha
    • 10400991 1:CAS:528:DyaK1MXltFagtLo%3D
    • Skoog T, van't Hooft FM, Kallin B, Jovinge S, Boquist S, Nilsson J, Eriksson P, Hamsten A (1999) A common functional polymorphism (C-A substitution at position -863) in the promoter region of the tumour necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alpha. Hum Mol Genet 8:1443-1449
    • (1999) Hum Mol Genet , vol.8 , pp. 1443-1449
    • Skoog, T.1    Van'T Hooft, F.M.2    Kallin, B.3    Jovinge, S.4    Boquist, S.5    Nilsson, J.6    Eriksson, P.7    Hamsten, A.8
  • 103
    • 0034643905 scopus 로고    scopus 로고
    • TNF gene polymorphism and its relation to intracerebral production of TNFalpha and TNFbeta in AD
    • 10851366 1:CAS:528:DC%2BD3cXksVGisrw%3D
    • Tarkowski E, Liljeroth AM, Nilsson A, Ricksten A, Davidsson P, Minthon L, Blennow K (2000) TNF gene polymorphism and its relation to intracerebral production of TNFalpha and TNFbeta in AD. Neurology 54:2077-2081
    • (2000) Neurology , vol.54 , pp. 2077-2081
    • Tarkowski, E.1    Liljeroth, A.M.2    Nilsson, A.3    Ricksten, A.4    Davidsson, P.5    Minthon, L.6    Blennow, K.7
  • 104
    • 0032621790 scopus 로고    scopus 로고
    • TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs
    • 9872930 1:CAS:528:DyaK1MXlt1ygug%3D%3D
    • Blasko I, Marx F, Steiner E, Hartmann T, Grubeck-Loebenstein B (1999) TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs. Faseb J 13:63-68
    • (1999) Faseb J , vol.13 , pp. 63-68
    • Blasko, I.1    Marx, F.2    Steiner, E.3    Hartmann, T.4    Grubeck-Loebenstein, B.5
  • 105
    • 70349481490 scopus 로고    scopus 로고
    • Systematic review by meta-analyses on the possible role of TNF-alpha polymorphisms in association with Alzheimer's disease
    • 19445962
    • Di Bona D, Candore G, Franceschi C, Licastro F, Colonna-Romano G, Camma C, Lio D, Caruso C (2009) Systematic review by meta-analyses on the possible role of TNF-alpha polymorphisms in association with Alzheimer's disease. Brain Res Rev 61:60-68
    • (2009) Brain Res Rev , vol.61 , pp. 60-68
    • Di Bona, D.1    Candore, G.2    Franceschi, C.3    Licastro, F.4    Colonna-Romano, G.5    Camma, C.6    Lio, D.7    Caruso, C.8
  • 106
    • 0035835451 scopus 로고    scopus 로고
    • Association between polymorphism in regulatory region of gene encoding tumour necrosis factor alpha and risk of Alzheimer's disease and vascular dementia: A case-control study
    • 11273064 1:CAS:528:DC%2BD3MXhtFaktr0%3D
    • McCusker SM, Curran MD, Dynan KB, McCullagh CD, Urquhart DD, Middleton D, Patterson CC, McIlroy SP, Passmore AP (2001) Association between polymorphism in regulatory region of gene encoding tumour necrosis factor alpha and risk of Alzheimer's disease and vascular dementia: a case-control study. Lancet 357:436-439
    • (2001) Lancet , vol.357 , pp. 436-439
    • McCusker, S.M.1    Curran, M.D.2    Dynan, K.B.3    McCullagh, C.D.4    Urquhart, D.D.5    Middleton, D.6    Patterson, C.C.7    McIlroy, S.P.8    Passmore, A.P.9
  • 108
    • 1642503810 scopus 로고    scopus 로고
    • Major histocompatibility complex and sporadic Alzheimer's disease: A critical reappraisal
    • 15050301 1:CAS:528:DC%2BD2cXisF2nu7k%3D
    • Candore G, Balistreri CR, Colonna-Romano G, Lio D, Caruso C (2004) Major histocompatibility complex and sporadic Alzheimer's disease: a critical reappraisal. Exp Gerontol 39:645-652
    • (2004) Exp Gerontol , vol.39 , pp. 645-652
    • Candore, G.1    Balistreri, C.R.2    Colonna-Romano, G.3    Lio, D.4    Caruso, C.5
  • 110
    • 57549088664 scopus 로고    scopus 로고
    • Expression and genetic analysis of tumor necrosis factor-alpha (TNF-alpha) G -308A polymorphism in sporadic Alzheimer's disease in a Southern China population
    • 18992723 1:CAS:528:DC%2BD1cXhsV2ns7jO
    • Yang L, Lu R, Jiang L, Liu Z, Peng Y (2009) Expression and genetic analysis of tumor necrosis factor-alpha (TNF-alpha) G -308A polymorphism in sporadic Alzheimer's disease in a Southern China population. Brain Res 1247:178-181
    • (2009) Brain Res , vol.1247 , pp. 178-181
    • Yang, L.1    Lu, R.2    Jiang, L.3    Liu, Z.4    Peng, Y.5
  • 112
    • 53849138674 scopus 로고    scopus 로고
    • Lack of association between TNF-alpha polymorphisms and Alzheimer's disease in an Italian cohort
    • 18834925 1:CAS:528:DC%2BD1cXht1KmsrnE
    • Tedde A, Putignano AL, Nacmias B, Bagnoli S, Cellini E, Sorbi S (2008) Lack of association between TNF-alpha polymorphisms and Alzheimer's disease in an Italian cohort. Neurosci Lett 446:139-142
    • (2008) Neurosci Lett , vol.446 , pp. 139-142
    • Tedde, A.1    Putignano, A.L.2    Nacmias, B.3    Bagnoli, S.4    Cellini, E.5    Sorbi, S.6
