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Volumn 83, Issue 8, 2005, Pages 587-595

Human defensins

Author keywords

Antimicrobial peptides; HBD 3; HBD 4; Human defensins; Human neutrophil peptides

Indexed keywords

ALPHA DEFENSIN; AMINO ACID; BETA DEFENSIN; BETA DEFENSIN 1; BETA DEFENSIN 2; BETA DEFENSIN 3; BETA DEFENSIN 4; DEFENSIN; PEPTIDE;

EID: 23844442574     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-005-0657-1     Document Type: Review
Times cited : (311)

References (99)
  • 1
    • 0342369486 scopus 로고    scopus 로고
    • Antimicrobial peptides as potential new antifungals
    • Müller F-MC, Lyman CA, Walsh TJ (1999) Antimicrobial peptides as potential new antifungals. Mycoses 42 [Suppl 2]:77-82
    • (1999) Mycoses , vol.42 , Issue.2 SUPPL. , pp. 77-82
    • Müller, F.-M.C.1    Lyman, C.A.2    Walsh, T.J.3
  • 4
    • 0032313341 scopus 로고    scopus 로고
    • Epithelial antimicrobial peptides: Review and significance for oral applications
    • Weinberg A, Krisanaprakornkit S, Dale BA (1998) Epithelial antimicrobial peptides: review and significance for oral applications. Crit Rev Oral Biol Med 9:399-414
    • (1998) Crit Rev Oral Biol Med , vol.9 , pp. 399-414
    • Weinberg, A.1    Krisanaprakornkit, S.2    Dale, B.A.3
  • 5
    • 0033213989 scopus 로고    scopus 로고
    • Epithelial antimicrobial peptides: Innate local host response elements
    • Schröder J-M (1999) Epithelial antimicrobial peptides: innate local host response elements. Cell Mol Life Sci 56:32-46
    • (1999) Cell Mol Life Sci , vol.56 , pp. 32-46
    • Schröder, J.-M.1
  • 6
    • 0028933794 scopus 로고
    • Peptide antibiotics and their role in innate immunity
    • Boman HG (1995) Peptide antibiotics and their role in innate immunity. Annu Rev Immunol 13:61-92
    • (1995) Annu Rev Immunol , vol.13 , pp. 61-92
    • Boman, H.G.1
  • 7
    • 0032958766 scopus 로고    scopus 로고
    • Antifungal peptides: Novel therapeutic compounds against emerging pathogens
    • De Lucca AJ, Walsh TJ (1999) Antifungal peptides: novel therapeutic compounds against emerging pathogens. Antimicrob Agents Chemother 43:1-11
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 1-11
    • De Lucca, A.J.1    Walsh, T.J.2
  • 8
    • 0031039956 scopus 로고    scopus 로고
    • Peptide antibiotics
    • Hancock RE (1997) Peptide antibiotics. Lancet 249:418-422
    • (1997) Lancet , vol.249 , pp. 418-422
    • Hancock, R.E.1
  • 10
    • 0033067196 scopus 로고    scopus 로고
    • Antimicrobial peptides in mammalian and insect host defence
    • Lehrer RI, Ganz T (1999) Antimicrobial peptides in mammalian and insect host defence. Curr Opin Immunol 11:23-27
    • (1999) Curr Opin Immunol , vol.11 , pp. 23-27
    • Lehrer, R.I.1    Ganz, T.2
  • 12
    • 0033044786 scopus 로고    scopus 로고
    • Antimicrobial peptides as mediators of epithelial host defense
    • Huttner KM, Bevins CL (1999) Antimicrobial peptides as mediators of epithelial host defense. Pediatr Res 45:785-794
    • (1999) Pediatr Res , vol.45 , pp. 785-794
    • Huttner, K.M.1    Bevins, C.L.2
  • 14
    • 0030027096 scopus 로고    scopus 로고
    • Human enteric defensin genes: Chromosomal map position and a model of possible evolutionary relationships
    • Bevins CL, Jones DE, Dutra A, Schaffzin J, Muenke MM (1996) Human enteric defensin genes: chromosomal map position and a model of possible evolutionary relationships. Genomics 31:95-106
    • (1996) Genomics , vol.31 , pp. 95-106
    • Bevins, C.L.1    Jones, D.E.2    Dutra, A.3    Schaffzin, J.4    Muenke, M.M.5
  • 15
