Effect of a single dose of citalopram on amygdala response to emotional faces

British Journal of Psychiatry

Volumn 194, Issue 6, 2009, Pages 535-540

  Murphy, Susannah E ^a   Norbury, Raymond ^b   O'Sullivan, Ursula ^a   Cowen, Philip J ^a   Harmer, Catherine J ^a  

^a WARNEFORD HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CITALOPRAM; PLACEBO;

ADULT; AMYGDALOID NUCLEUS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; EMOTION; FACIAL EXPRESSION; FEAR; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; THREAT;

ADULT; AMYGDALA; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CITALOPRAM; EMOTIONS; FACIAL EXPRESSION; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; SEROTONIN UPTAKE INHIBITORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 67649223751     PISSN: 00071250     EISSN: 14721465     Source Type: Journal    
DOI: 10.1192/bjp.bp.108.056093     Document Type: Article

References (43)

1. Taylor MJ, Freemantle N, Geddes JR, Bhagwagar Z. Early onset of selective serotonin reuptake inhibitor antidepressant action: systematic review and meta-analysis. Arch Gen Psychiatry 2006; 63: 1217-1223 (Pubitemid 44708080)
2. Posternak MA, Zimmerman M. Is there a delay in the antidepressant effect? A meta-analysis. J Clin Psychiatry 2005; 66: 148-158 (Pubitemid 40314320)
3. Harmer CJ, Shelley NC, Cowen PJ, Goodwin GM. Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition. Am J Psychiatry 2004; 161: 1256-1263 (Pubitemid 38859176)
4. Browning M, Reid C, Cowen PJ, Goodwin GM, Harmer C. A single dose of citalopram increases fear recognition in healthy subjects. J Psychopharmacol 2007; 21: 684-690 (Pubitemid 47437913)
5. Harmer CJ, Bhagwagar Z, Perrett DI, Vollm BA, Cowen PJ, Goodwin GM. Acute SSRI administration affects the processing of social cues in healthy volunteers. Neuropsychopharmacology 2003; 28: 148-152
6. Drevets WC. Neuroimaging abnormalities in the amygdala in mood disorders. Ann NY Acad Sci 2003; 985: 420-444 (Pubitemid 36521131)
7. Sheline YI, Barch DM, Donnelly JM, Ollinger JM, Snyder AZ, Mintun MA. Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study. Biol Psychiatry 2001; 50: 651-658 (Pubitemid 33043767)
8. Fu CH, Williams SC, Cleare AJ, Brammer MJ, Walsh ND, Kim J, et al. Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study. Arch Gen Psychiatry 2004; 61: 877-889 (Pubitemid 39181077)
9. Harmer CJ, Mackay CE, Reid CB, Cowen PJ, Goodwin GM. Antidepressant drug treatment modifies the neural processing of nonconscious threat cues. Biol Psychiatry 2006; 59: 816-820
10. Del-Ben CM, Deakin JF, McKie S, Delvai NA, Williams SR, Elliott R, et al. The effect of citalopram pretreatment on neuronal responses to neuropsychological tasks in normal volunteers: an FMRI study. Neuropsychopharmacology 2005; 30: 1724-1734 (Pubitemid 43090698)
11. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). American Psychiatric Press, 1997.
12. Nelson HE, Willison J. National Adult Reading Test (NART). nferNelson, 1991.
13. Spielberger CD, Gorsuch RL, Lushene RD. Manual for the State-Trait Anxiety inventory (STAI). Consulting Psychologists Press, 1983.
14. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 1961; 4: 561-571
15. von Zerssen D, Strian F, Schwarz D. Evaluation of depressive states, especially in longitudinal studies. Mod Probl Pharmacopsychiatry 1974; 7: 189-202.
16. Watson D, Clark LA, Tellegen A. Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol 1988; 54: 1063-1070
17. Ekman P, Friesen, WV. Pictures of Facial Affect. Consulting Psychologists Press, 1976.
18. Jenkinson M, Bannister P, Brady M, Smith S. Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 2002; 17: 825-841 (Pubitemid 35317016)
19. Smith SM. Fast robust automated brain extraction. Hum Brain Mapp 2002; 17: 143-155 (Pubitemid 35253488)
20. Jenkinson M Smith S. A global optimisation method for robust affine registration of brain images. Med Image Anal 2001; 5: 143-156 (Pubitemid 35282800)
