Exaggerated neurobiological sensitivity to threat as a mechanism linking anxiety with increased risk for diseases of aging

Neuroscience and Biobehavioral Reviews

Volumn 37, Issue 1, 2013, Pages 96-108

  O'Donovan, Aoife ^a,b   Slavich, George M ^c   Epel, Elissa S ^a   Neylan, Thomas C ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anxiety; Attentional bias; Cellular aging; Diseases of aging; Hypothalamic pituitary adrenal axis; Inflammation; Information processing; Neurobiological; Parasympathetic nervous system; Psychoneuroimmunology; Sympathetic nervous system; Threat

Indexed keywords

AGING; ANXIETY; BIOLOGICAL MODEL; BRAIN FUNCTION; CELL AGING; COGNITIVE THERAPY; DISEASE ASSOCIATION; GENERALIZED ANXIETY DISORDER; HEALTH HAZARD; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INFLAMMATION; MENTAL STRESS; NERVE CELL NETWORK; NERVE STIMULATION; NEUROBIOLOGY; NEUROPHYSIOLOGY; NONHUMAN; PERCEPTIVE DISCRIMINATION; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; RISK REDUCTION; SENSITIVITY ANALYSIS; SENSORY ANALYSIS; STIMULUS RESPONSE;

AGING; ANIMALS; ANXIETY DISORDERS; AUTONOMIC NERVOUS SYSTEM; BRAIN; CENTRAL NERVOUS SYSTEM SENSITIZATION; FEAR; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INFLAMMATION; MODELS, NEUROLOGICAL; PITUITARY-ADRENAL SYSTEM; RISK FACTORS;

EID: 84870782404     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2012.10.013     Document Type: Review

References (235)

1. Akiyama H., Barger S., Barnum S., Bradt B., Bauer J., Cole G., Cooper N., Eikelenboom P., Emmerling M., Fiebich B., Finch C., Frautschy S., Griffin W., Hampel H., Hull M., Landreth G., Lue L., Mrak R., Mackenzie I., McGeer P., O'Banion M., Pachter J., Pasinetti G., Plata-Salaman C., Rogers J., Rydel R., Shen Y., Streit W., Strohmeyer R., Tooyoma I., Van Muiswinkel F., Veerhuis R., Walker D., Webster S., Wegrzyniak B., Wenk G., Wyss-Coray T. Inflammation and Alzheimer's disease. Neurobiology of Aging 2000, 21:383-421.
2. An X., Bandler R., Ongür D., Price J.L. Prefrontal cortical projections to longitudinal columns in the midbrain periaqueductal gray in macaque monkeys. The Journal of Comparative Neurology 1998, 401:455-479.
3. Anderson A.K., Christoff K., Panitz D., De Rosa E., Gabrieli J.D. Neural correlates of the automatic processing of threat facial signals. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2003, 23:5627-5633.
4. Antoni M.H., Lutgendorf S.K., Blomberg B., Carver C.S., Lechner S., Diaz A., Stagl J., Arevalo J.M., Cole S.W. Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics. Biological Psychiatry 2011, 71:366-372.
5. APA Diagnostic and Statistical Manual of Mental Disorders (4th ed., Text Revision), Washington, DC 2000.
6. Apfel B.A., Ross J., Hlavin J., Meyerhoff D.J., Metzler T.J., Marmar C.R., Weiner M.W., Schuff N., Neylan T.C. Hippocampal volume differences in Gulf War veterans with current versus lifetime posttraumatic stress disorder symptoms. Biological Psychiatry 2011, 69:541-548.
7. Armony J.L., Corbo V., Clément M.H., Brunet A. Amygdala response in patients with acute PTSD to masked and unmasked emotional facial expressions. The American Journal of Psychiatry 2005, 162:1961-1963.
8. Auphan N., DiDonato J.A., Rosette C., Helmberg A., Karin M. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 1995, 270:286-290.
9. Azevedo Da Silva M., Singh-Manoux A., Brunner E.J., Kaffashian S., Shipley M.J., Kivimäki M., Nabi H. Bidirectional association between physical activity and symptoms of anxiety and depression: the Whitehall II study. European Journal of Epidemiology 2012, 27:537-546.
10. Bar-Haim Y., Holoshitz Y., Eldar S., Frenkel T.I., Muller D., Charney D.S., Pine D.S., Fox N.A., Wald I. Life-threatening danger and suppression of attention bias to threat. The American Journal of Psychiatry 2011, 167:694-698.
11. Bar-Haim Y., Lamy D., Pergamin L., Bakermans-Kranenburg M.J., van IJzendoorn M.H. Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study. Psychological Bulletin 2007, 133:1-24.
12. Bar-Haim Y., Morag I., Glickman S. Training anxious children to disengage attention from threat: a randomized controlled trial. Journal of Child Psychology and Psychiatry, and Allied Disciplines 2011, 52:861-869.
13. Bechara A., Tranel D., Damasio H., Adolphs R., Rockland C., Damasio A.R. Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science 1995, 269:1115-1118.
14. Beck A.T. Cognitive Therapy and the Emotional Disorders 1976, International Universities Press, New York.
15. Beck A.T. Theoretical perspectives on clinical anxiety. Anxiety and the Anxiety Disorders 1985, 183-196. Lawrence Erlbaum Associates, Hillsdale, NJ. A.H. Tuma, J. Maser (Eds.).
16. Beck A.T., Emery G., Greenberg R.L. Anxiety Disorders and Phobias: a Cognitive Perspective 1985, Basic Books, New York.
17. Benninghoven D., Kaduk A., Wiegand U., Specht T., Kunzendorf S., Jantschek G. Influence of anxiety on the course of heart disease after acute myocardial infarction - risk factor or protective function?. Psychotherapy and Psychosomatics 2006, 75:56-61.
18. Bierhaus A., Wolf J., Andrassy M., Rohleder N., Humpert P.M., Petrov D., Ferstl R., von Eynatten M., Wendt T., Rudofsky G., Joswig M., Morcos M., Schwaninger M., McEwen B., Kirschbaum C., Nawroth P.P. A mechanism converting psychosocial stress into mononuclear cell activation. Proceedings of the National Academy of Sciences of the United States of America 2003, 100:1920-1925.
19. Bishop S.J. Neurocognitive mechanisms of anxiety: an integrative account. Trends in Cognitive Sciences 2007, 11:307-316.
20. Bishop S.J. Neural mechanisms underlying selective attention to threat. Annals of the New York Academy of Sciences 2008, 1129:141-152.
21. Black P.H. Stress and the inflammatory response: a review of neurogenic inflammation. Brain, Behavior, and Immunity 2002, 16:622-653.
