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Volumn 1, Issue , 2011, Pages 33-64

Pathophysiological and Vascular Characteristics of Solid Tumors in Relation to Drug Delivery

Author keywords

Acidosis; Angiogenesis; Blood flow; Convective transport; Diffusion; Drugs; Extravasation; Hypoxia; Interstitial hypertension; Interstitial transport; Interstitium; Intratumor pharmacokinetics; Microenvironment; Transport barrier; Tumors; Vasculature

Indexed keywords


EID: 84869487940     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527634057.ch2     Document Type: Chapter
Times cited : (5)

References (173)
  • 1
    • 0017171175 scopus 로고
    • Prolonged tumor dormancy by prevention of neovascularization in the vitreous
    • Brem, S., Brem, H., Folkman, J. et al. (1976) Prolonged tumor dormancy by prevention of neovascularization in the vitreous. Cancer Res., 36, 2807-2812.
    • (1976) Cancer Res. , vol.36 , pp. 2807-2812
    • Brem, S.1    Brem, H.2    Folkman, J.3
  • 2
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review
    • Vaupel, P., Kallinowski, F., and Okunieff, P. (1989) Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res., 49, 6449-6465.
    • (1989) Cancer Res. , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 4
    • 3142587028 scopus 로고    scopus 로고
    • Tumor microenvironmental physiology and its implications for radiation oncology
    • Vaupel, P. (2004) Tumor microenvironmental physiology and its implications for radiation oncology. Semin. Radiat. Oncol., 14, 198-206.
    • (2004) Semin. Radiat. Oncol. , vol.14 , pp. 198-206
    • Vaupel, P.1
  • 8
    • 0141961152 scopus 로고    scopus 로고
    • The vascular network of tumours - what is it not for?
    • Sivridis, E., Giatromanolaki, A., and Koukourakis, M.I. (2003) The vascular network of tumours - what is it not for? J. Pathol., 201, 173-180.
    • (2003) J. Pathol. , vol.201 , pp. 173-180
    • Sivridis, E.1    Giatromanolaki, A.2    Koukourakis, M.I.3
  • 9
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet, P. and Jain, R.K. (2000) Angiogenesis in cancer and other diseases. Nature, 407, 249-257.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 10
    • 0142089891 scopus 로고    scopus 로고
    • New non-angiogenesis dependent pathways for tumour growth
    • Ribatti, D., Vacca, A., and Dammacco, F. (2003) New non-angiogenesis dependent pathways for tumour growth. Eur. J. Cancer, 39, 1835-1841.
    • (2003) Eur. J. Cancer , vol.39 , pp. 1835-1841
    • Ribatti, D.1    Vacca, A.2    Dammacco, F.3
  • 11
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers, G. and Benjamin, L.E. (2003) Tumorigenesis and the angiogenic switch. Nat. Rev. Cancer, 3, 401-410.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 12
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D. and Weinberg, R.A. (2000) The hallmarks of cancer. Cell, 100, 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 13
    • 0034648793 scopus 로고    scopus 로고
    • Vascular-specific growth factors and blood vessel formation
    • Yancopoulos, G.D., Davis, S., Gale, N.W., et al. (2000) Vascular-specific growth factors and blood vessel formation. Nature, 407, 242-248.
    • (2000) Nature , vol.407 , pp. 242-248
    • Yancopoulos, G.D.1    Davis, S.2    Gale, N.W.3
  • 14
    • 0036088478 scopus 로고    scopus 로고
    • Mechanisms of normal and tumor-derived angiogenesis
    • Papetti, M. and Herman, I.M. (2002) Mechanisms of normal and tumor-derived angiogenesis. Am. J. Physiol, 282, C947-C970.
    • (2002) Am. J. Physiol , vol.282
    • Papetti, M.1    Herman, I.M.2
  • 15
    • 0034531766 scopus 로고    scopus 로고
    • HIF-1: using two hands to flip the angiogenic switch
    • Semenza, G.L. (2000) HIF-1: using two hands to flip the angiogenic switch. Cancer Metastasis Rev., 19, 59-65.
    • (2000) Cancer Metastasis Rev. , vol.19 , pp. 59-65
    • Semenza, G.L.1
  • 16
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: role of the HIF system
    • Pugh, C.W., and Ratcliffe, P.J. (2003) Regulation of angiogenesis by hypoxia: role of the HIF system. Nat. Med., 9, 677-684.
    • (2003) Nat. Med. , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 17
    • 0028870050 scopus 로고
    • Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis
    • Shweiki, D., Neeman, M., Itin, A., and Keshet, E. (1995) Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis. Proc. Natl. Acad. Sci. USA, 92, 768-772.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 768-772
    • Shweiki, D.1    Neeman, M.2    Itin, A.3    Keshet, E.4
  • 18
    • 0034092011 scopus 로고    scopus 로고
    • Tumor angiogenesis: past, present and the near future
    • Kerbel, R.S. (2000) Tumor angiogenesis: past, present and the near future. Carcinogenesis, 21, 505-515.
    • (2000) Carcinogenesis , vol.21 , pp. 505-515
    • Kerbel, R.S.1
  • 19
    • 0035173755 scopus 로고    scopus 로고
    • Overview of angiogenesis: biologic implications for antiangiogenic therapy
    • Ellis, L.M., Liu, W., Ahmad, S.A., et al. (2001) Overview of angiogenesis: biologic implications for antiangiogenic therapy. Semin. Oncol., 28, 94-104.
    • (2001) Semin. Oncol. , vol.28 , pp. 94-104
    • Ellis, L.M.1    Liu, W.2    Ahmad, S.A.3
  • 20
    • 0029986979 scopus 로고    scopus 로고
    • Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis
    • Patan, S., Munn, L.L., and Jain, R.K. (1996) Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis. Microvasc. Res., 51, 260-272.
    • (1996) Microvasc. Res. , vol.51 , pp. 260-272
    • Patan, S.1    Munn, L.L.2    Jain, R.K.3
  • 21
    • 0036488496 scopus 로고    scopus 로고
    • Specialization of tumour vasculature
    • Ruoslahti, E. (2002) Specialization of tumour vasculature. Nat. Rev. Cancer, 2, 83-90.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 83-90
    • Ruoslahti, E.1
  • 22
    • 0033873782 scopus 로고    scopus 로고
    • Vasculogenic mimicry: how convincing, how novel, and how significant?
    • McDonald, D.M., Munn, L., and Jain, R.K. (2000) Vasculogenic mimicry: how convincing, how novel, and how significant? Am. J. Pathol., 156, 383-388.
    • (2000) Am. J. Pathol. , vol.156 , pp. 383-388
    • Mcdonald, D.M.1    Munn, L.2    Jain, R.K.3
  • 23
    • 34547630698 scopus 로고    scopus 로고
    • Tumor angiogenesis: cause or consequence of cancer?
    • Shchors, K., and Evan, G. (2007) Tumor angiogenesis: cause or consequence of cancer? Cancer Res., 67, 7059-7061.
    • (2007) Cancer Res , vol.67 , pp. 7059-7061
    • Shchors, K.1    Evan, G.2
  • 24
    • 0036306121 scopus 로고    scopus 로고
    • Vascular growth factors and lymphangiogenesis
    • Jussila, L., and Alitalo, K. (2002) Vascular growth factors and lymphangiogenesis. Physiol. Rev., 82, 673-700.
