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Volumn 11, Issue 23, 2012, Pages 4344-4351

Developmental pathways in colon cancer: Crosstalk between WNT, BMP, Hedgehog and Notch

Author keywords

BMP; Cancer; Colon; Hedgehog; Notch; Stem cell; Target therapy; Tumor; WNT

Indexed keywords

CYCLOPAMINE; IRINOTECAN; NOTCH RECEPTOR; PF 3084014; RESVERATROL; SONIC HEDGEHOG PROTEIN; WNT PROTEIN;

EID: 84870940346     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.22134     Document Type: Review
Times cited : (144)

References (126)
  • 1
    • 84861429843 scopus 로고    scopus 로고
    • Pathways involved in Drosophila and human cancer development: The Notch, Hedgehog, Wingless, Runt, and Trithorax pathway
    • PMID:22418742
    • Geissler K, Zach O. Pathways involved in Drosophila and human cancer development: the Notch, Hedgehog, Wingless, Runt, and Trithorax pathway. Ann Hematol 2012; 91:645-69; PMID:22418742; http://dx.doi.org/10.1007/s00277-012- 1435-0.
    • (2012) Ann Hematol , vol.91 , pp. 645-669
    • Geissler, K.1    Zach, O.2
  • 2
    • 0030658039 scopus 로고    scopus 로고
    • Oncogenic transcription factors in the human acute leukemias
    • PMID:9353180
    • Look AT. Oncogenic transcription factors in the human acute leukemias. Science 1997; 278:1059-64; PMID:9353180; http://dx.doi.org/10.1126/science.278. 5340.1059.
    • (1997) Science , vol.278 , pp. 1059-1064
    • Look, A.T.1
  • 3
    • 84870890226 scopus 로고    scopus 로고
    • American Cancer Society, Colorectal Cancer Facts & Figures 2011-2013; http://www.cancer.org/Research/ CancerFactsFigures/ ColorectalCancerFactsFigures/ colorectal-cancer-facts-figures-2011-2013-page.
    • Colorectal Cancer Facts & Figures 2011-2013
  • 5
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • PMID:21685461
    • Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011; 61:212-36; PMID:21685461; http://dx.doi.org/10.3322/ caac.20121.
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 7
    • 77953696850 scopus 로고    scopus 로고
    • Controversies in cancer stem cells: Targeting embryonic signaling pathways
    • PMID:20530695
    • Takebe N, Ivy SP. Controversies in cancer stem cells: targeting embryonic signaling pathways. Clin Cancer Res 2010; 16:3106-12; PMID:20530695; http://dx.doi.org/10.1158/1078-0432.CCR-09-2934.
    • (2010) Clin Cancer Res , vol.16 , pp. 3106-3112
    • Takebe, N.1    Ivy, S.P.2
  • 8
    • 79551600015 scopus 로고    scopus 로고
    • Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
    • PMID:21151206
    • Takebe N, Harris PJ, Warren RQ, Ivy SP. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol 2011; 8:97-106; PMID:21151206; http://dx.doi.org/10.1038/nrclinonc.2010.196.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 97-106
    • Takebe, N.1    Harris, P.J.2    Warren, R.Q.3    Ivy, S.P.4
  • 9
    • 27844485675 scopus 로고    scopus 로고
    • Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease
    • PMID:16214417
    • van Es JH, Clevers H. Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease. Trends Mol Med 2005; 11:496-502; PMID:16214417; http://dx.doi.org/10.1016/j.molmed.2005.09.008.
    • (2005) Trends Mol Med , vol.11 , pp. 496-502
    • Van Es, J.H.1    Clevers, H.2
  • 10
    • 77957279353 scopus 로고    scopus 로고
    • Recently identified and potential targets for colon cancer treatment
    • PMID:20528236
    • Lea MA. Recently identified and potential targets for colon cancer treatment. Future Oncol 2010; 6:993-1002; PMID:20528236; http://dx.doi.org/10. 2217/fon.10.53.
    • (2010) Future Oncol , vol.6 , pp. 993-1002
    • Lea, M.A.1
  • 11
    • 79959238013 scopus 로고    scopus 로고
    • Microenvironmental regulation of stem cells in intestinal homeostasis and cancer
    • PMID:21677748
    • Medema JP, Vermeulen L. Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. Nature 2011; 474:318-26; PMID:21677748; http:// dx.doi.org/10.1038/nature10212.
    • (2011) Nature , vol.474 , pp. 318-326
    • Medema, J.P.1    Vermeulen, L.2
  • 13
    • 80455173856 scopus 로고    scopus 로고
    • Wnt signaling and colon tumorigenesis - A view from the periphery
    • PMID:21884696
    • Burgess AW, Faux MC, Layton MJ, Ramsay RG. Wnt signaling and colon tumorigenesis - a view from the periphery. Exp Cell Res 2011; 317:2748-58; PMID:21884696; http://dx.doi.org/10.1016/j.yexcr.2011.08.010.
    • (2011) Exp Cell Res , vol.317 , pp. 2748-2758
    • Burgess, A.W.1    Faux, M.C.2    Layton, M.J.3    Ramsay, R.G.4
  • 14
    • 52549113913 scopus 로고    scopus 로고
    • Bone morphogenetic protein signalling in colorectal cancer
    • PMID:18756288
    • Hardwick JC, Kodach LL, Offerhaus GJ, van den Brink GR. Bone morphogenetic protein signalling in colorectal cancer. Nat Rev Cancer 2008; 8:806-12; PMID:18756288; http://dx.doi.org/10.1038/nrc2467.
    • (2008) Nat Rev Cancer , vol.8 , pp. 806-812
    • Hardwick, J.C.1    Kodach, L.L.2    Offerhaus, G.J.3    Van Den Brink, G.R.4
  • 15
    • 34848868159 scopus 로고    scopus 로고
    • Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors
    • PMID:17881565
    • Kosinski C, Li VSW, Chan ASY, Zhang J, Ho C, Tsui WY, et al. Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. Proc Natl Acad Sci USA 2007; 104:15418-23; PMID:17881565; http://dx.doi.org/10.1073/pnas.0707210104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15418-15423
    • Kosinski, C.1    Li, V.S.W.2    Chan, A.S.Y.3    Zhang, J.4    Ho, C.5    Tsui, W.Y.6
  • 16
    • 84882902414 scopus 로고    scopus 로고
    • Colon cancer stem cells - From basic to clinical application
    • epub ahead of print PMID:22537805
    • Botchkina G. Colon cancer stem cells - From basic to clinical application. [epub ahead of print]. Cancer Lett 2012; PMID:22537805; http://dx.doi.org/10.1016/j.canlet.2012.04.006.
    • (2012) Cancer Lett
    • Botchkina, G.1
  • 17
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • PMID:17934449
    • Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007; 449:1003-7; PMID:17934449; http://dx.doi.org/10.1038/ nature06196.
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1    Van Es, J.H.2    Kuipers, J.3    Kujala, P.4    Van Den Born, M.5    Cozijnsen, M.6
  • 18
    • 79957467315 scopus 로고    scopus 로고
    • Molecular identification and targeting of colorectal cancer stem cells
    • PMID:21311095
    • Kemper K, Grandela C, Medema JP. Molecular identification and targeting of colorectal cancer stem cells. Oncotarget 2010; 1:387-95; PMID:21311095.
    • (2010) Oncotarget , vol.1 , pp. 387-395
    • Kemper, K.1    Grandela, C.2    Medema, J.P.3
  • 19
    • 79751489596 scopus 로고    scopus 로고
    • Molecular genetics of colorectal cancer
    • PMID:21090969
    • Fearon ER. Molecular genetics of colorectal cancer. Annu Rev Pathol 2011; 6:479-507; PMID:21090969; http://dx.doi.org/10.1146/annurev-pathol-11110- 130235.