22. Blackburn E.H. Telomere states and cell fates. Nature 2000, 408:53-56.
23. Blanchard D.C., Griebel G., Pobbe R., Blanchard R.J. Risk assessment as an evolved threat detection and analysis process. Neuroscience and Biobehavioral Reviews 2011, 35:991-998.
24. Blascovich J., Mendes W.B. Social psychophysiology and embodiment. The Handbook of Social Psychology 2010, Wiley, New York. 5th ed. S.T. Fiske, D.T. Gilbert (Eds.).
25. Blechert J., Michael T., Grossman P., Lajtman M., Wilhelm F.H. Autonomic and respiratory characteristics of posttraumatic stress disorder and panic disorder. Psychosomatic Medicine 2007, 69:935-943.
26. Boddez Y., Vervliet B., Baeyens F., Lauwers S., Hermans D., Beckers T. Expectancy bias in a selective conditioning procedure: trait anxiety increases the threat value of a blocked stimulus. Journal of Behavior Therapy and Experimental Psychiatry 2012, 43:832-837.
27. Borkovec T.D., Hu S. The effect of worry on cardiovascular response to phobic imagery. Behaviour Research and Therapy 1990, 28:69-73.
28. Borkovec T.D., Inz J. The nature of worry in generalized anxiety disorder: a predominance of thought activity. Behaviour Research and Therapy 1990, 28:153-158.
29. Borkovec T.D., Lyonfields J.D., Wiser S.L., Deihl L. The role of worrisome thinking in the suppression of cardiovascular response to phobic imagery. Behaviour Research and Therapy 1993, 31:321-324.
30. Borkovec T.D., Roemer L. Perceived functions of worry among generalized anxiety disorder subjects: distraction from more emotionally distressing topics?. Journal of Behavior Therapy and Experimental Psychiatry 1995, 26:25-30.
31. Borovikova L.V., Ivanova S., Zhang M., Yang H., Botchkina G.I., Watkins L.R., Wang H., Abumrad N., Eaton J.W., Tracey K.J. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000, 405:458-462.
32. Brennan A.M., Fargnoli J.L., Williams C.J., Li T., Willett W., Kawachi I., Qi L., Hu F.B., Mantzoros C.S. Phobic anxiety is associated with higher serum concentrations of adipokines and cytokines in women with diabetes. Diabetes Care 2009, 32:926-931.
33. Britton J.C., Lissek S., Grillon C., Norcross M.A., Pine D.S. Development of anxiety: the role of threat appraisal and fear learning. Depression and Anxiety 2011, 28:5-17.
34. Browning M., Holmes E.A., Harmer C.J. The modification of attentional bias to emotional information: a review of the techniques, mechanisms, and relevance to emotional disorders. Cognitive, Affective & Behavioral Neuroscience 2010, 10:8-20.
35. Browning M., Reid C., Cowen P.J., Goodwin G.M., Harmer C.J. A single dose of citalopram increases fear recognition in healthy subjects. Journal of Psychopharmacology 2007, 21:684-690.
36. Bruunsgaard H., Pedersen M., Pedersen B.K. Aging and proinflammatory cytokines. Current Opinion in Hematology 2001, 8:131-136.
37. Buffalari D.M., Grace A.A. Noradrenergic modulation of basolateral amygdala neuronal activity: opposing influences of alpha-2 and beta receptor activation. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2007, 27:12358-12366.
38. Carroll D., Phillips A.C., Thomas G.N., Gale C.R., Deary I., Batty G.D. Generalized anxiety disorder is associated with metabolic syndrome in the Vietnam experience study. Biological Psychiatry 2009, 66:91-93.
39. Carroll J.E., Low C.A., Prather A.A., Cohen S., Fury J.M., Ross D.C., Marsland A.L. Negative affective responses to a speech task predict changes in interleukin (IL)-6. Brain, Behavior, and Immunity 2011, 25:232-238.
40. Cawthon R.M., Smith K.R., O'Brien E., Sivatchenko A., Kerber R.A. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003, 361:393-395.
41. Chen E., Langer D.A., Raphaelson Y.E., Matthews K.A. Socioeconomic status and health in adolescents: the role of stress interpretations. Child Development 2004, 75:1039-1052.
42. Chen E., Miller G.E., Kobor M.S., Cole S.W. Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood. Molecular Psychiatry 2011, 16:729-737.
43. Cherkas L.F., Aviv A., Valdes A.M., Hunkin J.L., Gardner J.P., Surdulescu G.L., Kimura M., Spector T.D. The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell 2006, 5:361-365.
44. Chida Y., Hamer M. Chronic psychosocial factors and acute physiological responses to laboratory-induced stress in healthy populations: a quantitative review of 30 years of investigations. Psychological Bulletin 2008, 134:829-885.
45. Cisler J.M., Koster E.H. Mechanisms of attentional biases towards threat in anxiety disorders: an integrative review. Clinical Psychology Review 2010, 30:203-216.
46. Cohen B.E., Marmar C., Ren L., Bertenthal D., Seal K.H. Association of cardiovascular risk factors with mental health diagnoses in Iraq and Afghanistan war veterans using VA health care. JAMA: the Journal of the American Medical Association 2009, 302:489-492.
47. Cohen H.J., Pieper C.F., Harris T., Rao K.M.K., Currie M.S. The association of plasma IL-6 levels with functional disability in community-dwelling elderly. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 1997, 52:M201-M208.
48. Cohen S., Janicki-Deverts D., Miller G.E. Psychological stress and disease. JAMA: the Journal of the American Medical Association 2007, 298:1685-1687.
49. Cole S.W., Arevalo J.M., Takahashi R., Sloan E.K., Lutgendorf S.K., Sood A.K., Sheridan J.F., Seeman T.E. Computational identification of gene-social environment interaction at the human IL6 locus. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:5681-5686.
50. Cole S.W., Yan W., Galic Z., Arevalo J., Zack J.A. Expression-based monitoring of transcription factor activity: the TELiS database. Bioinformatics 2005, 21:803-810.
51. Copeland W.E., Shanahan L., Worthman C., Angold A., Costello E.J. Generalized anxiety and C-reactive protein levels: a prospective, longitudinal analysis. Psychological Medicine 2012, 42:2641-2650.
52. Coppé J.P., Desprez P.Y., Krtolica A., Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annual Review of Pathology 2010, 5:99-118.
53. Cornwell B.R., Heller R., Biggs A., Pine D.S., Grillon C. Becoming the center of attention in social anxiety disorder: startle reactivity to a virtual audience during speech anticipation. The Journal of Clinical Psychiatry 2011, 72:942-948.
54. Critchley H.D. Neural mechanisms of autonomic, affective, and cognitive integration. The Journal of Comparative Neurology 2005, 493:154-166.
