Localization of human intestinal defensin 5 in paneth cell granules

Infection and Immunity

Volumn 65, Issue 6, 1997, Pages 2389-2395

  Porter, Edith Martin ^a,d   Liu, Lide ^a   Oren, Ami ^b   Anton, Peter A ^c   Ganz, Tomas ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UCLA MEDICAL CENTER   (United States)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DEFENSIN;

ANTIMICROBIAL ACTIVITY; ARTICLE; HOST RESISTANCE; HUMAN; HUMAN CELL; INFECTION RESISTANCE; MUCOSAL IMMUNITY; PANETH CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

EID: 0030914439     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.6.2389-2395.1997     Document Type: Article

References (83)

1. Albores-Saavedra, J., M. Nadji, and D. E. Henson. 1986. Intestinal-type adenocarcinoma of the gallbladder: a clinicopathologic study of seven cases. Am. J. Surg. Pathol. 10:19-25.
2. Aley, S. B., M. Zimmerman, M. Hetsko, M. E. Selsted, and F. D. Gillin. 1994. Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides. Infect. Immun. 62:5397-5403.
3. Apel, R., Z. Cohen, C. W. Andrews, R. McLeod, H. Steinhart, and R. D. Odze. 1994. Prospective evaluation of early morphological changes in pelvic ileal pouches [sec comments]. Gastroenterology 107:435-443.
4. Ariza, A., D. Lopez, E. M. Castella, C. Munoz, M. J. Zujar, and J. L. Mate. 1996. Expression of CD15 in normal and metaplastic Paneth cells of the digestive tract. J. Clin. Pathol. 49:474-477.
5. Bell, W. J., P. F. Weller, M. A. Peppercorn, S. J. Galli, and A. M. Dvorak. 1995. Ultrastructural immunogold localization of subcellular sites of TNF-alpha in colonic Crohn's disease. J. Leukocyte Biol. 58:284-298.
6. Bensch, K. W., M. Raida, H. J. Magert, P. Schulz-Knappe, and W. G. Forssmann. 1995. hBD-1: a novel beta-defens in from human plasma. FEBS Lett. 368:331-335.
7. Bernheimer, A. W., and B. Rudy. 1986. Interactions between membranes and cytolytic peptides. Biochim. Biophys. Acta 864:123-141.
8. Bone, M., A. Borgstrom, C. Lindstrom, and K. Ohlsson. 1986. Pancreatic endoproteases and pancreatic secretory trypsin inhibitor immunoreactivily in human Paneth cells. J. Clin. Pathol, 39:786-793.
9. Bone, M., C. Lindstrom, and K. Ohlsson. 1988. Immunoreactive pancreatic secretory trypsin inhibitor in gastrointestinal mucosa. Adv. Exp. Med. Biol. 240:101-105.
10. Bry, L., P. Falk, K. Huttner, A. Ouellette, T. Midtvedt, and J. I. Gordon. 1994. Paneth cell differentiation in the developing intestine of normal and transgcnic mice. Proc. Natl. Acad. Sci. USA 91:10335-10339.
11. Caffrey, M. S., and M. A. Cusanovich. 1993. Role of the highly conserved trypiophan of cytochrome c in stability. Arch. Biochem. Biophys, 304:205-208.
12. Commans, S., S. Blanquet, and P. Plateau. 1995. A single substitution in the motif 1 of Escherichia coli lysyl-tRNA synthetase induces cooperatively to- ward amino acid binding, Biochemistry 34:8180-8189.
13. Dagert, M., and S. D. Ehrlich. 1979. Prolonged incubation in calcium chloride improves ihc competence of Escheiichia coli cells. Gene 6:23-28.
14. Daher, K. A., R. I. Lehrer, T. Ganz, and M. Kronenberg. 1988. Isolation and characterization of human defensin cDNA clones. Proc. Natl. Acad. Sci. USA 85:7327-7331.