    • (2011) Annu Rev Pathol , vol.6 , pp. 479-507
    • Fearon, E.R.1
  • 20
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • PMID:2188735
    • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61:759-67; PMID:2188735; http://dx.doi.org/10.1016/0092-8674(90) 90186-I.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 21
    • 0001201784 scopus 로고
    • Mutation and human cancer
    • Knudson AG. Mutation and human cancer. Adv Cancer Res 1973; 17:317-52; http://dx.doi.org/10.1016/S0065-230X(08)60534-5.
    • (1973) Adv Cancer Res , vol.17 , pp. 317-352
    • Knudson, A.G.1
  • 22
    • 0035522894 scopus 로고    scopus 로고
    • Two genetic hits (more or less) to cancer
    • PMID:11905807
    • Knudson AG. Two genetic hits (more or less) to cancer. Nat Rev Cancer 2001; 1:157-62; PMID:11905807; http://dx.doi.org/10.1038/35101031.
    • (2001) Nat Rev Cancer , vol.1 , pp. 157-162
    • Knudson, A.G.1
  • 23
    • 77953562049 scopus 로고    scopus 로고
    • Chromosome missegregation causes colon cancer by APC loss of heterozygosity
    • PMID:20404532
    • Baker DJ, van Deursen JM. Chromosome missegregation causes colon cancer by APC loss of heterozygosity. Cell Cycle 2010; 9:1711-6; PMID:20404532; http://dx.doi.org/10.4161/cc.9.9.11314.
    • (2010) Cell Cycle , vol.9 , pp. 1711-1716
    • Baker, D.J.1    Van Deursen, J.M.2
  • 24
    • 10944225680 scopus 로고    scopus 로고
    • Linear model of colon cancer initiation
    • PMID:14726709
    • Michor F, Iwasa Y, Rajagopalan H, Lengauer C, Nowak MA. Linear model of colon cancer initiation. Cell Cycle 2004; 3:358-62; PMID:14726709; http://dx.doi.org/10.4161/cc.3.3.690.
    • (2004) Cell Cycle , vol.3 , pp. 358-362
    • Michor, F.1    Iwasa, Y.2    Rajagopalan, H.3    Lengauer, C.4    Nowak, M.A.5
  • 25
    • 84860323891 scopus 로고    scopus 로고
    • The many ways to open the gate to colon cancer
    • PMID:22421162
    • Amos-Landgraf JM, Clipson L, Newton MA, Dove WF. The many ways to open the gate to colon cancer. Cell Cycle 2012; 11:1261-2; PMID:22421162; http://dx.doi.org/10.4161/cc.19888.
    • (2012) Cell Cycle , vol.11 , pp. 1261-1262
    • Amos-Landgraf, J.M.1    Clipson, L.2    Newton, M.A.3    Dove, W.F.4
  • 26
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling and disease
    • PMID:22682243
    • Clevers H, Nusse R. Wnt/β-catenin signaling and disease. Cell 2012; 149:1192-205; PMID:22682243; http://dx.doi.org/10.1016/j.cell.2012.05.012.
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 27
    • 4644266015 scopus 로고    scopus 로고
    • Wnts as essential growth factors for the adult small intestine and colon
    • PMID:15044853
    • Hoffman J, Kuhnert F, Davis CR, Kuo CJ. Wnts as essential growth factors for the adult small intestine and colon. Cell Cycle 2004; 3:554-7; PMID:15044853; http://dx.doi.org/10.4161/cc.3.5.858.
    • (2004) Cell Cycle , vol.3 , pp. 554-557
    • Hoffman, J.1    Kuhnert, F.2    Davis, C.R.3    Kuo, C.J.4
  • 28
    • 84862207240 scopus 로고    scopus 로고
    • Three decades of Wnts: A personal perspective on how a scientific field developed
    • PMID:22617420
    • Nusse R, Varmus H. Three decades of Wnts: a personal perspective on how a scientific field developed. EMBO J 2012; 31:2670-84; PMID:22617420; http://dx.doi.org/10.1038/emboj.2012.146.
    • (2012) EMBO J , vol.31 , pp. 2670-2684
    • Nusse, R.1    Varmus, H.2
  • 29
    • 80054975678 scopus 로고    scopus 로고
    • Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation
    • PMID:21793042
    • Lin GL, Hankenson KD. Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation. J Cell Biochem 2011; 112:3491-501; PMID:21793042; http://dx.doi.org/10.1002/jcb.23287.
    • (2011) J Cell Biochem , vol.112 , pp. 3491-3501
    • Lin, G.L.1    Hankenson, K.D.2
  • 30
    • 24644499046 scopus 로고    scopus 로고
    • Wnt and calcium signaling: Beta-catenin-independent pathways
    • PMID:16099039
    • Kohn AD, Moon RT. Wnt and calcium signaling: beta-catenin-independent pathways. Cell Calcium 2005; 38:439-46; PMID:16099039; http://dx.doi.org/10. 1016/j.ceca.2005.06.022.
    • (2005) Cell Calcium , vol.38 , pp. 439-446
    • Kohn, A.D.1    Moon, R.T.2
  • 31
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-MYC as a target of the APC pathway
    • PMID:9727977
    • He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, et al. Identification of c-MYC as a target of the APC pathway. Science 1998; 281:1509-12; PMID:9727977; http://dx.doi.org/10.1126/science.281.5382.1509.
    • (1998) Science , vol.281 , pp. 1509-1512
    • He, T.C.1    Sparks, A.B.2    Rago, C.3    Hermeking, H.4    Zawel, L.5    Da Costa, L.T.6
  • 32
    • 0033578918 scopus 로고    scopus 로고
    • Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1
    • PMID:10489374
    • Roose J, Huls G, van Beest M, Moerer P, van der Horn K, Goldschmeding R, et al. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science 1999; 285:1923-6; PMID:10489374; http://dx.doi.org/10.1126/ science.285.5435.1923.
    • (1999) Science , vol.285 , pp. 1923-1926
    • Roose, J.1    Huls, G.2    Van Beest, M.3    Moerer, P.4    Van Der Horn, K.5    Goldschmeding, R.6
  • 33
    • 0035033521 scopus 로고    scopus 로고
    • Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer
    • PMID:11326276
    • Hovanes K, Li TW, Munguia JE, Truong T, Milovanovic T, Lawrence Marsh J, et al. Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. Nat Genet 2001; 28:53-7; PMID:11326276; http://dx.doi.org/10.1038/ng0501-53.
    • (2001) Nat Genet , vol.28 , pp. 53-57
    • Hovanes, K.1    Li, T.W.2    Munguia, J.E.3    Truong, T.4    Milovanovic, T.5    Lawrence Marsh, J.6
  • 34
    • 0037031887 scopus 로고    scopus 로고
    • WNT3A/Beta-catenin signaling induces transcription from the LEF-1 promoter
    • Mj F, Cheng N, Abott D, Leonticu V, Engelhardt JF. WNT3A/Beta-catenin signaling induces transcription from the LEF-1 promoter. J Biol Chem 2002; 227:33398-410.