55. Critchley H.D. Psychophysiology of neural, cognitive and affective integration: fMRI and autonomic indicants. International Journal of Psychophysiology: Official Journal of the International Organization of Psychophysiology 2009, 73:88-94.
56. Cunningham W.A., Van Bavel J.J., Johnsen I.R. Affective flexibility: evaluative processing goals shape amygdala activity. Psychological Science: A Journal of the American Psychological Society 2008, 19:152-160.
57. Dalgleish T., Taghavi R., Neshat-Doost H., Moradi A., Canterbury R., Yule W. Patterns of processing bias for emotional information across clinical disorders: a comparison of attention, memory, and prospective cognition in children and adolescents with depression, generalized anxiety, and posttraumatic stress disorder. Journal of Clinical Child and Adolescent Psychology 2003, 32:10-21.
58. Damjanovic A.K., Yang Y., Glaser R., Kiecolt-Glaser J.K., Nguyen H., Laskowski B., Zou Y., Beversdorf D.Q., Weng N. Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer's Disease patients. Journal of Immunology 2007, 179:4249-4254.
59. Danese A., Caspi A., Williams B., Ambler A., Sugden K., Mika J., Werts H., Freeman J., Pariante C.M., Moffitt T.E., Arseneault L. Biological embedding of stress through inflammation processes in childhood. Molecular Psychiatry 2011, 16:244-246.
60. Dantzer R., O'Connor J.C., Freund G.G., Johnson R.W., Kelley K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nature Reviews. Neuroscience 2008, 9:46-56.
61. Dash S.R., Davey G.C. An experimental investigation of the role of negative mood in worry: the role of appraisals that facilitate systematic information processing. Journal of Behavior Therapy and Experimental Psychiatry 2012, 43:823-831.
62. Davis M., Montgomery I., Wilson G. Worry and heart rate variables: autonomic rigidity under challenge. Journal of Anxiety Disorders 2002, 16:639-659.
63. Davis M., Walker D.L., Miles L., Grillon C. Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology 2009, 35:105-135.
64. Davis M., Whalen P.J. The amygdala: vigilance and emotion. Molecular Psychiatry 2001, 6:13-34.
65. Demyttenaere K., Bruffaerts R., Posada-Villa J., Gasquet I., Kovess V., Lepine J.P., Angermeyer M.C., Bernert S., de Girolamo G., Morosini P., Polidori G., Kikkawa T., Kawakami N., Ono Y., Takeshima T., Uda H., Karam E.G., Fayyad J.A., Karam A.N., Mneimneh Z.N., Medina-Mora M.E., Borges G., Lara C., de Graaf R., Ormel J., Gureje O., Shen Y., Huang Y., Zhang M., Alonso J., Haro J.M., Vilagut G., Bromet E.J., Gluzman S., Webb C., Kessler R.C., Merikangas K.R., Anthony J.C., Von Korff M.R., Wang P.S., Brugha T.S., Aguilar-Gaxiola S., Lee S., Heeringa S., Pennell B.E., Zaslavsky A.M., Ustun T.B., Chatterji S. Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys. JAMA: the Journal of the American Medical Association 2004, 291:2581-2590.
66. Dickerson S.S., Gable S.L., Irwin M.R., Aziz N., Kemeny M.E. Social-evaluative threat and proinflammatory cytokine regulation: an experimental laboratory investigation. Psychological Science: A Journal of the American Psychological Society 2009, 20:1237-1244.
67. Dickerson S.S., Gruenewald T.L., Kemeny M.E. Psychobiological responses to social self threat: functional or detrimental?. Self Identity 2009, 8:270-285.
68. Dickerson S.S., Kemeny M.E. Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychological Bulletin 2004, 130:355-391.
69. Dolan R.J. Emotion, cognition, and behavior. Science 2002, 298:1191-1194.
70. Eaker E.D., Sullivan L.M., Kelly-Hayes M., D'Agostino R.B.Sr., Benjamin E.J. Tension and anxiety and the prediction of the 10-year incidence of coronary heart disease, atrial fibrillation, and total mortality: the Framingham Offspring Study. Psychosomatic Medicine 2005, 67:692-696.
71. Eifert G.H., Hodson S.E., Tracey D.R., Seville J.L., Gunawardane K. Heart-focused anxiety, illness beliefs, and behavioral impairment: comparing healthy heart-anxious patients with cardiac and surgical inpatients. Journal of Behavioral Medicine 1996, 19:385-399.
72. Eisenberger N.I., Lieberman M.D., Williams K.D. Does rejection hurt? An FMRI study of social exclusion. Science 2003, 302:290-292.
73. El Khoury-Malhame M., Reynaud E., Soriano A., Michael K., Salgado-Pineda P., Zendjidjian X., Gellato C., Eric F., Lefebvre M.N., Rouby F., Samuelian J.C., Anton J.L., Blin O., Khalfa S. Amygdala activity correlates with attentional bias in PTSD. Neuropsychologia 2011, 49:1969-1973.
74. Eldar S., Yankelevitch R., Lamy D., Bar-Haim Y. Enhanced neural reactivity and selective attention to threat in anxiety. Biological Psychology 2011, 85:252-257.
75. Elenkov I.J., Chrousos G.P. Stress system - organization, physiology and immunoregulation. Neuroimmunomodulation 2006, 13:257-267.
76. Enoch M.A., White K.V., Waheed J., Goldman D. Neurophysiological and genetic distinctions between pure and comorbid anxiety disorders. Depression and Anxiety 2008, 25:383-392.
77. Epel E.S., Blackburn E.H., Lin J., Dhabhar F.S., Adler N.E., Morrow J.D., Cawthon R.M. Accelerated telomere shortening in response to life stress. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:17312-17315.
78. Epel E.S., McEwen B., Seeman T., Matthews K., Castellazzo G., Brownell K.D., Bell J., Ickovics J.R. Stress and body shape: stress-induced cortisol secretion is consistently greater among women with central fat. Psychosomatic Medicine 2000, 62:623-632.
79. Flierl M.A., Rittirsch D., Huber-Lang M., Sarma J.V., Ward P.A. Catecholamines-crafty weapons in the inflammatory arsenal of immune/inflammatory cells or opening pandora's box?. Molecular Medicine 2008, 14:195-204.
80. Foa E.B. Prolonged exposure therapy: past, present, and future. Depression and Anxiety 2011, 28:1043-1047.
81. Foa E.B., Kozak M.J. Emotional processing of fear: exposure to corrective information. Psychological Bulletin 1986, 99:20-35.