  • 113
    • 0027534914 scopus 로고
    • An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles
    • 8426126 1:CAS:528:DyaK3sXnvFWgtw%3D%3D
    • Wilson AG, de Vries N, Pociot F, di Giovine FS, van der Putte LB, Duff GW (1993) An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles. J Exp Med 177:557-560
    • (1993) J Exp Med , vol.177 , pp. 557-560
    • Wilson, A.G.1    De Vries, N.2    Pociot, F.3    Di Giovine, F.S.4    Van Der Putte, L.B.5    Duff, G.W.6
  • 114
    • 0141840911 scopus 로고    scopus 로고
    • Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: Effect of multiple gene interactions
    • 12849055 1:CAS:528:DC%2BD38Xlt1ClsLs%3D
    • Candore G, Lio D, Romano GC, Caruso C (2002) Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: effect of multiple gene interactions. Autoimmun Rev 1:29-35
    • (2002) Autoimmun Rev , vol.1 , pp. 29-35
    • Candore, G.1    Lio, D.2    Romano, G.C.3    Caruso, C.4
  • 116
    • 81255176365 scopus 로고    scopus 로고
    • Tumour necrosis factor gene polymorphism and disease prevalence
    • 21790707 1:CAS:528:DC%2BC3MXhs1Glt7zF
    • Qidwai T, Khan F (2011) Tumour necrosis factor gene polymorphism and disease prevalence. Scand J Immunol 74:522-547
    • (2011) Scand J Immunol , vol.74 , pp. 522-547
    • Qidwai, T.1    Khan, F.2
  • 117
    • 0028178281 scopus 로고
    • Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients
    • 8015728 1:CAS:528:DyaK2cXitFCqsbY%3D
    • Mogi M, Harada M, Riederer P, Narabayashi H, Fujita K, Nagatsu T (1994) Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients. Neurosci Lett 165:208-210
    • (1994) Neurosci Lett , vol.165 , pp. 208-210
    • Mogi, M.1    Harada, M.2    Riederer, P.3    Narabayashi, H.4    Fujita, K.5    Nagatsu, T.6
  • 120
    • 0035929486 scopus 로고    scopus 로고
    • Tumor necrosis factor gene polymorphisms in patients with sporadic Parkinson's disease
    • 11585553 1:CAS:528:DC%2BD3MXms1Olsb0%3D
    • Nishimura M, Mizuta I, Mizuta E, Yamasaki S, Ohta M, Kaji R, Kuno S (2001) Tumor necrosis factor gene polymorphisms in patients with sporadic Parkinson's disease. Neurosci Lett 311:1-4
    • (2001) Neurosci Lett , vol.311 , pp. 1-4
    • Nishimura, M.1    Mizuta, I.2    Mizuta, E.3    Yamasaki, S.4    Ohta, M.5    Kaji, R.6    Kuno, S.7
  • 121
    • 1342328026 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha gene polymorphism is associated with cerebral infarction
    • 14992821 1:CAS:528:DC%2BD2cXhs12ms7c%3D
    • Um JY, Kim HM (2004) Tumor necrosis factor alpha gene polymorphism is associated with cerebral infarction. Brain Res Mol Brain Res 122:99-102
    • (2004) Brain Res Mol Brain Res , vol.122 , pp. 99-102
    • Um, J.Y.1    Kim, H.M.2
  • 123
    • 33644986199 scopus 로고    scopus 로고
    • Decreased frequency of the TNF2 allele of TNF-alpha -308 promoter polymorphism is associated with lacunar infarction
    • 16473522 1:CAS:528:DC%2BD28XisF2ht7s%3D
    • Harcos P, Laki J, Kiszel P, Szeplaki Z, Szolnoki Z, Kovacs M, Melegh B, Szeplaki G, Fust G, Blasko B (2006) Decreased frequency of the TNF2 allele of TNF-alpha -308 promoter polymorphism is associated with lacunar infarction. Cytokine 33:100-105
    • (2006) Cytokine , vol.33 , pp. 100-105
    • Harcos, P.1    Laki, J.2    Kiszel, P.3    Szeplaki, Z.4    Szolnoki, Z.5    Kovacs, M.6    Melegh, B.7    Szeplaki, G.8    Fust, G.9    Blasko, B.10
  • 125
    • 34548269532 scopus 로고    scopus 로고
    • Confirmation of an association between the TNF(-308) promoter polymorphism and stroke risk in children with sickle cell anemia
    • 17600229 1:CAS:528:DC%2BD2sXotVansLo%3D
    • Hoppe C, Klitz W, D'Harlingue K, Cheng S, Grow M, Steiner L, Noble J, Adams R, Styles L (2007) Confirmation of an association between the TNF(-308) promoter polymorphism and stroke risk in children with sickle cell anemia. Stroke 38:2241-2246
    • (2007) Stroke , vol.38 , pp. 2241-2246
    • Hoppe, C.1    Klitz, W.2    D'Harlingue, K.3    Cheng, S.4    Grow, M.5    Steiner, L.6    Noble, J.7    Adams, R.8    Styles, L.9
  • 126
    • 10744224902 scopus 로고    scopus 로고
    • Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-alpha genes, but not the interleukin-1beta gene
    • 15036607 1:CAS:528:DC%2BD2cXhtFCit7w%3D
    • Lee BC, Ahn SY, Doo HK, Yim SV, Lee HJ, Jin SY, Hong SJ, Lee SH, Kim SD, Seo JC, Leem KH, Chung JH (2004) Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-alpha genes, but not the interleukin-1beta gene. Neurosci Lett 357:33-36
    • (2004) Neurosci Lett , vol.357 , pp. 33-36
