Modulation of age at onset of Huntington disease patients by variations in TP53 and human caspase activated DNase (hCAD) genes

Neuroscience Letters

Volumn 374, Issue 2, 2005, Pages 81-86

  Chattopadhyay, Biswanath ^a   Baksi, Kanad ^a   Mukhopadhyay, Saikat ^a   Bhattacharyya, Nitai P ^a  

^a SAHA INSTITUTE OF NUCLEAR PHYSICS   (India)

Author keywords

hCAD; Huntingtin; Polymorphism; TP53

Indexed keywords

ARTICLE; GENE; GENE FUNCTION; GENETIC VARIABILITY; HUMAN; HUMAN CASPASE ACTIVATED DNASE GENE; HUNTINGTON CHOREA; LINEAR REGRESSION ANALYSIS; NUCLEOTIDE REPEAT; ONSET AGE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL ANALYSIS; TP53 GENE;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; ARGININE; DEOXYRIBONUCLEASES; FEMALE; GENOTYPE; GLUCAN 1,3-BETA-GLUCOSIDASE; HUMANS; HUNTINGTON DISEASE; LYSINE; MALE; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PROLINE; TRINUCLEOTIDE REPEAT EXPANSION; TUMOR SUPPRESSOR PROTEIN P53; VARIATION (GENETICS);

EID: 11844250016     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.10.018     Document Type: Article

References (21)