82. Fredrikson M., Furmark T. Amygdaloid regional cerebral blood flow and subjective fear during symptom provocation in anxiety disorders. Annals of the New York Academy of Sciences 2003, 985:341-347.
83. Freund A., Orjalo A.V., Desprez P.Y., Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends in Molecular Medicine 2010, 16:238-246.
84. Gilbert D.T., Wilson T.D. Prospection: experiencing the future. Science 2007, 317:1351-1354.
85. Gilbertson M.W., Shenton M.E., Ciszewski A., Kasai K., Lasko N.B., Orr S.P., Pitman R.K. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nature Neuroscience 2002, 5:1242-1247.
86. Gill J.M., Saligan L., Woods S., Page G. PTSD is associated with an excess of inflammatory immune activities. Perspectives in Psychiatric Care 2009, 45:262-277.
87. Grillon C. Models and mechanisms of anxiety: evidence from startle studies. Psychopharmacology 2008, 199:421-437.
88. Grillon C., Levenson J., Pine D.S. A single dose of the selective serotonin reuptake inhibitor citalopram exacerbates anxiety in humans: a fear-potentiated startle study. Neuropsychopharmacology 2007, 32:225-231.
89. Grodstein F., van Oijen M., Irizarry M.C., Rosas H.D., Hyman B.T., Growdon J.H., De Vivo I. Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study. PloS ONE 2008, 3:e1590.
90. Gross C., Hen R. Genetic and environmental factors interact to influence anxiety. Neurotoxicity Research 2004, 6:493-501.
91. Gruenewald T.L., Kemeny M.E., Aziz N. Subjective social status moderates cortisol responses to social threat. Brain, Behavior, and Immunity 2006, 20:410-419.
92. Haensel A., Mills P.J., Nelesen R.A., Ziegler M.G., Dimsdale J.E. The relationship between heart rate variability and inflammatory markers in cardiovascular diseases. Psychoneuroendocrinology 2008, 33:1305-1312.
93. Hariri A.R., Drabant E.M., Munoz K.E., Kolachana B.S., Mattay V.S., Egan M.F., Weinberger D.R. A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry 2005, 62:146-152.
94. Hariri A.R., Mattay V.S., Tessitore A., Kolachana B., Fera F., Goldman D., Egan M.F., Weinberger D.R. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002, 297:400-403.
95. Harmer C.J., Mackay C.E., Reid C.B., Cowen P.J., Goodwin G.M. Antidepressant drug treatment modifies the neural processing of nonconscious threat cues. Biological Psychiatry 2006, 59:816-820.
96. Hennenlotter A., Schroeder U., Erhard P., Castrop F., Haslinger B., Stoecker D., Lange K.W., Ceballos-Baumann A.O. A common neural basis for receptive and expressive communication of pleasant facial affect. NeuroImage 2005, 26:581-591.
97. Hertzman C. The biological embedding of early experience and its effects on health in adulthood. Annals of the New York Academy of Sciences 1999, 896:85-95.
98. Hoge E.A., Brandstetter K., Moshier S., Pollack M.H., Wong K.K., Simon N.M. Broad spectrum of cytokine abnormalities in panic disorder and posttraumatic stress disorder. Depression and Anxiety 2009, 26:447-455.
99. Indovina I., Robbins T.W., Núñez-Elizalde A.O., Dunn B.D., Bishop S.J. Fear-conditioning mechanisms associated with trait vulnerability to anxiety in humans. Neuron 2011, 69:563-571.
100. Jaiswal M., LaRusso N.F., Burgart L.J., Gores G.J. Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism. Cancer Research 2000, 60:184-190.
101. Jöels M. Corticosteroid effects in the brain: U-shape it. Trends in Pharmacological Sciences 2006, 27:244-250.
102. Kananen L., Surakka I., Pirkola S., Suvisaari J., Lönnqvist J., Peltonen L., Ripatti S., Hovatta I. Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls. PloS ONE 2010, 5:e10826.
103. Kemeny M.E. Psychobiological responses to social threat: evolution of a psychological model in psychoneuroimmunology. Brain, Behavior, and Immunity 2009, 23:1-9.
104. Kessler R.C., Berglund P., Demler O., Jin R., Merikangas K.R., Walters E.E. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry 2005, 62:593-602.
105. Koenig W., Khuseyinova N., Baumert J., Meisinger C. Prospective study of high-sensitivity C-reactive protein as a determinant of mortality: results from the MONICA/KORA Augsburg Cohort Study, 1984-1998. Clinical Chemistry 2008, 54:335-342.
106. Koster E.H., Crombez G., Verschuere B., Van Damme S., Wiersema J.R. Components of attentional bias to threat in high trait anxiety: Facilitated engagement, impaired disengagement, and attentional avoidance. Behaviour Research and Therapy 2006, 44:1757-1771.
107. Kross E., Berman M.G., Mischel W., Smith E.E., Wager T.D. Social rejection shares somatosensory representations with physical pain. Proceedings of the National Academy of Sciences of the United States of America 2011, 108:6270-6275.
108. Krusemark E.A., Li W. Do all threats work the same way? Divergent effects of fear and disgust on sensory perception and attention. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience 2011, 31:3429-3434.
109. Kubzansky L.D., Kawachi I. Going to the heart of the matter: do negative emotions cause coronary heart disease?. Journal of Psychosomatic Research 2000, 48:323-337.
110. Lara D.R., Pinto O., Akiskal K., Akiskal H.S. Toward an integrative model of the spectrum of mood, behavioral and personality disorders based on fear and anger traits: I. Clinical implications. Journal of Affective Disorders 2006, 94:67-87.
111. Lazarus R.S., Folkman S. Stress, Appraisal and Coping 1984, Springer-Verlag, New York.
112. LeDoux J.E. Emotion circuits in the brain. Annual Review of Neuroscience 2000, 23:155-184.
113. Li C., Barker L., Ford E.S., Zhang X., Strine T.W., Mokdad A.H. Diabetes and anxiety in US adults: findings from the 2006 Behavioral Risk Factor Surveillance System. Diabetic Medicine: A Journal of the British Diabetic Association 2008, 25:878-881.
114. Li S.C., Brehmer Y., Shing Y.L., Werkle-Bergner M., Lindenberger U. Neuromodulation of associative and organizational plasticity across the life span: empirical evidence and neurocomputational modeling. Neuroscience and Biobehavioral Reviews 2006, 30:775-790.
115. Llera S.J., Newman M.G. Effects of worry on physiological and subjective reactivity to emotional stimuli in generalized anxiety disorder and nonanxious control participants. Emotion 2010, 10:640-650.
116. MacLeod C., Mathews A., Tata P. Attentional bias in emotional disorders. Journal of Abnormal Psychology 1986, 95:15-20.