    • Lee, B.C.1    Ahn, S.Y.2    Doo, H.K.3    Yim, S.V.4    Lee, H.J.5    Jin, S.Y.6    Hong, S.J.7    Lee, S.H.8    Kim, S.D.9    Seo, J.C.10    Leem, K.H.11    Chung, J.H.12
  • 127
    • 77956086548 scopus 로고    scopus 로고
    • Association between tumor necrosis factor-alpha (-308G-A and -238G-A) polymorphisms and homocysteine levels in patients with ischemic strokes and silent brain infarctions
    • 20798494 1:CAS:528:DC%2BC3cXht1OqtbzJ
    • Kim OJ, Lee JH, Choi JK, Oh SH, Hong SH, Oh D, Kim NK (2010) Association between tumor necrosis factor-alpha (-308G-A and -238G-A) polymorphisms and homocysteine levels in patients with ischemic strokes and silent brain infarctions. Cerebrovasc Dis 30:483-490
    • (2010) Cerebrovasc Dis , vol.30 , pp. 483-490
    • Kim, O.J.1    Lee, J.H.2    Choi, J.K.3    Oh, S.H.4    Hong, S.H.5    Oh, D.6    Kim, N.K.7
  • 128
    • 14144253851 scopus 로고    scopus 로고
    • TNF-alpha -308G/A and IL-6-174 G/C polymorphisms in the Turkish pediatric stroke patients
    • 15733973 1:CAS:528:DC%2BD2MXhslWms74%3D
    • Karahan ZC, Deda G, Sipahi T, Elhan AH, Akar N (2005) TNF-alpha -308G/A and IL-6-174 G/C polymorphisms in the Turkish pediatric stroke patients. Thromb Res 115:393-398
    • (2005) Thromb Res , vol.115 , pp. 393-398
    • Karahan, Z.C.1    Deda, G.2    Sipahi, T.3    Elhan, A.H.4    Akar, N.5
  • 129
    • 0035664134 scopus 로고    scopus 로고
    • Activation of caspase-8 in the Alzheimer's disease brain
    • 11741396 1:CAS:528:DC%2BD3MXptVWhtb0%3D
    • Rohn TT, Head E, Nesse WH, Cotman CW, Cribbs DH (2001) Activation of caspase-8 in the Alzheimer's disease brain. Neurobiol Dis 8:1006-1016
    • (2001) Neurobiol Dis , vol.8 , pp. 1006-1016
    • Rohn, T.T.1    Head, E.2    Nesse, W.H.3    Cotman, C.W.4    Cribbs, D.H.5
  • 130
    • 34247624135 scopus 로고    scopus 로고
    • A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
    • 17450141 1:CAS:528:DC%2BD2sXksFersbs%3D
    • Sun T, Gao Y, Tan W, Ma S, Shi Y, Yao J, Guo Y, Yang M, Zhang X, Zhang Q, Zeng C, Lin D (2007) A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers. Nat Genet 39:605-613
    • (2007) Nat Genet , vol.39 , pp. 605-613
    • Sun, T.1    Gao, Y.2    Tan, W.3    Ma, S.4    Shi, Y.5    Yao, J.6    Guo, Y.7    Yang, M.8    Zhang, X.9    Zhang, Q.10    Zeng, C.11    Lin, D.12
  • 131
    • 0035313071 scopus 로고    scopus 로고
    • Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis
    • 11264300 1:CAS:528:DC%2BD3MXjslCmu7g%3D
    • Hartmann A, Troadec JD, Hunot S, Kikly K, Faucheux BA, Mouatt-Prigent A, Ruberg M, Agid Y, Hirsch EC (2001) Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis. J Neurosci 21:2247-2255
    • (2001) J Neurosci , vol.21 , pp. 2247-2255
    • Hartmann, A.1    Troadec, J.D.2    Hunot, S.3    Kikly, K.4    Faucheux, B.A.5    Mouatt-Prigent, A.6    Ruberg, M.7    Agid, Y.8    Hirsch, E.C.9
  • 134
    • 65249113795 scopus 로고    scopus 로고
    • A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter associated with risk and progression of bladder cancer
    • 19276244 1:CAS:528:DC%2BD1MXjvVWktro%3D
    • Wang M, Zhang Z, Tian Y, Shao J, Zhang Z (2009) A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter associated with risk and progression of bladder cancer. Clin Cancer Res 15:2567-2572
    • (2009) Clin Cancer Res , vol.15 , pp. 2567-2572
    • Wang, M.1    Zhang, Z.2    Tian, Y.3    Shao, J.4    Zhang, Z.5
  • 135
    • 80051552713 scopus 로고    scopus 로고
    • Polymorphisms in the CASP8 gene and the risk of epithelial ovarian cancer
    • 21714991 1:CAS:528:DC%2BC3MXpvFChu7k%3D
    • Ma X, Zhang J, Liu S, Huang Y, Chen B, Wang D (2011) Polymorphisms in the CASP8 gene and the risk of epithelial ovarian cancer. Gynecol Oncol 122:554-559
    • (2011) Gynecol Oncol , vol.122 , pp. 554-559
    • Ma, X.1    Zhang, J.2    Liu, S.3    Huang, Y.4    Chen, B.5    Wang, D.6
  • 136
    • 80051749177 scopus 로고    scopus 로고
    • Caspases and cancer
    • 21455218 1:CAS:528:DC%2BC3MXhtVWnt7rO
    • Olsson M, Zhivotovsky B (2011) Caspases and cancer. Cell Death Differ 18:1441-1449
    • (2011) Cell Death Differ , vol.18 , pp. 1441-1449
    • Olsson, M.1    Zhivotovsky, B.2
  • 138
    • 34347248415 scopus 로고    scopus 로고
    • Genomics in multiple sclerosis-current state and future directions
    • 17400297 1:CAS:528:DC%2BD2sXnsFKmt70%3D
    • Comabella M, Martin R (2007) Genomics in multiple sclerosis-current state and future directions. J Neuroimmunol 187:1-8
    • (2007) J Neuroimmunol , vol.187 , pp. 1-8
    • Comabella, M.1    Martin, R.2
  • 140
    • 78650979810 scopus 로고    scopus 로고
    • CASP8 in MS
    • 20947178 1:CAS:528:DC%2BC3MXntVahsw%3D%3D