    • 0031213832 scopus 로고    scopus 로고
    • The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: Two peptide families with differing disulfide topology share a common ancestry
    • Liu L, Zhao C, Heng HH, Ganz T (1997) The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry. Genomics 43:316-320
    • (1997) Genomics , vol.43 , pp. 316-320
    • Liu, L.1    Zhao, C.2    Heng, H.H.3    Ganz, T.4
  • 17
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ, Ganz T (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276:7806-7810
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 18
    • 0033569410 scopus 로고    scopus 로고
    • A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins
    • Tang YQ, Yuan J, Osapay G, Osapay K, Tran D, Miller CJ, Ouellette AJ, Selsted ME (1999) A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science 286:489-502
    • (1999) Science , vol.286 , pp. 489-502
    • Tang, Y.Q.1    Yuan, J.2    Osapay, G.3    Osapay, K.4    Tran, D.5    Miller, C.J.6    Ouellette, A.J.7    Selsted, M.E.8
  • 19
    • 33645343332 scopus 로고    scopus 로고
    • Angiogenin: An antimicrobial ribonuclease
    • Ganz T (2003) Angiogenin: an antimicrobial ribonuclease. Nat Immunol 5:836-843
    • (2003) Nat Immunol , vol.5 , pp. 836-843
    • Ganz, T.1
  • 20
    • 4444246183 scopus 로고    scopus 로고
    • Increased diversity of intestinal antimicrobial peptides by covalent dimmer formation
    • Hornef MW, Pütsep K, Karlsson J, Refai E, Andersson M (2004) Increased diversity of intestinal antimicrobial peptides by covalent dimmer formation. Nat Immunol 5:836-843
    • (2004) Nat Immunol , vol.5 , pp. 836-843
    • Hornef, M.W.1    Pütsep, K.2    Karlsson, J.3    Refai, E.4    Andersson, M.5
  • 21
    • 0028844134 scopus 로고
    • Cathelicidins: A novel protein family with a common proregion and a variable C-terminal antimicrobial domain
    • Zanetti M, Gennaro R, Romeo D (1995) Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain. FEBS Lett 374:1-5
    • (1995) FEBS Lett , vol.374 , pp. 1-5
    • Zanetti, M.1    Gennaro, R.2    Romeo, D.3
  • 22
    • 0028331319 scopus 로고
    • Defensins: A family of antimicrobial and cytotoxic peptides
    • Kagan BL, Ganz T, Lehrer RI (1994) Defensins: a family of antimicrobial and cytotoxic peptides. Toxicology 87:131-149
    • (1994) Toxicology , vol.87 , pp. 131-149
    • Kagan, B.L.1    Ganz, T.2    Lehrer, R.I.3
  • 23
    • 0025903814 scopus 로고
    • Crystal structure of defensin HNP-3, an amphiphilic dimer: Mechanisms of membrane permeabilization
    • Hill CP, Yee J, Selsted ME, Eisenberg D (1991) Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization. Science 251:1481-1485
    • (1991) Science , vol.251 , pp. 1481-1485
    • Hill, C.P.1    Yee, J.2    Selsted, M.E.3    Eisenberg, D.4
  • 24
    • 0035188391 scopus 로고    scopus 로고
    • Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity
    • Bauer F, Schweimer K, Klüver E, Conejo-Garcia JR, Forssmann WG, Rösch P, Adermann K, Sticht H (2001) Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity. Protein Sci 10:2470-2479
    • (2001) Protein Sci , vol.10 , pp. 2470-2479
    • Bauer, F.1    Schweimer, K.2    Klüver, E.3    Conejo-Garcia, J.R.4    Forssmann, W.G.5    Rösch, P.6    Adermann, K.7    Sticht, H.8
  • 25
    • 0028825285 scopus 로고
    • Solution structure of bovine neutrophil beta-defensin-2: The peptide fold of the beta-defensins is identical to that of the classical defensins