117. MacLeod C., McLaughlin K. Implicit and explicit memory bias in anxiety: a conceptual replication. Behaviour Research and Therapy 1995, 33:1-14.
118. MacLeod C., Soong L.Y., Rutherford E.M., Campbell L.W. Internet-delivered assessment and manipulation of anxiety-linked attentional bias: validation of a free-access attentional probe software package. Behavior Research Methods 2007, 39:533-538.
119. Maes M., Lin A., Bonaccorso S., van Hunsel F., Van Gastel A., Delmeire L., Biondi M., Bosmans E., Kenis G., Sharpé S. Increased 24-hour urinary cortisol excretion in patients with post-traumatic stress disorder and patients with major depression, but not in patients with fibromyalgia. Acta Psychiatrica Scandinavica 1998, 98:328-335.
120. Martens E.J., de Jonge P., Na B., Cohen B.E., Lett H., Whooley M.A. Scared to death? Generalized anxiety disorder and cardiovascular events in patients with stable coronary heart disease: The Heart and Soul Study. Archives of General Psychiatry 2010, 67:750-758.
121. Mathews A., May J., Mogg K., Eysenck M. Attentional bias in anxiety: selective search or defective filtering. Journal of Abnormal Psychology 1990, 99:166-173.
122. Mathews A., Mogg K., May J., Eysenck M. Implicit and explicit memory bias in anxiety. Journal of Abnormal Psychology 1989, 98:236-240.
123. Maunder R., Toner B., de Rooy E., Moskovitz D. Influence of sex and disease on illness-related concerns in inflammatory bowel disease. Canadian Journal of Gastroenterology 1999, 13:728-732.
124. McEwen B.S. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiological Reviews 2007, 87:873-904.
125. McEwen B.S. Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling. Annals of the New York Academy of Sciences 2010, 1204(Suppl.):E38-E59.
126. McEwen B.S., Eiland L., Hunter R.G., Miller M.M. Stress and anxiety: structural plasticity and epigenetic regulation as a consequence of stress. Neuropharmacology 2012, 62:3-12.
127. Meiser-Stedman R., Dalgleish T., Glucksman E., Yule W., Smith P. Maladaptive cognitive appraisals mediate the evolution of posttraumatic stress reactions: a 6-month follow-up of child and adolescent assault and motor vehicle accident survivors. Journal of Abnormal Psychology 2009, 118:778-787.
128. Melamed S., Shirom A., Toker S., Berliner S., Shapira I. Association of fear of terror with low-grade inflammation among apparently healthy employed adults. Psychosomatic Medicine 2004, 66:484-491.
129. Mendes W.B., Blascovich J., Hunter S.B., Lickel B., Jost J.T. Threatened by the unexpected: physiological responses during social interactions with expectancy-violating partners. Journal of Personality and Social Psychology 2007, 92:698-716.
130. Mendes W.B., Major B., McCoy S., Blascovich J. How attributional ambiguity shapes physiological and emotional responses to social rejection and acceptance. Journal of Personality and Social Psychology 2008, 94:278-291.
131. Milad M.R., Quirk G.J. Neurons in medial prefrontal cortex signal memory for fear extinction. Nature 2002, 420:70-74.
132. Milad M.R., Rauch S.L., Pitman R.K., Quirk G.J. Fear extinction in rats: implications for human brain imaging and anxiety disorders. Biological Psychology 2006, 73:61-71.
133. Miller A.H., Maletic V., Raison C.L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biological Psychiatry 2009, 65:732-741.
134. Miller G.E., Cohen S., Ritchey A.K. Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model. Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association 2002, 21:531-541.
135. Mobbs D., Petrovic P., Marchant J.L., Hassabis D., Weiskopf N., Seymour B., Dolan R.J., Frith C.D. When fear is near: threat imminence elicits prefrontal-periaqueductal gray shifts in humans. Science 2007, 317:1079-1083.
136. Mogg K., Baldwin D.S., Brodrick P., Bradley B.P. Effect of short-term SSRI treatment on cognitive bias in generalised anxiety disorder. Psychopharmacology 2004, 176:466-470.
137. Monroe S.M., Slavich G.M., Georgiades K. The social environment and life stress in depression. Handbook of Depression 2009, 340-360. Guilford Press, New York. second ed. I.H. Gotlib, C.L. Hammen (Eds.).
138. Moons W.G., Eisenberger N.I., Taylor S.E. Anger and fear responses to stress have different biological profiles. Brain, Behavior, and Immunity 2010, 24:215-219.
139. Morrow D.A., Rifai N., Antman E.M., Weiner D.L., McCabe C.H., Cannon C.P., Braunwald E. C-reactive protein is a potent predictor of mortality independently of and in combination with troponin T in acute coronary syndromes: a T1M1A substudy. Journal of the American College of Cardiology 1998, 31:1460-1465.
140. Murphy, M.L.M., Slavich, G.M., Rohleder, N., Miller, G.E. Targeted rejection triggers differential pro- and anti-inflammatory gene expression in adolescents as a function of social status. Clinical Psychological Science, in press.
141. Murphy S.E., Norbury R., O'Sullivan U., Cowen P.J., Harmer C.J. Effect of a single dose of citalopram on amygdala response to emotional faces. The British Journal of Psychiatry: the Journal of Mental Science 2009, 194:535-540.
142. Nashold B.S., Wilson W.P., Slaughter D.G. Sensations evoked by stimulation in the midbrain of man. Journal of Neurosurgery 1969, 30:14-24.
143. Newman M.G., Llera S.J. A novel theory of experiential avoidance in generalized anxiety disorder: a review and synthesis of research supporting a contrast avoidance model of worry. Clinical Psychology Review 2011, 31:371-382.
144. O'Donovan A., Epel E., Lin J., Wolkowitz O., Cohen B., Maguen S., Metzler T., Lenoci M., Blackburn E., Neylan T.C. Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder. Biological Psychiatry 2011, 70:465-471.
145. O'Donovan A., Hughes B.M., Slavich G.M., Lynch L., Cronin M.T., O'Farrelly C., Malone K.M. Clinical anxiety, cortisol and interleukin-6: evidence for specificity in emotion-biology relationships. Brain, Behavior, and Immunity 2010, 24:1074-1077.
146. O'Donovan A., Lin J., Dhabhar F.S., Wolkowitz O., Tillie J.M., Blackburn E., Epel E. Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women. Brain, Behavior, and Immunity 2009, 23:446-449.
147. O'Donovan A., Pantell M.S., Puterman E., Dhabhar F.S., Blackburn E.H., Yaffe K., Cawthon R.M., Opresko P.L., Hsueh W.C., Satterfield S., Newman A.B., Ayonayon H.N., Rubin S.M., Harris T.B., Epel E.S. Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study. PloS ONE 2011, 6:e19687.