15. Diamond, G., M. Zasloff, H. Eck, M. Brasseur, W. L. Maloy, and C. L. Revins. 1991. Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc. Natl. Acad. Sci. USA 88:3952-3956.
16. Eisenhauer, P. B., S. S. Harwig, and R. I. Lehrer. 1992. Cryptdins: antimicrobial defensins of the murine small intestine. Infect. Immun. 60:3556-3565.
17. Eisenhauer, P. B., and R. I. Lehrer. 1992. Mouse neutrophils lack defensins. Infect. Immun. 60:3446-3447.
18. Evans, G. S., S. Chwalinski, G. Owen, C. Booth, A. Singh, and C. S. Potten. 1994. Expression of pokeweed lectin binding in murine intestinal Paneth cells. Epithelial Cell Biol. 3:7-15.
19. Fasoli, R., I. Talbot, M. Reid, C. Prince, and D. P. Jewell. 1992. Microscopic colitis: can it be qualitatively and quantitatively characterized? Ital. J. Gastroenterol. 24:393-396.
20. Freeman, T. C., R. J. Playford, C. Quinn, K. Beardshall, L. Poulter, J. Young, and J. Calam. 1990. Pancreatic secretory trypsin inhibitor in gastrointestinal mucosa and gastric juice. Gut 31:1318-1323.
21. Gabastou, J. M., S. Kerneis, M. F. Bernet-Camard, A. Barbat, M. H. Coconnier, J. B. Kaper, and A. L. Servin. 1995. Two stages of enteropathogenic Eschcrichia coli intestinal pathogenicity arc up and down-regulated by the epithelial cell differentiation. Differentiation 59:127-134.
22. Ganz, T., and R. I. Lehrer. 1994. Det'ensins. Curr. Opin. Immunol. 6:584-589.
23. Ganz, T., L. Liu, E. V. Valore, and A. Oren. 1993. Posttranslational processing and targeting of transgenic human defensin in murine granulocyte. macrophage, fibroblast, and pituitary adenoma cell lines. Blood 82:641-650.
24. Geboes, K., P. Rutgeerts, G. Vantrappen, and V. J. Desmet. 1983. Immunoreactivity of alpha-1-antitrypsin in the human colon. Hepatognstroenterology 30:24-26.
25. Geboes, K., J. J. Van den Oord, P. Rutgeerts, V. J. Desmet, and G. Vantrappen. 1983. Immunohistochemical Identification of lysozyme in pseudopyloric gland metaplasia in Crohn's disease, Hepatogastroenterology 30:158-160.
26. Harlow, E., and D. Lane. 1988. Antibodies: a laboratory manual, p. 80. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
27. Harwig, S. S., N. P. Chen, A. S. Park, and R. I. Lehrer. 1993. Purification of cysteine-rich bioactive peptides from leukocytes by continuous acid-urea-polyacrylamide gel electrophoresis. Anal. Biochem. 208:382-386.
28. Harwig, S. S., P. B. Eisenhauer, N. P. Chen, and R. I. Lehrer. 1995. Cryptdins: endogenous antibiotic peptides of small intestinal Paneth cells. Adv. Exp. Med. Biol. 371A:251-255.
29. Harwig, S. S., L. Tan, X. D. Qu, Y. Cho, P. B. Eisenhauer, and R. I. Lehrer. 1995. Bactericidal properties of murine intestinal phospholipasc A2. J. Clin. Invest. 95:603-610.
30. Horton, R. M., S. N. Ho, J. K. Pullen, H. D. Hunt, Z. Cai, and L. R. Pease. 1993. Gene splicing by overlap extension. Methods Enzymol. 217:270-279.
31. Jones, D. E., and C. L. Bevins. 1992, Paneth cells of the human small intestine express an antimicrobial peptidc gene. J. Biol. Chem. 267:23216-23225.
