Amygdaloid regional cerebral blood flow and subjective fear during symptom provocation in anxiety disorders

Annals of the New York Academy of Sciences

Volumn 985, Issue , 2003, Pages 341-347

  Fredrikson, Mats ^a   Furmark, Tomas ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Amygdala; Anxiety; Fear; Phobia; Positron emission tomography; Trauma

Indexed keywords

SEROTONIN UPTAKE INHIBITOR;

AMYGDALOID NUCLEUS; ANXIETY DISORDER; BEHAVIOR THERAPY; BRAIN BLOOD FLOW; CONFERENCE PAPER; CORRELATION ANALYSIS; DISTRESS SYNDROME; EMOTION; FEAR; FOLLOW UP; HUMAN; PERCEPTION; PHOBIA; POSITRON EMISSION TOMOGRAPHY; PROSPECTIVE STUDY; PROVOCATION; TECHNIQUE;

EID: 0037277395     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2003.tb07092.x     Document Type: Conference Paper

References (29)

1. WHALEN, P.J. 1998. Fear, vigilance and ambiguity: initial neuroimaging studies of the human amygdala. Curr. Direct. Psychol. Sciences 7: 177-188.
2. AMARAL, D.G. 2002. The primate amygdala and the neurobiology of social behavior: implications for understanding social anxiety. Biol. Psychiatry 51: 11-17.
3. LIBERZON, I., S.F. TAYLOR, R. AMDUR, et al. 1999. Brain activation in PTSD in response to trauma-related stimuli. Biol. Psychiatry 45: 817-826.
4. PISSIOTA, A., Ö. FRANS, M. FERNANDEZ, et al. 2002. Neurofunctional correlates of posttraumatic stress disorder: A PET symptom provocation study. Fur. Arch. Psychiatr. Clin. Neurosci. 252: 68-75.
5. RAUCH, S.L., B.A. VAN DER KOLK, R.E. FISLER, et al. 1996. A symptom provocation study of post traumatic stress disorder using positron emission tomography and script-driven imagery. Arch. Gen. Psychiatry 53: 380-387.
6. SEMPLE, W.E., P.F. GOYER, R. McCORMICK, et al. 2000. Higher brain blood flow at amygdala and lower frontal cortex blood flow in PTSD patients with comorbid cocaine and alcohol abuse compared with normals. Psychiatry 63: 65-74.
7. SHIN, L.M., R.J. MCNALLY, S.M. KOSSLYN, et al. 1999. Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD. A PET investigation. Am. J. Psychiatry 156: 575-584.
8. SHIN, L.M., S.M. KOSSLYN, R.J. MCNALLY, et al. 1997. Visual imagery and perception in post traumatic stress disorder. A positron emission tomographic investigation. Arch. Gen. Psychiatry 54: 233-241.
9. BREMNER, J.D., M. NARAYAN, L.H. STAIB, et al. 1999. Neural correlates of memories of childhood sexual abuse in women with and without post traumatic stress disorder. Am. J. Psychiatry. 156: 1787-1795.
10. FREDRIKSON, M., G. WIK, T. GREITZ, et al. 1993. Regional cerebral blood flow during experimental phobic fear. Psychophysiology 30: 126-130.
11. WIK, G., M. FREDRIKSON, K. ERICSON, et al. 1993. A functional cerebral response to frightening visual stimulation. Psychiat. Res. (Neuroimaging) 50: 15-24.
12. FREDRIKSON, M., G. WIK, P. ANNAS, et al. 1995. Functional neuroanatomy of visually elicited simple phobic fear: additional data and theoretical analysis. Psychophysiology 32: 43-48.
13. MOUNTZ, J.M., J.G. MODELL, M.W. WILSON, et al. 1989. Positron emission tomographic evaluation of cerebral blood flow during state anxiety in simple phobia. Arch. Gen. Psychiatry 46: 501-504.
14. RAUCH, S.L., C.R. SAVAGE, N.M. ALPERT, et al. 1995. A positron emission tomographic study of simple phobic symptom provocation. Arch. Gen. Psychiatry 52: 20-28.
15. HETTEMA, J.M., M.C. NEALE & K.S. KENDLER. 2001. A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am. J. Psychiatry 150: 1568-1578.
16. ÖST, L.G. 1987. Age of onset in different phobias. J. Abnorm. Psychol. 96: 223-229.
17. BÜCHEL, C. & R.J. DOLAN. 2000. Classical fear conditioning in functional neuroimaging. Curr. Opin. Neurobiol. 10: 219-223.
18. DAVIS, M. & P.J. WHALEN. 2001. The amygdala: vigilance and emotion. Mol. Psychiatry 6: 13-34.
19. NYBERG, L., A.R. MCINTOSH, S. HOULE, et al. 1996. Activation of medial temporal structures during episodic memory retrieval. Nature 380: 715-717.
20. FURMARK, T., H. FISCHER, G. WIK, et al. 1997. The amygdala and individual differences in human fear conditioning. Neuroreport 8: 3957-3960.
21. FREDRIKSON, M., G. WIK, H. FISCHER & J. ANDERSSON. 1995. Affective and attentive neural networks in humans: a PET study of Pavlovian conditioning. Neuroreport 7: 97-101.
22. TILLFORS, M., T. FURMARK, I. MARTEINSDOTTIR, et al. 2001. Cerebral blood flow in patients with social phobia during stressful speaking tasks: a PET-study. Am. J. Psychiatry 158: 1220-1226.
23. PISSIOTA, A., M.A. FLATEN, Ö. FRANS, et al. 2002. Startle modulation in snake and spider phobics: a regional cerebral blood flow study. Neuroimage Human Brain Mapping 2002 meeting, Sendai.
24. MAI, J.K. 1997. Atlas of the Human Brain. Academic Press. San Diego, CA.
25. GREITZ, T., C. BOHM, S. HOLTE & L. ERIKSSON. 1991. A computerized brain atlas: construction, anatomical content, and some applications. J. Comput. Assist. Tomogr. 15: 26-38.
26. TILLFORS, M., T. FURMARK, I. MARTEINSDOTTIR & M. FREDRIKSON. 2002. Cerebral blood flow during anticipation of public speaking in social phobia: a PET study. Biol. Psychiatry 52: 1113-1119.
27. LABAR K.S., J.C. GATENBY, J.C. GORE, et al. 1998. Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study. Neuron 20: 937-945.
28. LANE, R.D., E.M. REIMAN, B. AXELROD, et al. 1998. Neutral correlates of levels of emotional awareness. Evidence of an interaction between emotion and attention in the anterior cingulate cortex. J. Cogn. Neurosci. 10: 525-535.
29. FURMARK, T., M. TILLFORS, I. MARTEINSDOTTIR, et al. 2002. Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy. Arch. Gen. Psychiatry 59: 425-433.