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Volumn 96, Issue 5, 2012, Pages 572-587

P2Y12 receptor: Platelet thrombus formation and medical interventions

Author keywords

Direct inhibitors; Indirect inhibitors; P2Y12 receptor; Platelet; Signaling pathways

Indexed keywords

ABCIXIMAB; ACETYLSALICYLIC ACID; AR C 69931; CANGRELOR; CLOPIDOGREL; ELINOGREL; PM 103; PRASUGREL; PURINERGIC P2Y12 RECEPTOR; THIENOPYRIDINE DERIVATIVE; TICAGRELOR; TICLOPIDINE; UNCLASSIFIED DRUG; ADENOSINE DIPHOSPHATE; P2RY12 PROTEIN, HUMAN; PURINERGIC P2Y RECEPTOR ANTAGONIST;

EID: 84872198260     PISSN: 09255710     EISSN: 18653774     Source Type: Journal    
DOI: 10.1007/s12185-012-1188-5     Document Type: Review
Times cited : (12)

References (165)
  • 1
    • 27444447117 scopus 로고    scopus 로고
    • The platelet P2 receptors as molecular targets for old and new antiplatelet drugs
    • Gachet C. The platelet P2 receptors as molecular targets for old and new antiplatelet drugs. Pharmacol Ther. 2005;108:180-92.
    • (2005) Pharmacol Ther , vol.108 , pp. 180-192
    • Gachet, C.1
  • 2
    • 12444305616 scopus 로고    scopus 로고
    • Australian Institute of Health and Welfare (AIHW). Cardiovascular Disease Series No. 22 Canberra: AIHW and National Heart Foundation of Australia 2004
    • Australian Institute of Health and Welfare (AIHW). Heart, stroke and vascular diseases, Australian facts 2004. Cardiovascular Disease Series No. 22. Canberra: AIHW and National Heart Foundation of Australia; 2004.
    • (2004) Heart, Stroke and Vascular Diseases, Australian Facts
  • 3
    • 0032483550 scopus 로고    scopus 로고
    • Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow
    • Savage B, Almus-Jacobs F, Ruggeri ZM. Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. Cell. 1998;94:657-66.
    • (1998) Cell , vol.94 , pp. 657-666
    • Savage, B.1    Almus-Jacobs, F.2    Ruggeri, Z.M.3
  • 4
    • 0038494921 scopus 로고    scopus 로고
    • Platelet-collagen interaction: Is GPVI the central receptor?
    • Nieswandt B, Watson SP. Platelet-collagen interaction: is GPVI the central receptor? Blood. 2003;102:449-61.
    • (2003) Blood , vol.102 , pp. 449-461
    • Nieswandt, B.1    Watson, S.P.2
  • 5
    • 0037452681 scopus 로고    scopus 로고
    • Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding
    • Cattaneo M, Zighetti ML, Lombardi R, Martinez C, Lecchi A, Conley PB, et al. Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding. Proc Natl Acad Sci USA. 2003;100:1978-83.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1978-1983
    • Cattaneo, M.1    Zighetti, M.L.2    Lombardi, R.3    Martinez, C.4    Lecchi, A.5    Conley, P.B.6
  • 6
    • 85047693299 scopus 로고    scopus 로고
    • Central role of the P2Y12 receptor in platelet activation
    • Dorsam RT, Kunapuli SP. Central role of the P2Y12 receptor in platelet activation. J Clin Invest. 2004;113:340-5.
    • (2004) J Clin Invest , vol.113 , pp. 340-345
    • Dorsam, R.T.1    Kunapuli, S.P.2
  • 8
    • 33646424353 scopus 로고    scopus 로고
    • Pharmacological profiles of cloned mammalian P2Y-receptor subtypes
    • Von Kugelgen I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther. 2006;110:415-32.
    • (2006) Pharmacol Ther , vol.110 , pp. 415-432
    • Von Kugelgen, I.1
  • 9
    • 0031754497 scopus 로고    scopus 로고
    • Receptors for purines and pyrimidines
    • Ralevic V, Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev. 1998;50:413-92.
    • (1998) Pharmacol Rev , vol.50 , pp. 413-492
    • Ralevic, V.1    Burnstock, G.2
  • 10
    • 0035107660 scopus 로고    scopus 로고
    • International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits
    • Khakh BS, Burnstock G, Kennedy C, King BF, North RA, Seguela P, et al. International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol Rev. 2001;53:107-18.
    • (2001) Pharmacol Rev , vol.53 , pp. 107-118
    • Khakh, B.S.1    Burnstock, G.2    Kennedy, C.3    King, B.F.4    North, R.A.5    Seguela, P.6
  • 12
    • 0034125277 scopus 로고    scopus 로고
    • Advances in signalling by extracellular nucleotides: The role and transduction mechanisms of P2Y receptors
    • Communi D, Janssens R, Suarez-Huerta N, Robaye B, Boeynaems JM. Advances in signalling by extracellular nucleotides: the role and transduction mechanisms of P2Y receptors. Cell Signal. 2000;12:351-60.
    • (2000) Cell Signal , vol.12 , pp. 351-360
    • Communi, D.1    Janssens, R.2    Suarez-Huerta, N.3    Robaye, B.4    Boeynaems, J.M.5
  • 13
    • 0034865992 scopus 로고    scopus 로고
    • Identification of the P2Y(12) receptor: A novel member of the P2Y family of receptors activated by extracellular nucleotides
    • Nicholas RA. Identification of the P2Y(12) receptor: a novel member of the P2Y family of receptors activated by extracellular nucleotides. Mol Pharmacol. 2001;60:416-20.
    • (2001) Mol Pharmacol , vol.60 , pp. 416-420
    • Nicholas, R.A.1
  • 14
    • 0037380778 scopus 로고    scopus 로고
    • Knock-out mice reveal tissue-specific roles of P2Y receptor subtypes in different epithelia
    • Dubyak GR. Knock-out mice reveal tissue-specific roles of P2Y receptor subtypes in different epithelia. Mol Pharmacol. 2003;63:773-6.
    • (2003) Mol Pharmacol , vol.63 , pp. 773-776
    • Dubyak, G.R.1
  • 16
    • 0342723744 scopus 로고    scopus 로고
    • Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice
    • Leon C, Hechler B, Freund M, Eckly A, Vial C, Ohlmann P, et al. Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice. J Clin Invest. 1999;104:1731-7.
    • (1999) J Clin Invest , vol.104 , pp. 1731-1737
    • Leon, C.1    Hechler, B.2    Freund, M.3    Eckly, A.4    Vial, C.5    Ohlmann, P.6
  • 17
    • 0031593698 scopus 로고    scopus 로고
    • The P2Y1 receptor, necessary but not sufficient to support full ADPinduced platelet aggregation, is not the target of the drug clopidogrel
    • Hechler B, Eckly A, Ohlmann P, Cazenave JP, Gachet C. The P2Y1 receptor, necessary but not sufficient to support full ADPinduced platelet aggregation, is not the target of the drug clopidogrel. Br J Haematol. 1998;103:858-66.
    • (1998) Br J Haematol , vol.103 , pp. 858-866
    • Hechler, B.1    Eckly, A.2    Ohlmann, P.3    Cazenave, J.P.4    Gachet, C.5
  • 18
    • 0032105512 scopus 로고    scopus 로고
    • The P2Y1 receptor is necessary for adenosine 50-diphosphate- induced platelet aggregation
    • Hechler B, Leon C, Vial C, Vigne P, Frelin C, Cazenave JP, et al. The P2Y1 receptor is necessary for adenosine 50-diphosphate- induced platelet aggregation. Blood. 1998;92:152-9.
    • (1998) Blood , vol.92 , pp. 152-159
    • Hechler, B.1    Leon, C.2    Vial, C.3    Vigne, P.4    Frelin, C.5    Cazenave, J.P.6
  • 21
    • 0034978187 scopus 로고    scopus 로고
    • Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs
    • Foster CJ, Prosser DM, Agans JM, Zhai Y, Smith MD, Lachowicz JE, et al. Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. J Clin Invest. 2001;107:1591-8.
    • (2001) J Clin Invest , vol.107 , pp. 1591-1598
    • Foster, C.J.1    Prosser, D.M.2    Agans, J.M.3    Zhai, Y.4    Smith, M.D.5    Lachowicz, J.E.6
  • 22
    • 0034858808 scopus 로고    scopus 로고
    • Molecular cloning of the platelet P2T(AC) ADP receptor: Pharmacological comparison with another ADP receptor, the P2Y(1) receptor
    • Takasaki J, Kamohara M, Saito T, Matsumoto M, Matsumoto S, Ohishi T, et al. Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y(1) receptor. Mol Pharmacol. 2001;60:432-9.
    • (2001) Mol Pharmacol , vol.60 , pp. 432-439
    • Takasaki, J.1    Kamohara, M.2    Saito, T.3    Matsumoto, M.4    Matsumoto, S.5    Ohishi, T.6
  • 23
  • 25
  • 26
    • 0037588974 scopus 로고    scopus 로고
    • Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues Cys17 and Cys270
    • Ding Z, Kim S, Dorsam RT, Jin J, Kunapuli SP. Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270. Blood. 2003;101:3908-14.
    • (2003) Blood , vol.101 , pp. 3908-3914
    • Ding, Z.1    Kim, S.2    Dorsam, R.T.3    Jin, J.4    Kunapuli, S.P.5
  • 27
    • 1642320995 scopus 로고    scopus 로고
    • N-linked glycosylation of platelet P2Y12 ADP receptor is essential for signal transduction but not for ligand binding or cell surface expression
    • Zhong X, Kriz R, Seehra J, Kumar R. N-linked glycosylation of platelet P2Y12 ADP receptor is essential for signal transduction but not for ligand binding or cell surface expression. FEBS Lett. 2004;562:111-7.