21. Beckmann CF, Jenkinson M, Smith SM. General multilevel linear modeling for group analysis in FMRI. Neuroimage 2003; 20: 1052-1063 (Pubitemid 37268124)
22. Woolrich MW, Behrens TE, Beckmann CF, Jenkinson M, Smith SM. Multilevel linear modelling for FMRI group analysis using Bayesian inference. Neuroimage 2004; 21: 1732-1747 (Pubitemid 38446594)
23. Worsley KJ, Evans AC, Marrett S, Neelin P. A three-dimensional statistical analysis for CBF activation studies in human brain. J Cereb Blood Flow Metab 1992; 12: 900-918
24. Talairach J, Tournoux P. Co-Planar Stereotactic Atlas of the Human Brain. Thieme, 1988.
25. Lancaster JL, Woldroff MG, Parsons LM, Liotti M, Freitas CS, Rainey L, et al. Automated Talairach atlas labels for function brain mapping. Hum Brain Mapp 2000; 10: 120-131 (Pubitemid 30456920)
26. Bhagwagar Z, Cowen PJ, Goodwin GM, Harmer CJ. Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression. Am J Psychiatry 2004; 161: 166-168 (Pubitemid 38419325)
27. Mogg K, Bradley BP. A cognitive-motivational analysis of anxiety. Behav Res Ther 1998; 36: 809-848 (Pubitemid 28377131)
28. Morris JS, Frith CD, Perrett DI, Rowland D, Young AW, Calder AJ, et al. A differential neural response in the human amygdala to fearful and happy facial expressions. Nature 1996; 383: 812-815 (Pubitemid 26372662)
29. Drevets WC, Videen TO, Price JL, Preskorn SH, Carmichael ST, Raichle ME. A functional anatomical study of unipolar depression. J Neurosci 1992; 12: 3628-3641
30. Rauch SL, Shin LM, Wright CI. Neuroimaging studies of amygdala function in anxiety disorders. Ann NY Acad Sci 2003; 985: 389-410. (Pubitemid 36521129)
31. Davidson RJ, Irwin W, Anderle MJ, Kalin NH. The neural substrates of affective processing in depressed patients treated with venlafaxine. Am J Psychiatry 2003; 160: 64-75. (Pubitemid 36042428)
32. Stutzmann GE, LeDoux JE. GABAergic antagonists block the inhibitory effects of serotonin in the lateral amygdala: a mechanism for modulation of sensory inputs related to fear conditioning. J Neurosci 1999; 19: RC8.
33. Drevets WC, Bogers W, Raichle ME. Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism. Eur Neuropsychopharmacol 2002; 12: 527-544 (Pubitemid 35408704)
34. Kent JM, Coplan JD, Gorman JM. Clinical utility of the selective serotonin reuptake inhibitors in the spectrum of anxiety. Biol Psychiatry 1998; 44: 812-24. (Pubitemid 28520220)
35. Burghardt NS, Sullivan GM, McEwen BS, Gorman JM, LeDoux JE. The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: a comparison with tianeptine. Biol Psychiatry 2004; 55: 1171-1178 (Pubitemid 38739451)
36. Attenburrow MJ, Williams C, Odontiadis J, Reed A, Powell J, Cowen PJ, et al. Acute administration of nutritionally sourced tryptophan increases fear recognition. Psychopharmacology (Berl) 2003; 169: 104-107 (Pubitemid 37088620)
37. Neumeister A, Hu XZ, Luckenbaugh DA, Schwarz M, Nugent AC, Bonne O, et al. Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch Gen Psychiatry 2006; 63: 978-986
38. Whalen PJ, Rauch SL, Etcoff NL, Mclnerney SC, Lee MB, Jenike MA. Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. J Neurosci 1998; 18: 411-418 (Pubitemid 28046798)
39. Phillips ML, Williams LM, Heining M, Herba CM, Russell T, Andrew C, et al. Differential neural responses to overt and covert presentations of facial expressions of fear and disgust. Neuroimage 2004; 21: 1484-1496 (Pubitemid 38446573)
40. Bishop SJ, Duncan J, Lawrence AD. State anxiety modulation of the amygdala response to unattended threat-related stimuli. J Neurosci 2004; 24: 10364-10368 (Pubitemid 39552620)
41. Pessoa L, McKenna M, Gutierrez E, Ungerleider LG. Neural processing of emotional faces requires attention. Proc Natl Acad Sci USA 2002; 99: 11458-11463 (Pubitemid 34920947)
42. Wise RG, Tracey I. The role of fMRI in drug discovery. J Magn ResonImaging 2006; 23: 862-876 (Pubitemid 43825441)
43. Iannetti GD, Wise RG. BOLD functional MRI in disease and pharmacological studies: room for improvement? Magn Reson Imaging 2007; 25: 978-988