    • Zimmermann GR, Legault P, Selsted ME, Pardi A (1995) Solution structure of bovine neutrophil beta-defensin-2: the peptide fold of the beta-defensins is identical to that of the classical defensins. Biochemistry 34:13663-13671
    • (1995) Biochemistry , vol.34 , pp. 13663-13671
    • Zimmermann, G.R.1    Legault, P.2    Selsted, M.E.3    Pardi, A.4
  • 26
    • 0027032002 scopus 로고
    • Defensins: Endogeneous antibiotic peptides from human leukocytes
    • Lehrer RI, Ganz T (1992) Defensins: endogeneous antibiotic peptides from human leukocytes. Ciba Found Symp 171:276-290
    • (1992) Ciba Found Symp , vol.171 , pp. 276-290
    • Lehrer, R.I.1    Ganz, T.2
  • 27
    • 0024511945 scopus 로고
    • Determination of the disulfide array in the human defensin HNP-2: A covalently cyclized peptide
    • Selsted ME, Harwig SS (1989) Determination of the disulfide array in the human defensin HNP-2: a covalently cyclized peptide. J Biol Chem 264:4003-4007
    • (1989) J Biol Chem , vol.264 , pp. 4003-4007
    • Selsted, M.E.1    Harwig, S.S.2
  • 28
    • 0027981211 scopus 로고
    • Structure and dynamics of the neutrophil defensins NP-2, NP-5, and HNP-1: NMR studies of amide hydrogen exchange kinetics
    • Skalicky JJ, Selsted ME, Pardi A (1994) Structure and dynamics of the neutrophil defensins NP-2, NP-5, and HNP-1: NMR studies of amide hydrogen exchange kinetics. Proteins 20:52-67
    • (1994) Proteins , vol.20 , pp. 52-67
    • Skalicky, J.J.1    Selsted, M.E.2    Pardi, A.3
  • 31
    • 0024370068 scopus 로고
    • Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family
    • Wilde CG, Griffith JE, Marra NN, Snable JL, Scott RW (1989) Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. J Biol Chem 264:11200-11203
    • (1989) J Biol Chem , vol.264 , pp. 11200-11203
    • Wilde, C.G.1    Griffith, J.E.2    Marra, N.N.3    Snable, J.L.4    Scott, R.W.5
  • 32
    • 0029811094 scopus 로고    scopus 로고
    • Interactions of monomeric rabbit neutrophil defensins with bilayers: Comparison with dimeric human defensin HNP-2
    • Hristova K, Selsted ME, White SH (1996) Interactions of monomeric rabbit neutrophil defensins with bilayers: comparison with dimeric human defensin HNP-2. Biochemistry 35:11888-11894
    • (1996) Biochemistry , vol.35 , pp. 11888-11894
    • Hristova, K.1    Selsted, M.E.2    White, S.H.3
  • 33
    • 0030942221 scopus 로고    scopus 로고
    • Purification and characterization of defensins from cystic fibrosis sputum
    • Soong LB, Ganz T, Ellison A, Caughey GH (1997) Purification and characterization of defensins from cystic fibrosis sputum. Inflamm Res 46:98-102
    • (1997) Inflamm Res , vol.46 , pp. 98-102
    • Soong, L.B.1    Ganz, T.2    Ellison, A.3    Caughey, G.H.4
  • 35
    • 0037417311 scopus 로고    scopus 로고
    • Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin
    • Salzman NH, Ghosh D, Huttner KM, Paterson Y, Bevins CL (2003) Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 422:522-526
    • (2003) Nature , vol.422 , pp. 522-526
    • Salzman, N.H.1    Ghosh, D.2    Huttner, K.M.3    Paterson, Y.4    Bevins, C.L.5
  • 38
    • 0031898688 scopus 로고    scopus 로고
    • Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract
    • Quayle AJ, Porter E, Nussbaum AA, Wang YM, Brabec C, Yip K-P, Mok SC (1998) Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract. Am J Pathol 152:1247-1258
    • (1998) Am J Pathol , vol.152 , pp. 1247-1258
    • Quayle, A.J.1    Porter, E.2    Nussbaum, A.A.3    Wang, Y.M.4    Brabec, C.5    Yip, K.-P.6    Mok, S.C.7
  • 40
    • 0027474382 scopus 로고
    • Defensins: Antimicrobial and cytotoxic peptides of mammalian cells