    • (2004) FEBS Lett , vol.562 , pp. 111-117
    • Zhong, X.1    Kriz, R.2    Seehra, J.3    Kumar, R.4
  • 28
    • 0023062991 scopus 로고
    • G proteins: Transducers of receptor-generated signals
    • Gilman AG. G proteins: transducers of receptor-generated signals. Annu Rev Biochem. 1987;56:615-49.
    • (1987) Annu Rev Biochem , vol.56 , pp. 615-649
    • Gilman, A.G.1
  • 29
    • 0034977188 scopus 로고    scopus 로고
    • ADP and platelets: The end of the beginning
    • Woulfe D, Yang J, Brass L. ADP and platelets: the end of the beginning. J Clin Invest. 2001;107:1503-5.
    • (2001) J Clin Invest , vol.107 , pp. 1503-1505
    • Woulfe, D.1    Yang, J.2    Brass, L.3
  • 30
    • 0025128408 scopus 로고
    • Identification of the pertussis toxin-sensitive G proteins in platelets, megakaryocytes, and human erythroleukemia cells
    • Williams AG, Woolkalis MJ, Poncz M, Manning DR, Gewirtz AM, Brass LF. Identification of the pertussis toxin-sensitive G proteins in platelets, megakaryocytes, and human erythroleukemia cells. Blood. 1990;76:721-30.
    • (1990) Blood , vol.76 , pp. 721-730
    • Williams, A.G.1    Woolkalis, M.J.2    Poncz, M.3    Manning, D.R.4    Gewirtz, A.M.5    Brass, L.F.6
  • 31
    • 0025924957 scopus 로고
    • Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes
    • Gagnon AW, Manning DR, Catani L, Gewirtz A, Poncz M, Brass LF. Identification of Gz alpha as a pertussis toxin-insensitive G protein in human platelets and megakaryocytes. Blood. 1991;78:1247-53.
    • (1991) Blood , vol.78 , pp. 1247-1253
    • Gagnon, A.W.1    Manning, D.R.2    Catani, L.3    Gewirtz, A.4    Poncz, M.5    Brass, L.F.6
  • 33
    • 0032493295 scopus 로고    scopus 로고
    • Coactivation of two different G proteincoupled receptors is essential for ADP-induced platelet aggregation
    • Jin J, Kunapuli SP. Coactivation of two different G proteincoupled receptors is essential for ADP-induced platelet aggregation. Proc Natl Acad Sci USA. 1998;95:8070-4.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8070-8074
    • Jin, J.1    Kunapuli, S.P.2
  • 34
    • 0029662218 scopus 로고    scopus 로고
    • Galpha12 and galpha13 are phosphorylated during platelet activation
    • Offermanns S, Hu YH, Simon MI. Galpha12 and galpha13 are phosphorylated during platelet activation. J Biol Chem. 1996;271:26044-8.
    • (1996) J Biol Chem , vol.271 , pp. 26044-26048
    • Offermanns, S.1    Hu, Y.H.2    Simon, M.I.3
  • 35
    • 0030756508 scopus 로고    scopus 로고
    • Defective platelet activation in G alpha(q)-deficient mice
    • Offermanns S, Toombs CF, Hu YH, Simon MI. Defective platelet activation in G alpha(q)-deficient mice. Nature. 1997;389:183-6.
    • (1997) Nature , vol.389 , pp. 183-186
    • Offermanns, S.1    Toombs, C.F.2    Hu, Y.H.3    Simon, M.I.4
  • 36
    • 0034730185 scopus 로고    scopus 로고
    • Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs
    • Yang J, Wu J, Kowalska MA, Dalvi A, Prevost N, O'brien PJ, et al. Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Proc Natl Acad Sci USA. 2000;97:9984-9.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9984-9989
    • Yang, J.1    Wu, J.2    Kowalska, M.A.3    Dalvi, A.4    Prevost, N.5    O'Brien, P.J.6
  • 39
    • 0032798247 scopus 로고    scopus 로고
    • CAMP is an important messenger for ADP-induced platelet aggregation
    • Weber AA, Hohlfeld T, Schror K. cAMP is an important messenger for ADP-induced platelet aggregation. Platelets. 1999; 10:238-41.
    • (1999) Platelets , vol.10 , pp. 238-241
    • Weber, A.A.1    Hohlfeld, T.2    Schror, K.3
  • 40
    • 0037195456 scopus 로고    scopus 로고
    • Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors
    • Yang J, Wu J, Jiang H, Mortensen R, Austin S, Manning DR, et al. Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors. J Biol Chem. 2002;277:46035-42.
    • (2002) J Biol Chem , vol.277 , pp. 46035-46042
    • Yang, J.1    Wu, J.2    Jiang, H.3    Mortensen, R.4    Austin, S.5    Manning, D.R.6
  • 42
    • 17144370263 scopus 로고    scopus 로고
    • Resistance to clopidogrel: A review of the evidence
    • Nguyen TA, Diodati JG, Pharand C. Resistance to clopidogrel: a review of the evidence. J Am Coll Cardiol. 2005;45:1157-64.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1157-1164
    • Nguyen, T.A.1    Diodati, J.G.2    Pharand, C.3
  • 43
    • 0023265447 scopus 로고
    • Vasodilator-stimulated protein phosphorylation in platelets is mediated by cAMP- and cGMP-dependent protein kinases
    • Waldmann R, Nieberding M, Walter U. Vasodilator-stimulated protein phosphorylation in platelets is mediated by cAMP- and cGMP-dependent protein kinases. Eur J Biochem. 1987;167: 441-8.
    • (1987) Eur J Biochem , vol.167 , pp. 441-448
    • Waldmann, R.1    Nieberding, M.2    Walter, U.3
  • 44
    • 0028146120 scopus 로고
    • Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Ser157 in intact human platelets correlates with fibrinogen receptor inhibition
    • Horstrup K, Jablonka B, Honig-Liedl P, Just M, Kochsiek K, Walter U. Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Ser157 in intact human platelets correlates with fibrinogen receptor inhibition. Eur J Biochem. 1994;225:21-7.
    • (1994) Eur J Biochem , vol.225 , pp. 21-27
    • Horstrup, K.1    Jablonka, B.2    Honig-Liedl, P.3    Just, M.4    Kochsiek, K.5    Walter, U.6
  • 45
    • 15944383861 scopus 로고    scopus 로고
    • Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases
    • Aleil B, Ravanat C, Cazenave JP, Rochoux G, Heitz A, Gachet C. Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases. J Thromb Haemost. 2005;3:85-92.
    • (2005) J Thromb Haemost , vol.3 , pp. 85-92
    • Aleil, B.1    Ravanat, C.2    Cazenave, J.P.3    Rochoux, G.4    Heitz, A.5    Gachet, C.6
  • 47
    • 13044263119 scopus 로고    scopus 로고
    • A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase
    • Trumel C, Payrastre B, Plantavid M, Hechler B, Viala C, Presek P, et al. A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase. Blood. 1999;94:4156-65.
    • (1999) Blood , vol.94 , pp. 4156-4165
    • Trumel, C.1    Payrastre, B.2    Plantavid, M.3    Hechler, B.4    Viala, C.5    Presek, P.6
  • 48
    • 0035860407 scopus 로고    scopus 로고
    • The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin - A phosphoinositide 3-kinase-dependent mechanism
    • Kauffenstein G, Bergmeier W, Eckly A, Ohlmann P, Leon C, Cazenave JP, et al. The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin- a phosphoinositide 3-kinase-dependent mechanism. FEBS Lett. 2001;505:281-90.
    • (2001) FEBS Lett , vol.505 , pp. 281-290
    • Kauffenstein, G.1    Bergmeier, W.2    Eckly, A.3    Ohlmann, P.4    Leon, C.5    Cazenave, J.P.6
  • 49
    • 0037414793 scopus 로고    scopus 로고
    • A selective role for phosphatidylinositol 3, 4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B
    • Lova P, Paganini S, Hirsch E, Barberis L, Wymann M, Sinigaglia F, et al. A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B. J Biol Chem. 2003;278:131-8.
    • (2003) J Biol Chem , vol.278 , pp. 131-138
    • Lova, P.1    Paganini, S.2    Hirsch, E.3    Barberis, L.4    Wymann, M.5    Sinigaglia, F.6
  • 50
    • 33751187650 scopus 로고    scopus 로고
    • Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization
    • Cosemans JM, Munnix IC, Wetzker R, Heller R, Jackson SP, Heemskerk JW. Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization. Blood. 2006;108:3045-52.
    • (2006) Blood , vol.108 , pp. 3045-3052
    • Cosemans, J.M.1    Munnix, I.C.2    Wetzker, R.3    Heller, R.4    Jackson, S.P.5    Heemskerk, J.W.6
  • 53
    • 0033604577 scopus 로고    scopus 로고
    • Signaling by distinct classes of phosphoinositide 3-kinases
    • Vanhaesebroeck B, Waterfield MD. Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res. 1999;253:239-54.
    • (1999) Exp Cell Res , vol.253 , pp. 239-254
    • Vanhaesebroeck, B.1    Waterfield, M.D.2
  • 54
    • 0037023134 scopus 로고    scopus 로고
    • A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human platelets
    • Lova P, Paganini S, Sinigaglia F, Balduini C, Torti M. A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human platelets. J Biol Chem. 2002;277: 12009-15.