148. O'Donovan A., Sun B., Cole S., Rempel H., Lenoci M., Pulliam L., Neylan T. Transcriptional control of monocyte gene expression in post-traumatic stress disorder. Disease Markers 2011, 30:123-132.
149. O'Donovan A., Tomiyama A.J., Lin J., Puterman E., Adler N.E., Kemeny M., Wolkowitz O.M., Blackburn E.H., Epel E.S. Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere length. Brain, Behavior, and Immunity 2012, 26:573-579.
150. Okereke O.I., Prescott J., Wong J.Y.Y., Han J., Rexrode K.M., De Vivo I. High phobic anxiety is related to lower leukocyte telomere length in women. PLoS ONE 2012, 7:e40516.
151. Ongür D., An X., Price J.L. Prefrontal cortical projections to the hypothalamus in macaque monkeys. The Journal of Comparative Neurology 1998, 401:480-505.
152. Pace T.W., Heim C.M. A short review on the psychoneuroimmunology of posttraumatic stress disorder: from risk factors to medical comorbidities. Brain, Behavior, and Immunity 2011, 25:6-13.
153. Padgett D.A., Glaser R. How stress influences the immune response. Trends in Immunology 2003, 24:444-448.
154. Phan K.L., Fitzgerald D.A., Nathan P.J., Tancer M.E. Association between amygdala hyperactivity to harsh faces and severity of social anxiety in generalized social phobia. Biological Psychiatry 2006, 59:424-429.
155. Phelps E.A. Human emotion and memory: interactions of the amygdala and hippocampal complex. Current Opinion in Neurobiology 2004, 14:198-202.
156. Phelps E.A., O'Connor K.J., Gatenby J.C., Gore J.C., Grillon C., Davis M. Activation of the left amygdala to a cognitive representation of fear. Nature Neuroscience 2001, 4:437-441.
157. Piazza J.R., Charles S.T., Sliwinski M.J., Mogle J., Almeida D.M. Affective reactivity to daily stressors and long-term risk of reporting a chronic physical health condition. Annals of Behavioral Medicine 2012, in press.
158. Pine D.S., Mogg K., Bradley B.P., Montgomery L., Monk C.S., McClure E., Guyer A.E., Ernst M., Charney D.S., Kaufman J. Attention bias to threat in maltreated children: implications for vulnerability to stress-related psychopathology. The American Journal of Psychiatry 2005, 162:291-296.
159. Pitsavos C., Panagiotakos D.B., Papageorgiou C., Tsetsekou E., Soldatos C., Stefanadis C. Anxiety in relation to inflammation and coagulation markers, among healthy adults: the ATTICA Study. Atherosclerosis 2006, 185:320-326.
160. Pradhan A.D., Manson J.E., Rifai N., Buring J.E., Ridker P.M. C-reactive protein, interleukin 6, and risk of developing type-2 diabetes mellitus. JAMA: the Journal of the American Medical Association 2001, 286:327-334.
161. Prenoveau J.M., Craske M.G., Zinbarg R.E., Mineka S., Rose R.D., Griffith J.W. Are anxiety and depression just as stable as personality during late adolescence? Results from a three-year longitudinal latent variable study. Journal of Abnormal Psychology 2011, 120:832-843.
162. Protopopescu X., Pan H., Tuescher O., Cloitre M., Goldstein M., Engelien W., Epstein J., Yang Y., Gorman J., LeDoux J., Silbersweig D., Stern E. Differential time courses and specificity of amygdala activity in posttraumatic stress disorder subjects and normal control subjects. Biological Psychiatry 2005, 57:464-473.
163. Puterman E., O'Donovan A., Adler N.E., Tomiyama A.J., Kemeny M., Wolkowitz O.M., Epel E. Physical activity moderates effects of stressor-induced rumination on cortisol reactivity. Psychosomatic Medicine 2011, 73:604-611.
164. Raison C.L., Capuron L., Miller A.H. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends in Immunology 2006, 27:24-31.
165. Rao U., Chen L.A., Bidesi A.S., Shad M.U., Thomas M.A., Hammen C.L. Hippocampal changes associated with early-life adversity and vulnerability to depression. Biological Psychiatry 2010, 67:357-364.
166. Rauch S.L., Shin L.M., Wright C.I. Neuroimaging studies of amygdala function in anxiety disorders. Annals of the New York Academy of Sciences 2003, 985:389-410.
167. Rauch S.L., Whalen P.J., Shin L.M., McInerney S.C., Macklin M.L., Lasko N.B., Orr S.P., Pitman R.K. Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study. Biological Psychiatry 2000, 47:769-776.
168. Rawlings N.B., Norbury R., Cowen P.J., Harmer C.J. A single dose of mirtazapine modulates neural responses to emotional faces in healthy people. Psychopharmacology 2010, 212:625-634.
169. Ridker P., Hennekens C., Buring J., Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. The New England Journal of Medicine 2000, 342:836-843.
170. Ridker P., Morrow D. C-reactive protein, inflammation, and coronary risk. Cardiology Clinics 2003, 21:315-325.
171. Ridker P., Rifai N., Rose L., Buring J., Cook N. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. The New England Journal of Medicine 2002, 347:1557-1565.
172. Robinson O.J., Charney D.R., Overstreet C., Vytal K., Grillon C. The adaptive threat bias in anxiety: amygdala-dorsomedial prefrontal cortex coupling and aversive amplification. NeuroImage 2012, 60:523-529.
173. Robinson O.J., Overstreet C., Allen P.S., Pine D.S., Grillon C. Acute tryptophan depletion increases translational indices of anxiety but not fear: serotonergic modulation of the bed nucleus of the stria terminalis. Neuropsychopharmacology 2012, 37:1963-1971.
174. Rohleder N., Marin T.J., Ma R., Miller G.E. Biologic cost of caring for a cancer patient: dysregulation of pro- and anti-inflammatory signaling pathways. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 2009, 27:2909-2915.
175. Rohleder N., Wolf J.M., Wolf O.T. Glucocorticoid sensitivity of cognitive and inflammatory processes in depression and posttraumatic stress disorder. Neuroscience and Biobehavioral Reviews 2010, 35:104-114.
176. Röntgen P., Sablotzki A., Simm A., Silber R.E., Czeslick E. Effect of catecholamines on intracellular cytokine synthesis in human monocytes. European Cytokine Network 2004, 15:14-23.
177. Roy-Byrne P.P., Davidson K.W., Kessler R.C., Asmundson G.J., Goodwin R.D., Kubzansky L., Lydiard R.B., Massie M.J., Katon W., Laden S.K., Stein M.B. Anxiety disorders and comorbid medical illness. General Hospital Psychiatry 2008, 30:208-225.
