Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women

Brain, Behavior, and Immunity

Volumn 23, Issue 4, 2009, Pages 446-449

  O'Donovan, A ^a,b   Lin, J ^c   Dhabhar, F S ^d   Wolkowitz, O ^a   Tillie, J M ^d   Blackburn, E ^c   Epel, E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d STANFORD UNIVERSITY   (United States)

Author keywords

Aging; Interleukin 6; Optimism; Pessimism; Telomere length

Indexed keywords

INTERLEUKIN 6;

ADULT; AGED; AGING; ARTICLE; FEMALE; HEALTH STATUS; HUMAN; LEUKOCYTE; OPTIMISM; PESSIMISM; POSTMENOPAUSE; PRIORITY JOURNAL; SENESCENCE; TELOMERE;

AFFECT; AGED; AGED, 80 AND OVER; AGING; ATTITUDE; CAREGIVERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEALTH BEHAVIOR; HUMANS; INTERLEUKIN-6; LEUKOCYTES; MIDDLE AGED; PATIENT SELECTION; PERSONALITY; PERSONALITY INVENTORY; QUESTIONNAIRES; REGRESSION ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STRESS, PSYCHOLOGICAL; TELOMERE;

EID: 63249093574     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2008.11.006     Document Type: Article

References (31)

1. Allison P.J., Guichard C., Fung K., and Gilain L. Dispositional optimism predicts survival status 1 year after diagnosis in head and neck cancer patients. J. Clin. Oncol. 21 (2003) 543-548
2. Bastien C.H., Vallieres A., and Morin C.M. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2 (2001) 297-307
3. Blackburn E.H. Switching and signaling at the telomere. Cell 106 (2001) 661-673
4. Carrero J.J., Stenvinkel P., Fellstrom B., Qureshi A.R., Lamb K., Heimburger O., Barany P., Radhakrishnan K., Lindholm B., Soveri I., Nordfors L., and Shiels P.G. Telomere attrition is associated with inflammation, low fetuin-A levels and high mortality in prevalent haemodialysis patients. J. Intern. Med. 263 (2008) 302-312
5. Carver C.S., Pozo C., Harris S.D., Noriega V., Scheier M.F., Robinson D.S., Ketcham A.S., Moffat J., Frederick L., and Clark K.C. How coping mediates the effect of optimism on distress: a study of women with early stage breast cancer. J. Pers. Soc. Psychol. 65 (1993) 375-390
6. Cawthon R.M. Telomere measurement by quantitative PCR. Nucleic Acids Res. 30 (2002) e47
7. Cawthon R.M., Smith K.R., O'Brien E., Sivatchenko A., and Kerber R.A. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 361 (2003) 393-395
8. Cohen S., Kamarck T., and Mermelstein R. A global measure of perceived stress. J. Health Soc. Behav. 24 (1983) 385-396
9. Cruess S., Antoni M., Kilbourn K., Ironson G., Klimas N., Fletcher M.A., Baum A., and Schneiderman N. Optimism, distress, and immunologic status in HIV-infected gay men following Hurricane Andrew. Int. J. Behav. Med. 7 (2000) 160-182
10. Damjanovic A.K., Yang Y., Glaser R., Kiecolt-Glaser J.K., Nguyen H., Laskowski B., Zou Y., Beversdorf D.Q., and Weng N. Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer's disease patients. J. Immunol. 179 (2007) 4249-4254
11. Dipietro L., Caspersen C.J., Ostfeld A.M., and Nadel E.R. A survey for assessing physical activity among older adults. Med. Sci. Sports Exer. 25 (1993) 628-642
12. Effros R.B. From Hayflick to Walford: the role of T cell replicative senescence in human aging. Exp. Gerontol. 39 (2004) 885-890
13. Epel E.S., Blackburn E.H., Lin J., Dhabhar F.S., Adler N.E., Morrow J.D., and Cawthon R.M. Accelerated telomere shortening in response to life stress. Proc. Nat. Acad. Sci. USA 101 (2004) 17312-17315