    • (2002) J Biol Chem , vol.277 , pp. 12009-12015
    • Lova, P.1    Paganini, S.2    Sinigaglia, F.3    Balduini, C.4    Torti, M.5
  • 55
    • 0037441754 scopus 로고    scopus 로고
    • Identification of P2Y12-dependent and - Independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets
    • Larson MK, Chen H, Kahn ML, Taylor AM, Fabre JE, Mortensen RM, et al. Identification of P2Y12-dependent and - independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets. Blood. 2003;101:1409-15.
    • (2003) Blood , vol.101 , pp. 1409-1415
    • Larson, M.K.1    Chen, H.2    Kahn, M.L.3    Taylor, A.M.4    Fabre, J.E.5    Mortensen, R.M.6
  • 57
    • 0037067748 scopus 로고    scopus 로고
    • Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton
    • Bertoni A, Tadokoro S, Eto K, Pampori N, Parise LV, White GC, et al. Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton. J Biol Chem. 2002;277:25715-21.
    • (2002) J Biol Chem , vol.277 , pp. 25715-25721
    • Bertoni, A.1    Tadokoro, S.2    Eto, K.3    Pampori, N.4    Parise, L.V.5    White, G.C.6
  • 58
    • 0037077201 scopus 로고    scopus 로고
    • A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid
    • Yart A, Roche S, Wetzker R, Laffargue M, Tonks N, Mayeux P, et al. A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid. J Biol Chem. 2002;277:21167-78.
    • (2002) J Biol Chem , vol.277 , pp. 21167-21178
    • Yart, A.1    Roche, S.2    Wetzker, R.3    Laffargue, M.4    Tonks, N.5    Mayeux, P.6
  • 59
    • 1042301420 scopus 로고    scopus 로고
    • Akt activation in platelets depends on Gi signaling pathways
    • Kim S, Jin J, Kunapuli SP. Akt activation in platelets depends on Gi signaling pathways. J Biol Chem. 2004;279:4186-95.
    • (2004) J Biol Chem , vol.279 , pp. 4186-4195
    • Kim, S.1    Jin, J.2    Kunapuli, S.P.3
  • 60
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidylinositol- 3-OH kinase signal transduction
    • Burgering BM, Coffer PJ. Protein kinase B (c-Akt) in phosphatidylinositol- 3-OH kinase signal transduction. Nature. 1995;376:599-602.
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 61
    • 0034623228 scopus 로고    scopus 로고
    • Dual regulation of platelet protein kinase B
    • Kroner C, Eybrechts K, Akkerman JW. Dual regulation of platelet protein kinase B. J Biol Chem. 2000;275:27790-8.
    • (2000) J Biol Chem , vol.275 , pp. 27790-27798
    • Kroner, C.1    Eybrechts, K.2    Akkerman, J.W.3
  • 62
    • 0030799706 scopus 로고    scopus 로고
    • Dual role of phosphatidylinositol-3, 4,5-trisphosphate in the activation of protein kinase B
    • Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF, et al. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science. 1997;277:567-70.
    • (1997) Science , vol.277 , pp. 567-570
    • Stokoe, D.1    Stephens, L.R.2    Copeland, T.3    Gaffney, P.R.4    Reese, C.B.5    Painter, G.F.6
  • 63
    • 0034708482 scopus 로고    scopus 로고
    • Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site
    • Toker A, Newton AC. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J Biol Chem. 2000;275:8271-4.
    • (2000) J Biol Chem , vol.275 , pp. 8271-8274
    • Toker, A.1    Newton, A.C.2
  • 64
    • 0037666792 scopus 로고    scopus 로고
    • Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation
    • Troussard AA, Mawji NM, Ong C, Mui A, St-Arnaud R, Dedhar S. Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem. 2003;278:22374-8.
    • (2003) J Biol Chem , vol.278 , pp. 22374-22378
    • Troussard, A.A.1    Mawji, N.M.2    Ong, C.3    Mui, A.4    St-Arnaud, R.5    Dedhar, S.6
  • 65
    • 1542317617 scopus 로고    scopus 로고
    • Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2
    • Woulfe D, Jiang H, Morgans A, Monks R, Birnbaum M, Brass LF. Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2. J Clin Invest. 2004;113: 441-50.
    • (2004) J Clin Invest , vol.113 , pp. 441-450
    • Woulfe, D.1    Jiang, H.2    Morgans, A.3    Monks, R.4    Birnbaum, M.5    Brass, L.F.6
  • 66
    • 33750081484 scopus 로고    scopus 로고
    • G-protein-gated inwardly rectifying potassium channels regulate ADP-induced cPLA2 activity in platelets through Src family kinases
    • Shankar H, Kahner BN, Prabhakar J, Lakhani P, Kim S, Kunapuli SP. G-protein-gated inwardly rectifying potassium channels regulate ADP-induced cPLA2 activity in platelets through Src family kinases. Blood. 2006;108:3027-34.
    • (2006) Blood , vol.108 , pp. 3027-3034
    • Shankar, H.1    Kahner, B.N.2    Prabhakar, J.3    Lakhani, P.4    Kim, S.5    Kunapuli, S.P.6
  • 67
    • 4444375609 scopus 로고    scopus 로고
    • Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses
    • Shankar H, Murugappan S, Kim S, Jin J, Ding Z, Wickman K, et al. Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses. Blood. 2004;104:1335-43.
    • (2004) Blood , vol.104 , pp. 1335-1343
    • Shankar, H.1    Murugappan, S.2    Kim, S.3    Jin, J.4    Ding, Z.5    Wickman, K.6
  • 68
    • 0034268796 scopus 로고    scopus 로고
    • Src tyrosine kinase is a novel direct effector of G proteins
    • Ma YC, Huang J, Ali S, Lowry W, Huang XY. Src tyrosine kinase is a novel direct effector of G proteins. Cell. 2000;102: 635-46.
    • (2000) Cell , vol.102 , pp. 635-646
    • Ma, Y.C.1    Huang, J.2    Ali, S.3    Lowry, W.4    Huang, X.Y.5
  • 69
    • 0027328791 scopus 로고
    • Thrombin and thrombin receptor agonist peptide induce tyrosine phosphorylation and tyrosine kinases in the platelet cytoskeleton. Translocation of pp 60c-src and integrin alpha IIb beta 3 (glycoprotein IIb/IIIa) is not required for aggregation, but is dependent on formation of large aggregate structures
    • Pumiglia KM, Feinstein MB. Thrombin and thrombin receptor agonist peptide induce tyrosine phosphorylation and tyrosine kinases in the platelet cytoskeleton. Translocation of pp 60c-src and integrin alpha IIb beta 3 (glycoprotein IIb/IIIa) is not required for aggregation, but is dependent on formation of large aggregate structures. Biochem J. 1993;294(Pt 1):253-60.
    • (1993) Biochem J , vol.294 , Issue.PART 1 , pp. 253-260
    • Pumiglia, K.M.1    Feinstein, M.B.2
  • 70
    • 0026597050 scopus 로고
    • Translocation of pp60c-src to the cytoskeleton during platelet aggregation
    • Horvath AR, Muszbek L, Kellie S. Translocation of pp60c-src to the cytoskeleton during platelet aggregation. EMBO J. 1992;11:855-61.
    • (1992) EMBO J , vol.11 , pp. 855-861
    • Horvath, A.R.1    Muszbek, L.2    Kellie, S.3
  • 71
    • 15944385972 scopus 로고    scopus 로고
    • Differential requirements for calcium and Src family kinases in platelet GPIIb/IIIa activation and thromboxane generation downstream of different G-protein pathways
    • Dorsam RT, Kim S, Murugappan S, Rachoor S, Shankar H, Jin J, et al. Differential requirements for calcium and Src family kinases in platelet GPIIb/IIIa activation and thromboxane generation downstream of different G-protein pathways. Blood. 2005;105:2749-56.
    • (2005) Blood , vol.105 , pp. 2749-2756
    • Dorsam, R.T.1    Kim, S.2    Murugappan, S.3    Rachoor, S.4    Shankar, H.5    Jin, J.6
  • 72
    • 4444257333 scopus 로고    scopus 로고
    • Reciprocal crosstalk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets
    • Hardy AR, Jones ML, Mundell SJ, Poole AW. Reciprocal crosstalk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets. Blood. 2004;104:1745-52.
    • (2004) Blood , vol.104 , pp. 1745-1752
    • Hardy, A.R.1    Jones, M.L.2    Mundell, S.J.3    Poole, A.W.4
  • 73
    • 27744525934 scopus 로고    scopus 로고
    • Src family kinase-mediated and Erk-mediated thromboxane A2 generation are essential for VWF/GPIb-induced fibrinogen receptor activation in human platelets
    • Garcia A, Quinton TM, Dorsam RT, Kunapuli SP. Src family kinase-mediated and Erk-mediated thromboxane A2 generation are essential for VWF/GPIb-induced fibrinogen receptor activation in human platelets. Blood. 2005;106:3410-4.
    • (2005) Blood , vol.106 , pp. 3410-3414
    • Garcia, A.1    Quinton, T.M.2    Dorsam, R.T.3    Kunapuli, S.P.4
  • 74
    • 0035834714 scopus 로고    scopus 로고
    • A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3
    • Li Z, Xi X, Du X. A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3. J Biol Chem. 2001;276:42226-32.
    • (2001) J Biol Chem , vol.276 , pp. 42226-42232
    • Li, Z.1    Xi, X.2    Du, X.3
  • 75
    • 0028174007 scopus 로고
    • P42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation
    • Papkoff J, Chen RH, Blenis J, Forsman J. p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation. Mol Cell Biol. 1994;14:463-72.