32. Jones, D. E., and C. L. Bevins. 1993. Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human howel. FEBS Lett. 315:187-192.
33. Killion, J. J., and J. D. Dunn. 1986. Differential cytolysis of murine spleen, hone-marrow and leukemia cells by molittin reveals differences in membrane topography. Biochem. Biophys. Res. Commun. 139:222-227.
34. Kiyohara, H., H. Egami, Y. Shibata, K. Murata, S. Ohshima, and M. Ogawa. 1942. Light microscopic immunohistochemical analysis of the distribution of group II phospholipase A2 in human digestive organs. J. Histochem. Cytochem. 40:1659-1664.
35. Klockars, M., and S. Reitamo. 1975. Tissue distribution of lysozyme in man. J. Histochem. Cytochem. 23:932-940.
36. Kurumaya, H., T. Terada, and Y. Nakanuma. 1990. 'Metaplastic lesions' in intrahepatic bile ducts in hepatolithiasis: a histochemical and immunohistochemical study. J. Gastroenterol. Hepatol. 5:530-536.
37. Lacasse, J., and L. H. Martin. 1992. Detection of CD1 mRNA in Paneth cells of the mouse intestine by in situ hybridization. J. Histochem. Cytochem. 40:1527-1534.
38. Lehrer, R. I., M. Rosenman, S. S. Harwig, R. Jackson, and P. Eisenhauer. 1991. Ultrasensitive assays for endogenous antimicrobial polypeptides. J. Immunol. Methods 137:167-173.
39. Levy, O. 1996. Antibiotic proteins of polymorphonuclear leukocytes. Eur. J. Haematol. 56:263-277.
40. Lichtenstein, A., T. Ganz, M. E. Selsted, and R. I. Lehrer. 1986. In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes. Blood 68:1407-1410.
41. Liu, L., and T. Ganz. 1995. The pro region of human neutrophil defensin contains a motif that is essential for normal subcellular sorting. Blood 85: 1095-1103.
42. Makapugay, L. M., and P. J. Dean. 1996. Diverticular disease-associated chronic colitis. Am. J. Surg. Pathol. 20:94-102.
43. Mallow, E. B., A. Harris, N. Salzman, J. P. Russell, R. J. DeBerardinis, E. Ruchelli, and C. L. Bevins. 1996. Human enteric defensins: gene structure and developmental expression, J. Biol. Chem. 271:4038-4045.
44. Mason, D. Y., and C. R. Taylor. 1975. The distribution of muramidase (lysozyme) in human tissues. J. Clin. Pathol. 28:124-132.
45. Masty, J., and R. P. Stradley. 1991, Paneth cell degranulation and lysozyme secretion during acute equine alimentary laminitis. Histochemistry 95:529-533.
46. McCluggage, W. G., N. Roberts, and H. Bharucha. 1995. Enteric differentiation in endometrial adenocarcinomas: a mucin histochemical study. Int. J. Gynecol. Pathol. 14:250-254.
47. Molmenti, E. P., D. H. Perlmutter, and D. C. Rubin. 1993. Cell-specific expression of alpha 1-antitrypsin in human intestinal epithelium. J. Clin. Invest. 92:2022-2034.
48. Murphy, C. J., B. A. Foster, M. J. Mannis, M. E. Selsted, and T. W. Reid. 1993. Defensins are mitogenic for epithelial cells and fibroblasts. J. Cell. Physiol. 155:408-413.
49. Nevalainen, T. J., J. M. Gronroos, and M. Kallajoki. 1995. Expression of group H phospholipase A2 in the human gastrointestinal tract. Lab. Invest. 72:201-208.
50. Odze, R., D. Antonioli, M. Peppercorn, and H. Goldman. 1993. Effect of topical 5-aminosalicylic acid (5-ASA) therapy on rectal mucosal biopsy morphology in chronic ulcerative colitis. Am. J. Surg. Pathol. 17:869-875.