    • (2002) J Biol Chem , vol.227 , pp. 33398-33410
    • Mj, F.1    Cheng, N.2    Abott, D.3    Leonticu, V.4    Engelhardt, J.F.5
  • 35
    • 13044281685 scopus 로고    scopus 로고
    • Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas
    • PMID:9990071
    • Mann B, Gelos M, Siedow A, Hanski ML, Gratchev A, Ilyas M, et al. Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci USA 1999; 96:1603-8; PMID:9990071; http://dx.doi.org/10.1073/pnas.96.4.1603.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1603-1608
    • Mann, B.1    Gelos, M.2    Siedow, A.3    Hanski, M.L.4    Gratchev, A.5    Ilyas, M.6
  • 36
    • 0032884884 scopus 로고    scopus 로고
    • betacatenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
    • PMID:10514384
    • Brabletz T, Jung A, Dag S, Hlubek F, Kirchner T. betacatenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol 1999; 155:1033-8; PMID:10514384; http://dx.doi.org/10.1016/S0002- 9440(10)65204-2.
    • (1999) Am J Pathol , vol.155 , pp. 1033-1038
    • Brabletz, T.1    Jung, A.2    Dag, S.3    Hlubek, F.4    Kirchner, T.5
  • 37
    • 0033529126 scopus 로고    scopus 로고
    • The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors
    • PMID:10362259
    • Crawford HC, Fingleton BM, Rudolph-Owen LA, Goss KJ, Rubinfeld B, Polakis P, et al. The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors. Oncogene 1999; 18:2883-91; PMID:10362259; http://dx.doi.org/10.1038/sj.onc.1202627.
    • (1999) Oncogene , vol.18 , pp. 2883-2891
    • Crawford, H.C.1    Fingleton, B.M.2    Rudolph-Owen, L.A.3    Goss, K.J.4    Rubinfeld, B.5    Polakis, P.6
  • 38
    • 0032912720 scopus 로고    scopus 로고
    • Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway
    • PMID:10027409
    • Wielenga VJ, Smits R, Korinek V, Smit L, Kielman M, Fodde R, et al. Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am J Pathol 1999; 154:515-23; PMID:10027409; http://dx.doi.org/10.1016/ S0002-9440(10)65297-2.
    • (1999) Am J Pathol , vol.154 , pp. 515-523
    • Wielenga, V.J.1    Smits, R.2    Korinek, V.3    Smit, L.4    Kielman, M.5    Fodde, R.6
  • 39
    • 0035882030 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia
    • PMID:11507052
    • Zhang X, Gaspard JP, Chung DC. Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia. Cancer Res 2001; 61:6050-4; PMID:11507052.
    • (2001) Cancer Res , vol.61 , pp. 6050-6054
    • Zhang, X.1    Gaspard, J.P.2    Chung, D.C.3
  • 41
    • 0037093072 scopus 로고    scopus 로고
    • Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells
    • PMID:12019147
    • Kim JS, Crooks H, Dracheva T, Nishanian TG, Singh B, Jen J, et al. Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells. Cancer Res 2002; 62:2744-8; PMID:12019147.
    • (2002) Cancer Res , vol.62 , pp. 2744-2748
    • Kim, J.S.1    Crooks, H.2    Dracheva, T.3    Nishanian, T.G.4    Singh, B.5    Jen, J.6
  • 42
    • 0036149985 scopus 로고    scopus 로고
    • Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors
    • PMID:11809809
    • Lustig B, Jerchow B, Sachs M, Weiler S, Pietsch T, Karsten U, et al. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol 2002; 22:1184-93; PMID:11809809; http://dx.doi.org/10.1128/MCB.22.4.1184-1193.2002.
    • (2002) Mol Cell Biol , vol.22 , pp. 1184-1193
    • Lustig, B.1    Jerchow, B.2    Sachs, M.3    Weiler, S.4    Pietsch, T.5    Karsten, U.6
  • 43
    • 0034644526 scopus 로고    scopus 로고
    • Linking colorectal cancer to Wnt signaling
    • PMID:11057903
    • Bienz M, Clevers H. Linking colorectal cancer to Wnt signaling. Cell 2000; 103:311-20; PMID:11057903; http://dx.doi.org/10.1016/S0092-8674(00)00122- 7.
    • (2000) Cell , vol.103 , pp. 311-320
    • Bienz, M.1    Clevers, H.2
  • 44
    • 0030949463 scopus 로고    scopus 로고
    • Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
    • PMID:9065402
    • Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, et al. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 1997; 275:1787-90; PMID:9065402; http://dx.doi.org/10.1126/science.275.5307.1787.
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6
  • 45
    • 1642430935 scopus 로고    scopus 로고
    • Wnt breakers in colon cancer
    • PMID:14749120
    • Clevers H. Wnt breakers in colon cancer. Cancer Cell 2004; 5:5-6; PMID:14749120; http://dx.doi.org/10.1016/S1535-6108(03)00339-8.
    • (2004) Cancer Cell , vol.5 , pp. 5-6
    • Clevers, H.1
  • 46
    • 1642512639 scopus 로고    scopus 로고
    • Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex
    • PMID:14749129
    • Lepourcelet M, Chen Y-NP, France DS, Wang H, Crews P, Petersen F, et al. Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell 2004; 5:91-102; PMID:14749129; http://dx.doi.org/10.1016/S1535- 6108(03)00334-9.
    • (2004) Cancer Cell , vol.5 , pp. 91-102
    • Lepourcelet, M.1    Chen, Y.-N.P.2    France, D.S.3    Wang, H.4    Crews, P.5    Petersen, F.6
  • 47
    • 79957989939 scopus 로고    scopus 로고
    • Drug discovery approaches to target Wnt signaling in cancer stem cells
    • PMID:21317452
    • Curtin JC, Lorenzi MV. Drug discovery approaches to target Wnt signaling in cancer stem cells. Oncotarget 2010; 1:563-77; PMID:21317452.
    • (2010) Oncotarget , vol.1 , pp. 563-577
    • Curtin, J.C.1    Lorenzi, M.V.2
  • 48
    • 79958099432 scopus 로고    scopus 로고
    • Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer
    • PMID:21188121
    • Nguyen AV, Martinez M, Stamos MJ, Moyer MP, Planutis K, Hope C, et al. Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res 2009; 1:25-37; PMID:21188121.
    • (2009) Cancer Manag Res , vol.1 , pp. 25-37
    • Nguyen, A.V.1    Martinez, M.2    Stamos, M.J.3    Moyer, M.P.4    Planutis, K.5    Hope, C.6
  • 49
    • 78049510453 scopus 로고    scopus 로고
    • Taming the beast within: Resveratrol suppresses colitis and prevents colon cancer
    • Hofseth LJ. singh UP, Singh NP, Nagarkatti M, Nagarkatti PS. Taming the beast within: resveratrol suppresses colitis and prevents colon cancer. Aging 2012; 2L:183-4.
    • (2012) Aging , vol.2 L , pp. 183-184
    • Hofseth, L.J.1    Singh, U.P.2    Singh, N.P.3    Nagarkatti, M.4    Nagarkatti, P.S.5
  • 50
    • 0035252741 scopus 로고    scopus 로고
    • The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling
    • PMID:11313997
    • Dihlmann S, Siermann A, von Knebel Doeberitz M. The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. Oncogene 2001; 20:645-53; PMID:11313997; http://dx.doi.org/10.1038/ sj.onc.1204123.
    • (2001) Oncogene , vol.20 , pp. 645-653
    • Dihlmann, S.1    Siermann, A.2    Von Knebel Doeberitz, M.3
  • 51
    • 17744418769 scopus 로고    scopus 로고
    • The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
    • PMID:10874062
    • Steinbach G, Lynch PM, Phillips RK, Wallace MH, Hawk E, Gordon GB, et al. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med 2000; 342:1946-52; PMID:10874062; http://dx.doi.org/10. 1056/NEJM200006293422603.