    • (1994) Mol Cell Biol , vol.14 , pp. 463-472
    • Papkoff, J.1    Chen, R.H.2    Blenis, J.3    Forsman, J.4
  • 76
    • 34249803276 scopus 로고    scopus 로고
    • Regulation and functional consequences of ADP receptormediated ERK2 activation in platelets
    • Garcia A, Shankar H, Murugappan S, Kim S, Kunapuli SP. Regulation and functional consequences of ADP receptormediated ERK2 activation in platelets. Biochem J. 2007;404: 299-308.
    • (2007) Biochem J , vol.404 , pp. 299-308
    • Garcia, A.1    Shankar, H.2    Murugappan, S.3    Kim, S.4    Kunapuli, S.P.5
  • 77
    • 0041829104 scopus 로고    scopus 로고
    • Distinct regulation of cytosolic phospholipase A2 phosphorylation, translocation, proteolysis and activation by tumour necrosis factor-receptor subtypes
    • Jupp OJ, Vandenabeele P, Macewan DJ. Distinct regulation of cytosolic phospholipase A2 phosphorylation, translocation, proteolysis and activation by tumour necrosis factor-receptor subtypes. Biochem J. 2003;374:453-61.
    • (2003) Biochem J , vol.374 , pp. 453-461
    • Jupp, O.J.1    Vandenabeele, P.2    MacEwan, D.J.3
  • 78
    • 0026611170 scopus 로고
    • Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid
    • Lin LL, Lin AY, Knopf JL. Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid. Proc Natl Acad Sci USA. 1992;89:6147-51.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6147-6151
    • Lin, L.L.1    Lin, A.Y.2    Knopf, J.L.3
  • 79
    • 80052352679 scopus 로고    scopus 로고
    • Molecular defects of the platelet P2 receptors
    • Cattaneo M. Molecular defects of the platelet P2 receptors. Purinergic Signal. 2011;7:333-9.
    • (2011) Purinergic Signal , vol.7 , pp. 333-339
    • Cattaneo, M.1
  • 80
  • 81
    • 66349105667 scopus 로고    scopus 로고
    • Haploinsufficiency of the platelet P2Y12 gene in a family with congenital bleeding diathesis
    • Fontana G, Ware J, Cattaneo M. Haploinsufficiency of the platelet P2Y12 gene in a family with congenital bleeding diathesis. Haematologica. 2009;94:581-4.
    • (2009) Haematologica , vol.94 , pp. 581-584
    • Fontana, G.1    Ware, J.2    Cattaneo, M.3
  • 82
    • 28444439191 scopus 로고    scopus 로고
    • Impaired platelet function in a patient with P2Y12 deficiency caused by a mutation in the translation initiation codon
    • Shiraga M, Miyata S, Kato H, Kashiwagi H, Honda S, Kurata Y, et al. Impaired platelet function in a patient with P2Y12 deficiency caused by a mutation in the translation initiation codon. J Thromb Haemost. 2005;3:2315-23.
    • (2005) J Thromb Haemost , vol.3 , pp. 2315-2323
    • Shiraga, M.1    Miyata, S.2    Kato, H.3    Kashiwagi, H.4    Honda, S.5    Kurata, Y.6
  • 83
    • 65449142910 scopus 로고    scopus 로고
    • Identification and characterization of a novel P2Y12 variant in a patient diagnosed with type 1 von Willebrand disease in the European MCMDM-1VWD study
    • Daly ME, Dawood BB, Lester WA, Peake IR, Rodeghiero F, Goodeve AC, et al. Identification and characterization of a novel P2Y12 variant in a patient diagnosed with type 1 von Willebrand disease in the European MCMDM-1VWD study. Blood. 2009;113:4110-3.
    • (2009) Blood , vol.113 , pp. 4110-4113
    • Daly, M.E.1    Dawood, B.B.2    Lester, W.A.3    Peake, I.R.4    Rodeghiero, F.5    Goodeve, A.C.6
  • 84
    • 0028942659 scopus 로고
    • An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function
    • Nurden P, Savi P, Heilmann E, Bihour C, Herbert JM, Maffrand JP, et al. An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function. J Clin Invest. 1995;95:1612-22.
    • (1995) J Clin Invest , vol.95 , pp. 1612-1622
    • Nurden, P.1    Savi, P.2    Heilmann, E.3    Bihour, C.4    Herbert, J.M.5    Maffrand, J.P.6
  • 85
    • 0034323126 scopus 로고    scopus 로고
    • Platelets from a patient heterozygous for the defect of P2CYC receptors for ADP have a secretion defect despite normal thromboxane A2 production and normal granule stores: Further evidence that some cases of platelet 'primary secretion defect' are heterozygous for a defect of P2CYC receptors
    • Cattaneo M, Lecchi A, Lombardi R, Gachet C, Zighetti ML. Platelets from a patient heterozygous for the defect of P2CYC receptors for ADP have a secretion defect despite normal thromboxane A2 production and normal granule stores: further evidence that some cases of platelet 'primary secretion defect' are heterozygous for a defect of P2CYC receptors. Arterioscler Thromb Vasc Biol. 2000;20:E101-6.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20
    • Cattaneo, M.1    Lecchi, A.2    Lombardi, R.3    Gachet, C.4    Zighetti, M.L.5
  • 86
    • 0026486964 scopus 로고
    • Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate
    • Cattaneo M, Lecchi A, Randi AM, Mcgregor JL, Mannucci PM. Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate. Blood. 1992;80:2787-96.
    • (1992) Blood , vol.80 , pp. 2787-2796
    • Cattaneo, M.1    Lecchi, A.2    Randi, A.M.3    McGregor, J.L.4    Mannucci, P.M.5
  • 87
    • 0030482497 scopus 로고    scopus 로고
    • Ultrastructural studies of platelet aggregates from human subjects receiving clopidogrel and from a patient with an inherited defect of an ADP-dependent pathway of platelet activation
    • Humbert M, Nurden P, Bihour C, Pasquet JM, Winckler J, Heilmann E, et al. Ultrastructural studies of platelet aggregates from human subjects receiving clopidogrel and from a patient with an inherited defect of an ADP-dependent pathway of platelet activation. Arterioscler Thromb Vasc Biol. 1996;16: 1532-43.
    • (1996) Arterioscler Thromb Vasc Biol , vol.16 , pp. 1532-1543
    • Humbert, M.1    Nurden, P.2    Bihour, C.3    Pasquet, J.M.4    Winckler, J.5    Heilmann, E.6
  • 88
    • 78649371969 scopus 로고    scopus 로고
    • Usefulness of a flow cytometric analysis of intraplatelet vasodilator-stimulated phosphoprotein phosphorylation for the detection of patients with genetic defects of the platelet P2Y(12) receptor for ADP
    • Zighetti ML, Carpani G, Sinigaglia E, Cattaneo M. Usefulness of a flow cytometric analysis of intraplatelet vasodilator-stimulated phosphoprotein phosphorylation for the detection of patients with genetic defects of the platelet P2Y(12) receptor for ADP. J Thromb Haemost. 2010;8:2332-4.
    • (2010) J Thromb Haemost , vol.8 , pp. 2332-2334
    • Zighetti, M.L.1    Carpani, G.2    Sinigaglia, E.3    Cattaneo, M.4
  • 89
    • 74549137908 scopus 로고    scopus 로고
    • Rfaut New P2Y(12) inhibitors
    • Cattaneo M. New P2Y(12) inhibitors. Circulation. 2010;121: 171-9.
    • (2010) Circulation , vol.121 , pp. 171-179
    • Cattaneo, M.1
  • 91
    • 7844220998 scopus 로고    scopus 로고
    • Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting. The full anticoagulation versus aspirin and ticlopidine (fantastic) study
    • Bertrand ME, Legrand V, Boland J, Fleck E, Bonnier J, Emmanuelson H, et al. Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting. The full anticoagulation versus aspirin and ticlopidine (fantastic) study. Circulation. 1998;98:1597-603.
    • (1998) Circulation , vol.98 , pp. 1597-1603
    • Bertrand, M.E.1    Legrand, V.2    Boland, J.3    Fleck, E.4    Bonnier, J.5    Emmanuelson, H.6
  • 92
    • 9244251971 scopus 로고    scopus 로고
    • A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents
    • Schomig A, Neumann FJ, Kastrati A, Schuhlen H, Blasini R, Hadamitzky M, et al. A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. N Engl J Med. 1996;334:1084-9.
    • (1996) N Engl J Med , vol.334 , pp. 1084-1089
    • Schomig, A.1    Neumann, F.J.2    Kastrati, A.3    Schuhlen, H.4    Blasini, R.5    Hadamitzky, M.6
  • 93
    • 0032481092 scopus 로고    scopus 로고
    • A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting
    • Stent Anticoagulation Restenosis Study Investigators
    • Leon MB, Baim DS, Popma JJ, Gordon PC, Cutlip DE, Ho KK, et al. A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. Stent Anticoagulation Restenosis Study Investigators. N Engl J Med. 1998;339: 1665-71.
    • (1998) N Engl J Med , vol.339 , pp. 1665-1671
    • Leon, M.B.1    Baim, D.S.2    Popma, J.J.3    Gordon, P.C.4    Cutlip, D.E.5    Ho, K.K.6
  • 94
    • 0032542028 scopus 로고    scopus 로고
    • Randomized evaluation of anticoagulation versus antiplatelet therapy after coronary stent implantation in high-risk patients: The multicenter aspirin and ticlopidine trial after intracoronary stenting (MATTIS)
    • Urban P, Macaya C, Rupprecht HJ, Kiemeneij F, Emanuelsson H, Fontanelli A, et al. Randomized evaluation of anticoagulation versus antiplatelet therapy after coronary stent implantation in high-risk patients: the multicenter aspirin and ticlopidine trial after intracoronary stenting (MATTIS). Circulation. 1998;98: 2126-32.