    • (2002) Physiol. Rev. , vol.82 , pp. 673-700
    • Jussila, L.1    Alitalo, K.2
  • 25
    • 0037036136 scopus 로고    scopus 로고
    • Lymphatic metastasis in the absence of functional intratumor lymphatics
    • Padera, T.P., Kadambi, A., di Tomaso, E., et al. (2002) Lymphatic metastasis in the absence of functional intratumor lymphatics. Science, 296, 1883-1886.
    • (2002) Science , vol.296 , pp. 1883-1886
    • Padera, T.P.1    Kadambi, A.2    di Tomaso, E.3
  • 27
    • 0033170557 scopus 로고    scopus 로고
    • Causes and effects of heterogeneous perfusion in tumors
    • Gillies, R.J., Schornack, P.A., Secomb, T.W., and Raghunand, N. (1999) Causes and effects of heterogeneous perfusion in tumors. Neoplasia, 1, 197-207.
    • (1999) Neoplasia , vol.1 , pp. 197-207
    • Gillies, R.J.1    Schornack, P.A.2    Secomb, T.W.3    Raghunand, N.4
  • 28
    • 0034321578 scopus 로고    scopus 로고
    • Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance
    • Vaupel, P., and Höckel, M. (2000) Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance. Int. J. Oncol., 17, 869-879.
    • (2000) Int. J. Oncol. , vol.17 , pp. 869-879
    • Vaupel, P.1    Höckel, M.2
  • 29
    • 0035677961 scopus 로고    scopus 로고
    • Treatment resistance of solid tumors: role of hypoxia and anemia
    • Vaupel, P., Thews, O., and Hoeckel, M. (2001) Treatment resistance of solid tumors: role of hypoxia and anemia. Med. Oncol., 18, 243-259.
    • (2001) Med. Oncol. , vol.18 , pp. 243-259
    • Vaupel, P.1    Thews, O.2    Hoeckel, M.3
  • 31
    • 0035906856 scopus 로고    scopus 로고
    • 3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon
    • Konerding, M.A., Fait, E., and Gaumann, A. (2001) 3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon. Br. J. Cancer, 84, 1354-1362.
    • (2001) Br. J. Cancer , vol.84 , pp. 1354-1362
    • Konerding, M.A.1    Fait, E.2    Gaumann, A.3
  • 33
    • 0030476061 scopus 로고    scopus 로고
    • Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma
    • Kimura, H., Braun, R.D., Ong, E.T., et al. (1996) Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. Cancer Res., 56, 5522-5528.
    • (1996) Cancer Res. , vol.56 , pp. 5522-5528
    • Kimura, H.1    Braun, R.D.2    Ong, E.T.3
  • 34
    • 0242298635 scopus 로고    scopus 로고
    • Tumor microenvironment and hemorheological abnormalities
    • Baronzio, G., Freitas, I., and Kwaan, H.C. (2003) Tumor microenvironment and hemorheological abnormalities. Semin. Thromb. Hemost., 29, 489-497.
    • (2003) Semin. Thromb. Hemost. , vol.29 , pp. 489-497
    • Baronzio, G.1    Freitas, I.2    Kwaan, H.C.3
  • 35
    • 0011026251 scopus 로고    scopus 로고
    • Microtopology of local perfusion, oxygenation, metabolic and energetic status, and interstitial pH in malignant tumors
    • Vaupel, P., Kelleher, D.K., and Thews, O. (2000) Microtopology of local perfusion, oxygenation, metabolic and energetic status, and interstitial pH in malignant tumors. Techniques and characterization. Exp. Oncol., 22, 15-25.
    • (2000) Techniques and characterization. Exp. Oncol. , vol.22 , pp. 15-25
    • Vaupel, P.1    Kelleher, D.K.2    Thews, O.3
  • 36
    • 0017767072 scopus 로고
    • Intracapillary HbO2 saturation in tumor tissue of DS-carcinosarcoma during normoxia
    • Vaupel, P., Grunewald, W.A., Manz, R., and Sowa, W. (1978) Intracapillary HbO2 saturation in tumor tissue of DS-carcinosarcoma during normoxia. Adv. Exp. Med. Biol., 94, 367-375.
    • (1978) Adv. Exp. Med. Biol. , vol.94 , pp. 367-375
    • Vaupel, P.1    Grunewald, W.A.2    Manz, R.3    Sowa, W.4
  • 37
    • 0018424634 scopus 로고
    • Blood flow characteristics in induced rat mammary neoplasia
    • Weiss, L., Hultborn, R., and Tveit, E. (1979) Blood flow characteristics in induced rat mammary neoplasia. Microvasc. Res., 17, S119.
    • (1979) Microvasc. Res. , vol.17
    • Weiss, L.1    Hultborn, R.2    Tveit, E.3
  • 38
    • 0020065252 scopus 로고
    • Microcirculatory blood flow, capillary morphology, and local oxygen pressure of the hamster amelanotic melanoma A-Mel-3
    • Endrich, B., Hammersen, F., Goetz, A., and Messmer, K. (1982) Microcirculatory blood flow, capillary morphology, and local oxygen pressure of the hamster amelanotic melanoma A-Mel-3. J. Natl. Cancer Inst., 68, 475-485.
    • (1982) J. Natl. Cancer Inst. , vol.68 , pp. 475-485
    • Endrich, B.1    Hammersen, F.2    Goetz, A.3    Messmer, K.4
  • 39
    • 0022453890 scopus 로고
    • Tumor blood flow and systemic shunting in patients receiving intraarterial chemotherapy for head and neck cancer
    • Wheeler, R.H., Ziessman, H.A., Medvec, B.R., et al. (1986) Tumor blood flow and systemic shunting in patients receiving intraarterial chemotherapy for head and neck cancer. Cancer Res., 46, 4200-4204.
    • (1986) Cancer Res. , vol.46 , pp. 4200-4204
    • Wheeler, R.H.1    Ziessman, H.A.2    Medvec, B.R.3
  • 40
    • 0242415815 scopus 로고
    • Interstitieller Raum und Mikromilieu in malignen Tumoren
    • Vaupel, P., and Mueller-Klieser, W. (1983) Interstitieller Raum und Mikromilieu in malignen Tumoren. Prog. Appl. Microcirc., 2, 78-90.
    • (1983) Prog. Appl. Microcirc. , vol.2 , pp. 78-90
    • Vaupel, P.1    Mueller-Klieser, W.2
  • 41
    • 0015107981 scopus 로고
    • Improved microcirculation in irradiated tumours
    • Reinhold, H.S. (1971) Improved microcirculation in irradiated tumours. Eur. J. Cancer, 7, 273-280.
    • (1971) Eur. J. Cancer , vol.7 , pp. 273-280
    • Reinhold, H.S.1
  • 42
    • 34447258681 scopus 로고    scopus 로고
    • Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize
    • Fukumura, D., and Jain, R.K. (2007) Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize. J. Cell. Biochem., 101, 937-949.
