The human Tp53 Arg72Pro polymorphism explains different functional prognosis in stroke

Journal of Experimental Medicine

Volumn 208, Issue 3, 2011, Pages 429-437

  Gomez Sanchez, Jose C ^a   Delgado Esteban, Maria ^a   Rodriguez Hernandez, Irene ^b   Sobrino, Tomas ^c   De La Ossa, Natalia Perez ^d   Reverte, Silvia ^d   Bolaños, Juan P ^b   Gonzalez Sarmiento, Rogelio ^b   Castillo, Jose ^c   Almeida, Angeles ^a,b  

^a HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^b UNIVERSITY OF SALAMANCA   (Spain)

^c Instituto de Salud Carlos III   (Spain)

^d HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL XL; PROTEIN P53;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CELL DEATH; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTEIN POLYMORPHISM; RAT; SINGLE NUCLEOTIDE POLYMORPHISM; STROKE;

AGED; APOPTOSIS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC MARKERS; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; STROKE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79952716608     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20101523     Document Type: Article

References (38)

1. Adams, H.P. Jr., B.H. Bendixen, L.J. Kappelle, J. Biller, B.B. Love, D.L. Gordon, and E.E. Marsh III. 1993. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 24:35-41. (Pubitemid 23014379)
2. Almeida, A., and J.M. Medina. 1997. Isolation and characterization of tightly coupled mitochondria from neurons and astrocytes in primary culture. Brain Res. 764:167-172. doi:10.1016/S0006-8993(97)00453-8 (Pubitemid 27380652)
3. Almeida, A., and J.P. Bolaños. 2001. A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons. J. Neurochem. 77:676-690. doi:10.1046/j.1471-4159.2001.00276.x (Pubitemid 32298762)
4. Almeida, A., M. Delgado-Esteban, J.P. Bolaños, and J.M. Medina. 2002. Oxygen and glucose deprivation induces mitochondrial dysfunction and oxidative stress in neurones but not in astrocytes in primary culture. J. Neurochem. 81:207-217. doi:10.1046/j.1471-4159.2002.00827.x (Pubitemid 34809346)
5. Almeida, A., J.P. Bolaños, and S. Moreno. 2005. Cdh1/Hct1-APC is essential for the survival of postmitotic neurons. J. Neurosci. 25:8115-8121. doi:10.1523/JNEUROSCI.1143-05.2005 (Pubitemid 41292106)
6. Baird, A.E. 2007. Blood genomics in human stroke. Stroke. 38:694-698. doi:10.1161/01.STR.0000250431.99687.7b (Pubitemid 46184244)
7. Baird, A.E., J. Dambrosia, S. Janket, Q. Eichbaum, C. Chaves, B. Silver, P.A. Barber, M. Parsons, D. Darby, S. Davis, et al. 2001. A three-item scale for the early prediction of stroke recovery. Lancet. 357:2095-2099. doi:10.1016/S0140-6736(00)05183-7 (Pubitemid 32607454)
8. Banks, J.L., and C.A. Marotta. 2007. Outcomes validity and reliability of the modified Rankin scale: implications for stroke clinical trials: a literature review and synthesis. Stroke. 38:1091-1096. doi:10.1161/01.STR. 0000258355.23810.c6 (Pubitemid 46568483)
9. Biros, E., A. Kohút, I. Biros, I. Kalina, E. Bogyiová, and J. Stubna. 2002. A link between the p53 germ line polymorphisms and white blood cells apoptosis in lung cancer patients. Lung Cancer. 35:231-235. doi:10.1016/S0169-5002(01)00446-9 (Pubitemid 34158654)