1. K.D. Anderson, N. Panayotatos, T.L. Corcoran, R.M. Lindsay, and S.J. Wiegand Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease Proc. Natl. Acad. Sci. U.S.A. 93 1996 7346 7351
2. J.M. Canals, N. Checa, S. Marco, P. Akerud, A. Michels, E. Perez-Navarro, E. Tolosa, E. Arenas, and J. Alberch Expression of brain-derived neurotrophic factor in cortical neurons is regulated by striatal target area J. Neurosci. 21 2001 117 124
3. B. Chattopadhyay, P.K. Gangopadhyay, S.K. Das, T. Roy, K.K. Sinha, D.K. Jha, S.K. Mukherjee, A. Chakraborty, B.H. Singhal, A.K. Bhattacharya, and N.P. Bhattacharyya Modulation of age of onset in Huntington's disease and spinocerebellar ataxia type 2 patients originated from eastern India Neurosci. Lett. 345 2003 93 96
4. L. Djoussé, B. Knowlton, M. Hayden, E.W. Almqvist, R. Brinkman, C. Ross, R. Margolis, A. Rosenblatt, A. Durr, C. Dode, P.J. Morrison, A. Novelletto, M. Frontali, R.J.A. Trent, E. McCusker, E. Gómez-Tortosa, D. Mayo, R. Jones, A. Zanko, M. Nance, R. Abramson, O. Suchowersky, J. Paulsen, M. Harrison, Q. Yang, L.A. Cupples, J.F. Gusella, M.E. McDonald, and R.H. Myers Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease Am. J. Med. Genet. 119 2003 279 282
5. P. Dumont, J.I. Leu, A.C. Della Pietra 3rd, D.L. George, and M. Murphy The codon 72 polymorphic variants of p53 have markedly different apoptotic potential Nat. Genet. 33 2003 357 365
6. M. Enari, H. Sakahira, H. Yokoyama, K. Okawa, A. Iwamatsu, and S. Nagata A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD Nature 391 1998 43 50
7. G. Hoffner, and P. Djian Protein aggregation in Huntington's disease Biocheme 84 2002 273 278
8. S. Holbert, I. Denghien, T. Kiechle, A. Rosenblatt, C. Wellington, M.R. Hayden, R.L. Margolis, C.A. Ross, J. Dausset, R.J. Ferrante, and C. Neri The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis Proc. Natl. Acad. Sci. U.S.A. 98 2001 1811 1816
9. B. Kremer, F. Squitieri, H. Telenius, S.E. Andrew, J. Theilmann, N. Spence, Y.P. Goldberg, and M.R. Hayden Molecular analysis of late onset Huntington's disease J. Med. Genet. 30 1993 991 995
10. J.-L. Li, M.R. Hayden, E.W. Almqvist, R.R. Brinkman, A. Durr, C. Dodé, P.J. Morrison, O. Suchowersky, C.A. Ross, R.S. Margolis, A. Rosenblatt, E. Gómez-Tortosa, D. Mayo Cabrero, A. Novelletto, M. Frontali, M. Nance, R.J.A. Trent, E. McCusker, R. Jones, J.S. Paulsen, M. Harrison, A. Zanko, R.K. Abramson, A.L. Russ, B. Kbowlton, L. Djoussé, J.S. Mysore, S. Tariot, M.F. Gusella, V.C. Wheeler, L.D. Atwood, L.A. Cupples, M. Saint-Hilaire, J.J.-H. Cha, S.M. Hersch, W.J. Koroshetz, J.F. Gusella, M.E. MacDonald, and R.H. Myers A genome scan for modifiers of age of onset in Huntington's disease: The HD MAPS study Am. J. Hum. Genet. 73 2003 682 687
11. S.-H. Li, and X.-J. Li Huntingtin-protein interactions and the pathogenesis of Huntington's disease Trends Genet. 20 2004 146 154
12. S. Lovestone, S. Hodgson, P. Sham, A.M. Differ, and R. Levy Familial psychiatric presentation of Huntington's disease J. Med. Genet. 33 1996 128 131
13. S. Mitra, S. Chatterjee, C.K. Panda, K. Chaudhuri, K. Ray, N.P. Bhattacharyya, A. Sengupta, and S. Roychoudhury Haplotype structure of TP53 locus in Indian population and possible association with head and neck cancer Ann. Hum. Genet. 67 2003 26 34
14. P. Naze, I. Vuillaume, A. Destee, F. Pasquier, and B. Sablonniere Mutation analysis and association studies of the ubiquitin carboxy-terminal hydrolase L1 gene in Huntington's disease Neurosci. Lett. 328 2002 1 4
15. D.C. Rubinsztein, J. Leggo, M. Chiano, A. Dodge, G. Norbury, E. Rosser, and D. Craufurd Genotype at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington's disease Proc. Natl. Acad. Sci. U.S.A. 94 1997 3872 3876
16. F. Saudou, S. Finkbeiner, D. Devys, and M.E. Greenberg Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions Cell 95 1998 55 66
17. A. Sawa, G.W. Wiegand, J. Cooper, R.L. Margolis, A.H. Sharp, J.F. Lawler Jr., J.T. Greenamyre, S.H. Snyder, and C.A. Ross Increased apoptosis of Huntington disease lymphoblasts associated with repeat length dependent mitochondrial depolarization Nat. Med. 5 1999 1194 1198
18. F. Squitieri, M. Cannella, P. Giallonardo, V. Maglione, C. Mariotti, and M.R. Hayden Onset and pre-onset studies to define the Huntington's disease natural history Brain Res. Bull. 56 2001 233 238
19. J.S. Steffan, A. Kazantsev, O. Spasic-Boskovic, M. Greenwald, Y.Z. Zhu, H. Gohler, E.E. Wanker, G.P. Bates, D.E. Housman, and L.M. Thompson The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription Proc. Natl. Acad. Sci. U.S.A. 97 2000 6763 6768
20. N. Sugimoto, Y. Fukuda, F. Saito-Ohara, R. Kamiyama, A. Nakagawara, N. Mukae, S. Nagata, and J. Inazawa The human caspase-activated DNase gene (hCAD): genomic structure, exonic single-nucleotide polymorphisms, and a highly polymorphic dinucleotide repeat at the hCAD locus J. Hum. Genet. 44 1999 408 411
21. N.S. Wexler The U.S.-Venezuela Collaborative Research Project Venezuelan kindreds reveal that genetic environmental factors modulate Huntington's disease age of onset Proc. Natl. Acad. Sci. U.S.A. 101 2004 3498 3503