    • Sand PG (2011) CASP8 in MS. J Neuroimmunol 230:192
    • (2011) J Neuroimmunol , vol.230 , pp. 192
    • Sand, P.G.1
  • 142
    • 82955195421 scopus 로고    scopus 로고
    • Role of death receptor, mitochondrial and endoplasmic reticulum pathways in different stages of degenerative human lumbar disc
    • 21879322 1:CAS:528:DC%2BC3MXhtFyjtrzM
    • Wang H, Liu H, Zheng ZM, Zhang KB, Wang TP, Sribastav SS, Liu WS, Liu T (2011) Role of death receptor, mitochondrial and endoplasmic reticulum pathways in different stages of degenerative human lumbar disc. Apoptosis 16:990-1003
    • (2011) Apoptosis , vol.16 , pp. 990-1003
    • Wang, H.1    Liu, H.2    Zheng, Z.M.3    Zhang, K.B.4    Wang, T.P.5    Sribastav, S.S.6    Liu, W.S.7    Liu, T.8
  • 143
    • 79952297150 scopus 로고    scopus 로고
    • Association between caspase-9 promoter region polymorphisms and discogenic low back pain
    • 21091209 1:CAS:528:DC%2BC3MXisFaqs7s%3D
    • Guo TM, Liu M, Zhang YG, Guo WT, Wu SX (2011) Association between caspase-9 promoter region polymorphisms and discogenic low back pain. Connect Tissue Res 52:133-138
    • (2011) Connect Tissue Res , vol.52 , pp. 133-138
    • Guo, T.M.1    Liu, M.2    Zhang, Y.G.3    Guo, W.T.4    Wu, S.X.5
  • 144
    • 42949097468 scopus 로고    scopus 로고
    • Identification of polymorphisms in the caspase-3 gene and their association with lung cancer risk
    • 18058802 1:CAS:528:DC%2BD1cXls1ajsbg%3D
    • Jang JS, Kim KM, Choi JE, Cha SI, Kim CH, Lee WK, Kam S, Jung TH, Park JY (2008) Identification of polymorphisms in the caspase-3 gene and their association with lung cancer risk. Mol Carcinog 47:383-390
    • (2008) Mol Carcinog , vol.47 , pp. 383-390
    • Jang, J.S.1    Kim, K.M.2    Choi, J.E.3    Cha, S.I.4    Kim, C.H.5    Lee, W.K.6    Kam, S.7    Jung, T.H.8    Park, J.Y.9
  • 146
    • 0027286622 scopus 로고
    • A negative regulatory element in the bcl-2 5′-untranslated region inhibits expression from an upstream promoter
    • 8388542 1:CAS:528:DyaK3sXks1CksLc%3D
    • Young RL, Korsmeyer SJ (1993) A negative regulatory element in the bcl-2 5′-untranslated region inhibits expression from an upstream promoter. Mol Cell Biol 13:3686-3697
    • (1993) Mol Cell Biol , vol.13 , pp. 3686-3697
    • Young, R.L.1    Korsmeyer, S.J.2
  • 147
    • 33846004731 scopus 로고    scopus 로고
    • Association of a novel regulatory polymorphism (-938C > A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia
    • 16960146
    • Nuckel H, Frey UH, Bau M, Sellmann L, Stanelle J, Durig J, Jockel KH, Duhrsen U, Siffert W (2007) Association of a novel regulatory polymorphism (-938C > A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia. Blood 109:290-297
    • (2007) Blood , vol.109 , pp. 290-297
    • Nuckel, H.1    Frey, U.H.2    Bau, M.3    Sellmann, L.4    Stanelle, J.5    Durig, J.6    Jockel, K.H.7    Duhrsen, U.8    Siffert, W.9
  • 150
    • 77953448704 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death
    • 1:CAS:528:DC%2BC3cXltVKitLw%3D
    • Semaan SJ, Li Y, Nickells RW (2010) A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death. ASN Neuro 2:87-101
    • (2010) ASN Neuro , vol.2 , pp. 87-101
    • Semaan, S.J.1    Li, Y.2    Nickells, R.W.3
  • 151
    • 0037058662 scopus 로고    scopus 로고
    • Association of a novel single nucleotide polymorphism, G(-248)A, in the 5′-UTR of BAX gene in chronic lymphocytic leukemia with disease progression and treatment resistance
    • 12359369 1:CAS:528:DC%2BD38XnsVSnur4%3D
    • Saxena A, Moshynska O, Sankaran K, Viswanathan S, Sheridan DP (2002) Association of a novel single nucleotide polymorphism, G(-248)A, in the 5′-UTR of BAX gene in chronic lymphocytic leukemia with disease progression and treatment resistance. Cancer Lett 187:199-205
    • (2002) Cancer Lett , vol.187 , pp. 199-205
    • Saxena, A.1    Moshynska, O.2    Sankaran, K.3    Viswanathan, S.4    Sheridan, D.P.5
  • 152
    • 14944346868 scopus 로고    scopus 로고
    • Common polymorphism G(-248)A in the promoter region of the bax gene results in significantly shorter survival in patients with chronic lymphocytic leukemia once treatment is initiated
    • 15735127 1:CAS:528:DC%2BD2MXis1Gmsrs%3D
    • Starczynski J, Pepper C, Pratt G, Hooper L, Thomas A, Milligan D, Bentley P, Fegan C (2005) Common polymorphism G(-248)A in the promoter region of the bax gene results in significantly shorter survival in patients with chronic lymphocytic leukemia once treatment is initiated. J Clin Oncol 23:1514-1521
    • (2005) J Clin Oncol , vol.23 , pp. 1514-1521