    • (2000) N Engl J Med , vol.342 , pp. 1946-1952
    • Steinbach, G.1    Lynch, P.M.2    Phillips, R.K.3    Wallace, M.H.4    Hawk, E.5    Gordon, G.B.6
  • 52
    • 51649126752 scopus 로고    scopus 로고
    • Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice
    • PMID:18768809
    • Fujishita T, Aoki K, Lane HA, Aoki M, Taketo MM. Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. Proc Natl Acad Sci USA 2008; 105:13544-9; PMID:18768809; http://dx.doi.org/10.1073/pnas.0800041105.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 13544-13549
    • Fujishita, T.1    Aoki, K.2    Lane, H.A.3    Aoki, M.4    Taketo, M.M.5
  • 53
    • 79957993618 scopus 로고    scopus 로고
    • The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and noncanonical Wnt signaling
    • PMID:21317455
    • Sikandar S, Dizon D, Shen X, Li Z, Besterman J, Lipkin SM. The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and noncanonical Wnt signaling. Oncotarget 2010; 1:596-605; PMID:21317455.
    • (2010) Oncotarget , vol.1 , pp. 596-605
    • Sikandar, S.1    Dizon, D.2    Shen, X.3    Li, Z.4    Besterman, J.5    Lipkin, S.M.6
  • 54
    • 0034671686 scopus 로고    scopus 로고
    • Notch signaling: From the outside in
    • PMID:11112321
    • Mumm JS, Kopan R. Notch signaling: from the outside in. Dev Biol 2000; 228:151-65; PMID:11112321; http://dx.doi.org/10.1006/dbio.2000.9960.
    • (2000) Dev Biol , vol.228 , pp. 151-165
    • Mumm, J.S.1    Kopan, R.2
  • 55
    • 80051531363 scopus 로고    scopus 로고
    • Notch signaling: Simplicity in design, versatility in function
    • PMID:21828089
    • Andersson ER, Sandberg R, Lendahl U. Notch signaling: simplicity in design, versatility in function. Development 2011; 138:3593-612; PMID:21828089; http://dx.doi.org/10.1242/dev.063610.
    • (2011) Development , vol.138 , pp. 3593-3612
    • Andersson, E.R.1    Sandberg, R.2    Lendahl, U.3
  • 56
    • 50849125368 scopus 로고    scopus 로고
    • More complicated than it looks: Assembly of Notch pathway transcription complexes
    • PMID:18758478
    • Kovall RA. More complicated than it looks: assembly of Notch pathway transcription complexes. Oncogene 2008; 27:5099-109; PMID:18758478; http://dx.doi.org/10.1038/onc.2008.223.
    • (2008) Oncogene , vol.27 , pp. 5099-5109
    • Kovall, R.A.1
  • 57
    • 0036747296 scopus 로고    scopus 로고
    • Keeping a good pathway down: Transcriptional repression of Notch pathway target genes by CSL proteins
    • PMID:12223465
    • Lai EC. Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins. EMBO Rep 2002; 3:840-5; PMID:12223465; http://dx.doi.org/10.1093/embo-reports/kvf170.
    • (2002) EMBO Rep , vol.3 , pp. 840-845
    • Lai, E.C.1
  • 58
    • 50849100996 scopus 로고    scopus 로고
    • The many facets of Notch ligands
    • PMID:18758484
    • D'Souza B, Miyamoto A, Weinmaster G. The many facets of Notch ligands. Oncogene 2008; 27:5148-67; PMID:18758484; http://dx.doi.org/10.1038/onc.2008. 229.
    • (2008) Oncogene , vol.27 , pp. 5148-5167
    • D'Souza, B.1    Miyamoto, A.2    Weinmaster, G.3
  • 59
    • 0141995063 scopus 로고    scopus 로고
    • Glycosylation regulates Notch signalling
    • PMID:14570055
    • Haines N, Irvine KD. Glycosylation regulates Notch signalling. Nat Rev Mol Cell Biol 2003; 4:786-97; PMID:14570055.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 786-797
    • Haines, N.1    Irvine, K.D.2
  • 60
    • 35549010538 scopus 로고    scopus 로고
    • Regulation of Notch signaling by glycosylation
    • PMID:17964136
    • Stanley P. Regulation of Notch signaling by glycosylation. Curr Opin Struct Biol 2007; 17:530-5; PMID:17964136; http://dx.doi.org/10.1016/j.sbi.2007. 09.007.
    • (2007) Curr Opin Struct Biol , vol.17 , pp. 530-535
    • Stanley, P.1
  • 61
    • 0025856717 scopus 로고
    • TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
    • PMID:1831692
    • Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991; 66:649-61; PMID:1831692; http://dx.doi. org/10.1016/0092-8674(91)90111-B.
    • (1991) Cell , vol.66 , pp. 649-661
    • Ellisen, L.W.1    Bird, J.2    West, D.C.3    Soreng, A.L.4    Reynolds, T.C.5    Smith, S.D.6
  • 62
    • 0029942842 scopus 로고    scopus 로고
    • Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
    • PMID:8642337
    • Pear WS, Aster JC, Scott ML, Hasserjian RP, Soffer B, Sklar J, et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med 1996; 183:2283-91; PMID:8642337; http://dx.doi.org/10.1084/jem.183.5.2283.
    • (1996) J Exp Med , vol.183 , pp. 2283-2291
    • Pear, W.S.1    Aster, J.C.2    Scott, M.L.3    Hasserjian, R.P.4    Soffer, B.5    Sklar, J.6
  • 64
    • 79955915582 scopus 로고    scopus 로고
    • A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
    • PMID:21562564
    • Klinakis A, Lobry C, Abdel-Wahab O, Oh P, Haeno H, Buonamici S, et al. A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature 2011; 473:230-3; PMID:21562564; http://dx.doi.org/10.1038/nature09999.
    • (2011) Nature , vol.473 , pp. 230-233
    • Klinakis, A.1    Lobry, C.2    Abdel-Wahab, O.3    Oh, P.4    Haeno, H.5    Buonamici, S.6
  • 65
    • 28444485327 scopus 로고    scopus 로고
    • Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies
    • PMID:16118316
    • Zweidler-McKay PA, He Y, Xu L, Rodriguez CG, Karnell FG, Carpenter AC, et al. Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies. Blood 2005; 106:3898-906; PMID:16118316; http://dx.doi.org/10.1182/blood-2005-01-0355.
    • (2005) Blood , vol.106 , pp. 3898-3906
    • Zweidler-McKay, P.A.1    He, Y.2    Xu, L.3    Rodriguez, C.G.4    Karnell, F.G.5    Carpenter, A.C.6
  • 66
    • 79955460636 scopus 로고    scopus 로고
    • Notch signalling in solid tumours: A little bit of everything but not all the time
    • PMID:21508972
    • Ranganathan P, Weaver KL, Capobianco AJ. Notch signalling in solid tumours: a little bit of everything but not all the time. Nat Rev Cancer 2011; 11:338-51; PMID:21508972; http://dx.doi.org/10.1038/nrc3035.
    • (2011) Nat Rev Cancer , vol.11 , pp. 338-351
    • Ranganathan, P.1    Weaver, K.L.2    Capobianco, A.J.3
  • 67
    • 80052494506 scopus 로고    scopus 로고
    • Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence
    • PMID:21847123
    • Pandya K, Meeke K, Clementz AG, Rogowski A, Roberts J, Miele L, et al. Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence. Br J Cancer 2011; 105:796-806; PMID:21847123; http://dx.doi.org/10.1038/bjc.2011.321.