    • (2007) J. Cell. Biochem. , vol.101 , pp. 937-949
    • Fukumura, D.1    Jain, R.K.2
  • 43
    • 0001217379 scopus 로고
    • The significance of the tissue pressure of normal testicular and of neoplastic (Brown-Pearce carcinoma) tissue in the rabbit
    • Young, J.S., Llumsden, C.E., Stalker, A.L., (1950) The significance of the tissue pressure of normal testicular and of neoplastic (Brown-Pearce carcinoma) tissue in the rabbit. J. Pathol. Bacteriol., 62, 313-333.
    • (1950) J. Pathol. Bacteriol. , vol.62 , pp. 313-333
    • Young, J.S.1    Llumsden, C.E.2    Stalker, A.L.3
  • 44
    • 0026650318 scopus 로고
    • Interstitial hypertension in head and neck tumors in patients: correlation with tumor size
    • Gutmann, R., Leunig, M., Feyh, J., et al. (1992) Interstitial hypertension in head and neck tumors in patients: correlation with tumor size. Cancer Res., 52, 1993-1995.
    • (1992) Cancer Res. , vol.52 , pp. 1993-1995
    • Gutmann, R.1    Leunig, M.2    Feyh, J.3
  • 45
    • 0026475036 scopus 로고
    • Interstitial hypertension in human breast and colorectal tumors
    • Less, J.R., Posner, M.C., Boucher, Y., et al. (1992) Interstitial hypertension in human breast and colorectal tumors. Cancer Res., 52, 6371-6374.
    • (1992) Cancer Res. , vol.52 , pp. 6371-6374
    • Less, J.R.1    Posner, M.C.2    Boucher, Y.3
  • 46
    • 0035417889 scopus 로고    scopus 로고
    • Interstitial fluid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygen measurements
    • Milosevic, M., Fyles, A., Hedley, D., et al. (2001) Interstitial fluid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygen measurements. Cancer Res., 61, 6400-6405.
    • (2001) Cancer Res. , vol.61 , pp. 6400-6405
    • Milosevic, M.1    Fyles, A.2    Hedley, D.3
  • 47
    • 3142631966 scopus 로고    scopus 로고
    • The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure
    • Milosevic, M., Fyles, A., Hedley, D., and Hill, R. (2004) The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure. Semin. Radiat. Oncol., 14, 249-258.
    • (2004) Semin. Radiat. Oncol. , vol.14 , pp. 249-258
    • Milosevic, M.1    Fyles, A.2    Hedley, D.3    Hill, R.4
  • 48
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure - an obstacle in cancer therapy
    • Heldin, C.-H., Rubin, K., Pietras, K., and östman, A. (2004) High interstitial fluid pressure - an obstacle in cancer therapy. Nat. Rev. Cancer, 4, 806-813.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 806-813
    • Heldin, C.-H.1    Rubin, K.2    Pietras, K.3    Östman, A.4
  • 50
    • 39549099076 scopus 로고    scopus 로고
    • Interstitial fluid pressure, vascularity and metastasis in ectopic, orthotopic and spontaneous tumours
    • Lunt, S.J., Kalliomaki, T.M.K., Brown, A., et al. (2008) Interstitial fluid pressure, vascularity and metastasis in ectopic, orthotopic and spontaneous tumours. BMC Cancer, 8, 2.
    • (2008) BMC Cancer , vol.8 , pp. 2
    • Lunt, S.J.1    Kalliomaki, T.M.K.2    Brown, A.3
  • 52
    • 0028849284 scopus 로고
    • Time-dependent behavior of interstitial fluid pressure in solid tumors: Implication for drug delivery
    • Netti, P.A., Baxter, L.T., Boucher, Y., et al. (1995) Time-dependent behavior of interstitial fluid pressure in solid tumors: Implication for drug delivery. Cancer Res., 55, 5451-5458.
    • (1995) Cancer Res. , vol.55 , pp. 5451-5458
    • Netti, P.A.1    Baxter, L.T.2    Boucher, Y.3
  • 54
    • 0035694958 scopus 로고    scopus 로고
    • Intermittent blood flow in solid tumours - an under-appreciated source of drug resistance
    • Durand, R.E. (2001) Intermittent blood flow in solid tumours - an under-appreciated source of drug resistance. Cancer Metastasis Rev., 20, 57-61.
    • (2001) Cancer Metastasis Rev. , vol.20 , pp. 57-61
    • Durand, R.E.1
  • 55
    • 0035682917 scopus 로고    scopus 로고
    • Non-constant tumour blood flow: iplications for therapy
    • Durand, R.E., and Aquino-Parsons, C. (2001) Non-constant tumour blood flow: iplications for therapy. Acta Oncol., 40, 862-869.
    • (2001) Acta Oncol. , vol.40 , pp. 862-869
    • Durand, R.E.1    Aquino-Parsons, C.2
  • 56
    • 0035700693 scopus 로고    scopus 로고
    • Clinical relevance of intermittent tumour blood flow
    • Durand, R.E., and Aquino-Parsons, C. (2001) Clinical relevance of intermittent tumour blood flow. Acta Oncol., 40, 929-936.
    • (2001) Acta Oncol. , vol.40 , pp. 929-936
    • Durand, R.E.1    Aquino-Parsons, C.2
  • 57
    • 29344443251 scopus 로고    scopus 로고
    • The distribution of the anticancer drug doxorubicin in relation to blood vessels in solid tumors
    • Primeau, A.J., Rendon, A., Hedley, D., et al. (2005) The distribution of the anticancer drug doxorubicin in relation to blood vessels in solid tumors. Clin. Cancer Res., 11, 8782-8788.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 8782-8788
    • Primeau, A.J.1    Rendon, A.2    Hedley, D.3
  • 58
    • 77953535550 scopus 로고    scopus 로고
    • Three-dimensional analysis of tumour vascular corrosion casts using stereoimaging and micro-computed tomography
    • Folarin, A.A., Konerding, M.A., Timonen, J., et al. (2010) Three-dimensional analysis of tumour vascular corrosion casts using stereoimaging and micro-computed tomography. Microvasc. Res., 80, 89-98.
    • (2010) Microvasc. Res. , vol.80 , pp. 89-98
    • Folarin, A.A.1    Konerding, M.A.2    Timonen, J.3
  • 59
    • 33746491709 scopus 로고    scopus 로고
    • Drug penetration in solid tumours
    • Minchinton, A.L., and Tannock, I.F. (2006) Drug penetration in solid tumours. Nat. Rev. Cancer, 6, 583-592.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 583-592
    • Minchinton, A.L.1    Tannock, I.F.2
  • 60
    • 33847356987 scopus 로고    scopus 로고
    • Drug distribution in tumors: mechanisms, role in drug resistance, and methods for modification
    • Di Paolo, A., and Bocci, G. (2007) Drug distribution in tumors: mechanisms, role in drug resistance, and methods for modification. Curr. Oncol. Rep., 9, 109-114.
    • (2007) Curr. Oncol. Rep. , vol.9 , pp. 109-114
    • Di Paolo, A.1    Bocci, G.2
  • 61
    • 0014292997 scopus 로고
    • The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour
    • Tannock, I.F. (1968) The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour. Br. J. Cancer, 22, 258-273.
    • (1968) Br. J. Cancer , vol.22 , pp. 258-273
    • Tannock, I.F.1
  • 62
    • 0035689646 scopus 로고    scopus 로고
    • Tumor physiology and drug resistance
    • Tannock, I.F. (2001) Tumor physiology and drug resistance. Cancer Metastasis Rev., 20, 123-132.