178. Sahin E., Colla S., Liesa M., Moslehi J., Müller F.L., Guo M., Cooper M., Kotton D., Fabian A.J., Walkey C., Maser R.S., Tonon G., Foerster F., Xiong R., Wang Y.A., Shukla S.A., Jaskelioff M., Martin E.S., Heffernan T.P., Protopopov A., Ivanova E., Mahoney J.E., Kost-Alimova M., Perry S.R., Bronson R., Liao R., Mulligan R., Shirihai O.S., Chin L., DePinho R.A. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 2011, 470:359-365.
179. Saibeni S., Cortinovis I., Beretta L., Tatarella M., Ferraris L., Rondonotti E., Corbellini A., Bortoli A., Colombo E., Alvisi C., Imperiali G., de Franchis R. Gender and disease activity influence health-related quality of life in inflammatory bowel diseases. Hepato-Gastroenterology 2005, 52:509-515.
180. Salomé N., Ngampramuan S., Nalivaiko E. Intra-amygdala injection of GABAA agonist, muscimol, reduces tachycardia and modifies cardiac sympatho-vagal balance during restraint stress in rats. Neuroscience 2007, 148:335-341.
181. Sapolsky R.M., Romero L.M., Munck A.U. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocrine Reviews 2000, 21:55-89.
182. Schneider K.L., Appelhans B.M., Whited M.C., Oleski J., Pagoto S.L. Trait anxiety, but not trait anger, predisposes obese individuals to emotional eating. Appetite 2010, 55:701-706.
183. Seal K.H., Bertenthal D., Miner C.R., Sen S., Marmar C. Bringing the war back home: mental health disorders among 103,788 US veterans returning from Iraq and Afghanistan seen at Department of Veterans Affairs facilities. Archives of Internal Medicine 2007, 167:476-482.
184. Seal K.H., Shi Y., Cohen G., Cohen B.E., Maguen S., Krebs E.E., Neylan T.C. Association of mental health disorders with prescription opioids and high-risk opioid use in US veterans of Iraq and Afghanistan. JAMA: the Journal of the American Medical Association 2012, 307:940-947.
185. Seery M.D. Challenge or threat? Cardiovascular indexes of resilience and vulnerability to potential stress in humans. Neuroscience and Biobehavioral Reviews 2011, 35:1603-1610.
186. Sharma R.K., Balhara Y.P., Sagar R., Deepak K.K., Mehta M. Heart rate variability study of childhood anxiety disorders. Journal of Cardiovascular Disease Research 2011, 2:115-122.
187. Sheridan J.F., Stark J.L., Avitsur R., Padgett D.A. Social disruption, immunity, and susceptibility to viral infection. Role of glucocorticoid insensitivity and NGF. Annals of the New York Academy of Sciences 2000, 917:894-905.
188. Shin L.M., Rauch S.L., Pitman R.K. Amygdala, medial prefrontal cortex, and hippocampal function in PTSD. Annals of the New York Academy of Sciences 2006, 1071:67-79.
189. Slavich, G.M., Irwin, M.R. Stress, inflammation, and depression: a review of empirical evidence and underlying mechanisms, submitted for publication.
190. Slavich G.M., O'Donovan A., Epel E.S., Kemeny M.E. Black sheep get the blues: a psychobiological model of social rejection and depression. Neuroscience and Biobehavioral Reviews 2010, 35:39-45.
191. Slavich G.M., Way B.M., Eisenberger N.I., Taylor S.E. Neural sensitivity to social rejection is associated with inflammatory responses to social stress. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:14817-14822.
192. Smits J.A., Julian K., Rosenfield D., Powers M.B. Threat reappraisal as a mediator of symptom change in cognitive-behavioral treatment of anxiety disorders: a systematic review. Journal of Consulting and Clinical Psychology 2012, 80:624-635.
193. Somerville L.H., Kim H., Johnstone T., Alexander A.L., Whalen P.J. Human amygdala responses during presentation of happy and neutral faces: correlations with state anxiety. Biological Psychiatry 2004, 55:897-903.
194. Somerville L.H., Whalen P.J., Kelley W.M. Human bed nucleus of the stria terminalis indexes hypervigilant threat monitoring. Biological Psychiatry 2010, 68:416-424.
195. Sorrells S.F., Sapolsky R.M. An inflammatory review of glucocorticoid actions in the CNS. Brain, Behavior, and Immunity 2007, 21:259-272.
196. Spitzer C., Barnow S., Völzke H., John U., Freyberger H.J., Grabe H.J. Trauma, posttraumatic stress disorder, and physical illness: findings from the general population. Psychosomatic Medicine 2009, 71:1012-1017.
197. Stark J.L., Avitsur R., Hunzeker J., Padgett D.A., Sheridan J.F. Interleukin-6 and the development of social disruption-induced glucocorticoid resistance. Journal of Neuroimmunology 2002, 124:9-15.
198. Stein D.J., Nesse R.M. Threat detection, precautionary responses, and anxiety disorders. Neuroscience and Biobehavioral Reviews 2011, 35:1075-1079.
199. Sternberg E.M. Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens. Nature Reviews. Immunology 2006, 6:318-328.
200. Strandberg T.E., Tilvis R.S. C-reactive protein, cardiovascular risk factors, and mortality in a prospective study in the elderly. Arteriosclerosis, Thrombosis, and Vascular Biology 2000, 20:1057-1060.
201. Strine T.W., Chapman D.P., Kobau R., Balluz L. Associations of self-reported anxiety symptoms with health-related quality of life and health behaviors. Social Psychiatry and Psychiatric Epidemiology 2005, 40:432-438.
202. Suffredini A.F., Fantuzzi G., Badolato R., Oppenheim J.J., O'Grady N.P. New insights into the biology of the acute phase response. Journal of Clinical Immunology 1999, 19:203-214.
203. Surtees P.G., Wainwright N.W., Pooley K.A., Luben R.N., Khaw K.T., Easton D.F., Dunning A.M. Life stress, emotional health, and mean telomere length in the European Prospective Investigation into Cancer (EPIC) - Norfolk population study. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 2011, 66:1152-1162.
204. Taghavi M.R., Dalgleish T., Moradi A.R., Neshat-Doost H.T., Yule W. Selective processing of negative emotional information in children and adolescents with Generalized Anxiety Disorder. The British Journal of Clinical Psychology 2003, 42:221-230.
205. Taylor L., Loerbroks A., Herr R.M., Lane R.D., Fischer J.E., Thayer J.F. Depression and smoking: mediating role of vagal tone and inflammation. Annals of Behavioral Medicine: A Publication of the Society of Behavioral Medicine 2011, 42:334-340.