    • Lehrer RI, Lichtenstein AK, Ganz T (1993) Defensins: antimicrobial and cytotoxic peptides of mammalian cells. Annu Rev Immunol 11:105-128
    • (1993) Annu Rev Immunol , vol.11 , pp. 105-128
    • Lehrer, R.I.1    Lichtenstein, A.K.2    Ganz, T.3
  • 41
    • 0022977989 scopus 로고
    • Direct inactivation of viruses by human granulocyte defensins
    • Daher KA, Selsted ME, Lehrer RI (1986) Direct inactivation of viruses by human granulocyte defensins. J Virol 60:1068-1074
    • (1986) J Virol , vol.60 , pp. 1068-1074
    • Daher, K.A.1    Selsted, M.E.2    Lehrer, R.I.3
  • 42
    • 0023945703 scopus 로고
    • Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations
    • Lehrer RI, Ganz T, Szklarek D, Selsted ME (1988) Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations. J Clin Invest 81:1829-1835
    • (1988) J Clin Invest , vol.81 , pp. 1829-1835
    • Lehrer, R.I.1    Ganz, T.2    Szklarek, D.3    Selsted, M.E.4
  • 43
    • 0028362109 scopus 로고
    • Inhibition of intracellular Histoplasma capsulatum replication by murine macrophages that produce human defensin
    • Couto MA, Liu L, Lehrer RI, Ganz T (1994) Inhibition of intracellular Histoplasma capsulatum replication by murine macrophages that produce human defensin. Infect Immun 62:2375-2378
    • (1994) Infect Immun , vol.62 , pp. 2375-2378
    • Couto, M.A.1    Liu, L.2    Lehrer, R.I.3    Ganz, T.4
  • 44
    • 0030913746 scopus 로고    scopus 로고
    • Broad-spectrum antimicrobial activity of human intestinal defensin 5
    • Porter EM, Van Dam E, Valore EV, Ganz T (1997) Broad-spectrum antimicrobial activity of human intestinal defensin 5. Infect Immun 65:2396-2601
    • (1997) Infect Immun , vol.65 , pp. 2396-2601
    • Porter, E.M.1    Van Dam, E.2    Valore, E.V.3    Ganz, T.4
  • 45
    • 0027414945 scopus 로고
    • Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils
    • Tang YQ, Selsted ME (1993) Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils. J Biol Chem 268:6649-6653
    • (1993) J Biol Chem , vol.268 , pp. 6649-6653
    • Tang, Y.Q.1    Selsted, M.E.2
  • 46
    • 0025811874 scopus 로고
    • Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: Peptide isolation and cloning of a cDNA
    • Diamond G, Zasloff M, Eck H, Brasseur M, Maloy WL, Bevins CL (1991) Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc Natl Acad Sci USA 88:3952-3956
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3952-3956
    • Diamond, G.1    Zasloff, M.2    Eck, H.3    Brasseur, M.4    Maloy, W.L.5    Bevins, C.L.6
  • 47
    • 0028902757 scopus 로고
    • Epithelial antibiotics induced at sites of inflammation
    • Schonwetter BS, Stolzenberg ED, Zasloff MA (1995) Epithelial antibiotics induced at sites of inflammation. Science 267:1645-1648
    • (1995) Science , vol.267 , pp. 1645-1648
    • Schonwetter, B.S.1    Stolzenberg, E.D.2    Zasloff, M.A.3
  • 50
  • 51
    • 0030569343 scopus 로고    scopus 로고
    • Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells
    • Zhao C, Wang I, Lehrer RI (1996) Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett 396:319-322
    • (1996) FEBS Lett , vol.396 , pp. 319-322
    • Zhao, C.1    Wang, I.2    Lehrer, R.I.3
  • 53
    • 0031662487 scopus 로고    scopus 로고
    • Expression of the peptide antibiotic human β-defensin 1 in cultured gingival epithelial cells and gingival tissue
    • Krisanaprakornkit S, Weinberg A, Perez CN, Dale BA (1998) Expression of the peptide antibiotic human β-defensin 1 in cultured gingival epithelial cells and gingival tissue. Infect Immun 66:4222-4228