    • (1998) Circulation , vol.98 , pp. 2126-2132
    • Urban, P.1    MacAya, C.2    Rupprecht, H.J.3    Kiemeneij, F.4    Emanuelsson, H.5    Fontanelli, A.6
  • 95
    • 34047123414 scopus 로고    scopus 로고
    • ADP receptor antagonism what's in the pipeline?
    • Angiolillo DJ. ADP receptor antagonism: what's in the pipeline? Am J Cardiovasc Drugs. 2007;7:423-32.
    • (2007) Am J Cardiovasc Drugs , vol.7 , pp. 423-432
    • Angiolillo, D.J.1
  • 96
    • 0034622539 scopus 로고    scopus 로고
    • Doubleblind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: The clopidogrel aspirin stent international cooperative study (CLASSICS)
    • Bertrand ME, Rupprecht HJ, Urban P, Gershlick AH. Doubleblind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: the clopidogrel aspirin stent international cooperative study (CLASSICS). Circulation. 2000;102:624-9.
    • (2000) Circulation , vol.102 , pp. 624-629
    • Bertrand, M.E.1    Rupprecht, H.J.2    Urban, P.3    Gershlick, A.H.4
  • 97
    • 67650395569 scopus 로고    scopus 로고
    • The safety and efficacy of clopidogrel versus ticlopidine in Japanese stroke patients: Combined results of two Phase III, multicenter, randomized clinical trials
    • Uchiyama S, Fukuuchi Y, Yamaguchi T. The safety and efficacy of clopidogrel versus ticlopidine in Japanese stroke patients: combined results of two Phase III, multicenter, randomized clinical trials. J Neurol. 2009;256:888-97.
    • (2009) J Neurol , vol.256 , pp. 888-897
    • Uchiyama, S.1    Fukuuchi, Y.2    Yamaguchi, T.3
  • 98
    • 38349187347 scopus 로고    scopus 로고
    • Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: A preliminary case-control study
    • Hirata K, Takagi H, Yamamoto M, Matsumoto T, Nishiya T, Mori K, et al. Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study. Pharmacogenomics J. 2008;8:29-33.
    • (2008) Pharmacogenomics J , vol.8 , pp. 29-33
    • Hirata, K.1    Takagi, H.2    Yamamoto, M.3    Matsumoto, T.4    Nishiya, T.5    Mori, K.6
  • 99
    • 77958105401 scopus 로고    scopus 로고
    • Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: A pharmacogenetic analysis
    • Mega JL, Close SL, Wiviott SD, Shen L, Walker JR, Simon T, et al. Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis. Lancet. 2010;376:1312-9.
    • (2010) Lancet , vol.376 , pp. 1312-1319
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3    Shen, L.4    Walker, J.R.5    Simon, T.6
  • 100
    • 63149181056 scopus 로고    scopus 로고
    • Rationale and design of a randomized, double-blind, placebo-controlled trial of 6 versus 12 months clopidogrel therapy after implantation of a drug-eluting stent
    • The Intracoronary Stenting and Antithrombotic Regimen: Safety And EFficacy of 6 Months Dual Antiplatelet Therapy After Drug-Eluting Stenting (ISAR-SAFE) study e2
    • Byrne RA, Schulz S, Mehilli J, Iijima R, Massberg S, Neumann FJ, et al. Rationale and design of a randomized, double-blind, placebo-controlled trial of 6 versus 12 months clopidogrel therapy after implantation of a drug-eluting stent: The Intracoronary Stenting and Antithrombotic Regimen: Safety And EFficacy of 6 Months Dual Antiplatelet Therapy After Drug- Eluting Stenting (ISAR-SAFE) study. Am Heart J. 2009; 157(620-4):e2.
    • (2009) Am Heart J , vol.157 , pp. 620-624
    • Byrne, R.A.1    Schulz, S.2    Mehilli, J.3    Iijima, R.4    Massberg, S.5    Neumann, F.J.6
  • 102
    • 77954110993 scopus 로고    scopus 로고
    • Costs and consequences of clopidogrel versus aspirin for secondary prevention of ischaemic events in (high-risk) atherosclerotic patients in Sweden: A lifetime model based on the CAPRIE trial and high-risk CAPRIE subpopulations
    • Logman JF, Heeg BM, Herlitz J, Van Hout BA. Costs and consequences of clopidogrel versus aspirin for secondary prevention of ischaemic events in (high-risk) atherosclerotic patients in Sweden: a lifetime model based on the CAPRIE trial and high-risk CAPRIE subpopulations. Appl Health Econ Health Policy. 2010;8:251-65.
    • (2010) Appl Health Econ Health Policy , vol.8 , pp. 251-265
    • Logman, J.F.1    Heeg, B.M.2    Herlitz, J.3    Van Hout, B.A.4
  • 103
    • 38449086326 scopus 로고    scopus 로고
    • Cost-effectiveness of clopidogrel in acute coronary syndromes in Canada: A long-term analysis based on the CURE trial
    • Kolm P, Yuan Y, Veledar E, Mehta SR, O'brien JA, Weintraub WS. Cost-effectiveness of clopidogrel in acute coronary syndromes in Canada: a long-term analysis based on the CURE trial. Can J Cardiol. 2007;23:1037-42.
    • (2007) Can J Cardiol , vol.23 , pp. 1037-1042
    • Kolm, P.1    Yuan, Y.2    Veledar, E.3    Mehta, S.R.4    O'Brien, J.A.5    Weintraub, W.S.6
  • 104
    • 47949092342 scopus 로고    scopus 로고
    • Cost-effectiveness of clopidogrel treatment in percutaneous coronary intervention: A European model based on a meta-analysis of the PCI-CURE, CREDO and PCI-CLARITY trials
    • Berg J, Fidan D, Lindgren P. Cost-effectiveness of clopidogrel treatment in percutaneous coronary intervention: a European model based on a meta-analysis of the PCI-CURE, CREDO and PCI-CLARITY trials. Curr Med Res Opin. 2008;24:2089-101.
    • (2008) Curr Med Res Opin , vol.24 , pp. 2089-2101
    • Berg, J.1    Fidan, D.2    Lindgren, P.3
  • 105
    • 84855161374 scopus 로고    scopus 로고
    • Pharmacokinetics and platelet aggregation inhibitory effects of a novel intravenous formulation of clopidogrel in humans
    • Cushing DJ, Souney PF, Cooper WD, Mosher GL, Adams MP, Machatha S, et al. Pharmacokinetics and platelet aggregation inhibitory effects of a novel intravenous formulation of clopidogrel in humans. Clin Exp Pharmacol Physiol. 2012;39:3-8.
    • (2012) Clin Exp Pharmacol Physiol , vol.39 , pp. 3-8
    • Cushing, D.J.1    Souney, P.F.2    Cooper, W.D.3    Mosher, G.L.4    Adams, M.P.5    MacHatha, S.6
  • 106
    • 77449149717 scopus 로고    scopus 로고
    • Platelet adenosine diphosphate P2Y12 receptor antagonism: Benefits and limitations of current treatment strategies and future directions
    • Angiolillo DJ, Ferreiro JL. Platelet adenosine diphosphate P2Y12 receptor antagonism: benefits and limitations of current treatment strategies and future directions. Rev Esp Cardiol. 2010;63:60-76.
    • (2010) Rev Esp Cardiol , vol.63 , pp. 60-76
    • Angiolillo, D.J.1    Ferreiro, J.L.2
  • 107
    • 75749102996 scopus 로고    scopus 로고
    • Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans
    • Farid NA, Kurihara A, Wrighton SA. Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans. J Clin Pharmacol. 2010;50: 126-42.
    • (2010) J Clin Pharmacol , vol.50 , pp. 126-142
    • Farid, N.A.1    Kurihara, A.2    Wrighton, S.A.3
  • 108
    • 9144270451 scopus 로고    scopus 로고
    • Expert consensus document on the use of antiplatelet agents. The task force on the use of antiplatelet agents in patients with atherosclerotic cardiovascular disease of the European society of cardiology
    • Patrono C, Bachmann F, Baigent C, Bode C, De Caterina R, Charbonnier B, et al. Expert consensus document on the use of antiplatelet agents. The task force on the use of antiplatelet agents in patients with atherosclerotic cardiovascular disease of the European society of cardiology. Eur Heart J. 2004;25: 166-81.
    • (2004) Eur Heart J , vol.25 , pp. 166-181
    • Patrono, C.1    Bachmann, F.2    Baigent, C.3    Bode, C.4    De Caterina, R.5    Charbonnier, B.6
  • 109
    • 73449142798 scopus 로고    scopus 로고
    • Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
    • Kushner FG, Smith SC, King SB, Anderson JL, Antman EM, Bailey SR, et al. 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2009;120:2271-306.
    • (2009) Circulation 2009 , vol.120 , pp. 2271-2306
    • Kushner, F.G.1    Smith, S.C.2    King, S.B.3    Anderson, J.L.4    Antman, E.M.5    Bailey, S.R.6
  • 110
    • 84872186498 scopus 로고    scopus 로고
    • PLAVIX (clopidogrel bisulfate) Tablets [Prescribing Information] [internet]
    • Accessed 7 Feb 2012
    • PLAVIX (clopidogrel bisulfate) Tablets [Prescribing Information] [internet]. Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership; 2010. http://products.sanofi-aventis.us/PLAVIX/ PLAVIX.html Accessed 7 Feb 2012.