    • (2001) Cancer Metastasis Rev. , vol.20 , pp. 123-132
    • Tannock, I.F.1
  • 63
    • 0018330397 scopus 로고
    • Tumour cell proliferation in relation to the vasculature
    • Hirst, D.G., and Denekamp, J. (1979) Tumour cell proliferation in relation to the vasculature. Cell Tissue Kinet., 12, 31-42.
    • (1979) Cell Tissue Kinet. , vol.12 , pp. 31-42
    • Hirst, D.G.1    Denekamp, J.2
  • 66
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy
    • Jain, R.K. (2001) Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat. Med., 7, 987-989.
    • (2001) Nat. Med. , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 67
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain, R.K. (2005) Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science, 307, 58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 68
    • 10944242667 scopus 로고    scopus 로고
    • Antiangiogenic therapy: creating a unique "window" of opportunity
    • Lin, M.I., and Sessa, W.C. (2004) Antiangiogenic therapy: creating a unique "window" of opportunity. Cancer Cell, 6, 529-531.
    • (2004) Cancer Cell , vol.6 , pp. 529-531
    • Lin, M.I.1    Sessa, W.C.2
  • 69
    • 0034821994 scopus 로고    scopus 로고
    • Tumor transport physiology: Implications for imaging and imaging-guided therapy
    • Kuszyk, B., Corl, F.M., Franano, F.M., et al. (2001) Tumor transport physiology: Implications for imaging and imaging-guided therapy. Am. J. Radiol., 177, 747-753.
    • (2001) Am. J. Radiol. , vol.177 , pp. 747-753
    • Kuszyk, B.1    Corl, F.M.2    Franano, F.M.3
  • 70
    • 0023481357 scopus 로고
    • Transport of molecules across tumor vasculature
    • Jain, R.K. (1987) Transport of molecules across tumor vasculature. Cancer Metastasis Rev., 6, 559-593.
    • (1987) Cancer Metastasis Rev. , vol.6 , pp. 559-593
    • Jain, R.K.1
  • 71
    • 0025014962 scopus 로고
    • Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors
    • Jain, R.K. (1990) Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors. Cancer Res., 50, 814s-819s.
    • (1990) Cancer Res. , vol.50
    • Jain, R.K.1
  • 72
    • 33645123894 scopus 로고    scopus 로고
    • Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment
    • Cairns, R., Papandreou, I., and Denko, N. (2006) Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment. Mol. Cancer Res., 4, 61-70.
    • (2006) Mol. Cancer Res. , vol.4 , pp. 61-70
    • Cairns, R.1    Papandreou, I.2    Denko, N.3
  • 73
    • 0034193258 scopus 로고    scopus 로고
    • Role of extracellular matrix assembly in interstitial transport in solid tumors
    • Netti, P.A, Berk, D.A., Swartz, M.A., et al. (2000) Role of extracellular matrix assembly in interstitial transport in solid tumors. Cancer Res., 60, 2497-2503.
    • (2000) Cancer Res. , vol.60 , pp. 2497-2503
    • Netti, P.A.1    Berk, D.A.2    Swartz, M.A.3
  • 74
    • 0034306974 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions
    • Lee, C.G., Heijn, M., di Tomaso, E., et al. (2000) Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res., 60, 5565-5570.
    • (2000) Cancer Res. , vol.60 , pp. 5565-5570
    • Lee, C.G.1    Heijn, M.2    di Tomaso, E.3
  • 75
    • 11144354392 scopus 로고    scopus 로고
    • Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
    • Willett, C.G., Boucher, Y., di Tomaso, E., et al. (2004) Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat. Med., 10, 145-147.
    • (2004) Nat. Med. , vol.10 , pp. 145-147
    • Willett, C.G.1    Boucher, Y.2    di Tomaso, E.3
  • 76
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor, T.T., Sorensen, A.G., di Tomaso, E., et al. (2007) AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell, 11, 83-95.
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    di Tomaso, E.3
  • 77
    • 30944452436 scopus 로고    scopus 로고
    • Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients
    • Willett, C.G., Boucher, Y., di Tomaso, E., et al. (2005) Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J. Clin. Oncol., 23, 8136-8139.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 8136-8139
    • Willett, C.G.1    Boucher, Y.2    di Tomaso, E.3
  • 78
    • 0023082510 scopus 로고
    • Tumor hypoxia: its impact on cancer therapy
    • Moulder, J.E., and Rockwell, S. (1987) Tumor hypoxia: its impact on cancer therapy. Cancer Metastasis Rev., 5, 313-341.
    • (1987) Cancer Metastasis Rev. , vol.5 , pp. 313-341
    • Moulder, J.E.1    Rockwell, S.2
  • 79
    • 0025974326 scopus 로고
    • Keynote address: the influence of microenvironmental factors on the activity of radiation and drugs
    • Durand, R.E. (1991) Keynote address: the influence of microenvironmental factors on the activity of radiation and drugs. Int.J. Radiat. Oncol. Biol. Phys., 20, 253-258.
    • (1991) Int.J. Radiat. Oncol. Biol. Phys. , vol.20 , pp. 253-258
    • Durand, R.E.1
  • 80
    • 0028603270 scopus 로고
    • The influence of microenvironmental factors during cancer therapy
    • Durand, R.E. (1994) The influence of microenvironmental factors during cancer therapy. In Vivo, 8, 691-702.
    • (1994) In Vivo , vol.8 , pp. 691-702
    • Durand, R.E.1
  • 83
    • 0028307739 scopus 로고
    • Hypoxia and drug resistance
    • Teicher, B.A. (1994) Hypoxia and drug resistance. Cancer Metastasis, 13, 139-168.
    • (1994) Cancer Metastasis , vol.13 , pp. 139-168
    • Teicher, B.A.1
  • 84
    • 0028964971 scopus 로고
    • Physiologic mechanisms of therapeutic resistance
    • Teicher, B.A. (1995) Physiologic mechanisms of therapeutic resistance. Hematol. Oncol. Clin. North Am., 9, 475-506.
    • (1995) Hematol. Oncol. Clin. North Am. , vol.9 , pp. 475-506
    • Teicher, B.A.1
  • 85
    • 0028019213 scopus 로고
    • Molecular biology in radiation therapy: the potential impact of recombinant technology on clinical practice
    • Hall, E.J. (1994) Molecular biology in radiation therapy: the potential impact of recombinant technology on clinical practice. Int.J. Radiat. Oncol. Biol. Phys., 30, 1019-1028.
    • (1994) Int.J. Radiat. Oncol. Biol. Phys. , vol.30 , pp. 1019-1028
    • Hall, E.J.1
  • 86
    • 0030744577 scopus 로고    scopus 로고
    • The influence of tumor blood flow and microenvironmental factors on the efficacy of radiation, drugs and localized hyperthermia
    • Vaupel, P. (1997) The influence of tumor blood flow and microenvironmental factors on the efficacy of radiation, drugs and localized hyperthermia. Klin. Pädiat., 209, 243-249.
