P53-mediated neuronal cell death in ischemic brain injury

Neuroscience Bulletin

Volumn 26, Issue 3, 2010, Pages 232-240

  Hong, Li Zhi ^a   Zhao, Xiao Yuan ^a   Zhang, Hui Ling ^a  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

Author keywords

Apoptosis; Cerebral ischemia; P53

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYTOCHROME C; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PIFITHRIN ALPHA; PROTEIN P300; PROTEIN P53; PROTEIN PW1; PUMA PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; BRAIN INJURY; BRAIN ISCHEMIA; CELL SURVIVAL; DOSE RESPONSE; DRUG MECHANISM; GENE TARGETING; HUMAN; MOLECULAR DYNAMICS; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STRUCTURE; SHORT SURVEY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; CELL DEATH; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BRAIN ISCHEMIA; CELL DEATH; HUMANS; MODELS, NEUROLOGICAL; NEURONS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77955963832     PISSN: 16737067     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12264-010-1111-0     Document Type: Short Survey

References (63)

1. Herrmann O, Baumann B, De Lorenzi R, Muhammad S, Zhang W, Kleesiek J, et al. IKK mediates ischemia-induced neuronal death. Nat Med 2005, 11: 1322-1329.
2. Harms K, Nozell S, Chen X. The common and distinct target genes of the p53 family transcription factors. Cell Mol Life Sci 2004, 61: 822-842.
3. Harris SL, Levine AJ. The p53 pathway: positive and negative feed back loops. Oncogene 2005, 24: 2899-2908.
4. Mashima T, Tsuruo T. Defects of the apoptotic pathway as therapeutic target against cancer. Drug Resist Updat 2005, 8: 339-343.
5. Green DR, Chipuk JE. p53 and metabolism: inside the TIGAR. Cell 2006, 126: 30-32.
6. Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995, 80: 293-299.
7. Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53 -induced apoptosis. Science 2000a, 288: 1053-1058.
8. Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, et al. p53AIP1, a potential mediator of p53 -dependent apoptosis, and its regulation by Ser-46-phosphorylated p53 . Cell 2000b, 102: 849-862.
9. Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53 . Mol Cell 2001, 7: 683-694.
10. Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 2001, 7: 673-682.
11. Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004, 303: 1010-1014.
12. Marchenko ND, Zaika A, Moll UM. Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J Biol Chem 2000, 275: 16202-16212.
13. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, et al. p53 has a direct apoptogenic role at the mitochondria. Mol Cell 2003, 11: 577-590.
14. Erster S, Mihara M, Kim RH, Petrenko O, Moll UM. In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Mol Cell Biol 2004, 24: 6728-6741.
15. Toledo F, Wahl GM. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer 2006, 6: 909-923.
16. Murray-Zmijewski F, Lane DP, Bourdon JC. P53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress. Cell Death Differ 2006, 13: 962-972.
17. Crumrine R, Thomas A, Morgan P. Attenuation of p53 expression protects against focal ischemic damage in transgenic mice. J Cereb Blood Flow Metab 1994, 14: 887-891.
18. Li Y, Chopp M, Zhang ZG, Zaloga C, Niewenhuis L, Gautam S. p53 -immunoreactive protein and p53 messenger RNA expression after transient middle cerebral artery occlusion in rats. Stroke 1994, 25: 849-856.
19. McGahan L, Hakim AM, Robertson GS. Hippocampal myc and p53 expression following transient global ischemia. Mol Brain Res 1998, 56: 133-145.
20. Tomasevic G, Shamloo M, Israeli D, Wieloch T. Activation of p53 and its target genes p21 WAF1/Cip1 and PAG608/Wig-1 in ischemic preconditioning. Mol Brain Res 1999b, 70: 304-313.