    • (2010) Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership
  • 111
    • 7544239072 scopus 로고    scopus 로고
    • High clopidogrel loading dose during coronary stenting: Effects on drug response and interindividual variability
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Ramirez C, Sabate M, Banuelos C, et al. High clopidogrel loading dose during coronary stenting: effects on drug response and interindividual variability. Eur Heart J. 2004;25:1903-10.
    • (2004) Eur Heart J , vol.25 , pp. 1903-1910
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3    Ramirez, C.4    Sabate, M.5    Banuelos, C.6
  • 112
    • 17744376570 scopus 로고    scopus 로고
    • Randomized trial of high loading dose of clopidogrel for reduction of periprocedural myocardial infarction in patients undergoing coronary intervention: Results from the ARMYDA-2 (Antiplatelet therapy for reduction of MYocardial Damage during Angioplasty) study
    • Patti G, Colonna G, Pasceri V, Pepe LL, Montinaro A, Di Sciascio G. Randomized trial of high loading dose of clopidogrel for reduction of periprocedural myocardial infarction in patients undergoing coronary intervention: results from the ARMYDA-2 (Antiplatelet therapy for reduction of MYocardial Damage during Angioplasty) study. Circulation. 2005;111: 2099-106.
    • (2005) Circulation , vol.111 , pp. 2099-2106
    • Patti, G.1    Colonna, G.2    Pasceri, V.3    Pepe, L.L.4    Montinaro, A.5    Di Sciascio, G.6
  • 113
    • 33748948717 scopus 로고    scopus 로고
    • Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non- ST-segment elevation acute coronary syndrome undergoing coronary stenting
    • Cuisset T, Frere C, Quilici J, Morange PE, Nait-Saidi L, Carvajal J, et al. Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non- ST-segment elevation acute coronary syndrome undergoing coronary stenting. J Am Coll Cardiol. 2006;48:1339-45.
    • (2006) J Am Coll Cardiol , vol.48 , pp. 1339-1345
    • Cuisset, T.1    Frere, C.2    Quilici, J.3    Morange, P.E.4    Nait-Saidi, L.5    Carvajal, J.6
  • 114
    • 10444235983 scopus 로고    scopus 로고
    • Clopidogrel resistance: A new chapter in a fast-moving story
    • Wiviott SD, Antman EM. Clopidogrel resistance: a new chapter in a fast-moving story. Circulation. 2004;109:3064-7.
    • (2004) Circulation , vol.109 , pp. 3064-3067
    • Wiviott, S.D.1    Antman, E.M.2
  • 115
    • 0038649988 scopus 로고    scopus 로고
    • Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity
    • Gurbel PA, Bliden KP, Hiatt BL, O'connor CM. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation. 2003; 107:2908-13.
    • (2003) Circulation , vol.107 , pp. 2908-2913
    • Gurbel, P.A.1    Bliden, K.P.2    Hiatt, B.L.3    O'Connor, C.M.4
  • 116
    • 34447576539 scopus 로고    scopus 로고
    • Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: A systematic review and meta-analysis
    • Snoep JD, Hovens MM, Eikenboom JC, Van Der Bom JG, Jukema JW, Huisman MV. Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: a systematic review and meta-analysis. Am Heart J. 2007;154:221-31.
    • (2007) Am Heart J , vol.154 , pp. 221-231
    • Snoep, J.D.1    Hovens, M.M.2    Eikenboom, J.C.3    Van Der Bom, J.G.4    Jukema, J.W.5    Huisman, M.V.6
  • 117
    • 1642453779 scopus 로고    scopus 로고
    • Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance
    • Lau WC, Gurbel PA, Watkins PB, Neer CJ, Hopp AS, Carville DG, et al. Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance. Circulation. 2004;109:166-71.
    • (2004) Circulation , vol.109 , pp. 166-171
    • Lau, W.C.1    Gurbel, P.A.2    Watkins, P.B.3    Neer, C.J.4    Hopp, A.S.5    Carville, D.G.6
  • 118
    • 34249990913 scopus 로고    scopus 로고
    • Clopidogrel resistance?
    • Gurbel PA, Tantry US. Clopidogrel resistance? Thromb Res. 2007;120:311-21.
    • (2007) Thromb Res , vol.120 , pp. 311-321
    • Gurbel, P.A.1    Tantry, U.S.2
  • 119
    • 11144357878 scopus 로고    scopus 로고
    • Limited early antiplatelet effect of 300 mg clopidogrel in patients with aspirin therapy undergoing percutaneous coronary interventions
    • Lepantalo A, Virtanen KS, Heikkila J, Wartiovaara U, Lassila R. Limited early antiplatelet effect of 300 mg clopidogrel in patients with aspirin therapy undergoing percutaneous coronary interventions. Eur Heart J. 2004;25:476-83.
    • (2004) Eur Heart J , vol.25 , pp. 476-483
    • Lepantalo, A.1    Virtanen, K.S.2    Heikkila, J.3    Wartiovaara, U.4    Lassila, R.5
  • 120
    • 9644281092 scopus 로고    scopus 로고
    • Identification of low responders to a 300-mg clopidogrel loading dose in patients undergoing coronary stenting
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Ramirez C, Barrera-Ramirez C, Sabate M, et al. Identification of low responders to a 300-mg clopidogrel loading dose in patients undergoing coronary stenting. Thromb Res. 2005;115:101-8.
    • (2005) Thromb Res , vol.115 , pp. 101-108
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3    Ramirez, C.4    Barrera-Ramirez, C.5    Sabate, M.6
  • 121
    • 36348943475 scopus 로고    scopus 로고
    • Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel
    • Brandt JT, Close SL, Iturria SJ, Payne CD, Farid NA, Ernest CS 2nd, et al. Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel. J ThrombHaemost. 2007;5:2429-36.
    • (2007) J ThrombHaemost , vol.5 , pp. 2429-2436
    • Brandt, J.T.1    Close, S.L.2    Iturria, S.J.3    Payne, C.D.4    Farid, N.A.5    Ernest, I.I.C.S.6
  • 122
    • 33749339075 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    • Hulot JS, Bura A, Villard E, Azizi M, Remones V, Goyenvalle C, et al. Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects. Blood. 2006;108:2244-7.
    • (2006) Blood , vol.108 , pp. 2244-2247
    • Hulot, J.S.1    Bura, A.2    Villard, E.3    Azizi, M.4    Remones, V.5    Goyenvalle, C.6
  • 123
    • 79952048493 scopus 로고    scopus 로고
    • Ticagrelor: An investigational oral antiplatelet treatment for reduction of major adverse cardiac events in patients with acute coronary syndrome
    • Abergel E, Nikolsky E. Ticagrelor: an investigational oral antiplatelet treatment for reduction of major adverse cardiac events in patients with acute coronary syndrome. Vasc Health Risk Manag. 2010;6:963-77.
    • (2010) Vasc Health Risk Manag , vol.6 , pp. 963-977
    • Abergel, E.1    Nikolsky, E.2
  • 124
    • 33845451677 scopus 로고    scopus 로고
    • A comparison of prasugrel and clopidogrel loading doses on platelet function: Magnitude of platelet inhibition is related to active metabolite formation
    • Brandt JT, Payne CD, Wiviott SD, Weerakkody G, Farid NA, Small DS, et al. A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation. Am Heart J. 2007;153(66):e9-16.
    • (2007) Am Heart J , vol.153 , Issue.66
    • Brandt, J.T.1    Payne, C.D.2    Wiviott, S.D.3    Weerakkody, G.4    Farid, N.A.5    Small, D.S.6
  • 126
    • 33645105318 scopus 로고    scopus 로고
    • Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450
    • Rehmel JL, Eckstein JA, Farid NA, Heim JB, Kasper SC, Kurihara A, et al. Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450. Drug Metab Dispos. 2006;34:600-7.
    • (2006) Drug Metab Dispos , vol.34 , pp. 600-607
    • Rehmel, J.L.1    Eckstein, J.A.2    Farid, N.A.3    Heim, J.B.4    Kasper, S.C.5    Kurihara, A.6
  • 127
    • 0034068625 scopus 로고    scopus 로고
    • The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties
    • Sugidachi A, Asai F, Ogawa T, Inoue T, Koike H. The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. Br J Pharmacol. 2000;129:1439-46.
    • (2000) Br J Pharmacol , vol.129 , pp. 1439-1446
    • Sugidachi, A.1    Asai, F.2    Ogawa, T.3    Inoue, T.4    Koike, H.5
  • 128
    • 33646732608 scopus 로고    scopus 로고
    • Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease
    • Jernberg T, Payne CD, Winters KJ, Darstein C, Brandt JT, Jakubowski JA, et al. Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease. Eur Heart J. 2006;27:1166-73.
    • (2006) Eur Heart J , vol.27 , pp. 1166-1173
    • Jernberg, T.1    Payne, C.D.2    Winters, K.J.3    Darstein, C.4    Brandt, J.T.5    Jakubowski, J.A.6
  • 129
    • 80052214031 scopus 로고    scopus 로고
    • P2Y and EP3 antagonists promote the inhibitory effects of natural modulators of platelet aggregation that act via cAMP
    • Iyu D, Glenn JR, White AE, Fox SC, Dovlatova N, Heptinstall S. P2Y and EP3 antagonists promote the inhibitory effects of natural modulators of platelet aggregation that act via cAMP. Platelets. 2011;22:504-15.