14. Franceschi C., Bonafe M., Valensin S., Oliveri F., De Luca M., Ottaviani E., and De Benedictis G. Inflamm-aging: an evolutionary perspective on immunosenescence. Ann. NY Acad. Sci. 908 (2000) 244-254
15. Giltay E.J., Kamphuis M.H., Kalmijn S., Zitman F.G., and Kromhout D. Dispositional optimism and the risk of cardiovascular death: the Zutphen Elderly Study. Arch. Intern. Med. 166 (2006) 431-436
16. Hastie N.D., Dempster M., Dunlop M.G., Thompson A.M., Green D.K., and Allshire R.C. Telomere reduction in human colorectal carcinoma and with ageing. Nature 346 (1990) 866-868
17. Iwama H., Ohyashiki K., Ohyashiki J.H., Shigifumi H., Yahata N., Ando K., Taoyama K., Hoshika A., Takasaki M., Mori M., and Shay J.W. Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals. Hum. Genet. 102 (1998) 397-402
18. John, O.P., Donahue, E.M., Kentle, R.L., 1991. The Big Five Inventory: versions 4a and 54. Berkeley: University of California, Berkeley, Institute of Personality and Social Research.
19. Kiecolt-Glaser J.K., Preacher K.J., MacCallum R.C., Atkinson C., Malarkey W.B., and Glaser R. Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc. Natl. Acad. Sci. USA 100 (2003) 9090-9095
20. Kimura M., Hjelmborg J.V., Gardner J.P., Bathum L., Brimacombe M., Lu X., Christiansen L., Vaupel J.W., Aviv A., and Christensen K. Telomere length and mortality: a study of leukocytes in elderly Danish twins. Am. J. Epidemiol. 167 (2008) 799-806
21. Matthews K.A., Raikkonen K., Sutton-Tyrrell K., and Kuller L.H. Optimistic attitudes protect against progression of carotid atherosclerosis in healthy middle-aged women. Psychosom. Med. 66 (2004) 640-644
22. Milam J.E., Richardson J.L., Marks G., Kemper C.A., and Mccutchan A.J. The roles of dispositional optimism and pessimism in HIV disease progression. Psychol. Health 19 (2004) 167-181
23. Plomin R., Scheier M.F., Bergeman C.S., Pedersen N.L., Nesselroade J.R., and McClearn G.E. Optimism, pessimism and mental health: a twin/adoption analysis. Pers. Indiv. Diffs. 13 (1992) 921-930
24. Scheier M.F., and Carver C.S. Optimism, coping, and health: assessment and implications of generalized outcome expectancies. Health Psychol. 4 (1985) 219-247
25. Scheier M.F., Carver C.S., and Bridges M.W. Distinguishing optimism from neuroticism (and trait anxiety, self-mastery, and self-esteem): a reevaluation of the Life Orientation Test. J. Pers. Soc. Psychol. 67 (1994) 1063-1078
26. Schulz R., Bookwala J., Knapp J.E., Scheier M., and Williamson G.M. Pessimism, age, and cancer mortality. Psychol. Aging 11 (1996) 304-309
27. Segerstrom S.C. Optimism and immunity: do positive thoughts always lead to positive effects?. Brain Behav. Immun. 19 (2005) 195-200
28. Sharot T., Riccardi A.M., Raio C.M., and Phelps E.A. Neural mechanisms mediating optimism bias. Nat. Med. 450 (2007) 102-105
29. Steptoe A., Willemsen G., Owen N., Flower L., and Mohamed-Ali V. Acute mental stress elicits delayed increases in circulating inflammatory cytokine levels. Clin. Sci. 101 (2001) 185-192
30. Volpato S., Guralnik J.M., Ferrucci L., Balfour J., Chaves P., Fried L.P., and Harris T.B. Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women's health and aging study. Circulation 103 (2001) 947-953
31. Wu K., Higashi N., Hansen E.R., Lund M., Bang K., and Thestrup-Pedersen K. Telomerase activity is increased and telomere length shortened in T cells from blood of patients with atopic dermatitis and psoriasis. J. Immunol. 165 (2000) 4742-4747