Human amygdala responsivity to masked fearful eye whites

Science

Volumn 306, Issue 5704, 2004, Pages 2061-

  Walen, Paul J ^a   Kagan, Jerome ^b   Cook, Robert G ^c   Davis, F Caroline ^a   Kim, Hackjin ^a   Polis, Sara ^a   McLaren, Donald G ^a   Somerville, Leah H ^d   McLean, Ashly A ^a   Maxwell, Jeffrey S ^a   Johnstone, Tom ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b HARVARD UNIVERSITY   (United States)

^c TUFTS UNIVERSITY   (United States)

^d Dartmouth College   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEHAVIORAL RESPONSE; EYE;

AMYGDALOID NUCLEUS; ARTICLE; BRAIN MAPPING; FACIAL EXPRESSION; FEAR; HUMAN; NEUROPSYCHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SCLERA;

ADULT; AMYGDALA; FACIAL EXPRESSION; FEAR; FEMALE; HAPPINESS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PATTERN RECOGNITION, VISUAL; PERCEPTUAL MASKING; SCLERA;

PIERINAE;

EID: 19944408952     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1103617     Document Type: Article

References (14)

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7. H. Kim et al., Neuroreport 14, 2317 (2003).
8. H. Kim et al., J. Cogn. Neurosci., in press.
9. P. Ekman, V. Friesen, Pictures of Facial Affect (Consulting Psychologists Press, Palo Alto, CA, 1976).
10. We studied healthy, right-handed, male subjects (mean age 21.9 ± 1.34 years) for consistency with our previous study (1) and to minimize between-subject signal heterogeneity related to handedness and/or gender differences. We scanned 27 subjects and excluded data from seven for excessive movement (>1.5 mm, 4 subjects), brain or visual abnormalities (2 subjects), or post-scan Beck Depression Inventory scores > 10 (1 subject).
11. Materials and methods are available as supporting material on Science Online.
12. We used an imaging protocol focused on the amygdala (7) that provides excellent coverage even in ventral and medial regions. The mean signal-to-noise ratio after spatial filtering (full width at half maximum, 6 mm) at the ventral amygdala locus reported here was more than 100 to 1.
13. P. Vuilleumier, J. L. Armony, J. Driver, R. J. Dolan, Nature Neurosci. 6, 624 (2003).
14. We thank N. Kalin, R. Davidson, A. Alexander, R. Cai, H. Urry, and L. Shin. Supported by the National Institute of Mental Health (grant nos. 01866 and 069315) and the Howard Hughes Medical Institute.