    • (1998) Infect Immun , vol.66 , pp. 4222-4228
    • Krisanaprakornkit, S.1    Weinberg, A.2    Perez, C.N.3    Dale, B.A.4
  • 55
    • 0030949875 scopus 로고    scopus 로고
    • Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis
    • Goldman MJ, Anderson GM, Stolzenberg ED, Kart UP, Zasloff M, Wilson JM (1997) Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 88:553-580
    • (1997) Cell , vol.88 , pp. 553-580
    • Goldman, M.J.1    Anderson, G.M.2    Stolzenberg, E.D.3    Kart, U.P.4    Zasloff, M.5    Wilson, J.M.6
  • 56
    • 0030814886 scopus 로고    scopus 로고
    • Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease control subjects
    • Knowles MR, Robinson JM, Wood RE, Pue CA, Mentz WM, Wager GC, Gatzy JT, Boucher RC (1997) Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease control subjects. J Clin Invest 100:2588-2595
    • (1997) J Clin Invest , vol.100 , pp. 2588-2595
    • Knowles, M.R.1    Robinson, J.M.2    Wood, R.E.3    Pue, C.A.4    Mentz, W.M.5    Wager, G.C.6    Gatzy, J.T.7    Boucher, R.C.8
  • 57
    • 0032433707 scopus 로고    scopus 로고
    • Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
    • Matsui H, Grubb BR, Tarran R, Randell SH, Gatzy JT, Davis CW, Boucher RC (1998) Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 95:1005-1015
    • (1998) Cell , vol.95 , pp. 1005-1015
    • Matsui, H.1    Grubb, B.R.2    Tarran, R.3    Randell, S.H.4    Gatzy, J.T.5    Davis, C.W.6    Boucher, R.C.7
  • 59
    • 0032169557 scopus 로고    scopus 로고
    • Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung
    • Bals R, Wang X, Wu Z, Freeman T, Bafna V, Zasloff M, Wilson JM (1998) Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest 102:874-880
    • (1998) J Clin Invest , vol.102 , pp. 874-880
    • Bals, R.1    Wang, X.2    Wu, Z.3    Freeman, T.4    Bafna, V.5    Zasloff, M.6    Wilson, J.M.7
  • 61
    • 0347478183 scopus 로고    scopus 로고
    • Use of human reconstructed epidermis to analyze the regulation of beta-defensin hBD-1, hBD-2, and hBD-3 expression in response to LPS
    • Chadebech P, Goidin D, Jacquet C, Viac J, Schmitt D, Staquet MJ (2003) Use of human reconstructed epidermis to analyze the regulation of beta-defensin hBD-1, hBD-2, and hBD-3 expression in response to LPS. Cell Biol Toxicol 19:313-324
    • (2003) Cell Biol Toxicol , vol.19 , pp. 313-324
    • Chadebech, P.1    Goidin, D.2    Jacquet, C.3    Viac, J.4    Schmitt, D.5    Staquet, M.J.6
  • 62
    • 2142761642 scopus 로고    scopus 로고
    • Malassezia furfur induces the expression of β-defensin-2 in human keratinocytes in a protein kinase C-dependent manner
    • Donnarumma G, Paoletti I, Buommino E, Orlando M, Tufano MA, Baroni A (2004) Malassezia furfur induces the expression of β-defensin-2 in human keratinocytes in a protein kinase C-dependent manner. Arch Dermatol Res 295:474-481
    • (2004) Arch Dermatol Res , vol.295 , pp. 474-481
    • Donnarumma, G.1    Paoletti, I.2    Buommino, E.3    Orlando, M.4    Tufano, M.A.5    Baroni, A.6
  • 64
    • 6344248652 scopus 로고    scopus 로고
    • Protease-activated receptor signaling increases epithelial antimicrobial peptide expression
    • Chung WO, Hansen SR, Rao D, Dale BA (2004) Protease-activated receptor signaling increases epithelial antimicrobial peptide expression. J Immunol 173:5165-5170
    • (2004) J Immunol , vol.173 , pp. 5165-5170
    • Chung, W.O.1    Hansen, S.R.2    Rao, D.3    Dale, B.A.4
  • 65
    • 0035937107 scopus 로고    scopus 로고
    • Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic
    • Harder J, Bartels J, Christophers E, Schröder JM (2001) Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 276:5707-5713
    • (2001) J Biol Chem , vol.276 , pp. 5707-5713
    • Harder, J.1    Bartels, J.2    Christophers, E.3    Schröder, J.M.4
  • 67
    • 0033981142 scopus 로고    scopus 로고
    • Transcriptional regulation of β-defensin gene expression in tracheal epithelial cells
    • Diamond G, Kaiser V, Rhodes J, Russell JP, Bevins CL (2000) Transcriptional regulation of β-defensin gene expression in tracheal epithelial cells. Infect Immun 68:113-119
    • (2000) Infect Immun , vol.68 , pp. 113-119
    • Diamond, G.1    Kaiser, V.2    Rhodes, J.3    Russell, J.P.4    Bevins, C.L.5
  • 70
    • 0033605557 scopus 로고    scopus 로고
    • Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides
    • Peschel A, Otto M, Jack RW, Kalbacher H, Jung G, Gotz F (1999) Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides. J Biol Chem 274:8405-8410
    • (1999) J Biol Chem , vol.274 , pp. 8405-8410
    • Peschel, A.1    Otto, M.2    Jack, R.W.3    Kalbacher, H.4    Jung, G.5    Gotz, F.6
  • 71
    • 0024391711 scopus 로고
    • Interaction of human defensins with Escherichia coli: Mechanism of bactericidal activity
    • Lehrer RI, Barton A, Daher K, Harwig SS, Ganz T, Selsted ME (1989) Interaction of human defensins with Escherichia coli: mechanism of bactericidal activity. J Clin Invest 84:553-561
    • (1989) J Clin Invest , vol.84 , pp. 553-561
    • Lehrer, R.I.1    Barton, A.2    Daher, K.3    Harwig, S.S.4    Ganz, T.5    Selsted, M.E.6
  • 72
    • 0025021992 scopus 로고
    • Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes
    • Kagan BL, Selsted ME, Ganz T, Lehrer RI (1990) Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci USA 87:210-214
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 210-214
    • Kagan, B.L.1    Selsted, M.E.2    Ganz, T.3    Lehrer, R.I.4
  • 73
    • 0027218376 scopus 로고
    • Defensins promote fusion and lysis of negatively charged membranes
    • Fujii G, Selsted ME, Eisenberg D (1993) Defensins promote fusion and lysis of negatively charged membranes. Protein Sci 2:1301-1312
    • (1993) Protein Sci , vol.2 , pp. 1301-1312
    • Fujii, G.1    Selsted, M.E.2    Eisenberg, D.3
  • 74
    • 0028061984 scopus 로고
    • Interactions between human defensins and lipid bilayers: Evidence for formation of multimeric pores
    • Wimley WC, Selsted ME, White SH (1994) Interactions between human defensins and lipid bilayers: evidence for formation of multimeric pores. Protein Sci 3:1362-1373
    • (1994) Protein Sci , vol.3 , pp. 1362-1373
    • Wimley, W.C.1    Selsted, M.E.2    White, S.H.3
  • 75
    • 0031034840 scopus 로고    scopus 로고
    • Differential scanning microcalorimetry indicates that human defensin, HNP-2, interacts specifically with biomembrane mimetic systems
    • Lohner K, Latal A, Lehrer RI, Ganz T (1997) Differential scanning microcalorimetry indicates that human defensin, HNP-2, interacts specifically with biomembrane mimetic systems. Biochemistry 36:1525-1531
    • (1997) Biochemistry , vol.36 , pp. 1525-1531
    • Lohner, K.1    Latal, A.2    Lehrer, R.I.3    Ganz, T.4
  • 76
    • 0027249384 scopus 로고
    • Insect defensin, an inducible antibacterial peptide, forms voltage-dependent channels in Micrococcus luteus
    • Cociancich S, Ghazi A, Hetru C, Hoffmann JA, Letellier L (1993) Insect defensin, an inducible antibacterial peptide, forms voltage-dependent channels in Micrococcus luteus. J Biol Chem 268:19239-19245
    • (1993) J Biol Chem , vol.268 , pp. 19239-19245