    • (2011) Br J Cancer , vol.105 , pp. 796-806
    • Pandya, K.1    Meeke, K.2    Clementz, A.G.3    Rogowski, A.4    Roberts, J.5    Miele, L.6
  • 68
    • 74449091897 scopus 로고    scopus 로고
    • Notch-1 activates estrogen receptor-alphadependent transcription via IKKalpha in breast cancer cells
    • PMID:19838210
    • Hao L, Rizzo P, Osipo C, Pannuti A, Wyatt D, Cheung LW, et al. Notch-1 activates estrogen receptor-alphadependent transcription via IKKalpha in breast cancer cells. Oncogene 2010; 29:201-13; PMID:19838210; http://dx.doi.org/10. 1038/onc.2009.323.
    • (2010) Oncogene , vol.29 , pp. 201-213
    • Hao, L.1    Rizzo, P.2    Osipo, C.3    Pannuti, A.4    Wyatt, D.5    Cheung, L.W.6
  • 69
    • 80052158097 scopus 로고    scopus 로고
    • The mutational landscape of head and neck squamous cell carcinoma
    • PMID:21798893
    • Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, et al. The mutational landscape of head and neck squamous cell carcinoma. Science 2011; 333:1157-60; PMID:21798893; http://dx.doi.org/10.1126/science.1208130.
    • (2011) Science , vol.333 , pp. 1157-1160
    • Stransky, N.1    Egloff, A.M.2    Tward, A.D.3    Kostic, A.D.4    Cibulskis, K.5    Sivachenko, A.6
  • 70
    • 80052177544 scopus 로고    scopus 로고
    • Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
    • PMID:21798897
    • Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 2011; 333:1154-7; PMID:21798897; http://dx.doi.org/10.1126/science.1206923.
    • (2011) Science , vol.333 , pp. 1154-1157
    • Agrawal, N.1    Frederick, M.J.2    Pickering, C.R.3    Bettegowda, C.4    Chang, K.5    Li, R.J.6
  • 71
    • 80055092549 scopus 로고    scopus 로고
    • Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma
    • PMID:22006338
    • Wang NJ, Sanborn Z, Arnett KL, Bayston LJ, Liao W, Proby CM, et al. Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci USA 2011; 108:17761-6; PMID:22006338; http://dx.doi.org/10.1073/pnas.1114669108.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 17761-17766
    • Wang, N.J.1    Sanborn, Z.2    Arnett, K.L.3    Bayston, L.J.4    Liao, W.5    Proby, C.M.6
  • 72
    • 0037370310 scopus 로고    scopus 로고
    • Notch1 functions as a tumor suppressor in mouse skin
    • PMID:12590261
    • Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, van Noort M, et al. Notch1 functions as a tumor suppressor in mouse skin. Nat Genet 2003; 33:416-21; PMID:12590261; http://dx.doi.org/10.1038/ng1099.
    • (2003) Nat Genet , vol.33 , pp. 416-421
    • Nicolas, M.1    Wolfer, A.2    Raj, K.3    Kummer, J.A.4    Mill, P.5    Van Noort, M.6
  • 73
    • 42449147521 scopus 로고    scopus 로고
    • The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response
    • PMID:18388864
    • Mandinova A, Lefort K, Tommasi di Vignano A, Stonely W, Ostano P, Chiorino G, et al. The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response. EMBO J 2008; 27:1243-54; PMID:18388864; http://dx.doi.org/10.1038/emboj.2008.45.
    • (2008) EMBO J , vol.27 , pp. 1243-1254
    • Mandinova, A.1    Lefort, K.2    Di Tommasi Vignano, A.3    Stonely, W.4    Ostano, P.5    Chiorino, G.6
  • 75
    • 0037363922 scopus 로고    scopus 로고
    • HES and HERP families: Multiple effectors of the Notch signaling pathway
    • PMID:12548545
    • Iso T, Kedes L, Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol 2003; 194:237-55; PMID:12548545; http://dx.doi.org/10.1002/jcp.10208.
    • (2003) J Cell Physiol , vol.194 , pp. 237-255
    • Iso, T.1    Kedes, L.2    Hamamori, Y.3
  • 76
    • 80455155120 scopus 로고    scopus 로고
    • Notch signaling in intestinal homeostasis across species: The cases of Drosophila, Zebrafish and the mouse
    • PMID:21745469
    • Fre S, Bardin A, Robine S, Louvard D. Notch signaling in intestinal homeostasis across species: the cases of Drosophila, Zebrafish and the mouse. Exp Cell Res 2011; 317:2740-7; PMID:21745469; http://dx.doi.org/10.1016/j.yexcr. 2011.06.012.
    • (2011) Exp Cell Res , vol.317 , pp. 2740-2747
    • Fre, S.1    Bardin, A.2    Robine, S.3    Louvard, D.4
  • 77
    • 80051497491 scopus 로고    scopus 로고
    • Notch: Architect, landscaper, and guardian of the intestine
    • PMID:21689653
    • Vooijs M, Liu Z, Kopan R. Notch: architect, landscaper, and guardian of the intestine. Gastroenterology 2011; 141:448-59; PMID:21689653; http://dx.doi.org/10.1053/j.gastro.2011.06.003.
    • (2011) Gastroenterology , vol.141 , pp. 448-459
    • Vooijs, M.1    Liu, Z.2    Kopan, R.3
  • 78
    • 80055009326 scopus 로고    scopus 로고
    • Role of Notch signaling in colon homeostasis and carcinogenesis
    • PMID:21801279
    • Miyamoto S, Rosenberg DW. Role of Notch signaling in colon homeostasis and carcinogenesis. Cancer Sci 2011; 102:1938-42; PMID:21801279; http://dx.doi.org/10.1111/j.1349-7006.2011.02049.x.
    • (2011) Cancer Sci , vol.102 , pp. 1938-1942
    • Miyamoto, S.1    Rosenberg, D.W.2
  • 79
    • 58349091690 scopus 로고    scopus 로고
    • γ-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity
    • PMID:19147571
    • Meng RD, Shelton CC, Li Y-M, Qin L-X, Notterman D, Paty PB, et al. γ-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res 2009; 69:573-82; PMID:19147571; http://dx.doi.org/10.1158/0008-5472.CAN-08-2088.
    • (2009) Cancer Res , vol.69 , pp. 573-582
    • Meng, R.D.1    Shelton, C.C.2    Li, Y.-M.3    Qin, L.-X.4    Notterman, D.5    Paty, P.B.6
  • 81
    • 84859484685 scopus 로고    scopus 로고
    • A phase II study of RO4929097 in metastatic colorectal cancer
    • PMID:22445247
    • Strosberg JR, Yeatman T, Weber J, Coppola D, Schell MJ, Han G, et al. A phase II study of RO4929097 in metastatic colorectal cancer. Eur J Cancer 2012; 48:997-1003; PMID:22445247; http://dx.doi.org/10.1016/j.ejca.2012.02.056.
    • (2012) Eur J Cancer , vol.48 , pp. 997-1003
    • Strosberg, J.R.1    Yeatman, T.2    Weber, J.3    Coppola, D.4    Schell, M.J.5    Han, G.6
  • 82
    • 84861461140 scopus 로고    scopus 로고
    • ALDH+ tumorinitiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ-secretase inhibitor and irinotecan in colorectal cancer
    • PMID:22521243
    • Arcaroli JJ, Powell RW, Varella-Garcia M, McManus M, Tan AC, Quackenbush KS, et al. ALDH+ tumorinitiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ-secretase inhibitor and irinotecan in colorectal cancer. Mol Oncol 2012; 6:370-81; PMID:22521243; http://dx.doi.org/10.1016/j.molonc.2012.03.004.
    • (2012) Mol Oncol , vol.6 , pp. 370-381
    • Arcaroli, J.J.1    Powell, R.W.2    Varella-Garcia, M.3    McManus, M.4    Tan, A.C.5    Quackenbush, K.S.6
  • 83
    • 0031685620 scopus 로고    scopus 로고
    • TGF-beta signal transduction
    • PMID:9759503
    • Massagué J. TGF-beta signal transduction. Annu Rev Biochem 1998; 67:753-91; PMID:9759503; http:// dx.doi.org/10.1146/annurev.biochem.67.1.753.
