Hippocampal Changes Associated with Early-Life Adversity and Vulnerability to Depression

Biological Psychiatry

Volumn 67, Issue 4, 2010, Pages 357-364

  Rao, Uma ^a   Chen, Li Ann ^a   Bidesi, Anup S ^a   Shad, Mujeeb U ^a   Thomas, M Albert ^b   Hammen, Constance L ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Abuse; adolescent; depression; high risk; hippocampus; stress

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BRAIN SIZE; CHILD; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; EARLY LIFE STRESS; FOLLOW UP; HIGH RISK POPULATION; HIPPOCAMPUS; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PERSONAL EXPERIENCE; PRIORITY JOURNAL; SCHOOL CHILD;

ADOLESCENT; ANALYSIS OF VARIANCE; CHI-SQUARE DISTRIBUTION; CHILD; DEPRESSIVE DISORDER, MAJOR; FEMALE; FOLLOW-UP STUDIES; FUNCTIONAL LATERALITY; HIPPOCAMPUS; HUMANS; LIFE CHANGE EVENTS; MAGNETIC RESONANCE IMAGING; MALE; YOUNG ADULT;

EID: 74749105155     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2009.10.017     Document Type: Article

References (75)

1. The World Bank. The Global Burden of Disease and Risk Factors (2006), International Bank for Reconstruction and Development /The World Bank, Washington, DC New York: Oxford University Press
2. Hankin B.L., Abramson L.Y., Moffitt T.E., Silva P.A., McGee R., and Angell K.E. Development of depression from preadolescence to young adulthood: Emerging gender differences in a 10-year longitudinal study. J Abnorm Psychol 107 (1998) 128-140
3. Kessler R.C., Berglund P., Demler O., Jin R., Merikangas K.R., and Walters E.E. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 62 (2005) 593-602
4. Rao U., and Chen L.A. Characteristics, correlates, and outcomes of childhood and adolescent depressive disorders. Dialogues Clin Neurosci 11 (2009) 45-62
5. American Academy of Pediatrics, The Committee on Child Abuse and Neglect and Section on Adoption and Foster Care, American Academy of Child and Adolescent Psychiatry, National Center for Child Traumatic Stress, Stirling Jr. J., and Amaya-Jackson L. Understanding the behavioral and emotional Consequences of child abuse. Pediatrics 122 (2008) 667-673 Erratum in Pediatrics (2009); 123:197
6. Brown G.W., and Harris T.O. Depression and the serotonin transporter 5-HTTLPR polymorphism: A review and a hypothesis concerning gene-environment interaction. J Affect Disord 111 (2008) 1-12
7. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., et al. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 301 (2003) 386-389
8. Edwards V.J., Holden G.W., Felitti V.J., and Anda R.F. Relationship between multiple forms of childhood maltreatment and adult mental health in community respondents: Results from the adverse childhood experiences study. Am J Psychiatry 160 (2003) 1453-1460
9. Espejo E.P., Hammen C.L., Connolly N.P., Brennan P.A., Najman J.M., and Bor W. Stress sensitization and adolescent depressive severity as a function of childhood adversity: A link to anxiety disorders. J Abnorm Child Psychol 35 (2007) 287-299
10. Widom C.S., DuMont K., and Czaja S.J. A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Arch Gen Psychiatry 64 (2007) 49-56
11. Heim C., and Nemeroff C.B. The role of childhood trauma in the neurobiology of mood and anxiety disorders: Preclinical and clinical studies. Biol Psychiatry 49 (2001) 1023-1039
12. Kaufman J., and Charney D. Effects of early stress on brain structure and function: Implications for understanding the relationship between child maltreatment and depression. Dev Psychopathol 13 (2001) 451-471
13. Bradley R.G., Binder E.B., Epstein M.P., Tang Y., Nair H.P., Liu W., et al. Influence of child abuse on adult depression: Moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry 65 (2008) 190-200