    • Starczynski, J.1    Pepper, C.2    Pratt, G.3    Hooper, L.4    Thomas, A.5    Milligan, D.6    Bentley, P.7    Fegan, C.8
  • 153
    • 0030245811 scopus 로고    scopus 로고
    • BAX is required for neuronal death after trophic factor deprivation and during development
    • 8816704 1:STN:280:DyaK28vhtlGmsg%3D%3D
    • Deckwerth TL, Elliott JL, Knudson CM, Johnson EM Jr, Snider WD, Korsmeyer SJ (1996) BAX is required for neuronal death after trophic factor deprivation and during development. Neuron 17:401-411
    • (1996) Neuron , vol.17 , pp. 401-411
    • Deckwerth, T.L.1    Elliott, J.L.2    Knudson, C.M.3    Johnson, Jr.E.M.4    Snider, W.D.5    Korsmeyer, S.J.6
  • 154
    • 0032520195 scopus 로고    scopus 로고
    • Widespread elimination of naturally occurring neuronal death in Bax-deficient mice
    • 9454852 1:CAS:528:DyaK1cXptlyjsA%3D%3D
    • White FA, Keller-Peck CR, Knudson CM, Korsmeyer SJ, Snider WD (1998) Widespread elimination of naturally occurring neuronal death in Bax-deficient mice. J Neurosci 18:1428-1439
    • (1998) J Neurosci , vol.18 , pp. 1428-1439
    • White, F.A.1    Keller-Peck, C.R.2    Knudson, C.M.3    Korsmeyer, S.J.4    Snider, W.D.5
  • 155
    • 15744395382 scopus 로고    scopus 로고
    • Neurons exclusively express N-Bak, a BH3 domain-only Bak isoform that promotes neuronal apoptosis
    • 15590665 1:CAS:528:DC%2BD2MXitVCit7c%3D
    • Uo T, Kinoshita Y, Morrison RS (2005) Neurons exclusively express N-Bak, a BH3 domain-only Bak isoform that promotes neuronal apoptosis. J Biol Chem 280:9065-9073
    • (2005) J Biol Chem , vol.280 , pp. 9065-9073
    • Uo, T.1    Kinoshita, Y.2    Morrison, R.S.3
  • 156
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • 7834749 1:CAS:528:DyaK2MXjtlGns7w%3D
    • Miyashita T, Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 157
    • 0027985453 scopus 로고
    • Attenuation of p53 expression protects against focal ischemic damage in transgenic mice
    • 7929653 1:CAS:528:DyaK2MXitFGju7k%3D
    • Crumrine RC, Thomas AL, Morgan PF (1994) Attenuation of p53 expression protects against focal ischemic damage in transgenic mice. J Cereb Blood Flow Metab 14:887-891
    • (1994) J Cereb Blood Flow Metab , vol.14 , pp. 887-891
    • Crumrine, R.C.1    Thomas, A.L.2    Morgan, P.F.3
  • 158
    • 0028263192 scopus 로고
    • P53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats
    • (discussion 855-846)
    • Li Y, Chopp M, Zhang ZG, Zaloga C, Niewenhuis L, and Gautam S (1994) p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats. Stroke 25:849-855 (discussion 855-846)
    • (1994) Stroke , vol.25 , pp. 849-855
    • Li, Y.1    Chopp, M.2    Zhang, Z.G.3    Zaloga, C.4    Niewenhuis, L.5    Gautam, S.6
  • 159
    • 12844268203 scopus 로고    scopus 로고
    • Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: Role of oxidative stress
    • 15678128 1:CAS:528:DC%2BD2MXitFOis7s%3D
    • Saito A, Hayashi T, Okuno S, Nishi T, Chan PH (2005) Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress. J Cereb Blood Flow Metab 25:267-280
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 267-280
    • Saito, A.1    Hayashi, T.2    Okuno, S.3    Nishi, T.4    Chan, P.H.5
  • 160
    • 33747056618 scopus 로고    scopus 로고
    • Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats
    • 16870742 1:CAS:528:DC%2BD28XnvF2itrc%3D
    • Endo H, Kamada H, Nito C, Nishi T, Chan PH (2006) Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats. J Neurosci 26:7974-7983
    • (2006) J Neurosci , vol.26 , pp. 7974-7983
    • Endo, H.1    Kamada, H.2    Nito, C.3    Nishi, T.4    Chan, P.H.5
  • 161
    • 0037352279 scopus 로고    scopus 로고
    • Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
    • 12563316 1:CAS:528:DC%2BD3sXhsFGgs7g%3D
    • Cheng T, Liu D, Griffin JH, Fernandez JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV (2003) Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med 9:338-342
    • (2003) Nat Med , vol.9 , pp. 338-342
    • Cheng, T.1    Liu, D.2    Griffin, J.H.3    Fernandez, J.A.4    Castellino, F.5    Rosen, E.D.6    Fukudome, K.7    Zlokovic, B.V.8
  • 163
    • 0029823454 scopus 로고    scopus 로고
    • Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice
    • 8833912 1:STN:280:DyaK28vjtVygsg%3D%3D
    • LaFerla FM, Hall CK, Ngo L, Jay G (1996) Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice. J Clin Invest 98:1626-1632
    • (1996) J Clin Invest , vol.98 , pp. 1626-1632
    • Laferla, F.M.1    Hall, C.K.2    Ngo, L.3    Jay, G.4
  • 167
    • 79952701436 scopus 로고    scopus 로고
    • Apoptosis in Parkinson's disease: Is p53 the missing link between genetic and sporadic Parkinsonism?