    • (1997) Klin. Pädiat. , vol.209 , pp. 243-249
    • Vaupel, P.1
  • 88
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: definitions and current clinical, biological and molecular aspects
    • Höckel, M., and Vaupel, P. (2001) Tumor hypoxia: definitions and current clinical, biological and molecular aspects. J. Natl. Cancer Inst., 93, 266-276.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 266-276
    • Höckel, M.1    Vaupel, P.2
  • 93
    • 30044436210 scopus 로고    scopus 로고
    • Hypoxic regulation of telomerase gene expression by transcriptional and posttranscriptional mechanisms
    • Anderson, C.J., Hoare, S.F., Ashcroft, M., et al. (2006) Hypoxic regulation of telomerase gene expression by transcriptional and posttranscriptional mechanisms. Oncogene, 25, 61-69.
    • (2006) Oncogene , vol.25 , pp. 61-69
    • Anderson, C.J.1    Hoare, S.F.2    Ashcroft, M.3
  • 94
    • 0004580887 scopus 로고
    • Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells
    • Rice, G.C., Hoy, C., and Schimke, R.T. (1986) Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells. Proc. Natl. Acad. Sci. USA, 83, 5978-5982.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 5978-5982
    • Rice, G.C.1    Hoy, C.2    Schimke, R.T.3
  • 96
    • 0025763309 scopus 로고
    • A possible role for a mammalian facilitative hexose transporter in the development of resistance to drugs
    • Vera, J.C., Castillo, G.R., and Rosen, O.M. (1991) A possible role for a mammalian facilitative hexose transporter in the development of resistance to drugs. Mol. Cell Biol., 11, 3407-3418.
    • (1991) Mol. Cell Biol. , vol.11 , pp. 3407-3418
    • Vera, J.C.1    Castillo, G.R.2    Rosen, O.M.3
  • 97
    • 0037096732 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene
    • Comerford, K.M., Wallace, T.J., Karhausen, J., et al. (2002) Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res., 62, 3387-3394.
    • (2002) Cancer Res. , vol.62 , pp. 3387-3394
    • Comerford, K.M.1    Wallace, T.J.2    Karhausen, J.3
  • 99
    • 0028268629 scopus 로고
    • Hypoxia causes the activation of nuclear factor κB through the phosphorylation of IκBa on tyrosine residues
    • Koong, A.C., Chen, E.Y., and Giaccia, A.J. (1994) Hypoxia causes the activation of nuclear factor κB through the phosphorylation of IκBa on tyrosine residues. Cancer Res., 54, 1425-1430.
    • (1994) Cancer Res. , vol.54 , pp. 1425-1430
    • Koong, A.C.1    Chen, E.Y.2    Giaccia, A.J.3
  • 100
    • 0033867776 scopus 로고    scopus 로고
    • Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation
    • Dachs, G.U., and Tozer, G.M. (2000) Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation. Eur. J. Cancer, 36, 1649-1660.
    • (2000) Eur. J. Cancer , vol.36 , pp. 1649-1660
    • Dachs, G.U.1    Tozer, G.M.2
  • 101
    • 0036210708 scopus 로고    scopus 로고
    • The response of c-Jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1a dependent
    • Laderoute, K.R., Calaoagan, J.M., Gustafson-Brown, C., et al. (2002) The response of c-Jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1a dependent. Mol. Cell Biol., 22, 2515-2523.
    • (2002) Mol. Cell Biol. , vol.22 , pp. 2515-2523
    • Laderoute, K.R.1    Calaoagan, J.M.2    Gustafson-Brown, C.3
  • 102
    • 0026758210 scopus 로고
    • Enhanced epidermal growth factor receptor synthesis in human squamous carcinoma cells exposed to low levels of oxygen
    • Laderoute, K.R., Grant, T.D., Murphy, B.J., and Sutherland, R.M. (1992) Enhanced epidermal growth factor receptor synthesis in human squamous carcinoma cells exposed to low levels of oxygen. Int. J. Cancer, 52, 428-432.
    • (1992) Int. J. Cancer , vol.52 , pp. 428-432
    • Laderoute, K.R.1    Grant, T.D.2    Murphy, B.J.3    Sutherland, R.M.4
  • 103
    • 0028129435 scopus 로고
    • Regulation of c-jun expression during hypoxic and low-glucose stress
    • Ausserer, W.A., Bourrat-Floeck, B., Green, C.J., et al. (1994) Regulation of c-jun expression during hypoxic and low-glucose stress. Mol. Cell Biol., 14, 5032-5042.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 5032-5042
    • Ausserer, W.A.1    Bourrat-Floeck, B.2    Green, C.J.3
  • 104
    • 0028110809 scopus 로고
    • Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status
    • Graeber, T.G., Peterson, J.F., Tsai, M., et al. (1994) Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol. Cell Biol., 14, 6264-6277.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 6264-6277
    • Graeber, T.G.1    Peterson, J.F.2    Tsai, M.3
  • 105
    • 0028061116 scopus 로고
    • Hypoxia-induced resistance to doxorubicin and methotrexate in human melanoma cell lines in vitro
    • Sanna, K., and Rofstad, E.K. (1994) Hypoxia-induced resistance to doxorubicin and methotrexate in human melanoma cell lines in vitro. Int. J. Cancer, 58, 258-262.
    • (1994) Int. J. Cancer , vol.58 , pp. 258-262
    • Sanna, K.1    Rofstad, E.K.2
  • 106
    • 0030067856 scopus 로고    scopus 로고
    • Hypoxic stress proteins: survival of the fittest
    • Giaccia, A.J. (1996) Hypoxic stress proteins: survival of the fittest. Semin. Radiat. Oncol., 6, 46-58.
    • (1996) Semin. Radiat. Oncol. , vol.6 , pp. 46-58
    • Giaccia, A.J.1
  • 107
    • 0030037148 scopus 로고    scopus 로고
    • Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer
    • Mattern, J., Kallinowski, F., Herfarth, C., and Volm, M. (1996) Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer. Int. J. Cancer, 67, 20-23.
    • (1996) Int. J. Cancer , vol.67 , pp. 20-23
    • Mattern, J.1    Kallinowski, F.2    Herfarth, C.3    Volm, M.4
  • 108
    • 0005860170 scopus 로고    scopus 로고
    • Hypoxia and its clinical significance
    • Raleigh, J.A. (1996) Hypoxia and its clinical significance. Semin. Radiat. Oncol., 6, 1-70.
    • (1996) Semin. Radiat. Oncol. , vol.6 , pp. 1-70
    • Raleigh, J.A.1
  • 109
    • 0032053823 scopus 로고    scopus 로고
    • The unique physiology of solid tumors: opportunities (and problems) for cancer therapy
    • Brown, J.M., and Giaccia, A.J. (1998) The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res., 58, 1408-1416.
    • (1998) Cancer Res. , vol.58 , pp. 1408-1416
    • Brown, J.M.1    Giaccia, A.J.2
  • 111
    • 0034021690 scopus 로고    scopus 로고
    • Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
    • Semenza, G.L. (2000) Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit. Rev. Biochem. Mol. Biol., 35, 71-103.
    • (2000) Crit. Rev. Biochem. Mol. Biol. , vol.35 , pp. 71-103
    • Semenza, G.L.1
  • 112
    • 0034006016 scopus 로고    scopus 로고
    • HIF-1: mediator of physiological and pathophysiological response to hypoxia
    • Semenza, G.L. (2000) HIF-1: mediator of physiological and pathophysiological response to hypoxia. J. Appl. Physiol., 88, 1474-1480.