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massagué, J.1
  • 84
    • 36448936383 scopus 로고    scopus 로고
    • TGFB-SMAD signal transduction: Molecular specificity and functional flexibility
    • Schmierer B, Hill CS. TGFB-SMAD signal transduction: molecular specificity and functional flexibility. Mol Cell Biol 2007; 8:970-82.
    • (2007) Mol Cell Biol , vol.8 , pp. 970-982
    • Schmierer, B.1    Hill, C.S.2
  • 85
    • 42949160593 scopus 로고    scopus 로고
    • The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers
    • PMID:18471510
    • Kodach LL, Wiercinska E, de Miranda NF, Bleuming SA, Musler AR, Peppelenbosch MP, et al. The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers. Gastroenterology 2008; 134:1332-41; PMID:18471510; http://dx.doi. org/10.1053/j.gastro.2008.02.059.
    • (2008) Gastroenterology , vol.134 , pp. 1332-1341
    • Kodach, L.L.1    Wiercinska, E.2    De Miranda, N.F.3    Bleuming, S.A.4    Musler, A.R.5    Peppelenbosch, M.P.6
  • 86
    • 0033555627 scopus 로고    scopus 로고
    • Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers
    • PMID:9927040
    • Grady WM, Myeroff LL, Swinler SE, Rajput A, Thiagalingam S, Lutterbaugh JD, et al. Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. Cancer Res 1999; 59:320-4; PMID:9927040.
    • (1999) Cancer Res , vol.59 , pp. 320-324
    • Grady, W.M.1    Myeroff, L.L.2    Swinler, S.E.3    Rajput, A.4    Thiagalingam, S.5    Lutterbaugh, J.D.6
  • 87
    • 0033587156 scopus 로고    scopus 로고
    • Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis
    • PMID:10340381
    • Miyaki M, Iijima T, Konishi M, Sakai K, Ishii A, Yasuno M, et al. Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. Oncogene 1999; 18:3098-103; PMID:10340381; http://dx.doi.org/10. 1038/sj.onc.1202642.
    • (1999) Oncogene , vol.18 , pp. 3098-3103
    • Miyaki, M.1    Iijima, T.2    Konishi, M.3    Sakai, K.4    Ishii, A.5    Yasuno, M.6
  • 88
    • 11144358223 scopus 로고    scopus 로고
    • Loss of Smad4 correlates with loss of the invasion suppressor E-cadherin in advanced colorectal carcinomas
    • PMID:15095268
    • Reinacher-Schick A, Baldus SE, Romdhana B, Landsberg S, Zapatka M, Mönig SP, et al. Loss of Smad4 correlates with loss of the invasion suppressor E-cadherin in advanced colorectal carcinomas. J Pathol 2004; 202:412-20; PMID:15095268; http://dx.doi.org/10.1002/path.1516.
    • (2004) J Pathol , vol.202 , pp. 412-420
    • Reinacher-Schick, A.1    Baldus, S.E.2    Romdhana, B.3    Landsberg, S.4    Zapatka, M.5    Mönig, S.P.6
  • 89
    • 84863125635 scopus 로고    scopus 로고
    • Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin
    • PMID:22115830
    • Freeman TJ, Smith JJ, Chen X, Washington MK, Roland JT, Means AL, et al. Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin. Gastroenterology 2012; 142:562-71, e2; PMID:22115830; http://dx.doi.org/10.1053/j.gastro.2011.11.026.
    • (2012) Gastroenterology , vol.142
    • Freeman, T.J.1    Smith, J.J.2    Chen, X.3    Washington, M.K.4    Roland, J.T.5    Means, A.L.6
  • 91
    • 79951483059 scopus 로고    scopus 로고
    • BMP signaling promotes the growth of primary human colon carcinomas in vivo
    • PMID:21098050
    • Lorente-Trigos A, Varnat F, Melotti A, Ruiz i Altaba A. BMP signaling promotes the growth of primary human colon carcinomas in vivo. J Mol Cell Biol 2010; 2:318-32; PMID:21098050; http://dx.doi.org/10.1093/jmcb/mjq035.
    • (2010) J Mol Cell Biol , vol.2 , pp. 318-332
    • Lorente-Trigos, A.1    Varnat, F.2    Melotti, A.3    Ruiz I Altaba, A.4
  • 92
    • 68049128117 scopus 로고    scopus 로고
    • Paracrine Hedgehog signaling in cancer
    • PMID:19638582
    • Theunissen J-W, de Sauvage FJ. Paracrine Hedgehog signaling in cancer. Cancer Res 2009; 69:6007-10; PMID:19638582; http://dx.doi.org/10.1158/0008-5472. CAN-09-0756.
    • (2009) Cancer Res , vol.69 , pp. 6007-6010
    • Theunissen, J.-W.1    De Sauvage, F.J.2
  • 93
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • PMID:11357142
    • Taipale J, Beachy PA. The Hedgehog and Wnt signalling pathways in cancer. Nature 2001; 411:349-54; PMID:11357142; http://dx.doi.org/10.1038/35077219.
    • (2001) Nature , vol.411 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 94
    • 34247843997 scopus 로고    scopus 로고
    • Hedgehog signaling pathway and gastrointestinal stem cell signaling network
    • (review). [review]. PMID:17089004
    • Katoh Y, Katoh M. Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). [review]. Int J Mol Med 2006; 18:1019-23; PMID:17089004.
    • (2006) Int J Mol Med , vol.18 , pp. 1019-1023
    • Katoh, Y.1    Katoh, M.2
  • 95
    • 84867868105 scopus 로고    scopus 로고
    • Metastatic basal cell carcinoma in the era of hedgehog signaling pathway inhibitors
    • Epub ahead of print PMID:22511370
    • Weiss GJ, Korn RL. Metastatic basal cell carcinoma in the era of hedgehog signaling pathway inhibitors. [Epub ahead of print]. Cancer 2012; http://dx.doi. org/10.1002/cncr.27532; PMID:22511370.
    • (2012) Cancer
    • Weiss, G.J.1    Korn, R.L.2
  • 96
    • 84861876867 scopus 로고    scopus 로고
    • Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome
    • PMID:22670904
    • Tang JY, Mackay-Wiggan JM, Aszterbaum M, Yauch RL, Lindgren J, Chang K, et al. Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome. N Engl J Med 2012; 366:2180-8; PMID:22670904; http://dx.doi.org/10. 1056/NEJMoa1113538.
    • (2012) N Engl J Med , vol.366 , pp. 2180-2188
    • Tang, J.Y.1    Mackay-Wiggan, J.M.2    Aszterbaum, M.3    Yauch, R.L.4    Lindgren, J.5    Chang, K.6
  • 97
    • 73649087231 scopus 로고    scopus 로고
    • Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling
    • PMID:19861162
    • Varnat F, Zacchetti G, Ruiz i Altaba A. Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling. Mech Dev 2010; 127:73-81; PMID:19861162; http:// dx.doi.org/10.1016/j.mod.2009.10.005.
    • (2010) Mech Dev , vol.127 , pp. 73-81
    • Varnat, F.1    Zacchetti, G.2    Ruiz I Altaba, A.3
  • 98
    • 0029670476 scopus 로고    scopus 로고
    • Interaction between Wingless and Notch signaling pathways mediated by dishevelled
    • PMID:8596950
    • Axelrod JD, Matsuno K, Artavanis-Tsakonas S, Perrimon N. Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science 1996; 271:1826-32; PMID:8596950; http://dx.doi. org/10.1126/science.271.5257. 1826.