    • 20969953 1:CAS:528:DC%2BC3MXjs1yrurw%3D
    • Alves da Costa C, Checler F (2011) Apoptosis in Parkinson's disease: is p53 the missing link between genetic and sporadic Parkinsonism? Cell Signal 23:963-968
    • (2011) Cell Signal , vol.23 , pp. 963-968
    • Alves Da Costa, C.1    Checler, F.2
  • 168
    • 18144410245 scopus 로고    scopus 로고
    • P53 in neuronal apoptosis
    • 15865932 1:CAS:528:DC%2BD2MXjslKjt7c%3D
    • Culmsee C, Mattson MP (2005) p53 in neuronal apoptosis. Biochem Biophys Res Commun 331:761-777
    • (2005) Biochem Biophys Res Commun , vol.331 , pp. 761-777
    • Culmsee, C.1    Mattson, M.P.2
  • 169
    • 0033931447 scopus 로고    scopus 로고
    • The p53 tumor suppressor gene: From molecular biology to clinical investigation
    • (discussion 137-129)
    • Soussi T (2000) The p53 tumor suppressor gene: from molecular biology to clinical investigation. Ann N Y Acad Sci 910:121-137 (discussion 137-129)
    • (2000) Ann N y Acad Sci , vol.910 , pp. 121-137
    • Soussi, T.1
  • 170
    • 43949107925 scopus 로고    scopus 로고
    • SnapShot: P53 posttranslational modifications
    • Kruse JP, Gu W (2008) SnapShot: p53 posttranslational modifications. Cell 133(930-930):e931
    • (2008) Cell , vol.133 , Issue.930 , pp. 931
    • Kruse, J.P.1    Gu, W.2
  • 171
    • 0037329056 scopus 로고    scopus 로고
    • The p53-Mdm2 module and the ubiquitin system
    • 12507556 1:CAS:528:DC%2BD38XpvVWksrw%3D
    • Michael D, Oren M (2003) The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol 13:49-58
    • (2003) Semin Cancer Biol , vol.13 , pp. 49-58
    • Michael, D.1    Oren, M.2
  • 172
    • 0032931517 scopus 로고    scopus 로고
    • The p53 pathway
    • 10341712 1:CAS:528:DyaK1MXmvVKrtQ%3D%3D
    • Prives C, Hall PA (1999) The p53 pathway. J Pathol 187:112-126
    • (1999) J Pathol , vol.187 , pp. 112-126
    • Prives, C.1    Hall, P.A.2
  • 173
    • 79959539790 scopus 로고    scopus 로고
    • Ubiquitylation in apoptosis: A post-translational modification at the edge of life and death
    • 21697901 1:CAS:528:DC%2BC3MXnvFSqu7o%3D
    • Vucic D, Dixit VM, Wertz IE (2011) Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death. Nat Rev Mol Cell Biol 12:439-452
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 439-452
    • Vucic, D.1    Dixit, V.M.2    Wertz, I.E.3
  • 174
    • 38849111754 scopus 로고    scopus 로고
    • MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: Evidence from 21 case-control studies
    • 18086778 1:CAS:528:DC%2BD2sXhsVenur3J
    • Hu Z, Jin G, Wang L, Chen F, Wang X, Shen H (2007) MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies. Cancer Epidemiol Biomarkers Prev 16:2717-2723
    • (2007) Cancer Epidemiol Biomarkers Prev , vol.16 , pp. 2717-2723
    • Hu, Z.1    Jin, G.2    Wang, L.3    Chen, F.4    Wang, X.5    Shen, H.6
  • 175
    • 13144249170 scopus 로고    scopus 로고
    • Mdmx and Mdm2: Brothers in arms?
    • 15254433 1:CAS:528:DC%2BD2MXmtlKqtA%3D%3D
    • Marine JC, Jochemsen AG (2004) Mdmx and Mdm2: brothers in arms? Cell Cycle 3:900-904
    • (2004) Cell Cycle , vol.3 , pp. 900-904
    • Marine, J.C.1    Jochemsen, A.G.2
  • 177
    • 58849120883 scopus 로고    scopus 로고
    • P53 polymorphisms: Cancer implications
    • 19165225 1:CAS:528:DC%2BD1MXpsVCntg%3D%3D
    • Whibley C, Pharoah PD, Hollstein M (2009) p53 polymorphisms: cancer implications. Nat Rev Cancer 9:95-107
    • (2009) Nat Rev Cancer , vol.9 , pp. 95-107
    • Whibley, C.1    Pharoah, P.D.2    Hollstein, M.3
  • 178
    • 70349438994 scopus 로고    scopus 로고
    • Tumour suppression by p53: A role for the DNA damage response?
    • 19730431 1:CAS:528:DC%2BD1MXhtVygsbbL
    • Meek DW (2009) Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer 9:714-723
    • (2009) Nat Rev Cancer , vol.9 , pp. 714-723
    • Meek, D.W.1
  • 180
    • 0034640281 scopus 로고    scopus 로고
    • Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
    • 10807576 1:CAS:528:DC%2BD3cXjsVSnsbg%3D
    • Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (2000) Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288:1053-1058
    • (2000) Science , vol.288 , pp. 1053-1058
    • Oda, E.1    Ohki, R.2    Murasawa, H.3    Nemoto, J.4    Shibue, T.5    Yamashita, T.6    Tokino, T.7    Taniguchi, T.8    Tanaka, N.9
  • 181
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic gene, is induced by p53
    • 11463392 1:CAS:528:DC%2BD3MXivVCmtLk%3D
    • Nakano K, Vousden KH (2001) PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7:683-694
    • (2001) Mol Cell , vol.7 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 182
    • 0035970721 scopus 로고    scopus 로고
    • Nuclear and mitochondrial apoptotic pathways of p53
    • 11286997 1:CAS:528:DC%2BD3MXitl2it7g%3D
    • Moll UM, Zaika A (2001) Nuclear and mitochondrial apoptotic pathways of p53. FEBS Lett 493:65-69
    • (2001) FEBS Lett , vol.493 , pp. 65-69
    • Moll, U.M.1    Zaika, A.2
  • 183
    • 0041330430 scopus 로고    scopus 로고
    • P53's believe it or not: Lessons on transcription-independent death
    • 14601643 1:CAS:528:DC%2BD3sXmsFWitr8%3D
    • Chipuk JE, Green DR (2003) p53's believe it or not: lessons on transcription-independent death. J Clin Immunol 23:355-361
    • (2003) J Clin Immunol , vol.23 , pp. 355-361
    • Chipuk, J.E.1    Green, D.R.2
  • 186
    • 0842278331 scopus 로고    scopus 로고
    • Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    • 14963330 1:CAS:528:DC%2BD2cXhtlWnu7o%3D
    • Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303:1010-1014
    • (2004) Science , vol.303 , pp. 1010-1014
    • Chipuk, J.E.1    Kuwana, T.2    Bouchier-Hayes, L.3    Droin, N.M.4    Newmeyer, D.D.5    Schuler, M.6    Green, D.R.7
  • 187
    • 77955963832 scopus 로고    scopus 로고
    • P53-mediated neuronal cell death in ischemic brain injury
    • 20502500 1:CAS:528:DC%2BC3cXntVenur4%3D
    • Hong LZ, Zhao XY, Zhang HL (2010) p53-mediated neuronal cell death in ischemic brain injury. Neurosci Bull 26:232-240
    • (2010) Neurosci Bull , vol.26 , pp. 232-240
    • Hong, L.Z.1    Zhao, X.Y.2    Zhang, H.L.3
  • 188
    • 67649460932 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabilization in neuronal injury
    • 19543220 1:CAS:528:DC%2BD1MXnsVylu7w%3D
    • Galluzzi L, Blomgren K, Kroemer G (2009) Mitochondrial membrane permeabilization in neuronal injury. Nat Rev Neurosci 10:481-494
    • (2009) Nat Rev Neurosci , vol.10 , pp. 481-494
    • Galluzzi, L.1    Blomgren, K.2    Kroemer, G.3
  • 189
    • 0033059025 scopus 로고    scopus 로고
    • The tumor-suppressor gene, p53, is induced in injured brain regions following experimental traumatic brain injury
    • 10407189 1:CAS:528:DyaK1MXks1GhtrY%3D
    • Napieralski JA, Raghupathi R, McIntosh TK (1999) The tumor-suppressor gene, p53, is induced in injured brain regions following experimental traumatic brain injury. Brain Res Mol Brain Res 71:78-86
    • (1999) Brain Res Mol Brain Res , vol.71 , pp. 78-86
    • Napieralski, J.A.1    Raghupathi, R.2    McIntosh, T.K.3
  • 190
    • 0034036534 scopus 로고    scopus 로고
    • Apoptosis occurs after cerebral contusions in humans
    • 10764270 1:STN:280:DC%2BD3c3isFensg%3D%3D
    • Ng I, Yeo TT, Tang WY, Soong R, Ng PY, Smith DR (2000) Apoptosis occurs after cerebral contusions in humans. Neurosurgery 46:949-956
    • (2000) Neurosurgery , vol.46 , pp. 949-956
    • Ng, I.1    Yeo, T.T.2    Tang, W.Y.3    Soong, R.4    Ng, P.Y.5    Smith, D.R.6
  • 191
    • 2442687858 scopus 로고    scopus 로고
    • Cell death mechanisms following traumatic brain injury
    • 15193035
    • Raghupathi R (2004) Cell death mechanisms following traumatic brain injury. Brain Pathol 14:215-222
    • (2004) Brain Pathol , vol.14 , pp. 215-222
    • Raghupathi, R.1
  • 192
    • 0035085210 scopus 로고    scopus 로고
    • A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide
    • 11279278 1:CAS:528:DC%2BD3MXis1KltLY%3D
    • Culmsee C, Zhu X, Yu QS, Chan SL, Camandola S, Guo Z, Greig NH, Mattson MP (2001) A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. J Neurochem 77:220-228
    • (2001) J Neurochem , vol.77 , pp. 220-228
    • Culmsee, C.1    Zhu, X.2    Yu, Q.S.3    Chan, S.L.4    Camandola, S.5    Guo, Z.6    Greig, N.H.7    Mattson, M.P.8
  • 193
    • 67249139255 scopus 로고    scopus 로고
    • Delayed treatment with a p53 inhibitor enhances recovery in stroke brain
    • 19475672 1:CAS:528:DC%2BD1MXnvFahsLs%3D
    • Luo Y, Kuo CC, Shen H, Chou J, Greig NH, Hoffer BJ, Wang Y (2009) Delayed treatment with a p53 inhibitor enhances recovery in stroke brain. Ann Neurol 65:520-530
    • (2009) Ann Neurol , vol.65 , pp. 520-530
    • Luo, Y.1    Kuo, C.C.2    Shen, H.3    Chou, J.4    Greig, N.H.5    Hoffer, B.J.6    Wang, Y.7
  • 194
    • 33748203767 scopus 로고    scopus 로고
    • P53 potentiates hippocampal neuronal death caused by global ischemia
    • 16538233 1:CAS:528:DC%2BD28XhtFCqs7rN
    • Yonekura I, Takai K, Asai A, Kawahara N, Kirino T (2006) p53 potentiates hippocampal neuronal death caused by global ischemia. J Cereb Blood Flow Metab 26:1332-1340
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 1332-1340
    • Yonekura, I.1    Takai, K.2    Asai, A.3    Kawahara, N.4    Kirino, T.5
  • 196
    • 33745010726 scopus 로고    scopus 로고
    • Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson's disease
    • 16544096 1:CAS:528:DC%2BD28XlsV2ksbw%3D
    • Nair VD (2006) Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson's disease. Apoptosis 11:955-966
    • (2006) Apoptosis , vol.11 , pp. 955-966
    • Nair, V.D.1
  • 197
    • 0030831489 scopus 로고    scopus 로고
    • Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease
    • 9395128
    • de la Monte SM, Sohn YK, Wands JR (1997) Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease. J Neurol Sci 152:73-83
    • (1997) J Neurol Sci , vol.152 , pp. 73-83
    • De La Monte, S.M.1    Sohn, Y.K.2    Wands, J.R.3
  • 198
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • 15295589 1:CAS:528:DC%2BD2cXmt1Gis7o%3D
    • Mattson MP (2004) Pathways towards and away from Alzheimer's disease. Nature 430:631-639
    • (2004) Nature , vol.430 , pp. 631-639
    • Mattson, M.P.1
  • 199
    • 0030249597 scopus 로고    scopus 로고
    • Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity
    • 8910901 1:STN:280:DyaK2s%2FmslCrug%3D%3D
    • Trimmer PA, Smith TS, Jung AB, Bennett JP Jr (1996) Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity. Neurodegeneration 5:233-239
    • (1996) Neurodegeneration , vol.5 , pp. 233-239
    • Trimmer, P.A.1    Smith, T.S.2    Jung, A.B.3    Bennett, Jr.J.P.4
  • 200
    • 0027253408 scopus 로고
    • Simple sequence repeat polymorphism within the p53 gene
    • 8502490 1:CAS:528:DyaK3sXkvVyisL8%3D