14. Rao U., Hammen C., Ortiz L.R., Chen L.A., and Poland R.E. Effects of early and recent adverse experiences on adrenal response to psychosocial stress in depressed adolescents. Biol Psychiatry 64 (2008) 521-526
15. Bansar M., and Duman R.S. Regulation of neurogenesis and gliogenesis by stress and antidepressant treatment. CNS Neurol Disord Drug Targets 6 (2007) 311-320
16. Gould E., and Tanapat P. Stress and hippocampal neurogenesis. Biol Psychiatry 46 (1999) 1472-1479
17. Sapolsky R.M., Uno H., Rebert C.S., and Finch C.E. Hippocampal damage associated with prolonged glucocorticoid exposure in primates. J Neurosci 10 (1990) 2897-2902
18. Teicher M.H., Andersen S.L., Polcari A., Anderson C.M., Navalta C.P., and Kim D.M. The neurobiological consequences of early stress and childhood maltreatment. Neurosci Biobehav Rev 27 (2003) 33-44
19. Woon F.L., and Hedges D.W. Hippocampal and amygdala volumes in children and adults with childhood maltreatment-related posttraumatic stress disorder: A meta-analysis. Hippocampus 18 (2008) 729-736
20. Campbell S., Marriott M., Nahmias C., and MacQueen G.M. Lower hippocampal volume in patients suffering from depression: A meta-analysis. Am J Psychiatry 161 (2004) 598-607
21. McKinnon M.C., Yucel K., Nazarov A., and MacQueen G.M. A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J Psychiatry Neurosci 34 (2009) 41-54
22. Vythilingam M., Heim C., Newport J., Miller A.H., Anderson E., Bronen R., et al. Childhood trauma associated with smaller hippocampal volume in women with major depression. Am J Psychiatry 159 (2002) 2072-2080
23. Frodl T.S., Koutsouleris N., Bottlender R., Born C., Jager M., Scupin I., et al. Depression-related variation in brain morphology over 3 years: Effects of stress?. Arch Gen Psychiatry 65 (2008) 1156-1165
24. Kronmuller K.T., Pantel J., Kohler S., Victor D., Giesel F., Magnotta V.A., et al. Hippocampal volume and 2-year outcome in depression. Br J Psychiatry 192 (2008) 472-473
25. MacQueen G.M., Campbell S., McEwen B.S., Macdonald K., Amano S., Joffe R.T., et al. Course of illness, hippocampal function, and hippocampal volume in major depression. Proc Natl Acad Sci U S A 100 (2003) 1387-1392
26. Sheline Y.I., Sanghavi M., Mintun M.A., and Gado M.H. Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. J Neurosci 19 (1999) 5034-5043
27. MacMaster F.P., Mirza Y., Szeszko P.R., Kmiecik L.E., Easter P.C., Taormina S.P., et al. Amygdala and hippocampal volumes in familial early onset major depressive disorder. Biol Psychiatry 63 (2008) 385-390
28. Park Y., Priebe C.E., Miller M.I., Mohan N.R., and Botteron K.N. Statistical analysis of twin populations using dissimilarity measurements in hippocampus shape space. J Biomed Biotechnol (2008) 694297
29. Marshall W.A., and Tanner J.M. Variations in the pattern of pubertal changes in girls. Arch Dis Child 44 (1969) 291-303
30. Marshall W.A., and Tanner J.M. Variations in the pattern of pubertal changes in boys. Arch Dis Child 45 (1970) 13-23
31. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. (1994), American Psychiatric Publishing, Washington, DC
32. Kaufman J., Birmaher B., Brent D., Rao U., Flynn C., Moreci P., et al. Schedule for affective disorders and schizophrenia for School-aged children-present and lifetime version (K-SADS-PL): Initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36 (1997) 980-988
33. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 25 (1960) 56-62
34. Shaffer D., Gould M.S., Brasic J., Ambrosini P., Fisher P., Bird H., et al. A children's global assessment scale (CGAS). Arch Gen Psychiatry 40 (1983) 1228-1231