    • (2000) J. Appl. Physiol. , vol.88 , pp. 1474-1480
    • Semenza, G.L.1
  • 113
    • 1842583652 scopus 로고    scopus 로고
    • Hypoxia, increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine
    • Yokoi, K., and Fidler, I.J. (2004) Hypoxia, increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine. Clin. Cancer Res., 10, 2299-2306.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 2299-2306
    • Yokoi, K.1    Fidler, I.J.2
  • 114
    • 54049134838 scopus 로고    scopus 로고
    • Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis
    • Vaupel, P. (2008) Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis. Oncologist, 13 (Suppl. 3), 21-36.
    • (2008) Oncologist , vol.13 , Issue.SUPPL. 3 , pp. 21-36
    • Vaupel, P.1
  • 115
    • 10644234769 scopus 로고    scopus 로고
    • The role of hypoxia-induced factors in tumor progression
    • Vaupel, P. (2004) The role of hypoxia-induced factors in tumor progression. Oncologist, 9, 10-17.
    • (2004) Oncologist , vol.9 , pp. 10-17
    • Vaupel, P.1
  • 116
    • 1642565876 scopus 로고    scopus 로고
    • Tumor hypoxia and malignant progression
    • Vaupel, P., Mayer, A., and Höckel, M. (2004) Tumor hypoxia and malignant progression. Methods Enzymol., 381, 335-354.
    • (2004) Methods Enzymol. , vol.381 , pp. 335-354
    • Vaupel, P.1    Mayer, A.2    Höckel, M.3
  • 117
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Höckel, M., Schlenger, K., Aral, B., et al. (1996) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res., 56, 4509-4515.
    • (1996) Cancer Res. , vol.56 , pp. 4509-4515
    • Höckel, M.1    Schlenger, K.2    Aral, B.3
  • 118
    • 0342857011 scopus 로고    scopus 로고
    • Tumor hypoxia in pelvic recurrences of cervical cancer
    • Höckel, M., Schlenger, K., Höckel, S., et al. (1998) Tumor hypoxia in pelvic recurrences of cervical cancer. Int. J. Cancer, 79, 365-369.
    • (1998) Int. J. Cancer , vol.79 , pp. 365-369
    • Höckel, M.1    Schlenger, K.2    Höckel, S.3
  • 119
    • 0010170555 scopus 로고
    • Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumour cells
    • Young, S.D., Marshall, R.S., and Hill, R.P. (1988) Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumour cells. Proc. Natl. Acad. Sci. USA, 85, 9533-9537.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 9533-9537
    • Young, S.D.1    Marshall, R.S.2    Hill, R.P.3
  • 120
    • 0026787669 scopus 로고
    • Anoxia-inducible endonuclease activity as a potential basis of the genomic instability of cancer cells
    • Stoler, D.L., Anderson, G.R., Russo, C.A., et al. (1992) Anoxia-inducible endonuclease activity as a potential basis of the genomic instability of cancer cells. Cancer Res., 52, 4372-4378.
    • (1992) Cancer Res. , vol.52 , pp. 4372-4378
    • Stoler, D.L.1    Anderson, G.R.2    Russo, C.A.3
  • 121
    • 0027354561 scopus 로고
    • Genomic instability and tumor progression: mechanistic considerations
    • Cheng, K.C., and Loeb, L.A. (1993) Genomic instability and tumor progression: mechanistic considerations. Adv. Cancer Res., 60, 121-156.
    • (1993) Adv. Cancer Res. , vol.60 , pp. 121-156
    • Cheng, K.C.1    Loeb, L.A.2
  • 122
    • 0028215744 scopus 로고
    • Benign-to-malignant B16 melanoma progression induced in two stages in vitro by exposure to hypoxia
    • Stackpole, C.W., Groszek, L., and Kalbag, S.S. (1994) Benign-to-malignant B16 melanoma progression induced in two stages in vitro by exposure to hypoxia. J. Natl. Cancer Inst., 86, 361-367.
    • (1994) J. Natl. Cancer Inst. , vol.86 , pp. 361-367
    • Stackpole, C.W.1    Groszek, L.2    Kalbag, S.S.3
  • 123
    • 0028931542 scopus 로고
    • An anoxia inducible endonuclease and enhanced DNA breakage as contributors to genomic instability in cancer
    • Russo, C.A., Weber, T.K., Volpe, C.M., et al. (1995) An anoxia inducible endonuclease and enhanced DNA breakage as contributors to genomic instability in cancer. Cancer Res., 55, 1122-1128.
    • (1995) Cancer Res. , vol.55 , pp. 1122-1128
    • Russo, C.A.1    Weber, T.K.2    Volpe, C.M.3
  • 124
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber, T.G., Osmanian, C., Jacks, T., et al. (1996) Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature, 379, 88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3
  • 125
    • 0029753768 scopus 로고    scopus 로고
    • Genetic instability induced by the tumor microenvironment
    • Reynolds, T.Y., Rockwell, S., and Glazer, P.M. (1996) Genetic instability induced by the tumor microenvironment. Cancer Res., 56, 5754-5757.
    • (1996) Cancer Res. , vol.56 , pp. 5754-5757
    • Reynolds, T.Y.1    Rockwell, S.2    Glazer, P.M.3
  • 126
    • 0030864485 scopus 로고    scopus 로고
    • Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions
    • Kim, C.Y., Tsai, M.H., Osmanian, C., et al. (1997) Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions. Cancer Res., 57, 4200-4204.
    • (1997) Cancer Res. , vol.57 , pp. 4200-4204
    • Kim, C.Y.1    Tsai, M.H.2    Osmanian, C.3
  • 127
    • 0037480606 scopus 로고    scopus 로고
    • Hypoxic cervical cancers with low apoptotic index are highly aggressive
    • Höckel, M., Schlenger, K., Höckel, S., and Vaupel, P. (1999) Hypoxic cervical cancers with low apoptotic index are highly aggressive. Cancer Res., 59, 4525-4528.
    • (1999) Cancer Res. , vol.59 , pp. 4525-4528
    • Höckel, M.1    Schlenger, K.2    Höckel, S.3    Vaupel, P.4
  • 128
    • 0019349297 scopus 로고
    • Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells
    • Teicher, B.A., Lazo, J.S., and Sartorelli, A.C. (1981) Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells. Cancer Res., 41, 73-81.
    • (1981) Cancer Res. , vol.41 , pp. 73-81
    • Teicher, B.A.1    Lazo, J.S.2    Sartorelli, A.C.3
  • 129
    • 0025354292 scopus 로고
    • Classification of antineoplastic treatments by their differential toxicity toward putative oxygenated and hypoxic tumor subpopulations in vivo in the FSaII murine fibrosarcoma
    • Teicher, B.A., Holden, S.A., Al-Achi, A., and Herman, T.S. (1990) Classification of antineoplastic treatments by their differential toxicity toward putative oxygenated and hypoxic tumor subpopulations in vivo in the FSaII murine fibrosarcoma. Cancer Res., 50, 3339-3344.
