Antidepressant Drug Treatment Modifies the Neural Processing of Nonconscious Threat Cues

Biological Psychiatry

Volumn 59, Issue 9, 2006, Pages 816-820

  Harmer, Catherine J ^a   Mackay, Clare E ^a   Reid, Catriona B ^a   Cowen, Philip J ^a   Goodwin, Guy M ^a  

^a WARNEFORD HOSPITAL   (United Kingdom)

Author keywords

Amygdala; antidepressant; fear; healthy volunteers

Indexed keywords

ANTIDEPRESSANT AGENT; CITALOPRAM; PLACEBO; SEROTONIN UPTAKE INHIBITOR;

ADULT; AMYGDALOID NUCLEUS; ARTICLE; ASSOCIATION; BLOOD OXYGENATION LEVEL DEPENDENT FUNCTIONAL MAGNETIC RESONANCE IMAGING; BRAIN FUNCTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; EMOTION; FACIAL EXPRESSION; FEAR; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HAPPINESS; HUMAN; MALE; NERVE CELL PLASTICITY; NEUROMODULATION; NORMAL HUMAN; PRIORITY JOURNAL; PSYCHIATRIC TREATMENT; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; THREAT; VOLUNTEER;

ADOLESCENT; ADULT; BRAIN; CASE-CONTROL STUDIES; CITALOPRAM; CUES; DOUBLE-BLIND METHOD; EMOTIONS; FACIAL EXPRESSION; FEAR; FEMALE; FUNCTIONAL LATERALITY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; OXYGEN; RECOGNITION (PSYCHOLOGY); SEROTONIN UPTAKE INHIBITORS; UNCONSCIOUS (PSYCHOLOGY);

EID: 33646087196     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2005.10.015     Document Type: Article

References (38)

