pH and chemotherapy

Novartis Foundation Symposium

Volumn 240, Issue , 2001, Pages 199-211

  Raghunand, Natarajan ^a   Gillies, Robert J ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

ANIMAL; EXTRACELLULAR SPACE; HUMAN; METABOLISM; NEOPLASM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PHYSIOLOGY; REVIEW;

ANIMAL; ANTINEOPLASTIC AGENTS; EXTRACELLULAR SPACE; HUMAN; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; NEOPLASMS;

EID: 0035232925     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (34)

1. Bearman SI, Overmoyer BA, Bolwell BJ et al 1997 High-dose chemotherapy with autologous peripheral blood progenitor cell support for primary breast cancer in patients with 4-9 involved axillary lymph nodes. Bone Marrow Transplant 20:931-937
2. Bonilla-Felix M, Villegas-Medina O, Vehaskari VM 1994 Renal acidification in children with idiopathic hypercalciuria. J Pediatr 124:529-534 (erratum: 1994 J Pediatr 125:674)
3. Chabner BA, Allegra CJ, Curt GA, Calabresi P 1996 Antineoplastic agents. In: Hardman JG, Limbird LE (eds) Goodman and Gilman's: the pharmacological basis of therapeutics. McGraw-Hill, New York, p 1225-1287
4. Corbett TH, Leopold WR, Dykes DJ, Roberts BJ, Griswold DP, Schabel FM 1982 Toxicity and anticancer activity of a new triazine antifolate (NSC 127755). Cancer Res 42:1707-1715
5. Di Marco A, Casazza AM, Dasdia T et al 1977 Changes of activity of daunorubicin, adriamycin and stereoisomers following the introduction or removal of hydroxyl groups in the amino sugar moiety. Chem Biol Interact 19:291-302
6. Duchateau AM 1987 Mitoxantrone (Novantrone). Pharm Weekbl 122:286-289
7. Gerweck LE 2000 The pH difference between tumour and normal tissue offers a tumour specific target for the treatment of cancer. Drug Resistance Updates 3:49-50
8. Gerweck LE, Seetharaman K 1996 Cellular pH gradient in tumour versus normal tissue: Potential for exploitation for the treatment of cancer. Cancer Res 56:1194-1198
9. Gillies RJ, Lynch RM 2001 Frontiers in the measurement of cell and tumour pH. In: The tumour microenvironment: causes and consequences of hypoxia and acidity. Wiley, Chichester (Novartis Found Symp 240) p 7-22
10. Kohnoe S, Emi Y, Takahashi I, Yoshida M, Machara Y, Sugimachi K 1991 Hypoxia and acidity increase the cytotoxicity of mitomycin C and carboquone to human tumour cells in vitro. Anticancer Res 11:1401-1404
11. Kozin SV, Gerweck LE 1998 Cytotoxicity of weak electrolytes after the adaptation of cells to low pH: role of the transmembrane pH gradient. Br J Cancer 77:1580-1585
12. Krarup-Hansen A, Wasserman K, Rasmussen SN, Dalmark M 1988 Pharmacokinetics of doxorubicin in man with induced acid or alkaline urine. Acta Oncologica 27:25-30
13. Leung JM, Landow L, Franks M et al 1994 Safety and efficacy of intravenous Carbicarb in patients undergoing surgery: comparison with sodium bicarbonate in the treatment of mild metabolic acidosis. SPI Research Group. Study of Perioperative Ischemia. Crit Care Med 22:1540-1549 (erratum: 1995 Crit Care Med 23:420)
14. Mankhetkorn S, Garnier-Suillerot A 1998 The ability of verapamil to restore intracellular accumulation of anthracyclines in multidrug resistant cells depends on the kinetics of their uptake. Eur J Pharmacol 343:313-321
15. McCoy CL, Parkins CS, Chaplin DJ, Griffiths JR, Rodrigues LM, Stubbs M 1995 The effect of blood flow modification on intra- and extracellular pH measured by 31P magnetic resonance spectroscopy in murine tumours. Br J Cancer 72:905-911
16. McNaughton L, Dalton B, Palmer G 1999 Sodium bicarbonate can be used as an ergogenic aid in high-intensity, competitive cycle ergometry of 1 h duration. Eur J Appl Physiol 80:64-69
17. Merino V, López A, Kalia YN, Guy RH 1999 Electrorepulsion versus electroosmosis: effect of pH on the iontophoretic flux of 5-fluorouracil. Pharm Res 16:758-761
18. Mikkelsen RB, Asher C, Hicks T 1985 Extracellular pH, transmembrane distribution and cytotoxicity of chlorambucil. Biochem Pharmacol 34:2531-2534
19. Mooberry ES, Dallas JL, Sakai TT, Glickson JD 1980 Carbon-13 N.M.R. study of bleomycin-A2 protonation. Int J Peptide Prot Res 15:365-376
20. Owellen RJ, Donigian DW, Hartke CA, Hains FO 1977 Correlation of biologic data with physico-chemical properties among the vinca alkaloids and their congeners. Biochem Pharmacol 26:1213-1219
21. Raghunand N, Gillies RJ 2000 pH and drug resistance in tumours. Drug Resistance Updates 3:39-47
22. Raghunand N, Altbach MI, van Sluis R et al 1999a Plasmalemmal pH-gradients in drug-sensitive and drug-resistant MCF-7 human breast carcinoma xenografts measured by 31P magnetic resonance spectroscopy. Biochem Pharmacol 57:309-312
23. Raghunand N, He X, van Sluis R et al 1999b Enhancement of chemotherapy by manipulation of tumour pH. Br J Cancer 80:1005-1011
24. Raghunand N, Martinez-Zaguilán R, Wright SH, Gillies RJ 1999c pH and drug resistance. II. Turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs. Biochem Pharmacol 57:1047-1058
25. Raghunand N, Mahoney B, van Sluis R, Baggett B, Gillies RJ 2000 Acute metabolic alkalosis enhances response of C3H mouse mammary tumours to the weak-base mitoxantrone. Neoplasia 3:227-235
26. Rentsch KM, Horber DH, Schwendener RA, Wunderli-Allenspach H, Hänseler E 1997 Comparative pharmacokinetic and cytotoxic analysis of three different formulations of mitoxantrone in mice. Br J Cancer 75:986-992
27. Roepe PD 1992 Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug-resistant cells expressing different levels of p-glycoprotein. Biochemistry 31:12555-12564
28. Roos A 1978 Weak acids, weak bases, and intracellular pH. Respir Physiology 33:27-30
29. Skarsgard LD, Skwarchuk MW, Vinczan A, Kristl J, Chaplin DJ 1995 The cytotoxicity of melphalan and its relationship to pH, hypoxia and drug uptake. Anticancer Res 15:219-223
30. Stubbs M, Bhujwalla ZM, Tozer GM et al 1992 An assessment of 31P MRS as a method of measuring pH in rat tumours. NMR Biomed 5:351-359
31. Tannock IF, Rotin D 1989 Acid pH in tumours and its potential for therapeutic exploitation. Cancer Res 49:4373-4384
32. van de Ven MJ, Colier WN, Oeseburg B, Folgering HT 1999 Induction of acute metabolic acid/ base changes in humans. Clin Physiol 19:290-293
33. van Sluis R, Bhuj walla ZM, Raghunand N et al 1999 In vivo imaging of extracellular pH using 1H MRSI. Magn Reson Med 41:743-750
34. Vukovic V, Tannock IF 1997 Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan. Br J Cancer 75:1167-1172