    • (1990) Cancer Res. , vol.50 , pp. 3339-3344
    • Teicher, B.A.1    Holden, S.A.2    Al-Achi, A.3    Herman, T.S.4
  • 130
    • 0025228518 scopus 로고
    • Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo
    • Teicher, B.A., Herman, T.S., Holden, S.A., et al. (1990) Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo. Science, 247, 1457-1461.
    • (1990) Science , vol.247 , pp. 1457-1461
    • Teicher, B.A.1    Herman, T.S.2    Holden, S.A.3
  • 131
    • 34447117505 scopus 로고    scopus 로고
    • Implications of in vitro research on the effect of radiotherapy and chemotherapy under hypoxic conditions
    • Wóuters, A., Páuwels, B., Lardon, F. Vermorken, J.B. (2007) Implications of in vitro research on the effect of radiotherapy and chemotherapy under hypoxic conditions. Oncologist, 12, 690-712.
    • (2007) Oncologist , vol.12 , pp. 690-712
    • Wóuters, A.1    Páuwels, B.2    Lardon, F.3    Vermorken, J.B.4
  • 132
    • 0026003123 scopus 로고
    • Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance
    • Sakata, K., Kwok, T.T., Murphy, B.J., et al. (1991) Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance. Br. J. Cancer, 64, 809-814.
    • (1991) Br. J. Cancer , vol.64 , pp. 809-814
    • Sakata, K.1    Kwok, T.T.2    Murphy, B.J.3
  • 134
    • 0042411985 scopus 로고    scopus 로고
    • Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies
    • Shannon, A.M., Bouchier-Hayes, D.J., Condron, C.M., and Toomey, D. (2003) Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies. Cancer Treat. Rev., 29, 297-307.
    • (2003) Cancer Treat. Rev. , vol.29 , pp. 297-307
    • Shannon, A.M.1    Bouchier-Hayes, D.J.2    Condron, C.M.3    Toomey, D.4
  • 135
    • 70149113948 scopus 로고    scopus 로고
    • Hypoxia-induced decrease in p53 protein level and increase in c-jun DNA binding activity results in cancer cell resistance to etoposide
    • Cosse, J.-P., Ronvaux, M., and Ninane, N., et al. (2009) Hypoxia-induced decrease in p53 protein level and increase in c-jun DNA binding activity results in cancer cell resistance to etoposide. Neoplasia, 11, 976-986.
    • (2009) Neoplasia , vol.11 , pp. 976-986
    • Cosse, J.-P.1    Ronvaux, M.2    Ninane, N.3
  • 136
    • 10644283057 scopus 로고    scopus 로고
    • Hypoxia and anemia: factors in decreased sensitivity to radiation therapy and chemotherapy?
    • Harrison, L., and Blackwell, K. (2004) Hypoxia and anemia: factors in decreased sensitivity to radiation therapy and chemotherapy?. Oncologist, 9, 31-40.
    • (2004) Oncologist , vol.9 , pp. 31-40
    • Harrison, L.1    Blackwell, K.2
  • 137
    • 10644233934 scopus 로고    scopus 로고
    • rHuEPO and treatment outcomes: the preclinical experience
    • Ludwig, H. (2004) rHuEPO and treatment outcomes: the preclinical experience. Oncologist, 9, 48-54.
    • (2004) Oncologist , vol.9 , pp. 48-54
    • Ludwig, H.1
  • 139
    • 0038350531 scopus 로고    scopus 로고
    • Impact of hemoglobin levels on the outcome of cancers treated with chemotherapy
    • Van Belle, S.J.P., and Cocquyt, V. (2003) Impact of hemoglobin levels on the outcome of cancers treated with chemotherapy. Crit. Rev. Oncol. Hematol., 47, 1-11.
    • (2003) Crit. Rev. Oncol. Hematol. , vol.47 , pp. 1-11
    • Van Belle, S.J.P.1    Cocquyt, V.2
  • 141
    • 0030716456 scopus 로고    scopus 로고
    • Activated oxazaphosphorines are transported predominantly by erythrocytes
    • Highley, M.S., Schrijvers, D., van Oosterom, A.T., et al. (1997) Activated oxazaphosphorines are transported predominantly by erythrocytes. Ann. Oncol., 8, 1139-1144.
    • (1997) Ann. Oncol. , vol.8 , pp. 1139-1144
    • Highley, M.S.1    Schrijvers, D.2    van Oosterom, A.T.3
  • 142
    • 0034983539 scopus 로고    scopus 로고
    • Contradistinction between doxorubicin and epirubicin: in vitro interaction with blood components
    • Ramanathan-Girish, S., and Boroujerdi, M. (2001) Contradistinction between doxorubicin and epirubicin: in vitro interaction with blood components. J. Pharm. Pharmacol., 53, 815-821.
    • (2001) J. Pharm. Pharmacol. , vol.53 , pp. 815-821
    • Ramanathan-Girish, S.1    Boroujerdi, M.2
  • 143
    • 0042664107 scopus 로고    scopus 로고
    • Role of red blood cells in pharmacokinetics of chemotherapeutic agents
    • Schrijvers, D. (2003) Role of red blood cells in pharmacokinetics of chemotherapeutic agents. Clin. Pharmacokinet., 42, 779-791.
    • (2003) Clin. Pharmacokinet. , vol.42 , pp. 779-791
    • Schrijvers, D.1
  • 145
    • 33646543307 scopus 로고    scopus 로고
    • Erythrocyte concentrations of metabolites or cumulative doses of 6-mercaptopurine and methotrexate do not predict liver changes in children treated for acute lymphoblastic leukemia
    • Halonen, P., Mattila, J., Mäkipernaa, A., et al. (2006) Erythrocyte concentrations of metabolites or cumulative doses of 6-mercaptopurine and methotrexate do not predict liver changes in children treated for acute lymphoblastic leukemia. Pediatr. Blood Cancer, 46, 762-766.
    • (2006) Pediatr. Blood Cancer , vol.46 , pp. 762-766
    • Halonen, P.1    Mattila, J.2    Mäkipernaa, A.3
  • 146
    • 0032989376 scopus 로고    scopus 로고
    • Pharmacokinetics and biotransformations of oxaliplatin in comparison with ormaplatin following a single bolus injection in rats
    • Luo, F.R., Wyrick, S.D., and Chaney, S.G. (1999) Pharmacokinetics and biotransformations of oxaliplatin in comparison with ormaplatin following a single bolus injection in rats. Cancer Chemother. Pharmacol., 44, 19-28.
    • (1999) Cancer Chemother. Pharmacol. , vol.44 , pp. 19-28
    • Luo, F.R.1    Wyrick, S.D.2    Chaney, S.G.3
  • 147
    • 0036605051 scopus 로고    scopus 로고
    • Melphalan availability in hypoxia-inducible factor-1alpha+/+ and factor-1alpha-/- tumors is independent of tumor vessel density and correlates with melphalan erythrocyte transport
    • Wildiers, H., Guetens, G., de Boeck, G., et al. (2002) Melphalan availability in hypoxia-inducible factor-1alpha+/+ and factor-1alpha-/- tumors is independent of tumor vessel density and correlates with melphalan erythrocyte transport. Int. J. Cancer, 99, 514-519.