35. Beck A.T., Ward C.H., Mendelson M., Mock J., and Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 4 (1961) 561-571
36. Andreasen N.C., Endicott J., Spitzer R.L., and Winokur G. The family history method using diagnostic criteria. Reliability and validity. Arch Gen Psychiatry 34 (1977) 1229-1235
37. Hollingshead A.B. Four Factor Index of Social Status (1975), Yale University Department of Sociology, New Haven, CT
38. Dienes K.A., Hammen C., Henry R.M., Cohen A.N., and Daley S.E. The stress sensitization hypothesis: Understanding the course of bipolar disorder. J Affect Disord 95 (2006) 43-49
39. Hammen C.L., Burge D., Daley S.E., Davila J., Paley B., and Rudolph K.D. Interpersonal attachment cognitions and prediction of symptomatic responses to interpersonal stress. J Abnorm Psychol 104 (1995) 436-443
40. Hammen C., and Brennan P.A. Depressed adolescents of depressed and nondepressed mothers: Tests of an interpersonal impairment hypothesis. J Consult Clin Psychol 69 (2001) 284-294
41. Cox R.W. AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 29 (1996) 162-173
42. Magnotta V.A., Harris G., Andreasen N.C., O'Leary D.S., Yuh W.T., and Heckel D. Structural MR image processing using the BRAINS2 toolbox. Comput Med Imaging Graph 26 (2002) 251-264
43. Shenton M.E., Dickey C.C., Frumin M., and McCarley R.W. A review of MRI findings in schizophrenia. Schizophr Res 49 (2001) 1-52
44. Shenton M.E., Gerig G., McCarley R.W., Szekely G., and Kikinis R. Amygdala-hippocampal shape differences in schizophrenia: The application of 3D shape models to volumetric MR data. Psychiatry Res 115 (2002) 15-35
45. Duvernoy H.M. The Human Hippocampus: Functional Anatomy Vascularization and Serial Sections with MRI. 3rd ed. (2005), Springer Publishing Company, New York
46. Cook M.J., Fish D.R., Shorvon S.D., Straughan K., and Stevens J.M. Hippocampal volumetric and morphometric studies in frontal and temporal lobe epilepsy. Brain 115 (1992) 1001-1015
47. Gilbert A.R., Rosenberg D.R., Harenski K., Spencer S., Sweeney J.A., and Keshavan M.S. Thalamic volumes in patients with first-episode schizophrenia. Am J Psychiatry 158 (2001) 618-624
48. Shapiro R., and Keller M. Longitudinal Interval Follow-Up Evaluation (LIFE) (1979), Massachusetts General Hospital, Boston
49. Frank E., Prien R.F., Jarrett R.B., Keller M.B., Kupfer D.J., Lavori P.W., et al. Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Remission, recovery, relapse, and recurrence. Arch Gen Psychiatry 48 (1991) 851-855
50. Kaufman J., Martin A., King R.A., and Charney D. Are child-, adolescent-, and adult-onset depression one and the same disorder?. Biol Psychiatry 49 (2001) 980-1001
51. MacKinnon D.P., Lockwood C.M., Hoffman J.M., West S.G., and Sheets V. A comparison of methods to test mediation and other intervening variable effects. Psychol Methods 7 (2002) 83-104
52. Mackinnon D.P., and Dwyer J.H. Estimating mediated effects in prevention studies. Eval Rev 17 (1993) 144-158
53. MacKinnon D.P., Fritz M.S., Williams J., and Lockwood C.M. Distribution of the product confidence limits for the indirect effect: Program PRODCLIN. Behav Res Methods 39 (2007) 384-389
54. MacKinnon D.P., Fritz M.S., Williams J., and Lockwood C.M. Distribution of the product confidence limits for the indirect effect: Program PRODCLIN. Behav Res Methods 39 (2007) 384-389
55. Cohen R.A., Paul R.H., Stroud L., Gunstad J., Hitsman B.L., McCaffery J., et al. Early life stress and adult emotional experience: An international perspective. Int J Psychiatry Med 36 (2006) 35-52