10. Bonafé, M., S. Salvioli, C. Barbi, C. Trapassi, F. Tocco, G. Storci, L. Invidia, I. Vannini, M. Rossi, E. Marzi, et al. 2004. The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death. Cell Death Differ. 11:962-973. doi:10.1038/sj.cdd.4401415 (Pubitemid 39232356)
11. Broughton, B.R., D.C. Reutens, and C.G. Sobey. 2009. Apoptotic mechanisms after cerebral ischemia. Stroke. 40:e331-e339. doi:10.1161/STROKEAHA.108.531632
12. Castillo, J. 1999. Deteriorating stroke: diagnostic criteria, predictors, mechanisms and treatment. Cerebrovasc. Dis. 9:1-8. doi:10.1159/000047548
13. Castillo, J., A. Dávalos, and M. Noya. 1997. Progression of ischaemic stroke and excitotoxic aminoacids. Lancet. 349:79-83. doi:10.1016/S0140-6736(96)04453-4 (Pubitemid 27023423)
14. Cerebrovascular Disease Study Group of the Spanish Society of Neurology. 2004. Guidelines for the diagnosis and treatment of stroke. Prous Science, Barcelona. 258 pp.
15. Costa, S., D. Pinto, D. Pereira, H. Rodrigues, J. Cameselle-Teijeiro, R. Medeiros, and F. Schmitt. 2008. Importance of TP53 codon 72 and intron 3 duplication 16bp polymorphisms in prediction of susceptibility on breast cancer. BMC Cancer. 8:32. doi:10.1186/1471-2407-8-32
16. Dumont, P., J.I. Leu, A.C. Della Pietra III, D.L. George, and M. Murphy. 2003. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat. Genet. 33:357-365. doi:10.1038/ng1093 (Pubitemid 36278852)
17. Kwan, J., and P. Hand. 2006. Early neurological deterioration in acute stroke: clinical characteristics and impact on outcome. QJM. 99:625-633. doi:10.1093/qjmed/hcl082 (Pubitemid 44540538)
18. Lazar, V., F. Hazard, F. Bertin, N. Janin, D. Bellet, and B. Bressac. 1993. Simple sequence repeat polymorphism within the p53 gene. Oncogene. 8:1703-1705. (Pubitemid 23189070)
19. Levy, O.A., C. Malagelada, and L.A. Greene. 2009. Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps. Apoptosis. 14:478-500. doi:10.1007/s10495-008-0309-3
20. Luo, Y., C.C. Kuo, H. Shen, J. Chou, N.H. Greig, B.J. Hoffer, and Y. Wang. 2009. Delayed treatment with a p53 inhibitor enhances recovery in stroke brain. Ann. Neurol. 65:520-530. doi:10.1002/ana.21592
21. Maestre, C., M. Delgado-Esteban, J.C. Gomez-Sanchez, J.P. Bolaños, and A. Almeida. 2008. Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity. EMBO J. 27:2736-2745. doi:10.1038/emboj.2008.195
22. Matlashewski, G.J., S. Tuck, D. Pim, P. Lamb, J. Schneider, and L.V. Crawford. 1987. Primary structure polymorphism at amino acid residue 72 of human p53. Mol. Cell. Biol. 7:961-963. (Pubitemid 17004567)
23. Morris, L.G.T., S. Veeriah, and T.A. Chan. 2010. Genetic determinants at the interface of cancer and neurodegenerative disease. Oncogene. 29:3453-3464. doi:10.1038/onc.2010.127
24. Muir, K.W., A. Buchan, R. von Kummer, J. Rother, and J.C. Baron. 2006. Imaging of acute stroke. Lancet Neurol. 5:755-768. doi:10.1016/S1474-4422(06) 70545-2 (Pubitemid 44205513)
25. Olivier, M., R. Eeles, M. Hollstein, M.A. Khan, C.C. Harris, and P. Hainaut. 2002. The IARC TP53 database: new online mutation analysis and recommendations to users. Hum. Mutat. 19:607-614. doi:10.1002/humu.10081 (Pubitemid 34556481)
