-
1
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D. & R. A. Weinberg: Hallmarks of cancer: the next generation. Cell, 144, 646-74 (2011)
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
33645072212
-
ATMdependent DNA damage surveillance in T-cell development and leukemogenesis: The DSB connection
-
Matei, I. R., C. J. Guidos & J. S. Danska: ATMdependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection. Immunol Rev, 209, 142-58 (2006)
-
(2006)
Immunol Rev
, vol.209
, pp. 142-158
-
-
Matei, I.R.1
Guidos, C.J.2
Danska, J.S.3
-
3
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
DOI 10.1038/nrc1011
-
Shiloh, Y.: ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer, 3, 155-68 (2003) (Pubitemid 37328868)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.3
, pp. 155-168
-
-
Shiloh, Y.1
-
4
-
-
21744452376
-
Cancer in xeroderma pigmentosum and related disorders of DNA repair
-
DOI 10.1038/nrc1652
-
Cleaver, J. E.: Cancer in xeroderma pigmentosum and related disorders of DNA repair. Nat Rev Cancer, 5, 564-73 (2005) (Pubitemid 40942832)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.7
, pp. 564-573
-
-
Cleaver, J.E.1
-
5
-
-
34249989689
-
Retinoblastoma epidemiology: Does the evidence matter?
-
DOI 10.1016/j.ejca.2007.04.019, PII S0959804907003255
-
Mastrangelo, D., S. De Francesco, A. Di Leonardo, L. Lentini & T. Hadjistilianou: Retinoblastoma epidemiology: does the evidence matter? Eur J Cancer, 43, 1596-603 (2007) (Pubitemid 46891808)
-
(2007)
European Journal of Cancer
, vol.43
, Issue.10
, pp. 1596-1603
-
-
Mastrangelo, D.1
De Francesco, S.2
Di Leonardo, A.3
Lentini, L.4
Hadjistilianou, T.5
-
6
-
-
70349985246
-
Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice
-
Lin, P. P., M. K. Pandey, F. Jin, A. K. Raymond, H. Akiyama & G. Lozano: Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice. Carcinogenesis, 30, 1789-95 (2009)
-
(2009)
Carcinogenesis
, vol.30
, pp. 1789-1795
-
-
Lin, P.P.1
Pandey, M.K.2
Jin, F.3
Raymond, A.K.4
Akiyama, H.5
Lozano, G.6
-
7
-
-
67649424560
-
P21 in cancer: Intricate networks and multiple activities
-
Abbas, T. & A. Dutta: p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer, 9, 400-14 (2009)
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 400-414
-
-
Abbas, T.1
Dutta, A.2
-
8
-
-
40049087659
-
Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer
-
DOI 10.1016/j.cancergencyto.2007.12.004, PII S0165460807008096
-
Kang, J. U., S. H. Koo, K. C. Kwon, J. W. Park & J. M. Kim: Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer. Cancer Genet Cytogenet, 182, 1-11 (2008) (Pubitemid 351323956)
-
(2008)
Cancer Genetics and Cytogenetics
, vol.182
, Issue.1
, pp. 1-11
-
-
Kang, J.U.1
Koo, S.H.2
Kwon, K.C.3
Park, J.W.4
Kim, J.M.5
-
9
-
-
59149091340
-
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types
-
Rafnar, T., P. Sulem, S. N. Stacey, F. Geller, J. Gudmundsson, A. Sigurdsson, M. Jakobsdottir, H. Helgadottir, S. Thorlacius, K. K. Aben, T. Blondal, T. E. Thorgeirsson, G. Thorleifsson, K. Kristjansson, K. Thorisdottir, R. Ragnarsson, B. Sigurgeirsson, H. Skuladottir, T. Gudbjartsson, H. J. Isaksson, G. V. Einarsson, K. R. Benediktsdottir, B. A. Agnarsson, K. Olafsson, A. Salvarsdottir, H. Bjarnason, M. Asgeirsdottir, K. T. Kristinsson, S. Matthiasdottir, S. G. Sveinsdottir, S. Polidoro, V. Hoiom, R. Botella-Estrada, K. Hemminki, P. Rudnai, D. T. Bishop, M. Campagna, E. Kellen, M. P. Zeegers, P. de Verdier, A. Ferrer, D. Isla, M. J. Vidal, R. Andres, B. Saez, P. Juberias, J. Banzo, S. Navarrete, A. Tres, D. Kan, A. Lindblom, E. Gurzau, K. Koppova, F. de Vegt, J. A. Schalken, H. F. van der Heijden, H. J. Smit, R. A. Termeer, E. Oosterwijk, O. van Hooij, E. Nagore, S. Porru, G. Steineck, J. Hansson, F. Buntinx, W. J. Catalona, G. Matullo, P. Vineis, A. E. Kiltie, J. I. Mayordomo, R. Kumar, L. A. Kiemeney, M. L. Frigge, T. Jonsson, H. Saemundsson, R. B. Barkardottir, E. Jonsson, S. Jonsson, J. H. Olafsson, J. R. Gulcher, G. Masson, D. F. Gudbjartsson, A. Kong, U. Thorsteinsdottir & K. Stefansson: Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat Genet, 41, 221-7 (2009)