    • (1996) Science , vol.271 , pp. 1826-1832
    • Axelrod, J.D.1    Matsuno, K.2    Artavanis-Tsakonas, S.3    Perrimon, N.4
  • 99
    • 38949091712 scopus 로고    scopus 로고
    • Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression
    • PMID:18057099
    • Alvarez-Medina R, Cayuso J, Okubo T, Takada S, Martí E. Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression. Development 2008; 135:237- 47; PMID:18057099; http://dx.doi.org/10.1242/ dev.012054.
    • (2008) Development , vol.135 , pp. 237-247
    • Alvarez-Medina, R.1    Cayuso, J.2    Okubo, T.3    Takada, S.4    Martí, E.5
  • 100
    • 9644262425 scopus 로고    scopus 로고
    • Unexpected Hedgehog-Wnt interactions in epithelial differentiation
    • PMID:15567325
    • Watt FM. Unexpected Hedgehog-Wnt interactions in epithelial differentiation. Trends Mol Med 2004; 10:577-80; PMID:15567325; http://dx.doi.org/10.1016/j.molmed.2004.10.008.
    • (2004) Trends Mol Med , vol.10 , pp. 577-580
    • Watt, F.M.1
  • 101
    • 10744233571 scopus 로고    scopus 로고
    • Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation
    • PMID:14770182
    • van den Brink GR, Bleuming SA, Hardwick JC, Schepman BL, Offerhaus GJ, Keller JJ, et al. Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat Genet 2004; 36:277-82; PMID:14770182; http://dx.doi.org/10.1038/ng1304.
    • (2004) Nat Genet , vol.36 , pp. 277-282
    • Van Den Brink, G.R.1    Bleuming, S.A.2    Hardwick, J.C.3    Schepman, B.L.4    Offerhaus, G.J.5    Keller, J.J.6
  • 102
    • 33845892748 scopus 로고    scopus 로고
    • Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis
    • PMID:17035290
    • Estrach S, Ambler CA, Lo Celso C, Hozumi K, Watt FM. Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development 2006; 133:4427-38; PMID:17035290; http://dx.doi.org/10. 1242/dev.02644.
    • (2006) Development , vol.133 , pp. 4427-4438
    • Estrach, S.1    Ambler, C.A.2    Lo Celso, C.3    Hozumi, K.4    Watt, F.M.5
  • 103
    • 79959443076 scopus 로고    scopus 로고
    • Jagged1 expression regulated by Notch3 and Wnt/β-catenin signaling pathways in ovarian cancer
    • PMID:20953350
    • Chen X, Stoeck A, Lee SJ, Shih IeM, Wang MM, Wang T-L. Jagged1 expression regulated by Notch3 and Wnt/β-catenin signaling pathways in ovarian cancer. Oncotarget 2010; 1:210-8; PMID:20953350.
    • (2010) Oncotarget , vol.1 , pp. 210-218
    • Chen, X.1    Stoeck, A.2    Lee, S.J.3    IeM, S.4    Wang, M.M.5    Wang, T.-L.6
  • 104
    • 59849104344 scopus 로고    scopus 로고
    • Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity
    • PMID:19124651
    • Wall DS, Mears AJ, McNeill B, Mazerolle C, Thurig S, Wang Y, et al. Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J Cell Biol 2009; 184:101-12; PMID:19124651; http://dx.doi.org/10.1083/jcb.200805155.
    • (2009) J Cell Biol , vol.184 , pp. 101-112
    • Wall, D.S.1    Mears, A.J.2    McNeill, B.3    Mazerolle, C.4    Thurig, S.5    Wang, Y.6
  • 105
    • 73449115693 scopus 로고    scopus 로고
    • Hijacking HES1: How tumors co-opt the anti-differentiation strategies of quiescent cells
    • PMID:20022559
    • Sang L, Roberts JM, Coller HA. Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells. Trends Mol Med 2010; 16:17-26; PMID:20022559; http://dx.doi.org/10.1016/j.molmed. 2009.11.001.
    • (2010) Trends Mol Med , vol.16 , pp. 17-26
    • Sang, L.1    Roberts, J.M.2    Coller, H.A.3
  • 106
    • 65949098368 scopus 로고    scopus 로고
    • Hedgehog to Hes1: The heist of a Notch target
    • PMID:19342879
    • Wall DS, Wallace VA. Hedgehog to Hes1: the heist of a Notch target. Cell Cycle 2009; 8:1301-2; 2; PMID:19342879; http://dx.doi.org/10.4161/ cc.8.9.8284.
    • (2009) Cell Cycle , vol.8
    • Wall, D.S.1    Wallace, V.A.2
  • 107
    • 22044454171 scopus 로고    scopus 로고
    • Bridging the BMP and Wnt pathways by PI3 kinase/Akt and 14-3-3ζ
    • PMID:15655376
    • Tian Q, He X-C, Hood L, Li L. Bridging the BMP and Wnt pathways by PI3 kinase/Akt and 14-3-3ζ. Cell Cycle 2005; 4:215-6; PMID:15655376; http://dx.doi.org/10.4161/cc.4.2.1412.
    • (2005) Cell Cycle , vol.4 , pp. 215-216
    • Tian, Q.1    He, X.-C.2    Hood, L.3    Li, L.4
  • 108
    • 77954167982 scopus 로고    scopus 로고
    • Transcriptional crosstalk between TGF-β and stem cell pathways in tumor cell invasion: Role of EMT promoting Smad complexes
    • PMID:20519943
    • Fuxe J, Vincent T, Garcia de Herreros A. Transcriptional crosstalk between TGF-β and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes. Cell Cycle 2010; 9:2363-74; PMID:20519943; http://dx.doi.org/10.4161/cc.9.12.12050.
    • (2010) Cell Cycle , vol.9 , pp. 2363-2374
    • Fuxe, J.1    Vincent, T.2    De Garcia Herreros, A.3
  • 109
    • 20544460148 scopus 로고    scopus 로고
    • Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
    • PMID:15959515
    • van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, et al. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 2005; 435:959-63; 63; PMID:15959515; http://dx.doi.org/10.1038/nature03659.
    • (2005) Nature , vol.435
    • Van Es, J.H.1    Van Gijn, M.E.2    Riccio, O.3    Van Den Born, M.4    Vooijs, M.5    Begthel, H.6
  • 110
    • 80053568372 scopus 로고    scopus 로고
    • Notch post-translationally regulates β-catenin protein in stem and progenitor cells
    • PMID:21841793
    • Kwon C, Cheng P, King IN, Andersen P, Shenje L, Nigam V, et al. Notch post-translationally regulates β-catenin protein in stem and progenitor cells. Nat Cell Biol 2011; 13:1244-51; PMID:21841793; http://dx.doi.org/10.1038/ ncb2313.
    • (2011) Nat Cell Biol , vol.13 , pp. 1244-1251
    • Kwon, C.1    Cheng, P.2    King, I.N.3    Andersen, P.4    Shenje, L.5    Nigam, V.6
  • 111
    • 81855173503 scopus 로고    scopus 로고
    • Hedgehog signaling and the Gli code in stem cells, cancer, and metastases
    • PMID:22114144
    • Ruiz i Altaba A. Hedgehog signaling and the Gli code in stem cells, cancer, and metastases. Sci Signal 2011; 4:pt9; PMID:22114144; http://dx.doi.org/10.1126/scisignal.2002540.
    • (2011) Sci Signal , vol.4
    • Ruiz I Altaba, A.1
  • 112
    • 39749112553 scopus 로고    scopus 로고
    • BMP suppresses PTEN expression via RAS/ERK signaling
    • PMID:18059158
    • Beck SE, Carethers JM. BMP suppresses PTEN expression via RAS/ERK signaling. Cancer Biol Ther 2007; 6:1313-7; PMID:18059158.
