Abnormal Microvasculature and Defective Microcirculatory Function in Solid Tumors

Vascular-Targeted Therapies in Oncology

Volumn , Issue , 2006, Pages 9-29

  Vaupel, Peter ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

'crucial Ps' in tumors; Diffusion limited hypoxia; Microvasculature in solid tumors; Tumor angiogenesis vascular endothelial growth factor (VEGF); Tumor interstitial space volume and composition; Tumor lymphangiogenesis; Tumor microvasculature; Tumor vascularity and blood flow; Tumor to tumor variability

Indexed keywords

EID: 34447580974     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/0470035439.ch2     Document Type: Chapter

References (60)

1. Baronzio, G., Freitas, I. and Kwaan, H.C. (2003). Tumor microenvironment and hemorheological abnormalities. Semin Thrombosis Hemostasis 29, 489-497.
2. Becker, A., Stadler, P., Lavey, R.S., Hänsgen, G., Kuhnt, T., Lautenschläger, C., Feldmann, H.J., Molls, M. and Dunst, J. (2000). Severe anemia is associated with poor tumor oxygenation in head and neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys 46, 459-466.
3. Brem, S., Brem, H., Folkman, J., Finkelstein, D. and Platz, A. (1976). Prolonged tumor dormancy by prevention of neovascularization in the vitreous. Cancer Res 36, 2807-2812.
4. Brizel, D.M., Schroeder, T., Scher, R.L., Walenta, S., Clough, R.W., Dewhirst, M.W. and Mueller-Klieser, W. (2001). Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. Int J Radiat Oncol Biol Phys 51, 349-353.
5. Carmeliet, P. and Jain, R.K. (2000). Angiogenesis in cancer and other diseases. Nature 407, 249-257.
6. Coleman, C.N., Mitchell, J.B. and Camphausen, K. (2002). Tumor hypoxia: chicken, egg, or a piece of the farm? J Clin Oncol 20, 610-615.
7. Ellis, L.M., Liu, W., Ahmad, S.A., Fan, F., Jung, Y.D., Shaheen, R.M. and Reinmuth, N. (2001). Overview of angiogenesis: biologic implications for antiangiogenic therapy. Semin Oncol 28, 94-104.
8. Evans, S.M. and Koch, C.J. (2003). Prognostic significance of tumor oxygenation in humans. Cancer Lett 195, 1-16.
9. Giaccia, A.J. (1996). Hypoxic stress proteins: survival of the fittest. Semin Radiat Oncol 6, 46-58.
10. Gillies, R.J., Schornack, P.A., Secomb, T.W. and Raghunand, N. (1999). Causes and effects of heterogeneous perfusion in tumors. Neoplasia 1, 197-207.
11. Griffiths, J.R. (1991). Are cancer cells acidic? Br J Cancer 64, 425-427.
12. Gullino, P.M. (1970). Techniques for the study of tumor physiopathology. In Methods in Cancer Research (Vol. 5), H. Busch (ed.). Academic Press, New York, pp. 45-91.
13. Hanahan, D. and Weinberg, R.A. (2000). The hallmarks of cancer. Cell 100, 57-70.
14. Hirst, D.G. and Flitney, F.W. (1997). The physiological importance and therapeutic potential of nitric oxide in the tumour-associated vasculature. In Tumour Angiogenesis, R. Bicknell, C.E. Lewis and N. Ferrara (eds). Oxford University Press, Oxford, pp. 153-167.
15. Höckel, M., Schlenger, K., Aral, B., Mitze, M., Schäffer, U. and Vaupel, P. (1996). Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56, 4509-4515.
16. Höckel, M. and Vaupel, P. (2001). Tumor hypoxia: definitions and current clinical, biologic and molecular aspects. J Natl Cancer Inst 93, 266-276.
17. Jain, R.K. (1994). Barriers to drug delivery in solid tumors. Sci Am 271, 58-65.
18. Jussila, L. and Alitalo, K. (2002). Vascular growth factors and lymphangiogenesis. Physiol Rev 82, 673-700.
19. Kerbel, R.S. (2000). Tumor angiogenesis: past, present and the near future. Carcinogenesis 21, 505-515.
20. Kimura, H., Braun, R.D., Ong, E.T., Hsu, R., Secomb, T.W., Papahadjopoulos, D., Hong, K. and Dewhirst, M. (1996). Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. Cancer Res 56, 5522-5528.
21. Konerding, M.A., Fait, E. and Gaumann, A. (2001). 3D microvascular architecture of precancerous lesions and invasive carcinomas of the colon. Br J Cancer 84, 1354-1362.
22. McDonald, D.M., Munn, L. and Jain, R.K. (2000). Vasculogenic mimicry: how convincing, how novel, and how significant? Am J Pathol 156, 383-388.
23. Milosevic, M., Fyles, A., Hedley, D. and Hill, R. (2004). The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure. Semin Radiat Oncol 14, 249-258.
24. Nowell, P.C. (1976). The clonal evolution of tumor cell populations. Science 194, 23-28.
25. Okunieff, P., Ding, I., Vaupel, P. and Höckel, M. (2003). Evidence for and against hypoxia as the primary cause of tumor aggressiveness. Adv Exp Med Biol 510, 69-75.
26. Orive, G., Reshkin, S.J., Harguindey, S. and Pedraz, J.L. (2003). Hydrogen ion dynamics and the Na+/H+ exchanger in cancer angiogenesis and antiangiogenesis. Br J Cancer 89, 1395-1399.
27. Padera, T.P., Kadambi, A., di Tomaso, E., Carreira, C.M., Brown, E.B., Boucher, Y., Choi, N.C., Mathisen, D., Wain, J., Mark, E.J., Munn, L.L. and Jain, R.K. (2002). Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 296, 1883-1886.