-
(2009)
Nat Genet
, vol.41
, pp. 221-227
-
-
Rafnar, T.1
Sulem, P.2
Stacey, S.N.3
Geller, F.4
Gudmundsson, J.5
Sigurdsson, A.6
Jakobsdottir, M.7
Helgadottir, H.8
Thorlacius, S.9
Aben, K.K.10
Blondal, T.11
Thorgeirsson, T.E.12
Thorleifsson, G.13
Kristjansson, K.14
Thorisdottir, K.15
Ragnarsson, R.16
Sigurgeirsson, B.17
Skuladottir, H.18
Gudbjartsson, T.19
Isaksson, H.J.20
Einarsson, G.V.21
Benediktsdottir, K.R.22
Agnarsson, B.A.23
Olafsson, K.24
Salvarsdottir, A.25
Bjarnason, H.26
Asgeirsdottir, M.27
Kristinsson, K.T.28
Matthiasdottir, S.29
Sveinsdottir, S.G.30
Polidoro, S.31
Hoiom, V.32
Botella-Estrada, R.33
Hemminki, K.34
Rudnai, P.35
Bishop, D.T.36
Campagna, M.37
Kellen, E.38
Zeegers, M.P.39
De Verdier, P.40
Ferrer, A.41
Isla, D.42
Vidal, M.J.43
Andres, R.44
Saez, B.45
Juberias, P.46
Banzo, J.47
Navarrete, S.48
Tres, A.49
Kan, D.50
Lindblom, A.51
Gurzau, E.52
Koppova, K.53
De Vegt, F.54
Schalken, J.A.55
Van Der Heijden, H.F.56
Smit, H.J.57
Termeer, R.A.58
Oosterwijk, E.59
Van Hooij, O.60
Nagore, E.61
Porru, S.62
Steineck, G.63
Hansson, J.64
Buntinx, F.65
Catalona, W.J.66
Matullo, G.67
Vineis, P.68
Kiltie, A.E.69
Mayordomo, J.I.70
Kumar, R.71
Kiemeney, L.A.72
Frigge, M.L.73
Jonsson, T.74
Saemundsson, H.75
Barkardottir, R.B.76
Jonsson, E.77
Jonsson, S.78
Olafsson, J.H.79
Gulcher, J.R.80
Masson, G.81
Gudbjartsson, D.F.82
Kong, A.83
Thorsteinsdottir, U.84
Stefansson, K.85
more..
-
10
-
-
22944488871
-
Telomeres and human disease: Ageing, cancer and beyond
-
DOI 10.1038/nrg1656
-
Blasco, M. A.: Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet, 6, 611-22 (2005) (Pubitemid 41044298)
-
(2005)
Nature Reviews Genetics
, vol.6
, Issue.8
, pp. 611-622
-
-
Blasco, M.A.1
-
11
-
-
0036787840
-
Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development
-
Gonzalez-Suarez, E., J. M. Flores & M. A. Blasco: Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development. Mol Cell Biol, 22, 7291-301 (2002)
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7291-7301
-
-
Gonzalez-Suarez, E.1
Flores, J.M.2
Blasco, M.A.3
-
12
-
-
0343228751
-
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis
-
Gonzalez-Suarez, E., E. Samper, J. M. Flores & M. A. Blasco: Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat Genet, 26, 114-7 (2000)
-
(2000)
Nat Genet
, vol.26
, pp. 114-117
-
-
Gonzalez-Suarez, E.1
Samper, E.2
Flores, J.M.3
Blasco, M.A.4
-
14
-
-
22144489899
-
INK4a/ARF: A multifunctional tumor suppressor locus
-
DOI 10.1016/j.mrfmmm.2004.08.021, PII S002751070500151X, The Utility of Genetically Altered Mouse Models for Cancer Research
-
Sharpless, N. E.: INK4a/ARF: a multifunctional tumor suppressor locus. Mutat Res, 576, 22-38 (2005) (Pubitemid 40982680)
-
(2005)
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
, vol.576
, Issue.1-2
, pp. 22-38
-
-
Sharpless, N.E.1
-
15
-
-
0842281645
-
Cell death: Critical control points
-
DOI 10.1016/S0092-8674(04)00046-7
-
Danial, N. N. & S. J. Korsmeyer: Cell death: critical control points. Cell, 116, 205-19 (2004) (Pubitemid 38167313)
-
(2004)
Cell
, vol.116
, Issue.2
, pp. 205-219
-
-
Danial, N.N.1
Korsmeyer, S.J.2
-
16
-
-
2542549018
-
High expression levels of X-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia
-
DOI 10.1158/1078-0432.CCR-03-0642