    • (2011) Platelets , vol.22 , pp. 504-515
    • Iyu, D.1    Glenn, J.R.2    White, A.E.3    Fox, S.C.4    Dovlatova, N.5    Heptinstall, S.6
  • 130
    • 37349111065 scopus 로고    scopus 로고
    • Prasugrel compared with high loadingand maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: The Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial Infarction 44 trial
    • Wiviott SD, Trenk D, Frelinger AL, O'donoghue M, Neumann FJ, Michelson AD, et al. Prasugrel compared with high loadingand maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial Infarction 44 trial. Circulation. 2007;116:2923-32.
    • (2007) Circulation , vol.116 , pp. 2923-2932
    • Wiviott, S.D.1    Trenk, D.2    Frelinger, A.L.3    O'Donoghue, M.4    Neumann, F.J.5    Michelson, A.D.6
  • 132
    • 77954468084 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, tolerability and safety of single ascending doses of ticagrelor, a reversibly binding oral P2Y(12) receptor antagonist, in healthy subjects
    • Teng R, Butler K. Pharmacokinetics, pharmacodynamics, tolerability and safety of single ascending doses of ticagrelor, a reversibly binding oral P2Y(12) receptor antagonist, in healthy subjects. Eur J Clin Pharmacol. 2010;66:487-96.
    • (2010) Eur J Clin Pharmacol , vol.66 , pp. 487-496
    • Teng, R.1    Butler, K.2
  • 133
    • 34548841427 scopus 로고    scopus 로고
    • From ATP to AZD6140: The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis
    • Springthorpe B, Bailey A, Barton P, Birkinshaw TN, Bonnert RV, Brown RC, et al. From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis. Bioorg Med Chem Lett. 2007;17: 6013-8.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 6013-6018
    • Springthorpe, B.1    Bailey, A.2    Barton, P.3    Birkinshaw, T.N.4    Bonnert, R.V.5    Brown, R.C.6
  • 134
    • 69249213604 scopus 로고    scopus 로고
    • Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation
    • Van Giezen JJ, Nilsson L, Berntsson P, Wissing BM, Giordanetto F, Tomlinson W, et al. Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation. J Thromb Haemost. 2009;7: 1556-65.
    • (2009) J Thromb Haemost , Issue.7 , pp. 1556-1565
    • Van Giezen, J.J.1    Nilsson, L.2    Berntsson, P.3    Wissing, B.M.4    Giordanetto, F.5    Tomlinson, W.6
  • 136
    • 33646261670 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin
    • Husted S, Emanuelsson H, Heptinstall S, Sandset PM, Wickens M, Peters G. Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin. Eur Heart J. 2006;27:1038-47.
    • (2006) Eur Heart J , vol.27 , pp. 1038-1047
    • Husted, S.1    Emanuelsson, H.2    Heptinstall, S.3    Sandset, P.M.4    Wickens, M.5    Peters, G.6
  • 137
    • 35548933800 scopus 로고    scopus 로고
    • Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes
    • Storey RF, Husted S, Harrington RA, Heptinstall S, Wilcox RG, Peters G, et al. Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes. J Am Coll Cardiol. 2007;50:1852-6.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1852-1856
    • Storey, R.F.1    Husted, S.2    Harrington, R.A.3    Heptinstall, S.4    Wilcox, R.G.5    Peters, G.6
  • 138
    • 35548995394 scopus 로고    scopus 로고
    • Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome: Primary results of the DISPERSE-2 trial
    • Cannon CP, Husted S, Harrington RA, Scirica BM, Emanuelsson H, Peters G, et al. Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome: primary results of the DISPERSE-2 trial. J Am Coll Cardiol. 2007;50: 1844-51.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1844-1851
    • Cannon, C.P.1    Husted, S.2    Harrington, R.A.3    Scirica, B.M.4    Emanuelsson, H.5    Peters, G.6
  • 140
    • 80051550924 scopus 로고    scopus 로고
    • Ticagrelor compared with clopidogrel by geographic region in the Platelet Inhibition and Patient Outcomes (PLATO) trial
    • Mahaffey KW, Wojdyla DM, Carroll K, Becker RC, Storey RF, Angiolillo DJ, et al. Ticagrelor compared with clopidogrel by geographic region in the Platelet Inhibition and Patient Outcomes (PLATO) trial. Circulation. 2011;124:544-54.
    • (2011) Circulation , vol.124 , pp. 544-554
    • Mahaffey, K.W.1    Wojdyla, D.M.2    Carroll, K.3    Becker, R.C.4    Storey, R.F.5    Angiolillo, D.J.6
  • 141
    • 73949112820 scopus 로고    scopus 로고
    • Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: The ONSET/OFFSET study
    • Gurbel PA, Bliden KP, Butler K, Tantry US, Gesheff T, Wei C, et al. Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study. Circulation. 2009;120:2577-85.
    • (2009) Circulation , vol.120 , pp. 2577-2585
    • Gurbel, P.A.1    Bliden, K.P.2    Butler, K.3    Tantry, U.S.4    Gesheff, T.5    Wei, C.6
  • 142
    • 82255188048 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes intended for non-invasive management: Substudy from prospective randomised PLATelet inhibition and patient Outcomes (PLATO) trial
    • James SK, Roe MT, Cannon CP, Cornel JH, Horrow J, Husted S, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes intended for non-invasive management: substudy from prospective randomised PLATelet inhibition and patient Outcomes (PLATO) trial. BMJ. 2011;342:d3527.
    • (2011) BMJ , vol.342
    • James, S.K.1    Roe, M.T.2    Cannon, C.P.3    Cornel, J.H.4    Horrow, J.5    Husted, S.6
  • 143
    • 79951785678 scopus 로고    scopus 로고
    • First analysis of the relation between CYP2C19 genotype and pharmacodynamics in patients treated with ticagrelor versus clopidogrel: The ONSET/OFFSET and RESPOND genotype studies
    • Tantry US, Bliden KP, Wei C, Storey RF, Armstrong M, Butler K, et al. First analysis of the relation between CYP2C19 genotype and pharmacodynamics in patients treated with ticagrelor versus clopidogrel: the ONSET/OFFSET and RESPOND genotype studies. Circ Cardiovasc Genet. 2010;3:556-66.
    • (2010) Circ Cardiovasc Genet , vol.3 , pp. 556-566
    • Tantry, U.S.1    Bliden, K.P.2    Wei, C.3    Storey, R.F.4    Armstrong, M.5    Butler, K.6
  • 144
    • 77958100874 scopus 로고    scopus 로고
    • Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLATO trial
    • Wallentin L, James S, Storey RF, Armstrong M, Barratt BJ, Horrow J, et al. Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial. Lancet. 2010;376:1320-8.
    • (2010) Lancet , vol.376 , pp. 1320-1328
    • Wallentin, L.1    James, S.2    Storey, R.F.3    Armstrong, M.4    Barratt, B.J.5    Horrow, J.6
  • 145
    • 77950508416 scopus 로고    scopus 로고
    • Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: The RESPOND study
    • Gurbel PA, Bliden KP, Butler K, Antonino MJ, Wei C, Teng R, et al. Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study. Circulation. 2010;121:1188-99.
    • (2010) Circulation , vol.121 , pp. 1188-1199
    • Gurbel, P.A.1    Bliden, K.P.2    Butler, K.3    Antonino, M.J.4    Wei, C.5    Teng, R.6
  • 146
    • 33847050871 scopus 로고    scopus 로고
    • Dyspnoea after antiplatelet agents: The AZD6140 controversy
    • Serebruany VL, Stebbing J, Atar D. Dyspnoea after antiplatelet agents: the AZD6140 controversy. Int J Clin Pract. 2007;61: 529-33.
    • (2007) Int J Clin Pract , vol.61 , pp. 529-533
    • Serebruany, V.L.1    Stebbing, J.2    Atar, D.3
  • 147
    • 77955110385 scopus 로고    scopus 로고
    • Incidence of dyspnea and assessment of cardiac and pulmonary function in patients with stable coronary artery disease receiving ticagrelor, clopidogrel, or placebo in the ONSET/ OFFSET study
    • Storey RF, Bliden KP, Patil SB, Karunakaran A, Ecob R, Butler K, et al. Incidence of dyspnea and assessment of cardiac and pulmonary function in patients with stable coronary artery disease receiving ticagrelor, clopidogrel, or placebo in the ONSET/ OFFSET study. J Am Coll Cardiol. 2010;56:185-93.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 185-193
    • Storey, R.F.1    Bliden, K.P.2    Patil, S.B.3    Karunakaran, A.4    Ecob, R.5    Butler, K.6
  • 148
    • 78650174722 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: A Platelet Inhibition and Patient Outcomes (PLATO) trial subgroup analysis
    • Steg PG, James S, Harrington RA, Ardissino D, Becker RC, Cannon CP, et al. Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: A Platelet Inhibition and Patient Outcomes (PLATO) trial subgroup analysis. Circulation. 2010;122:2131-41.
    • (2010) Circulation , vol.122 , pp. 2131-2141
    • Steg, P.G.1    James, S.2    Harrington, R.A.3    Ardissino, D.4    Becker, R.C.5    Cannon, C.P.6
  • 149
    • 33344464928 scopus 로고    scopus 로고
    • Initial experience with an intravenous P2Y12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: Results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trial
    • Greenbaum AB, Grines CL, Bittl JA, Becker RC, Kereiakes DJ, Gilchrist IC, et al. Initial experience with an intravenous P2Y12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trial. Am Heart J. 2006;151(689):e1-10.