26. Pietsch, E.C., O. Humbey, and M.E. Murphy. 2006. Polymorphisms in the p53 pathway. Oncogene. 25:1602-1611. doi:10.1038/sj.onc.1209367
27. Qureshi, A.I., M.F. Suri, P.T. Ostrow, S.H. Kim, Z. Ali, A.A. Shatla, L.R. Guterman, and L.N. Hopkins. 2003. Apoptosis as a form of cell death in intracerebral hemorrhage. Neurosurgery. 52:1041-1047. doi:10.1227/01.NEU. 0000057694.96978.BC
28. Ribe, E.M., E. Serrano-Saiz, N. Akpan, and C.M. Troy. 2008. Mechanisms of neuronal death in disease: defining the models and the players. Biochem. J. 415:165-182. doi:10.1042/BJ20081118
29. Rosamond, W., K. Flegal, K. Furie, A. Go, K. Greenlund, N. Haase, S.M. Hailpern, M. Ho, V. Howard, B. Kissela, et al; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. 2008. Heart disease and stroke statistics-2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 117:e25-e146. doi:10.1161/CIRCULATIONAHA.107.187998
30. Sairanen, T., M.L. Karjalainen-Lindsberg, A. Paetau, P. Ijäs, and P.J. Lindsberg. 2006. Apoptosis dominant in the periinfarct area of human ischaemic stroke-a possible target of antiapoptotic treatments. Brain. 129:189-199. doi:10.1093/brain/awh645 (Pubitemid 43063770)
31. Sakamuro, D., P. Sabbatini, E. White, and G.C. Prendergast. 1997. The polyproline region of p53 is required to activate apoptosis but not growth arrest. Oncogene. 15:887-898. doi:10.1038/sj.onc.1201263 (Pubitemid 27399550)
32. Santos, A.M., H. Sousa, D. Pinto, C. Portela, D. Pereira, R. Catarino, I. Duarte, C. Lopes, and R. Medeiros. 2006. Linking TP53 codon 72 and P21 nt590 genotypes to the development of cervical and ovarian cancer. Eur. J. Cancer. 42:958-963. doi:10.1016/j.ejca.2006.01.015
33. Sulter, G., C. Steen, and J. De Keyser. 1999. Use of the Barthel index and modified Rankin scale in acute stroke trials. Stroke. 30:1538-1541. (Pubitemid 29379599)
34. Taylor, R.C., S.P. Cullen, and S.J. Martin. 2008. Apoptosis: controlled demolition at the cellular level. Nat. Rev. Mol. Cell Biol. 9:231-241. doi:10.1038/nrm2312 (Pubitemid 351301823)
35. Weimar, C., A. Ziegler, I.R. König, and H.C. Diener. 2002. Predicting functional outcome and survival after acute ischemic stroke. J. Neurol. 249:888-895. doi:10.1007/s00415-002-0755-8 (Pubitemid 34754227)
36. Whibley, C., P.D. Pharoah, and M. Hollstein. 2009. p53 polymorphisms: cancer implications. Nat. Rev. Cancer. 9:95-107. doi:10.1038/nrc2584
37. Zhu, F., M.E. Dollé, T.R. Berton, R.V. Kuiper, C. Capps, A. Espejo, M.J. McArthur, M.T. Bedford, H. van Steeg, A. de Vries, and D.G. Johnson. 2010. Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Res. 70:5851-5859. doi:10.1158/0008-5472.CAN-09-4646
38. Zhu, X., Q.S. Yu, R.G. Cutler, C.W. Culmsee, H.W. Holloway, D.K. Lahiri, M.P. Mattson, and N.H. Greig. 2002. Novel p53 inactivators with neuroprotective action: syntheses and pharmacological evaluation of 2-imino-2,3,4,5,6,7- hexahydrobenzothiazole and 2-imino-2,3,4,5,6,7-hexahydrobenzoxazole derivatives. J. Med. Chem. 45:5090-5097. doi: 10.1021/jm020044d (Pubitemid 35278705)