51. Okrent, D. G., A. K. Lichtenstein, and T. Ganz. 1990. Direct cytotoxicity of polymorphonuclear leukocyte granule proteins to human lung-derived cells and endothelial cells. Am. Rev. Respir. Dis. 141:179-185.
52. Olsen, J., G. M. Cowell, E. Konigshofer, E. M. Danielsen, J. Moller, L. Laustsen, O. C. Hansen, K. G. Welinder, J. Engberg, and W. Hunziker. 1988. Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA. FEBS Lett. 238:3117-314.
53. Ooi. A., I. Nakanlshi, T. Itoh, H. Ueda, and M. Mat. 1991. Predominant Paneth cell differentiation in an intestinal type gastric cancer. Pathol. Res. Pract. 187:2211-225.
54. Ouellette, A. J., and J. C. Lualdi. 1990. A novel mouse gene family coding for cationic, cysteinc-rich poptides: regulation in small intestine and cells of myeloid origin. J. Biol. Chem. 265:9831-9837.
55. Panyutich, A.V., N. N. Voitenok, R. I. Lehrer, and T. Ganz. 1991. An enzyme immunoassay for human defensins. J. Immunol. Methods 141:149-155.
56. 55a.Porter, E. M., E. van Dam, E. V. Valore, and T. Ganz, 1997. Broad-spectrum antimicrobial activity of human intestinal defensin 5. Infect. Immun. 65: 2396-2401.
57. Poulsen, S. S., E. Nexo, P. S. Olsen, J. Hess, and P. Kirkegaard. 1986. Immunohistochemical localization of epidermal growth factor in rat and man. Hisiochemisiry 85:389-394.
58. Russell, J. P., G. Diamond, A. P. Tarver, T. F. Scanlin, and C. L. Revins. 1996. Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha. Infect. Immun. 64:1565-1568.
59. Salto, H., T. Kasajima, A. Masuda, Y. Imai, and M. Ishikawa. 1988. Lysozyme localization in human gastric and duodenal epithelium: an immunocytochemical study. Cell Tissue Res. 251:307-313.
60. Sancho, J., and A. R. Fersht. 1992. Dissection of an enzyme by protein engineering: the N and C-terminal fragments of barnase form a native-like complex with restored enzymic activity. J. Mol. Biol. 224:741-747.
61. Santini, D., G. Pasquinelli, G. Mazzoleni, M. C. Gelli, P. Preda, M. Taffurelli, D. Marrano, and G. Martinelli. 1992. Lysozyme localization in normal and diseased human gastric and colonic mucosa: a correlative histochemical, immunohistochemical and immunoelectron microscopic investigation. APMIS 100:575-585.
62. Satoh, Y. 1988. Effect of live and heat-killed bacteria on the secretory activity of Paneth cells in germ-free mice. Cell Tissue Res. 251:87-93.
63. Satoh, Y., K. Ishikawa, Y. Oomori, S. Takeda, and K. Ono. 1992. Bethanechol and a G-protein activator. NaF/AICI3, induce secretory response in Paneth cells of mouse intestine. Cell Tissue Res. 269:213-220.
64. Satoh, Y., K. Ishikawa, H. Tanaka, and K. Ono. 1986. Immunohistochemical observations of immunoglobulin A in the Paneth cells of germ-free and formerly-germ-free rats. Histochemistry 85:197-201.
65. Schagger, H., and G. von Jagow. 1987. Tricine-sodium dodecyl sulfatepolyacrylamide gel elcctrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166:368-379.
66. Schattenfroh, S., M. Bartels, and E. Nagel. 1994. Early morphological changes in Crohn's disease. Transmission electron-microscopic findings and their interpretation: an overview. Acta Anat. (Basel) 149:237-246.
67. Schmauder-Chock, E. A., S. P. Chock, and M. L. Patchen. 1994. Ultrastructural localization of tumour necrosis factor-alpha. Histochem. J. 26:142-151.