    • (2007) Cancer Biol Ther , vol.6 , pp. 1313-1317
    • Beck, S.E.1    Carethers, J.M.2
  • 113
    • 34249340845 scopus 로고    scopus 로고
    • BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK
    • PMID:17317101
    • Beck SE, Jung BH, Del Rosario E, Gomez J, Carethers JM. BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK. Cell Signal 2007; 19:1465-72; PMID:17317101; http://dx.doi.org/10.1016/j.cellsig.2007.01.017.
    • (2007) Cell Signal , vol.19 , pp. 1465-1472
    • Beck, S.E.1    Jung, B.H.2    Del Rosario, E.3    Gomez, J.4    Carethers, J.M.5
  • 114
    • 79959712087 scopus 로고    scopus 로고
    • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: Rationale and importance to inhibiting these pathways in human health
    • PMID:21411864
    • Chappell WH, Steelman LS, Long JM, Kempf RC, Abrams SL, Franklin RA, et al. Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health. Oncotarget 2011; 2:135-64; PMID:21411864.
    • (2011) Oncotarget , vol.2 , pp. 135-164
    • Chappell, W.H.1    Steelman, L.S.2    Long, J.M.3    Kempf, R.C.4    Abrams, S.L.5    Franklin, R.A.6
  • 115
    • 84859713534 scopus 로고    scopus 로고
    • Ras stabilization through aberrant activation of Wnt/β-catenin signaling promotes intestinal tumorigenesis
    • PMID:22234611
    • Jeong WJ, Yoon J, Park JC, Lee SH, Lee SH, Kaduwal S, et al. Ras stabilization through aberrant activation of Wnt/β-catenin signaling promotes intestinal tumorigenesis. Sci Signal 2012; 5:1-12; PMID:22234611; http://dx.doi.org/10.1126/scisignal.2002242.
    • (2012) Sci Signal , vol.5 , pp. 1-12
    • Jeong, W.J.1    Yoon, J.2    Park, J.C.3    Lee, S.H.4    Lee, S.H.5    Kaduwal, S.6
  • 116
    • 84855660957 scopus 로고    scopus 로고
    • Wnt and Kras signaling-dark siblings in lung cancer
    • Pacheco-Pinedo EC, Morrisey EE. Wnt and Kras signaling-dark siblings in lung cancer. Oncotarget 2011; 569-74.
    • (2011) Oncotarget , pp. 569-574
    • Pacheco-Pinedo, E.C.1    Morrisey, E.E.2
  • 117
    • 84856058700 scopus 로고    scopus 로고
    • The GLI genes are the molecular switch in disrupting Hedgehog signaling in colon cancer
    • Mazumdar T, DeVecchio J, Agyeman A, Shi T, Houghton JA. The GLI genes are the molecular switch in disrupting Hedgehog signaling in colon cancer. Oncotarget 2011; 638-45.
    • (2011) Oncotarget , pp. 638-645
    • Mazumdar, T.1    DeVecchio, J.2    Agyeman, A.3    Shi, T.4    Houghton, J.A.5
  • 118
    • 80051668809 scopus 로고    scopus 로고
    • Activation of the PI3K/Akt pathway mediates bone morphogenetic protein 2-induced invasion of pancreatic cancer cells Panc-1
    • PMID:20848249
    • Chen X, Liao J, Lu Y, Duan X, Sun W. Activation of the PI3K/Akt pathway mediates bone morphogenetic protein 2-induced invasion of pancreatic cancer cells Panc-1. Pathol Oncol Res 2011; 17:257-61; PMID:20848249; http://dx.doi.org/10.1007/s12253-010-9307-1.
    • (2011) Pathol Oncol Res , vol.17 , pp. 257-261
    • Chen, X.1    Liao, J.2    Lu, Y.3    Duan, X.4    Sun, W.5
  • 119
    • 79960438373 scopus 로고    scopus 로고
    • Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab
    • PMID:21720213
    • Hart LS, Dolloff NG, Dicker DT, Koumenis C, Christensen JG, Grimberg A, et al. Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab. Cell Cycle 2011; 10:2331-8; PMID:21720213; http://dx.doi.org/10.4161/cc.10.14.16418.
    • (2011) Cell Cycle , vol.10 , pp. 2331-2338
    • Hart, L.S.1    Dolloff, N.G.2    Dicker, D.T.3    Koumenis, C.4    Christensen, J.G.5    Grimberg, A.6
  • 120
    • 77951935186 scopus 로고    scopus 로고
    • Protecting the hedgerow: P53 and hedgehog pathway interactions
    • PMID:20081367
    • Ho L, Alman B. Protecting the hedgerow: p53 and hedgehog pathway interactions. Cell Cycle 2010; 9:506-11; PMID:20081367; http://dx.doi.org/10. 4161/cc.9.3.10552.
    • (2010) Cell Cycle , vol.9 , pp. 506-511
    • Ho, L.1    Alman, B.2
  • 121
    • 33847768973 scopus 로고    scopus 로고
    • Notch, Myc and breast cancer
    • PMID:17329972
    • Efstratiadis A, Szabolcs M, Klinakis A. Notch, Myc and breast cancer. Cell Cycle 2007; 6:418-29; PMID:17329972; http://dx.doi.org/10.4161/cc.6.4.3838.
    • (2007) Cell Cycle , vol.6 , pp. 418-429
    • Efstratiadis, A.1    Szabolcs, M.2    Klinakis, A.3
  • 122
    • 84866923492 scopus 로고    scopus 로고
    • Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer.
    • Epub ahead of print PMID:22825584
    • Julien S, Merino-Trigo A, Lacroix L, Pocard M, Goere D, Mariani P, et al. Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer. [Epub ahead of print]. Clin Cancer Res 2012; PMID:22825584; http://dx.doi.org/10.1158/1078- 0432.CCR-12-0372.
    • (2012) Clin Cancer Res
    • Julien, S.1    Merino-Trigo, A.2    Lacroix, L.3    Pocard, M.4    Goere, D.5    Mariani, P.6
  • 123
    • 84863230091 scopus 로고    scopus 로고
    • Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor
    • PMID:22385958
    • Xu X, Hou Y, Yin X, Bao L, Tang A, Song L, et al. Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell 2012; 148:886-95; PMID:22385958; http://dx.doi.org/10.1016/j.cell.2012.02. 025.
    • (2012) Cell , vol.148 , pp. 886-895
    • Xu, X.1    Hou, Y.2    Yin, X.3    Bao, L.4    Tang, A.5    Song, L.6
  • 124
    • 84863229772 scopus 로고    scopus 로고
    • Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm
    • PMID:22385957
    • Hou Y, Song L, Zhu P, Zhang B, Tao Y, Xu X, et al. Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell 2012; 148:873-85; PMID:22385957; http://dx.doi.org/10.1016/j. cell.2012.02.028.
    • (2012) Cell , vol.148 , pp. 873-885
    • Hou, Y.1    Song, L.2    Zhu, P.3    Zhang, B.4    Tao, Y.5    Xu, X.6
  • 125
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas Network PMID:22810696
    • Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012; 487:330-7; PMID:22810696; http://dx.doi.org/10.1038/nature11252.
    • (2012) Nature , vol.487 , pp. 330-337
  • 126
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • PMID:22397650
    • Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012; 366:883-92; PMID:22397650; http://dx.doi.org/10. 1056/NEJMoa1113205.
    • (2012) N Engl J Med , vol.366 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3    Larkin, J.4    Endesfelder, D.5    Gronroos, E.6


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