1. Bannerman D.M., Rawlins J.N., McHugh S.B., Deacon R.M., Yee B.K., Bast T., et al. Regional dissociations within the hippocampus-memory and anxiety. Neurosci Biobehav Rev 28 (2004) 273-283
2. Beck A.T., Rush A.J., Shaw B.F., and Emery G. Cognitive Therapy of Depression (1979), Guildford Press, New York
3. Bhagwagar Z., Cowen P.J., Goodwin G.M., and Harmer C.J. Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression. Am J Psychiatry 161 (2004) 166-168
4. Bradley B.P., Mogg K., and Lee S.C. Attentional biases for negative information in induced and naturally occurring dysphoria. Behav Res Ther 35 (1997) 911-927
5. Burghardt N.S., Sullivan G.M., McEwen B.S., Gorman J.M., and LeDoux J.E. The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment. A comparison with tianeptine. Biol Psychiatry 55 (2004) 1171-1178
6. Davis M., and Whalen P.J. The amygdala. Vigilance and emotion. Mol Psychiatry 6 (2001) 13-34
7. Deakin J.F. The role of serotonin in panic, anxiety and depression. Int Clin Psychopharmacol 13 suppl 4 (1998) S1-S5
8. Drevets W.C. Neuroimaging abnormalities in the amygdala in mood disorders. Ann N Y Acad Sci 985 (2003) 420-444
9. Ekman P., and Friesen W.V. Pictures of Facial Affect (1976), Consulting Psychologists Press, Palo Alto, CA
10. Evans A.C., Collins D.L., Mills S.R., Brown E.D., Kelly R.L., and Peters III T.M. Statistical neuroanatomical models from 305 MRI volumes. Proceedings of IEEE-Nuclear Science Symposium and Medical Imaging Conference (2001), Nuclear and Plasma Sciences Society, Piscataway, NJ 1813-1817
11. Friston K.J., Worsley K.J., Frackowiak R.S.J., Mazziotta J.C., and Evans A.C. Assessing the significance of focal activations using their spatial extent. Hum Brain Mapp 1 (1994) 210-220
12. Fu C.H., Williams S.C., Cleare A.J., Brammer M.J., Walsh N.D., Kim J., et al. Attenuation of the neural response to sad faces in major depression by antidepressant treatment. A prospective, event-related functional magnetic resonance imaging study. Arch Gen Psychiatry 61 (2004) 877-889
13. Garcia R., Vouimba R.M., Baudry M., and Thompson R.F. The amygdala modulates prefrontal cortex activity relative to conditioned fear. Nature 402 6759 (1999) 294-296
14. Gray J.A., and McNaughton N. The Neuropsychology of Anxiety. 2nd ed. (2000), Oxford University Press, Oxford, UK
15. Harmer C.J., Shelley N.C., Cowen P.J., and Goodwin G.M. Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition. Am J Psychiatry 161 (2004) 1256-1263
16. Kent J.M., Coplan J.D., and Gorman J.M. Clinical utility of the selective serotonin reuptake inhibitors in the spectrum of anxiety. Biol Psychiatry 44 (1998) 812-824
17. Knutson B., Wolkowitz O.M., Cole S.W., Chan T., Moore E.A., Johnson R.C., et al. Selective alteration of personality and social behavior by serotonergic intervention. Am J Psychiatry 155 3 (1998) 373-379
18. McHugh S.B., Deacon R.M., Rawlins J.N., and Bannerman D.M. Amygdala and ventral hippocampus contribute differentially to mechanisms of fear and anxiety. Behav Neurosci 118 (2004) 63-78
19. Milad M.R., Vidal-Gonzalez I., and Quirk G.J. Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner. Behav Neurosci 118 (2004) 389-394
20. Mogg K., and Bradley B.P. Selective orienting of attention to masked threat faces in social anxiety. Behav Res Ther 40 (2002) 1403-1414
21. Morris J.S., Buchel C., and Dolan R.J. Parallel neural responses in amygdala subregions and sensory cortex during implicit fear conditioning. Neuroimage 13 (2001) 1044-1052
22. Morris J.S., DeGelder B., Weiskrantz L., and Dolan R.J. Differential extrageniculostriate and amygdala responses to presentation of emotional faces in a cortically blind field. Brain 124 (2001) 1241-1252
23. Morris J.S., Friston K.J., Buchel C., Frith C.D., Young A.W., Calder A.J., et al. A neuromodulatory role for the human amygdala in processing emotional facial expressions. Brain 121 Pt 1 (1998) 47-57
24. Morris J.S., Frith C.D., Perrett D.I., Rowland D., Young A.W., Calder A.J., et al. A differential neural response in the human amygdala to fearful and happy facial expressions. Nature 383 (1996) 812-815
25. Pegna A.J., Khateb A., Lazeyras F., and Seghier M.L. Discriminating emotional faces without primary visual cortices involves the right amygdala. Nat Neurosci 8 (2005) 24-25
26. Phelps E.A., O'Connor K.J., Gatenby J.C., Gore J.C., Grillon C., and Davis M. Activation of the left amygdala to a cognitive representation of fear. Nat Neurosci 4 (2001) 437-441
27. Phillips M.L., Drevets W.C., Rauch S.L., and Lane R. Neurobiology of emotion perception I. The neural basis of normal emotion perception. Biol Psychiatry 54 (2003) 504-514
28. Phillips M.L., Williams L.M., Heining M., Herba C.M., Russell T., Andrew C., et al. Differential neural responses to overt and covert presentations of facial expressions of fear and disgust. Neuroimage 21 (2004) 1484-1496
29. Rauch S.L., Shin L.M., and Wright C.I. Neuroimaging studies of amygdala function in anxiety disorders. Ann N Y Acad Sci 985 (2003) 389-410
30. Sheline Y.I., Barch D.M., Donnelly J.M., Ollinger J.M., Snyder A.Z., and Mintun M.A. Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment. An fMRI study. Biol Psychiatry 50 (2001) 651-658
31. Shin L.M., Wright C.I., Cannistraro P.A., Wedig M.M., McMullin K., Martis B., et al. A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch Gen Psychiatry 62 (2005) 273-281
32. Stutzmann G.E., and LeDoux J.E. GABAergic antagonists block the inhibitory effects of serotonin in the lateral amygdala. A mechanism for modulation of sensory inputs related to fear conditioning. J Neurosci 19 (1999) RC8
33. Surguladze S.A., Brammer M.J., Young A.W., Andrew C., Travis M.J., Williams S.C., et al. A preferential increase in the extrastriate response to signals of danger. Neuroimage 19 (2003) 1317-1328
34. Vuilleumier P., Richardson M.P., Armony J.L., Driver J., and Dolan R.J. Distant influences of amygdala lesion on visual cortical activation during emotional face processing. Nat Neurosci 7 (2004) 1271-1278
35. Whalen P.J., Rauch S.L., Etcoff N.L., McInerney S.C., Lee M.B., and Jenike M.A. Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. J Neurosci 18 (1998) 411-418
36. Whalen P.J., Shin L.M., Somerville L.H., McLean A.A., and Kim H. Functional neuroimaging studies of the amygdala in depression. Semin Clin Neuropsychiatry 7 (2002) 234-242
37. Williams L.M., Phillips M.L., Brammer M.J., Skerrett D., Lagopoulos J., Rennie C., et al. Arousal dissociates amygdala and hippocampal fear responses. Evidence from simultaneous fMRI and skin conductance recording. Neuroimage 14 (2001) 1070-1079
38. Woolrich M.W., Ripley B.D., Brady M., and Smith S.M. Temporal autocorrelation in univariate linear modeling of FMRI data. Neuroimage 14 (2001) 1370-1386