    • (2002) Int. J. Cancer , vol.99 , pp. 514-519
    • Wildiers, H.1    Guetens, G.2    de Boeck, G.3
  • 148
    • 0027216418 scopus 로고
    • The effect of hypoxia on cytotoxicity, accumulation and DNA binding of cisplatin in Chinese hamster ovary cells
    • Matthews, J.B., Adomat, H., and Skov, K.A. (1993) The effect of hypoxia on cytotoxicity, accumulation and DNA binding of cisplatin in Chinese hamster ovary cells. Anti-Cancer Drugs, 4, 463-470.
    • (1993) Anti-Cancer Drugs , vol.4 , pp. 463-470
    • Matthews, J.B.1    Adomat, H.2    Skov, K.A.3
  • 149
    • 0025790479 scopus 로고
    • Hypoxia and acidity increase the cytotoxicity of mitomycin C and carboquone to human tumor cells in vitro
    • Kohnoe, S., Emi, Y., Takahashi, I., et al. (1991) Hypoxia and acidity increase the cytotoxicity of mitomycin C and carboquone to human tumor cells in vitro. AntiCancer Res., 11, 1401-1404.
    • (1991) AntiCancer Res. , vol.11 , pp. 1401-1404
    • Kohnoe, S.1    Emi, Y.2    Takahashi, I.3
  • 151
    • 84934435478 scopus 로고    scopus 로고
    • Impact of hypoxic and acidic extracellular conditions on cytotoxicity of chemotherapeutic drugs
    • Thews, O., Gassner, B., Kelleher, D.K., et al. (2007) Impact of hypoxic and acidic extracellular conditions on cytotoxicity of chemotherapeutic drugs. Adv. Exp. Med. Biol., 599, 155-161.
    • (2007) Adv. Exp. Med. Biol. , vol.599 , pp. 155-161
    • Thews, O.1    Gassner, B.2    Kelleher, D.K.3
  • 153
    • 0025771650 scopus 로고
    • Are cancer cells acidic?
    • Griffiths, J.R. (1991) Are cancer cells acidic? Br. J. Cancer, 64, 425-427.
    • (1991) Br. J. Cancer , vol.64 , pp. 425-427
    • Griffiths, J.R.1
  • 154
    • 36349001899 scopus 로고    scopus 로고
    • Targeting vacuolar H+-ATPase as a new strategy against cancer
    • Fais, S., De Milito, A., You, H., and Qin, W. (2007) Targeting vacuolar H+-ATPase as a new strategy against cancer. Cancer Res., 67, 10627-10630.
    • (2007) Cancer Res. , vol.67 , pp. 10627-10630
    • Fais, S.1    De Milito, A.2    You, H.3    Qin, W.4
  • 155
    • 0021732164 scopus 로고
    • The relevance of tumour pH to the treatment of malignant disease
    • Wike-Hooley, J.L., Haveman, J., and Reinhold, H.S. (1984) The relevance of tumour pH to the treatment of malignant disease. Radiother. Oncol., 2, 343-366.
    • (1984) Radiother. Oncol. , vol.2 , pp. 343-366
    • Wike-Hooley, J.L.1    Haveman, J.2    Reinhold, H.S.3
  • 156
    • 0024379967 scopus 로고
    • Acid pH in tumors and its potential for therapeutic exploitation
    • Tannock, I.F., and Rotin, D. (1989) Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res., 49, 4373-4384.
    • (1989) Cancer Res. , vol.49 , pp. 4373-4384
    • Tannock, I.F.1    Rotin, D.2
  • 159
    • 0031927798 scopus 로고    scopus 로고
    • Tumor pH: implications for treatment and novel drug design
    • Gerweck, L.E. (1998) Tumor pH: implications for treatment and novel drug design. Semin. Radiat. Oncol., 8, 176-182.
    • (1998) Semin. Radiat. Oncol. , vol.8 , pp. 176-182
    • Gerweck, L.E.1
  • 161
    • 0033986761 scopus 로고    scopus 로고
    • Causes and consequences of tumour acidity and implications for treatment
    • Stubbs, M., McSheehy, P.M.J., Griffiths, J.R., and Bashford, C.L. (2000) Causes and consequences of tumour acidity and implications for treatment. Mol. Med. Today, 6, 15-19.
    • (2000) Mol. Med. Today , vol.6 , pp. 15-19
    • Stubbs, M.1    McSheehy, P.M.J.2    Griffiths, J.R.3    Bashford, C.L.4
  • 166
    • 0029971428 scopus 로고    scopus 로고
    • Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer
    • Gerweck, L.E., and Seetharaman, K. (1996) Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res., 56, 1194-1198.
    • (1996) Cancer Res. , vol.56 , pp. 1194-1198
    • Gerweck, L.E.1    Seetharaman, K.2
  • 167
    • 33745110220 scopus 로고    scopus 로고
    • Tumor pH controls the in-vivo efficacy of weak acid and base chemotherapies
    • Gerweck, L.E., Vijayappa, S., and Kozin, S. (2006) Tumor pH controls the in-vivo efficacy of weak acid and base chemotherapies. Mol. Cancer Ther., 5, 1275-1279.
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 1275-1279
    • Gerweck, L.E.1    Vijayappa, S.2    Kozin, S.3
  • 168
    • 0028289608 scopus 로고
    • Low external pH and osmotic shock increase the expression of human MDR protein
    • Wei, L.Y., and Roepe, P.D. (1994) Low external pH and osmotic shock increase the expression of human MDR protein. Biochemistry, 33, 7229-7238.
    • (1994) Biochemistry , vol.33 , pp. 7229-7238
    • Wei, L.Y.1    Roepe, P.D.2
  • 169
    • 0030964625 scopus 로고    scopus 로고
    • Human MDR1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts
    • Robinson, L.J., Roberts, W.K., Ling, T.T., et al. (1997) Human MDR1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts. Biochemistry, 36, 11169-11178.
    • (1997) Biochemistry , vol.36 , pp. 11169-11178
    • Robinson, L.J.1    Roberts, W.K.2    Ling, T.T.3
  • 170
    • 49649104978 scopus 로고    scopus 로고
    • Mechanisms of chemoresistance to alkylating agents in malignant glioma
    • Sarkaria, J.N., Kitange, G.J., James, D., et al. (2008) Mechanisms of chemoresistance to alkylating agents in malignant glioma. Clin. Cancer Res., 14, 2900-2908.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 2900-2908
    • Sarkaria, J.N.1    Kitange, G.J.2    James, D.3
  • 171
    • 0016836859 scopus 로고
    • Proliferation-dependent cytotoxicity of anticancer agents: a review
    • Valeriote, F., and van Putten, L. (1975) Proliferation-dependent cytotoxicity of anticancer agents: a review. Cancer Res., 35, 2619-2630.
    • (1975) Cancer Res. , vol.35 , pp. 2619-2630
    • Valeriote, F.1    van Putten, L.2
  • 172
    • 39049188220 scopus 로고    scopus 로고
    • Role of the tumor microenvironment in the activity and expression of the p-glycoprotein in human colon carcinoma cells
    • Lotz, C., Kelleher, D.K., Gassner, B., et al. (2007) Role of the tumor microenvironment in the activity and expression of the p-glycoprotein in human colon carcinoma cells. Oncol. Rep., 17, 239-244.
    • (2007) Oncol. Rep. , vol.17 , pp. 239-244
    • Lotz, C.1    Kelleher, D.K.2    Gassner, B.3


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