    • Cociancich, S.1    Ghazi, A.2    Hetru, C.3    Hoffmann, J.A.4    Letellier, L.5
  • 77
    • 0034194257 scopus 로고    scopus 로고
    • Large-scale synthesis and functional elements for the antimicrobial activity of defensins
    • Raj PA, Antonyraj KJ, Karuna S, Karan T (2000) Large-scale synthesis and functional elements for the antimicrobial activity of defensins. Biochem J 347:633-641
    • (2000) Biochem J , vol.347 , pp. 633-641
    • Raj, P.A.1    Antonyraj, K.J.2    Karuna, S.3    Karan, T.4
  • 78
    • 0031024551 scopus 로고    scopus 로고
    • Selective lysis of bacteria but not mammalian cells by diastereomers of melittin: Structure-function study
    • Oren Z, Shai Y (1997) Selective lysis of bacteria but not mammalian cells by diastereomers of melittin: structure-function study. Biochemistry 36:1826-1835
    • (1997) Biochemistry , vol.36 , pp. 1826-1835
    • Oren, Z.1    Shai, Y.2
  • 79
    • 0034283216 scopus 로고    scopus 로고
    • The role of cationic antimicrobial peptides in innate host defenses
    • Hancock REW, Diamond G (2000) The role of cationic antimicrobial peptides in innate host defenses. Trends Microbiol 8:402-410
    • (2000) Trends Microbiol , vol.8 , pp. 402-410
    • Hancock, R.E.W.1    Diamond, G.2
  • 80
    • 0029099061 scopus 로고
    • Morphology of defensin-treated Staphylococcus aureus
    • Shimoda M, Ohki K, Shimamoto Y, Kohashi O (1995) Morphology of defensin-treated Staphylococcus aureus. Infect Immun 63:2886-2891
    • (1995) Infect Immun , vol.63 , pp. 2886-2891
    • Shimoda, M.1    Ohki, K.2    Shimamoto, Y.3    Kohashi, O.4
  • 81
    • 0029947232 scopus 로고    scopus 로고
    • A class of highly potent antibacterial peptides derived from pardaxin, a pore-forming peptide isolated from Moses sole fish Pardachirus marmoratus
    • Oren Z, Shai Y (1996) A class of highly potent antibacterial peptides derived from pardaxin, a pore-forming peptide isolated from Moses sole fish Pardachirus marmoratus. Eur J Biochem 237:303-310
    • (1996) Eur J Biochem , vol.237 , pp. 303-310
    • Oren, Z.1    Shai, Y.2
  • 82
    • 0032200757 scopus 로고    scopus 로고
    • Microscopic observations of the different morphological changes caused by anti-bacterial peptides on Klebsiella pneumoniae and HL-60 leukemia cells
    • Chan SC, Yau WL, Wang W, Smith DK, Sheu FS, Chen HM (1998) Microscopic observations of the different morphological changes caused by anti-bacterial peptides on Klebsiella pneumoniae and HL-60 leukemia cells. J Pept Sci 4:413-425
    • (1998) J Pept Sci , vol.4 , pp. 413-425
    • Chan, S.C.1    Yau, W.L.2    Wang, W.3    Smith, D.K.4    Sheu, F.S.5    Chen, H.M.6
  • 83
    • 0026066649 scopus 로고
    • A comparative study on interactions of alpha-aminoisobutyric acid containing antibiotic peptides, trichopolyn I and hypelcin a with phosphatidylcholine bilayers
    • Matsuzaki K, Shioyama T, Okamura E, Umemura J, Takenaka T, Takaishi Y, Fujita T, Miyajima K (1991) A comparative study on interactions of alpha-aminoisobutyric acid containing antibiotic peptides, trichopolyn I and hypelcin A with phosphatidylcholine bilayers. Biochim Biophys Acta 1070:419-428
    • (1991) Biochim Biophys Acta , vol.1070 , pp. 419-428
    • Matsuzaki, K.1    Shioyama, T.2    Okamura, E.3    Umemura, J.4    Takenaka, T.5    Takaishi, Y.6    Fujita, T.7    Miyajima, K.8
  • 86
    • 4644322849 scopus 로고    scopus 로고
    • Bacterial evasion of innate host defenses - The Staphylococcus aureus lesson