68. Schonwetter, B. S., E. D. Stolzenberg, and M. A. Zasluff. 1995. Epithelial antibiotics induced at sites of inflammation. Science 267:1645-1648.
69. Scocchi, M., B. Skerlavaj, D. Romeo, and R. Gennaro. 1992. Proteolytic cleavage by neutrophil elastase converts inactive storage proforms to antibacterial bactenecins. Eur. J. Biochem. 209:589-595.
70. 68a.Selsted, M. Personal communication.
71. Selsted, M. E., S. I. Miller, A. H. Menschen, and A. J. Ouellette. 1992. Enteric defensins: antibiotic peptide components of intestinal host defense. J. Cell Biol. 118:929-936.
72. Selsted, M. E., Y. Q. Tang, W. L. Morris, P. A. McGuire, M. J. Novotny, W. Smith, A. H. Menschen, and J. S. Cullor. 1993. Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial pcptides from bovine neutrophils. J. Biol. Chem. 268:6641-6048.
73. Senegas-Balas, F. O., C. G. Figarella, M. A. Amouric, O. M. Guy-Crotte, C. A. Bertrand, and D. C. Balas. 1991. Immunocytochemical demonstration of a pancreatic secretory protein of unknown function in human duodenum. J. Histochem. Cytochem. 39:915-919.
74. Shenoy, B. C., D. Samols, and G. K. Kumar. 1993. The conserved methionines of the 1.3 S biotinyl subunit of transcarboxylase: effect of mutations on conformation and activity. Arch. Biochem. Biophys. 304:359-366.
75. Singh, P., B. Dai, U. Yallampalli, X. Lu, and P. C. Schroy. 1996. Proliferation and differentiation of a human colon cancer cell line (CaCo2) is associated with significant changes in the expression and secretion of insulin-like growth factor (IGF) IGF-II and IGF binding protein-4: role of IGF-II. Endocrinology 137:1764-1774.
76. Tan, X., W. Hsueh, and F. Gonzalez-Crussi. 1993. Cellular localization of tumor necrosis factor (TNF)-alpha transcripts in normal bowel and in necrotizing enterocolitis. TNF gene expression by Paneth cells, intestinal eosinophils, and macrophages. Am. J. Pathol. 142:1858-1865.
77. Taylor, A. 1993. Aminopeptidases: structure and function. FASEB J. 7:290-298.
78. Vallette, F., E. Mege, A. Reiss, and M. Adesnik. 1989. Construction of mutant and chimeric nenes using the polymerase chain reaction. Nucleic Acids Res. 17:723-733.
79. Valore, E., A. Quale, C. Robbins, and T. Ganz. 1996. A human beta-defensin is produced by urogenital epithelia, J. Invest. Mod. 44:268A. (Abstract.)
80. Valore, E. V., E. Martin, S. S. Harwig, and T. Ganz. 1996. Intramolecular inhibition of human defcnsin HNP-1 by its propiece. J. Clin. Invest. 97:1624-1629.
81. Villa, S., G. De Fazio, and U. Canosi. 1989, Cyanogen bromide cleavage at methionine residues of polypeptides containing disullide bonds. Anal. Biochem. 177:161-164.
82. Wakefield, J. K., S. A. Jahlonski, and C. D. Morrow. 1992. In vitro enzymatic activity of human immunodeficiency virus type 1 reverse transcriptase mutants in the highly conserved YMDD amino ncid motif correlates with the infectious potential of the proviral genome. J. Virol. 66:6806-6812.
83. Walev, I., M. Palmer, E. Martin, D. Jonas, U. Weller, H. Hohn-Bentz, M. Husmann, and S. Bhakdi. 1994. Recovery of human fibroblasts from attack by the pore-forming alpha-toxin of Staphylococcus aureus. Microb. Pathog. 17:187-201.