    • (2006) Am Heart J , vol.151 , Issue.689
    • Greenbaum, A.B.1    Grines, C.L.2    Bittl, J.A.3    Becker, R.C.4    Kereiakes, D.J.5    Gilchrist, I.C.6
  • 150
    • 0034954596 scopus 로고    scopus 로고
    • The P2Y12 receptor as a therapeutic target in cardiovascular disease
    • Storey RF. The P2Y12 receptor as a therapeutic target in cardiovascular disease. Platelets. 2001;12:197-209.
    • (2001) Platelets , vol.12 , pp. 197-209
    • Storey, R.F.1
  • 151
    • 67650230535 scopus 로고    scopus 로고
    • The P2Y12 antagonists, 2-methylthioadenosine 50-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels
    • Srinivasan S, Mir F, Huang JS, Khasawneh FT, Lam SC, Le Breton GC. The P2Y12 antagonists, 2-methylthioadenosine 50-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels. J Biol Chem. 2009;284:16108-17.
    • (2009) J Biol Chem , vol.284 , pp. 16108-16117
    • Srinivasan, S.1    Mir, F.2    Huang, J.S.3    Khasawneh, F.T.4    Lam, S.C.5    Le Breton, G.C.6
  • 152
    • 0036015034 scopus 로고    scopus 로고
    • Safety profile and tolerability of intravenous AR-C69931MX, a new antiplatelet drug, in unstable angina pectoris and non-Q-wave myocardial infarction
    • Jacobsson F, Swahn E, Wallentin L, Ellborg M. Safety profile and tolerability of intravenous AR-C69931MX, a new antiplatelet drug, in unstable angina pectoris and non-Q-wave myocardial infarction. Clin Ther. 2002;24:752-65.
    • (2002) Clin Ther , vol.24 , pp. 752-765
    • Jacobsson, F.1    Swahn, E.2    Wallentin, L.3    Ellborg, M.4
  • 153
    • 34548849756 scopus 로고    scopus 로고
    • Preliminary experience with intravenous P2Y12 platelet receptor inhibition as an adjunct to reduced-dose alteplase during acute myocardial infarction: Results of the Safety Tolerability and Effect on Patency in Acute Myocardial Infarction (STEP-AMI) angiographic trial
    • Greenbaum AB, Ohman EM, Gibson CM, Borzak S, Stebbins AL, Lu M, et al. Preliminary experience with intravenous P2Y12 platelet receptor inhibition as an adjunct to reduced-dose alteplase during acute myocardial infarction: results of the Safety, Tolerability and Effect on Patency in Acute Myocardial Infarction (STEP-AMI) angiographic trial. Am Heart J. 2007;154:702-9.
    • (2007) Am Heart J , vol.154 , pp. 702-709
    • Greenbaum, A.B.1    Ohman, E.M.2    Gibson, C.M.3    Borzak, S.4    Stebbins, A.L.5    Lu, M.6
  • 154
    • 38649113576 scopus 로고    scopus 로고
    • Transitioning patients from cangrelor to clopidogrel: Pharmacodynamic evidence of a competitive effect
    • Steinhubl SR, Oh JJ, Oestreich JH, Ferraris S, Charnigo R, Akers WS. Transitioning patients from cangrelor to clopidogrel: pharmacodynamic evidence of a competitive effect. Thromb Res. 2008;121:527-34.
    • (2008) Thromb Res , vol.121 , pp. 527-534
    • Steinhubl, S.R.1    Oh, J.J.2    Oestreich, J.H.3    Ferraris, S.4    Charnigo, R.5    Akers, W.S.6
  • 155
    • 45549095306 scopus 로고    scopus 로고
    • The reversible P2Y antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function
    • Dovlatova NL, Jakubowski JA, Sugidachi A, Heptinstall S. The reversible P2Y antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function. J Thromb Haemost. 2008;6:1153-9.
    • (2008) J Thromb Haemost , vol.6 , pp. 1153-1159
    • Dovlatova, N.L.1    Jakubowski, J.A.2    Sugidachi, A.3    Heptinstall, S.4
  • 158
    • 84856023997 scopus 로고    scopus 로고
    • Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery: A randomized controlled trial
    • Angiolillo DJ, Firstenberg MS, Price MJ, Tummala PE, Hutyra M, Welsby IJ, et al. Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery: a randomized controlled trial. JAMA. 2012;307:265-74.
    • (2012) JAMA , vol.307 , pp. 265-274
    • Angiolillo, D.J.1    Firstenberg, M.S.2    Price, M.J.3    Tummala, P.E.4    Hutyra, M.5    Welsby, I.J.6
  • 159
    • 47649131209 scopus 로고    scopus 로고
    • Initial intravenous experience with PRT060128 (PRT128), an orally available, direct-acting, and reversible P2Y12 inhibitor
    • P-T-292
    • Lieu H, Conley PB, Andre P, Leese PT, Romanko K, Phillips DR, et al. Initial intravenous experience with PRT060128 (PRT128), an orally available, direct-acting, and reversible P2Y12 inhibitor. J Thromb Haemost. 2007;5:P-T-292.
    • (2007) J Thromb Haemost , vol.5
    • Lieu, H.1    Conley, P.B.2    Andre, P.3    Leese, P.T.4    Romanko, K.5    Phillips, D.R.6
  • 160
    • 77954510334 scopus 로고    scopus 로고
    • Elinogrel: Pharmacological principles, preclinical and early phase clinical testing
    • Ueno M, Rao SV, Angiolillo DJ. Elinogrel: pharmacological principles, preclinical and early phase clinical testing. Future Cardiol. 2010;6:445-53.
    • (2010) Future Cardiol , vol.6 , pp. 445-453
    • Ueno, M.1    Rao, S.V.2    Angiolillo, D.J.3
  • 161
    • 70649090353 scopus 로고    scopus 로고
    • Safety and feasibility of adjunctive antiplatelet therapy with intravenous elinogrel
    • Berger JS, Roe MT, Gibson CM, Kilaru R, Green CL, Melton L, et al. Safety and feasibility of adjunctive antiplatelet therapy with intravenous elinogrel, a direct-acting and reversible P2Y12 ADP-receptor antagonist, before primary percutaneous intervention in patients with ST-elevation myocardial infarction: the Early Rapid ReversAl of platelet thromboSis with intravenous Elinogrel before PCI to optimize reperfusion in acute Myocardial Infarction (ERASE MI) pilot trial. Am Heart J. 2009; 158(998-1004):e1.
    • (2009) Am Heart J , vol.158 , Issue.998-1004
    • Berger, J.S.1    Roe, M.T.2    Gibson, C.M.3    Kilaru, R.4    Green, C.L.5    Melton, L.6
  • 162
    • 77955677366 scopus 로고    scopus 로고
    • Rationale and design of the randomized, doubleblind trial testing INtraveNous and Oral administration of elinogrel, a selective and reversible P2Y(12)-receptor inhibitor, versus clopidogrel to eVAluate Tolerability and Efficacy in nonurgent Percutaneous Coronary Interventions patients (INNOVATE-PCI)
    • Leonardi S, Rao SV, Harrington RA, Bhatt DL, Gibson CM, Roe MT, et al. Rationale and design of the randomized, doubleblind trial testing INtraveNous and Oral administration of elinogrel, a selective and reversible P2Y(12)-receptor inhibitor, versus clopidogrel to eVAluate Tolerability and Efficacy in nonurgent Percutaneous Coronary Interventions patients (INNOVATE-PCI). Am Heart J. 2010;160:65-72.
    • (2010) Am Heart J , vol.160 , pp. 65-72
    • Leonardi, S.1    Rao, S.V.2    Harrington, R.A.3    Bhatt, D.L.4    Gibson, C.M.5    Roe, M.T.6
  • 163
    • 73149118496 scopus 로고    scopus 로고
    • The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP2C19*2 genotype: First experience in patients
    • Gurbel PA, Bliden KP, Antonino MJ, Stephens G, Gretler DD, Jurek MM, et al. The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP2C19*2 genotype: first experience in patients. J Thromb Haemost. 2010;8:43-53.
    • (2010) J Thromb Haemost , vol.8 , pp. 43-53
    • Gurbel, P.A.1    Bliden, K.P.2    Antonino, M.J.3    Stephens, G.4    Gretler, D.D.5    Jurek, M.M.6
  • 164
    • 79959525976 scopus 로고    scopus 로고
    • Thienopyridines, but not elinogrel, result in offtarget effects at the vessel wall that contribute to bleeding
    • Andre P, Deguzman F, Haberstock-Debic H, Mills S, Pak Y, Inagaki M, et al. Thienopyridines, but not elinogrel, result in offtarget effects at the vessel wall that contribute to bleeding. J Pharmacol Exp Ther. 2011;338:22-30.
    • (2011) J Pharmacol Exp Ther , vol.338 , pp. 22-30
    • Andre, P.1    Deguzman, F.2    Haberstock-Debic, H.3    Mills, S.4    Pak, Y.5    Inagaki, M.6
  • 165
    • 80053138923 scopus 로고    scopus 로고
    • A clopidogrel-insensitive inducible pool of P2Y12 receptors contributes to thrombus formation: Inhibition by elinogrel, a direct-acting, reversible P2Y12 antagonist
    • Haberstock-Debic H, Andre P, Mills S, Phillips DR, Conley PB. A clopidogrel-insensitive inducible pool of P2Y12 receptors contributes to thrombus formation: inhibition by elinogrel, a direct-acting, reversible P2Y12 antagonist. J Pharmacol Exp Ther. 2011;339:54-61.
    • (2011) J Pharmacol Exp Ther , vol.339 , pp. 54-61
    • Haberstock-Debic, H.1    Andre, P.2    Mills, S.3    Phillips, D.R.4    Conley, P.B.5


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