    • Lazar V, Hazard F, Bertin F, Janin N, Bellet D, Bressac B (1993) Simple sequence repeat polymorphism within the p53 gene. Oncogene 8:1703-1705
    • (1993) Oncogene , vol.8 , pp. 1703-1705
    • Lazar, V.1    Hazard, F.2    Bertin, F.3    Janin, N.4    Bellet, D.5    Bressac, B.6
  • 201
    • 0030448650 scopus 로고    scopus 로고
    • Identification of a novel p53 functional domain that is necessary for efficient growth suppression
    • 8986812 1:CAS:528:DyaK2sXnt1Gk
    • Walker KK, Levine AJ (1996) Identification of a novel p53 functional domain that is necessary for efficient growth suppression. Proc Natl Acad Sci USA 93:15335-15340
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15335-15340
    • Walker, K.K.1    Levine, A.J.2
  • 202
    • 0030798557 scopus 로고    scopus 로고
    • The polyproline region of p53 is required to activate apoptosis but not growth arrest
    • 9285684 1:CAS:528:DyaK2sXlvFSisb0%3D
    • Sakamuro D, Sabbatini P, White E, Prendergast GC (1997) The polyproline region of p53 is required to activate apoptosis but not growth arrest. Oncogene 15:887-898
    • (1997) Oncogene , vol.15 , pp. 887-898
    • Sakamuro, D.1    Sabbatini, P.2    White, E.3    Prendergast, G.C.4
  • 203
    • 33645117454 scopus 로고    scopus 로고
    • Polymorphisms in the p53 pathway
    • 16550160 1:CAS:528:DC%2BD28XisFyhtLY%3D
    • Pietsch EC, Humbey O, Murphy ME (2006) Polymorphisms in the p53 pathway. Oncogene 25:1602-1611
    • (2006) Oncogene , vol.25 , pp. 1602-1611
    • Pietsch, E.C.1    Humbey, O.2    Murphy, M.E.3
  • 205
    • 0023709002 scopus 로고
    • A variation in the structure of the protein-coding region of the human p53 gene
    • 2905688 1:STN:280:DyaL1M7gvVSjug%3D%3D
    • Buchman VL, Chumakov PM, Ninkina NN, Samarina OP, Georgiev GP (1988) A variation in the structure of the protein-coding region of the human p53 gene. Gene 70:245-252
    • (1988) Gene , vol.70 , pp. 245-252
    • Buchman, V.L.1    Chumakov, P.M.2    Ninkina, N.N.3    Samarina, O.P.4    Georgiev, G.P.5
  • 206
    • 0032907105 scopus 로고    scopus 로고
    • Two polymorphic variants of wild-type p53 differ biochemically and biologically
    • 9891044 1:CAS:528:DyaK1MXhtVKhsL0%3D
    • Thomas M, Kalita A, Labrecque S, Pim D, Banks L, Matlashewski G (1999) Two polymorphic variants of wild-type p53 differ biochemically and biologically. Mol Cell Biol 19:1092-1100
    • (1999) Mol Cell Biol , vol.19 , pp. 1092-1100
    • Thomas, M.1    Kalita, A.2    Labrecque, S.3    Pim, D.4    Banks, L.5    Matlashewski, G.6
  • 208
    • 0036177619 scopus 로고    scopus 로고
    • A link between the p53 germ line polymorphisms and white blood cells apoptosis in lung cancer patients
    • 11844595
    • Biros E, Kohut A, Biros I, Kalina I, Bogyiova E, Stubna J (2002) A link between the p53 germ line polymorphisms and white blood cells apoptosis in lung cancer patients. Lung Cancer 35:231-235
    • (2002) Lung Cancer , vol.35 , pp. 231-235
    • Biros, E.1    Kohut, A.2    Biros, I.3    Kalina, I.4    Bogyiova, E.5    Stubna, J.6
  • 209
    • 0037372005 scopus 로고    scopus 로고
    • The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
    • 12567188 1:CAS:528:DC%2BD3sXhsV2ktbc%3D
    • Dumont P, Leu JI, Della Pietra AC III, George DL, Murphy M (2003) The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet 33:357-365
    • (2003) Nat Genet , vol.33 , pp. 357-365
    • Dumont, P.1    Leu, J.I.2    Della Pietra Iii, A.C.3    George, D.L.4    Murphy, M.5
  • 214
    • 11844250016 scopus 로고    scopus 로고
    • Modulation of age at onset of Huntington disease patients by variations in TP53 and human caspase activated DNase (hCAD) genes
    • 15644269 1:CAS:528:DC%2BD2MXis1SmsA%3D%3D
    • Chattopadhyay B, Baksi K, Mukhopadhyay S, Bhattacharyya NP (2005) Modulation of age at onset of Huntington disease patients by variations in TP53 and human caspase activated DNase (hCAD) genes. Neurosci Lett 374:81-86
    • (2005) Neurosci Lett , vol.374 , pp. 81-86
    • Chattopadhyay, B.1    Baksi, K.2    Mukhopadhyay, S.3    Bhattacharyya, N.P.4
  • 215
    • 77953475350 scopus 로고    scopus 로고
    • Age at onset of Huntington disease is not modulated by the R72P variation in TP53 and the R196K variation in the gene coding for the human caspase activated DNase (hCAD)
    • 16202123
    • Arning L, Kraus PH, Saft C, Andrich J, Epplen JT (2005) Age at onset of Huntington disease is not modulated by the R72P variation in TP53 and the R196K variation in the gene coding for the human caspase activated DNase (hCAD). BMC Med Genet 6:35
    • (2005) BMC Med Genet , vol.6 , pp. 35
    • Arning, L.1    Kraus, P.H.2    Saft, C.3    Andrich, J.4    Epplen, J.T.5
  • 217
    • 33748344945 scopus 로고    scopus 로고
    • MDM2 promoter SNP309 is associated with the risk of hepatocellular carcinoma in patients with chronic hepatitis C
    • 16914573 1:CAS:528:DC%2BD28XotFKgtr4%3D
    • Dharel N, Kato N, Muroyama R, Moriyama M, Shao RX, Kawabe T, Omata M (2006) MDM2 promoter SNP309 is associated with the risk of hepatocellular carcinoma in patients with chronic hepatitis C. Clin Cancer Res 12:4867-4871
    • (2006) Clin Cancer Res , vol.12 , pp. 4867-4871
    • Dharel, N.1    Kato, N.2    Muroyama, R.3    Moriyama, M.4    Shao, R.X.5    Kawabe, T.6    Omata, M.7


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