The P2Y12 antagonists, 2-methylthioadenosine 5′-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels

Journal of Biological Chemistry

Volumn 284, Issue 24, 2009, Pages 16108-16117

  Srinivasan, Subhashini ^a   Mir, Fozia ^a   Huang, Jin Sheng ^a   Khasawneh, Fadi T ^a,b   Lam, Stephen C T ^a   Le Breton, Guy C ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOPIDOGREL; DATA CHARACTERIZING; G PROTEIN; G PROTEIN COUPLED RECEPTORS; MOLECULAR MECHANISM; MONOPHOSPHATE; NEW CLASS; PLATELET ACTIVATION; PLATELET AGGREGATION; RECEPTOR ACTIVATION; SIGNALING PATHWAYS;

BLOOD SUBSTITUTES; FETAL MONITORING; SIGNALING;

PLATELETS;

2 METHYLTHIOADENOSINE 5' MONOPHOSPHATE TRIETHYLAMMONIUM; ADENOSINE DIPHOSPHATE; ARC 69931MX; CANGRELOR; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; PURINERGIC P2Y12 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; THROMBOXANE A2 RECEPTOR; UNCLASSIFIED DRUG; 2 METHYLTHIOADENOSINE TRIPHOSPHATE; 2-METHYLTHIO-ATP; ADENOSINE A2A RECEPTOR; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; DRUG DERIVATIVE; GUANOSINE 5' O (2 THIODIPHOSPHATE); GUANOSINE 5'-O-(2-THIODIPHOSPHATE); GUANOSINE DIPHOSPHATE; IMMUNOGLOBULIN RECEPTOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; NUCLEOTIDE; PROSTAGLANDIN D2 RECEPTOR; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN RECEPTOR; PTGER2 PROTEIN, HUMAN; PTGIR PROTEIN, HUMAN; PURINERGIC P2 RECEPTOR;

ARTICLE; CELL LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; METABOLISM; THROMBOCYTE;

ADENOSINE DIPHOSPHATE; ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; BLOOD PLATELETS; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE DIPHOSPHATE; HUMANS; PLATELET AGGREGATION; RECEPTOR, ADENOSINE A2A; RECEPTOR, PAR-1; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; RECEPTORS, PROSTAGLANDIN E; RECEPTORS, PURINERGIC P2; RECEPTORS, THROMBOXANE A2, PROSTAGLANDIN H2; SIGNAL TRANSDUCTION; THIONUCLEOTIDES;

EID: 67650230535     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809780200     Document Type: Article

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