206. Taylor S.E., Burklund L.J., Eisenberger N.I., Lehman B.J., Hilmert C.J., Lieberman M.D. Neural bases of moderation of cortisol stress responses by psychosocial resources. Journal of Personality and Social Psychology 2008, 95:197-211.
207. Thayer J.F. On the importance of inhibition: central and peripheral manifestations of nonlinear inhibitory processes in neural systems. Dose Response 2006, 4:2-21.
208. Thayer J.F., Ahs F., Fredrikson M., Sollers J.J., Wager T.D. A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health. Neuroscience and Biobehavioral Reviews 2012, 36:747-756.
209. Thayer J.F., Fischer J.E. Heart rate variability, overnight urinary norepinephrine and C-reactive protein: evidence for the cholinergic anti-inflammatory pathway in healthy human adults. Journal of Internal Medicine 2009, 265:439-447.
210. Thayer J.F., Hansen A.L., Saus-Rose E., Johnsen B.H. Heart rate variability, prefrontal neural function, and cognitive performance: the neurovisceral integration perspective on self-regulation, adaptation, and health. Annals of Behavioral Medicine: A Publication of the Society of Behavioral Medicine 2009, 37:141-153.
211. Thayer J.F., Lane R.D. Claude Bernard and the heart-brain connection: further elaboration of a model of neurovisceral integration. Neuroscience and Biobehavioral Reviews 2009, 33:81-88.
212. Thayer J.F., Loerbroks A., Sternberg E.M. Inflammation and cardiorespiratory control: the role of the vagus nerve. Respiratory Physiology & Neurobiology 2011, 178:387-394.
213. Thayer J.F., Sternberg E.M. Neural concomitants of immunity-focus on the vagus nerve. NeuroImage 2009, 47:908-910.
214. Thayer J.F., Sternberg E.M. Neural aspects of immunomodulation: focus on the vagus nerve. Brain, Behavior, and Immunity 2010, 24:1223-1228.
215. Thayer J.F., von Eye A., Rovine M.J. Assessment of neural network models using prediction analysis. Biomedical Sciences Instrumentation 1995, 31:25-28.
216. Tottenham N., Sheridan M.A. A review of adversity, the amygdala and the hippocampus: a consideration of developmental timing. Frontiers in Human Neuroscience 2010, 3:1477 68.
217. Tracey K.J. The inflammatory reflex. Nature 2002, 420:853-859.
218. Tsukiyama N., Saida Y., Kakuda M., Shintani N., Hayata A., Morita Y., Tanida M., Tajiri M., Hazama K., Ogata K., Hashimoto H., Baba A. PACAP centrally mediates emotional stress-induced corticosterone responses in mice. Stress 2011, 14:368-375.
219. Tyrka A.R., Price L.H., Kao H.T., Porton B., Marsella S.A., Carpenter L.L. Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging. Biological Psychiatry 2010, 67:531-534.
220. van Vollenhoven R.F. Sex differences in rheumatoid arthritis: more than meets the eye. BMC Medicine 2009, 7:12.
221. Volpato S., Guralnik J.M., Ferrucci L., Balfour J., Chaves P., Fried L.P., Harris T.B. Cardiovascular disease, interleukin-6, and risk of mortality in older women: The Women's Health and Aging Study. Circulation 2001, 103:947-953.
222. Von Känel R., Begre S., Abbas C.C., Saner H., Gander M.L., Schmid J.P. Inflammatory biomarkers in patients with posttraumatic stress disorder caused by myocardial infarction and the role of depressive symptoms. Neuroimmunomodulation 2010, 17:39-46.
223. von Känel R., Hepp U., Kraemer B., Traber R., Keel M., Mica L., Schnyder U. Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. Journal of Psychiatric Research 2007, 41:744-752.
224. Walker D.L., Toufexis D.J., Davis M. Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety. European Journal of Pharmacology 2003, 463:199-216.
225. Warner-Schmidt J.L., Vanover K.E., Chen E.Y., Marshall J.J., Greengard P. Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans. Proceedings of the National Academy of Sciences of the United States of America 2011, 108:9262-9267.
226. Watkins L.L., Grossman P., Krishnan R., Sherwood A. Anxiety and vagal control of heart rate. Psychosomatic Medicine 1998, 60:498-502.
227. Whalen P.J., Kagan J., Cook R.G., Davis F.C., Kim H., Polis S., McLaren D.G., Somerville L.H., McLean A.A., Maxwell J.S., Johnstone T. Human amygdala responsivity to masked fearful eye whites. Science 2004, 306:2061.
228. Willeit P., Willeit J., Mayr A., Weger S., Oberhollenzer F., Brandstäter A., Kronenberg F., Kiechl S. Telomere length and risk of incident cancer and cancer mortality. JAMA: the Journal of the American Medical Association 2010, 304:69-75.
229. Wolitzky-Taylor K., Bobova L., Zinbarg R.E., Mineka S., Craske M.G. Longitudinal investigation of the impact of anxiety and mood disorders in adolescence on subsequent substance use disorder onset and vice versa. Addictive Behaviors 2012, 37:982-985.
230. Woody E.Z., Szechtman H. Adaptation to potential threat: the evolution, neurobiology, and psychopathology of the security motivation system. Neuroscience and Biobehavioral Reviews 2011, 35:1019-1033.
231. Yehuda R. Status of glucocorticoid alterations in post-traumatic stress disorder. Annals of the New York Academy of Sciences 2009, 1179:56-69.
232. Yehuda R., Southwick S.M., Nussbaum G., Wahby V., Giller E.L., Mason J.W. Low urinary cortisol excretion in patients with posttraumatic stress disorder. The Journal of Nervous and Mental Disease 1990, 178:366-369.
233. Yin W.H., Chen J.W., Jen H.L., Chiang M.C., Huang W.P., Feng A.N., Young M.S., Lin S.J. Independent prognostic value of elevated high-sensitivity C-reactive protein in chronic heart failure. American Heart Journal 2004, 147:931-938.
234. Yirmiya R., Goshen I. Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain, Behavior, and Immunity 2011, 25:181-213.
235. Zhou Z., Zhu G., Hariri A.R., Enoch M.A., Scott D., Sinha R., Virkkunen M., Mash D.C., Lipsky R.H., Hu X.Z., Hodgkinson C.A., Xu K., Buzas B., Yuan Q., Shen P.H., Ferrell R.E., Manuck S.B., Brown S.M., Hauger R.L., Stohler C.S., Zubieta J.K., Goldman D. Genetic variation in human NPY expression affects stress response and emotion. Nature 2008, 452:997-1001.