    • Fedtke I, Gotz F, Peschel A (2004) Bacterial evasion of innate host defenses - the Staphylococcus aureus lesson. Int J Med Microbiol 294:189-194
    • (2004) Int J Med Microbiol , vol.294 , pp. 189-194
    • Fedtke, I.1    Gotz, F.2    Peschel, A.3
  • 87
    • 0034998629 scopus 로고    scopus 로고
    • Participation of mammalian defensins and cathelicidins in anti-microbial immunity: Receptors and activities of human defensins and cathelicidin (LL-37)
    • Yang D, Chertov O, Oppenheim JJ (2001) Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37). J Leukoc Biol 69:691-697
    • (2001) J Leukoc Biol , vol.69 , pp. 691-697
    • Yang, D.1    Chertov, O.2    Oppenheim, J.J.3
  • 88
    • 0034960109 scopus 로고    scopus 로고
    • The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity
    • Yang D, Chertov O, Oppenheim JJ (2001) The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity. Cell Mol Life Sci 58:978-989
    • (2001) Cell Mol Life Sci , vol.58 , pp. 978-989
    • Yang, D.1    Chertov, O.2    Oppenheim, J.J.3
  • 89
    • 0035576242 scopus 로고    scopus 로고
    • Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens
    • Biragyn A, Surenhu M, Yang D, Ruffini PA, Haines BA, Klyushnenkova E, Oppenheim JJ, Kwak LW (2001) Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens. J Immunol 167:6644-6653
    • (2001) J Immunol , vol.167 , pp. 6644-6653
    • Biragyn, A.1    Surenhu, M.2    Yang, D.3    Ruffini, P.A.4    Haines, B.A.5    Klyushnenkova, E.6    Oppenheim, J.J.7    Kwak, L.W.8
  • 90
    • 0033871574 scopus 로고    scopus 로고
    • Cationic antimicrobial peptides: Towards clinical applications
    • Hancock REW (2000) Cationic antimicrobial peptides: towards clinical applications. Expert Opin Investig Drugs 9:1723-1729
    • (2000) Expert Opin Investig Drugs , vol.9 , pp. 1723-1729
    • Hancock, R.E.W.1
  • 91
    • 0032916291 scopus 로고    scopus 로고
    • Host defense (cationic) peptides: What is their future clinical potential?
    • Hancock REW (1999) Host defense (cationic) peptides: what is their future clinical potential? Drugs 57:469-473
    • (1999) Drugs , vol.57 , pp. 469-473
    • Hancock, R.E.W.1
  • 93
    • 0028920870 scopus 로고
    • Structure-activity studies on magainins and other host defense peptides
    • Maloy WL, Kari UP (1995) Structure-activity studies on magainins and other host defense peptides. Biopolymers 37:105-122
    • (1995) Biopolymers , vol.37 , pp. 105-122
    • Maloy, W.L.1    Kari, U.P.2
  • 96
    • 0033763238 scopus 로고    scopus 로고
    • Transgenic plants expressing cationic peptide chimeras exhibit broad-spectrum resistance to phytopathogens
    • Osusky M, Zhou G, Osuska L, Hancock RE, Kay WW, Misra S (2000) Transgenic plants expressing cationic peptide chimeras exhibit broad-spectrum resistance to phytopathogens. Nat Biotechnol 18:1162-1166
    • (2000) Nat Biotechnol , vol.18 , pp. 1162-1166
    • Osusky, M.1    Zhou, G.2    Osuska, L.3    Hancock, R.E.4    Kay, W.W.5    Misra, S.6
  • 97
    • 0032007854 scopus 로고    scopus 로고
    • Cationic peptides: A new source of antibiotics
    • Hancock REW, Lehrer R (1998) Cationic peptides: a new source of antibiotics. Trends Biotechnol 16:82-88
    • (1998) Trends Biotechnol , vol.16 , pp. 82-88
    • Hancock, R.E.W.1    Lehrer, R.2
  • 99
    • 0036532403 scopus 로고    scopus 로고
    • How do bacteria resist human antimicrobial peptides?
    • Peschel A (2002) How do bacteria resist human antimicrobial peptides? Trends Microbiol 10:179-186
    • (2002) Trends Microbiol , vol.10 , pp. 179-186
    • Peschel, A.1


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