56. Lyons D.M., Yang C., Sawyer-Glover A.M., Moseley M.E., and Schatzberg A.F. Early life stress and inherited variation in monkey hippocampal volumes. Arch Gen Psychiatry 58 (2001) 1145-1151
57. Teicher M.H., Samson J.A., Polcari A., and McGreenery C.E. Sticks, stones, and hurtful words: Relative effects of various forms of childhood maltreatment. Am J Psychiatry 163 (2006) 993-1000
58. Gilbert R., Widom C.S., Browne K., Fergusson D., Webb E., and Janson S. Burden and consequences of child maltreatment in high-income countries. Lancet 373 (2009) 68-81
59. Angold A., Costello E.J., Erkanli A., and Worthman C.M. Pubertal changes in hormone levels and depression in girls. Psychol Med 29 (1999) 1043-1053
60. Neufang S., Specht K., Hausmann M., Gunturkun O., Herpertz-Dahlmann B., Fink G.R., et al. Sex differences and the impact of steroid hormones on the developing human brain. Cereb Cortex 19 (2009) 464-473
61. Gilbertson M.W., Shenton M.E., Ciszewski A., Kasai K., Lasko N.B., Orr S.P., et al. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci 5 (2002) 1242-1247
62. Kaufman J., Yang B.Z., Douglas-Palumberi H., Houshyar S., Lipschitz D., Krystal J.H., et al. Social supports and serotonin transporter gene moderate depression in maltreated children. Proc Natl Acad Sci U S A 101 (2004) 17316-17321
63. O'Brien J.T., Lloyd A., McKeith I., Gholkar A., and Ferrier N. A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects. Am J Psychiatry 161 (2004) 2081-2090
64. Rao U, Hammen CL, Poland RE (in press): Longitudinal course of adolescent depression: Neuroendocrine and psychosocial predictors. J Am Acad Child Adolesc Psychiatry.
65. Vythilingam M., Vermetten E., Anderson G.M., Luckenbaugh D., Anderson E.R., Snow J., et al. Hippocampal volume, memory, and cortisol status in major depressive disorder: Effects of treatment. Biol Psychiatry 56 (2004) 101-112
66. Patel P.D., Lopez J.F., Lyons D.M., Burke S., Wallace M., and Schatzberg A.F. Glucocorticoid and mineralocorticoid receptor mRNA expression in squirrel monkey brain. J Psychiatr Res 34 (2000) 383-392
67. Eckenhoff M.F., and Rakic P. A quantitative analysis of synaptogenesis in the molecular layer of the dentate gyrus in the rhesus monkey. Brain Res Dev Brain Res 64 (1991) 129-135
68. Sanchez M.M., Ladd C.O., and Plotsky P.M. Early adverse experience as a developmental risk factor for later psychopathology: Evidence from rodent and primate models. Dev Psychopathol 13 (2001) 419-449
69. Spinelli S., Chefer S., Suomi S.J., Higley J.D., Barr C.S., and Stein E. Early-life stress induces long-term morphologic changes in primate brain. Arch Gen Psychiatry 66 (2009) 658-665
70. Carrion V.G., Weems C.F., and Reiss A.L. Stress predicts brain changes in children: A pilot longitudinal study on youth stress, posttraumatic stress disorder, and the hippocampus. Pediatrics 119 (2007) 509-516
71. Gallagher P., Malik N., Newham J., Young A.H., Ferrier I.N., and Mackin P. Antiglucocorticoid treatments for mood disorders. Cochrane Database Syst Rev (2008) CD005168
72. Seymour P.A., Schmidt A.W., and Schulz D.W. The pharmacology of CP-154526, a non-peptide antagonist of the CRH1 receptor: A review. CNs Drugs Rev 9 (2003) 57-96
73. Holsboer F., and Ising M. Central CRH system in depression and anxiety-Evidence from clinical studies with CRH1 receptor antagonists. Eur J Pharmacol 583 (2008) 350-357
74. Holsboer F. Stress, hypercortisolism and corticosteroid receptors in depression: Implications for therapy. J Affect Disord 62 (2001) 77-91
75. Nemeroff C.B., Heim C.M., Thase M.E., Klein D.N., Rush A.J., Schatzberg A.F., et al. Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma. Proc Natl Acad Sci U S A 100 (2003) 14293-14296