21. Yamaguchi A, Taniguchi M, Hori O, Ogawa S, Tojo N, Matsuoka N, et al. Peg3/Pw1 is involved in p53 -mediated cell death pathway in brain ischemia/hypoxia. J Biol Chem 2002, 277: 623-629.
22. Culmsee C, Siewe J, Junker V, Retiounskaia M, Schwarz S, Camandola S, et al. Reciprocal inhibition of p53 and nuclear factor-κB transcriptional activities determines cell survival or death in neurons. J Neurosci 2003, 23: 8586-8595.
23. Saito A, Hayashi T, Okuno S, Nishi T, Chan PH. Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitinproteasome system during reperfusion after stroke: role of oxidative stress. J Cereb Blood Flow Metab 2005, 25: 267-280.
24. Yonekura I, Takai K, Asai A, Kawahara N, Kirino T. p53 potentiates hippocampal neuronal death caused by global ischemia. J Cereb Blood Flow Metab 2006, 26: 1332-1340.
25. Endo H, Kamada H, Nito C, Nishi T, Chan PH. Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats. J Neurosci 2006, 26: 7974-7983.
26. Chen C, Hu Q, Yan J, Yang X, Shi X, Lei J, et al. Early inhibition of HIF-1 alpha with small interfering RNA reduces ischemicreperfused brain injury in rats. Neurobiol Dis 2009, 33: 509-517.
27. Banasiak KJ, Haddad GG. Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death. Brain Res 1998, 797: 295-304.
28. Watanabe H, Ohta S, Kumon Y, Sakaki S, Sakanaka M. Increase in p53 protein expression following cortical infarction in the spontaneously hypertensive rat. Brain Res 1999, 837: 38-45.
29. van Lookeren Campagne M, Gill R. Increased expression of cyclin G1 and p21WAF1/CIP1 in neurons following transientforebrain ischemia: comparison with early DNA damage. J Neurosci Res 1998, 53: 279-296.
30. Cheng T, Liu D, Griffin JH, Fernandez JA, Castellino F, Rosen ED, et al. Activated protein C blocks p53 -mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med 2003, 9: 338-342.
31. Xiang H, Hochman DW, Saya H, Fujiwara T, Schwartzkroin PA, Morrison RS. Evidence for P53-mediated modulation of neuronal viability. J Neurosci 1996, 16: 6753-6765.
32. Leker RR, Aharonowiz M, Greig NH, Ovadia H. The role of p53 - induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin α. Exp Neurol 2004, 187: 478-486.
33. Wadgaonkar R, Phelps KM, Haque Z, Williams AJ, Silverman ES, Collins T. CREB-binding protein is a nuclear integrator of nuclear factor kappaB and p53 signaling. J Biol Chem 1999, 274: 1879-1882.
34. Webster GA, Perkins ND. Transcriptional cross talk between NF-kappaB and p53 . Mol Cell Biol 1999, 19: 3485-3495.
35. Ikeda A, Sun X, Li Y, Zhang Y, Eckner R, Doi TS, et al. p300/ CBP-dependent and -independent transcriptional interference between NF-kappaB RelA and p53 . Biochem Biophys Res Commun 2000, 272: 375-379.
36. Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 2000, 1: 120-129.
37. Bui TN, König HG, Culmsee C, Bauerbach E, Poppe M, Krieglstein J, et al. p75 neurotrophin receptor is required for constitutive and NGF-induced survival signaling in PC12 cells and rat hippocampal neurones. J Neurochem 2002, 81: 594-605.
38. Culmsee C, Gerling N, Lehmann M, Nikolova-Karakashian M, Prehn JH, Mattson MP, et al. Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75. Neuroscience 2002, 115: 1089-1108.
39. Niizuma K, Endo H, Nito C, Myer DJ, Chan PH. Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia. Stroke 2009, 40: 618-625.
40. Grilli M, Memo M. Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathway. Cell Death Differ 1999, 6: 22-27.
41. Ryan KM, Ernst MK, Rice NR, Vousden KH. Role of NF-κB in p53 -mediated programmed cell death. Nature 2000, 404: 892-897.