28. Papetti, M. and Herman, I.M. (2002). Mechanisms of normal and tumor-derived angiogenesis. Am J Physiol Cell Physiol 282, C947-C970.
29. Patan, S., Munn, L.L. and Jain, R.K. (1996). Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis. Microvasc Res 51, 260-272.
30. Pugh, C.W. and Ratcliffe, P.J. (2003). Regulation of angiogenesis by hypoxia: role of the HIF system. Nature Med 9, 677-684.
31. Reynolds, T.Y., Rockwell, S. and Glazer, P.M. (1996). Genetic instability induced by the tumor microenvironment. Cancer Res 56, 5754-5757.
32. Ribatti, D., Vacca, A. and Dammacco, F. (2003). New non-angiogenesis dependent pathways for tumour growth. Eur J Cancer 39, 1835-1841.
33. Rofstad, E.K. (2000). Microenvironment-induced cancer metastasis. Int J Radiat Biol 76, 589-605.
34. Ruoslahti, E. (2002). Specialization of tumour vasculature. Nature Rev Cancer 2, 83-90.
35. Semenza, G.L. (2000). HIF-1: using two hands to flip the angiogenic switch. Cancer Metab Rev 19, 59-65.
36. Shweiki, D., Neeman, M., Itin, A. and Keshet, E. (1995). Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis. Proc Natl Acad Sci USA 92, 768-772.
37. Sivridis, E., Giatromanolaki, A. and Koukourakis, M.I. (2003). The vascular network of tumours-what is it not for? J Pathol 201, 173-180.
38. Stubbs, M., McSheehy, P.M.J., Griffiths, J.R. and Bashford, C.L. (2000). Causes and consequences of tumour acidity and implications for treatment. Mol Med Today 6, 15-19.
39. Subarsky, P. and Hill, R.P. (2003). The hypoxic tumour microenvironment and metastatic progression. Clin Exp Metastasis 20, 237-250.
40. Vaupel, P. (1992). Physiological properties of malignant tumours. NMR Biomed 5, 220-225.
41. Vaupel, P.W. (1994). Blood Flow, Oxygenation, Tissue pH Distribution, and Bioenergetic Status of Tumors, Lecture 23, Ernst Schering Research Foundation.
42. Vaupel, P. (2004). Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 14, 198-206.
43. Vaupel, P., Briest, S. and Höckel, M. (2002a). Hypoxia in breast cancer: pathogenesis, characterization and biological/therapeutic implications. Wien Med Wschr 152, 334-342.
44. Vaupel, P. and Höckel, M. (2000). Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance. Int J Oncol 17, 869-879.
45. Vaupel, P. and Höckel, M. (2002). Tumor hypoxia and therapeutic resistance. In Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology, M.R. Nowrousian (ed.). Springer, Berlin, pp. 127-146.
46. Vaupel, P., Kallinowski, F. and Okunieff, P. (1989). Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49, 6449-6465.
47. Vaupel, P. and Kelleher, D.K. (eds). (1999). Tumor Hypoxia, Wissenschaftliche Verlagsgesellschaft, Stuttgart.
48. Vaupel, P., Mayer, A., Briest, S. and Höckel, M. (2003a). Oxygenation gain factor: a novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers. Cancer Res 63, 7634-7637.
49. Vaupel, P., Mayer, A. and Höckel, M. (2004). Tumor hypoxia and malignant progression. Methods Enzymol 381, 335-354.
50. Vaupel, P., Schaefer, C. and Okunieff, P. (1994). Intracellular acidosis in murine fibrosarcomas coincides with ATP depletion, hypoxia, and high levels of lactate and total Pi. NMR Biomed 7, 128-136.
51. Vaupel, P., Thews, O. and Hoeckel, M. (2001). Treatment resistance of solid tumors: role of hypoxia and anemia. Med Oncol 18, 243-259.
52. Vaupel, P., Thews, O., Kelleher, D.K. and Konerding, M.A. (2003b). O2 extraction is a key parameter determining the oxygenation status of malignant tumors and normal tissues. Int J Oncol 22, 795-798.
53. Vaupel, P., Thews, O., Mayer, A., Höckel, S. and Höckel, M. (2002b). Oxygenation status of gynecologic tumors: what is the optimal hemoglobin level? Strahlenther Onkol 178, 727-731.
54. Walenta, S., Chau, T.-V., Schroeder, T., Lehr, H.-A., Kunz-Schughart, L.A., Fuerst, A. and Mueller-Klieser, W. (2003). Metabolic classification of human rectal adenocarcinomas: a novel guideline for clinical oncologists? J Cancer Res Clin Oncol 129, 321-326.
55. Walenta, S. and Mueller-Klieser, W.F. (2004). Lactate: mirror and motor of tumor malignancy. Semin Radiat Oncol 14, 267-274.
56. Walenta, S., Salameh, A., Lyng, H., Evensen, J.F., Mitze, M., Rofstad, E.K. and Mueller-Klieser, W. (1997). Correlation of high lactate levels in head and neck tumors with incidence of metastasis. Am J Pathol 150, 409-415.
57. Walenta, S., Wetterling, M., Lehrke, M., Schwickert, G., Sundfor, K., Rofstad, E.K. and Mueller-Klieser, W. (2000). High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 60, 916-921.
58. Yancopoulos, G.D., Davis, S., Gale, N.W., Rudge, J.S., Wiegand, S.J. and Holash, J. (2000). Vascular-specific growth factors and blood vessel formation. Nature 407, 242-248.
59. Yuan, J. and Glazer, P.M. (1998). Mutagenesis induced by the tumor microenvironment. Mutation Res 400, 439-446.
60. Yuan, J., Narayanan, L., Rockwell, S. and Glazer, P.M. (2000). Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res 60, 4372-4376.