42. Uberti D, Grilli M, Memo M. Contribution of NF-kappaB and p53 in the glutamate-induced apoptosis. Int J Dev Neurosci 2000, 18: 447-454.
43. Cregan SP, Arbour NA, MacLaurin JG, Callaghan SM, Fortin A, Cheung ECC, et al. p53 activation domain 1 is essential for PUMA. J Neurosci 2004, 24: 10003-10012.
44. Chung YH, Shin CM, Kim MJ, Lee EY, Kim G, Cha CI. Enhanced expression of p53 in reactive astrocytes following transient focal ischemia. Neurol Res 2002, 24: 324-328.
45. Nijboer CH, Heijnen CJ, Groenendaal F, May MJ, van Bel F, Kavelaars A. A dual role of the NF-kappaB pathway in neonatal hypoxic-ischemic brain damage. Stroke 2008, 39: 2578-2586.
46. Zhang XD, Wang Y, Wang Y, Zhang X, Han R, Wu JC, et al. p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum. Autophagy 2009, 5: 339-350.
47. Wang Y, Qin ZH, Nakai M, Chen RW, Chuang DM, Chase TN. Co-stimulation of cyclic-AMP-linked metabotropic glutamate receptors in rat striatum attenuates excitotoxin-induced nuclear factor-kappaB activation and apoptosis. Neuroscience 1999, 94: 1153-1162.
48. Qin ZH, Chen RW, Wang Y, Nakai M, Chuang DM, Chase TN. Nuclear factor kappaB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum. J Neurosci 1999, 19: 4023-4033.
49. Nakai M, Qin ZH, Chen JF, Wang Y, Chase TN. Kainic acidinduced apoptosis in rat striatum is associated with nuclear factor- kappaB activation. J Neurochem 2000, 74: 647-658.
50. Cao Y, Gu ZL, Lin F, Han R, Qin ZH. Caspase-1 inhibitor Ac-YVAD-CHO attenuates quinolinic acid-induced increases in p53 and apoptosis in rat striatum. Acta Pharmacol Sin 2005, 26: 150-154.
51. Liang ZQ, Wang XX, Wang Y, Chuang DM, DiFiglia M, Chase TN, et al. Susceptibility of striatal neurons to excitotoxic injury correlates with basal levels of Bcl-2 and the induction of P53 and c-Myc immunoreactivity. Neurobiol Dis 2005, 20: 562-573.
52. Liang ZQ, Li YL, Zhao XL, Han R, Wang XX, Wang Y, et al. NF-kappaB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53 . Brain Res 2007, 1145: 190-203.
53. Caelles C, Helmberg A, Karin M. p53 -dependent apoptosis in the absence of transcriptional activation of p53 -target genes. Nature 1994, 370: 220-223.
54. Haupt Y, Rowan S, Shaulian E, Vousden KH, Oren M. Induction of apoptosis in HeLa cells by trans-activation-deficient p53 . Genes Dev 1995, 9: 2170-2183.
55. Vaseva AV, Moll UM. The mitochondrial p53 pathway. Biochim Biophys Acta 2009, 1787: 414-420.
56. Ding HF, McGill G, Rowan S, Schmaltz C, Shimamura A, Fisher DE. Oncogene dependent regulation of caspase activation by p53 protein in a cell-free system. J Biol Chem 1998, 273: 28378-28383.
57. Gottlieb E, Oren M. p53 facilitates pRb cleavage in IL-3-deprived cells: novel proapoptotic activity of p53 . EMBO J 1998, 17: 3587-3596.
58. Kroemer G, Galluzzi L, Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol Rev 2007, 87: 99-163.
59. Endo H, Saito A, Chan PH. Mitochondrial translocation of p53 underlies the selective death of hippocampal CA1 neurons after global cerebral ischemia. Biochem Soc Trans 2006, 34: 1283-1286.
60. Bonini P, Cicconi S, Cardinale A, Vitale C, Serafino AL, Ciotti MT, et al. Oxidative stress induces p53 -mediated apoptosis in glia: p53 transcription-independent way to die. J Neurosci Res 2004, 75: 83-95.
61. Racay P, Tatarkova Z, Drgova A, Kaplan P, Dobrota D. Effect of ischemic preconditioning on mitochondrial dysfunction and mitochondrial p53 translocation after transient global cerebral ischemia in rats. Neurochem Res 2007, 32: 1823-1832.
62. Vogelstein B, Lane DP, Levine AJ. Surfing the p53 network. Nature 2000, 408: 307-310.
63. Yang L, Tao LY, Chen XP. Roles of NF-kappaB in central nervous system damage and repair. Neurosci Bull 2007, 23: 307-313.