-
Tamm, I., S. Richter, D. Oltersdorf, U. Creutzig, J. Harbott, F. Scholz, L. Karawajew, W. D. Ludwig & C. Wuchter: High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia. Clin Cancer Res, 10, 3737-44 (2004) (Pubitemid 38697607)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.11
, pp. 3737-3744
-
-
Tamm, I.1
Richter, S.2
Oltersdorf, D.3
Creutzig, U.4
Harbott, J.5
Scholz, F.6
Karawajew, L.7
Ludwig, W.-D.8
Wuchter, C.9
-
17
-
-
34247862306
-
Overexpression of XIAP expression in renal cell carcinoma predicts a worse prognosis
-
Mizutani, Y., H. Nakanishi, Y. N. Li, H. Matsubara, K. Yamamoto, N. Sato, T. Shiraishi, T. Nakamura, K. Mikami, K. Okihara, N. Takaha, O. Ukimura, A. Kawauchi, N. Nonomura, B. Bonavida & T. Miki: Overexpression of XIAP expression in renal cell carcinoma predicts a worse prognosis. Int J Oncol, 30, 919-25 (2007)
-
(2007)
Int J Oncol
, vol.30
, pp. 919-925
-
-
Mizutani, Y.1
Nakanishi, H.2
Li, Y.N.3
Matsubara, H.4
Yamamoto, K.5
Sato, N.6
Shiraishi, T.7
Nakamura, T.8
Mikami, K.9
Okihara, K.10
Takaha, N.11
Ukimura, O.12
Kawauchi, A.13
Nonomura, N.14
Bonavida, B.15
Miki, T.16
-
18
-
-
3843059163
-
Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients
-
DOI 10.1038/sj.onc.1207725
-
Elhasid, R., D. Sahar, A. Merling, Y. Zivony, A. Rotem, M. Ben-Arush, S. Izraeli, D. Bercovich & S. Larisch: Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients. Oncogene, 23, 5468-75 (2004) (Pubitemid 39044057)
-
(2004)
Oncogene
, vol.23
, Issue.32
, pp. 5468-5475
-
-
Elhasid, R.1
Sahar, D.2
Merling, A.3
Zivony, Y.4
Rotem, A.5
Ben-Arush, M.6
Izraeli, S.7
Bercovich, D.8
Larisch, S.9
-
19
-
-
8844275871
-
ARTS in astrocytic tumors: Correlation with malignancy grade and survival rate
-
Gottfried, Y., E. Voldavsky, L. Yodko, E. Sabo, O. Ben-Itzhak & S. Larisch: ARTS in astrocytic tumors: correlation with malignancy grade and survival rate. Cancer, 101, 2614-21 (2004)
-
(2004)
Cancer
, vol.101
, pp. 2614-2621
-
-
Gottfried, Y.1
Voldavsky, E.2
Yodko, L.3
Sabo, E.4
Ben-Itzhak, O.5
Larisch, S.6
-
20
-
-
77958538177
-
Sept4/ARTS is required for stem cell apoptosis and tumor suppression
-
Garcia-Fernandez, M., H. Kissel, S. Brown, T. Gorenc, A. J. Schile, S. Rafii, S. Larisch & H. Steller: Sept4/ARTS is required for stem cell apoptosis and tumor suppression. Genes Dev, 24, 2282-93 (2010)
-
(2010)
Genes Dev
, vol.24
, pp. 2282-2293
-
-
Garcia-Fernandez, M.1
Kissel, H.2
Brown, S.3
Gorenc, T.4
Schile, A.J.5
Rafii, S.6
Larisch, S.7
Steller, H.8
-
21
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin 1
-
Liang, X. H., S. Jackson, M. Seaman, K. Brown, B. Kempkes, H. Hibshoosh & B. Levine: Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature, 402, 672-6 (1999) (Pubitemid 129516338)
-
(1999)
Nature
, vol.402
, Issue.6762
, pp. 672-676
-
-
Liang, X.H.1
Jackson, S.2
Seaman, M.3
Brown, K.4
Kempkes, B.5
Hibshoosh, H.6
Levine, B.7
-
22
-
-
70349641918
-
Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1alpha expression
-
Chen, Y., Y. Lu, C. Lu & L. Zhang: Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1alpha expression. Pathol Oncol Res, 15, 487-93 (2009)
-
(2009)
Pathol Oncol Res
, vol.15
, pp. 487-493
-
-
Chen, Y.1
Lu, Y.2
Lu, C.3
Zhang, L.4
-
23
-
-
77954242444
-
Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas
-
Nicotra, G., F. Mercalli, C. Peracchio, R. Castino, C. Follo, G. Valente & C. Isidoro: Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas. Mod Pathol, 23, 937-50 (2010)
-
(2010)
Mod Pathol
, vol.23
, pp. 937-950
-
-
Nicotra, G.1
Mercalli, F.2
Peracchio, C.3
Castino, R.4
Follo, C.5
Valente, G.6
Isidoro, C.7
-
24
-
-
79955166274
-
Clinicopathologic correlation of beclin-1 expression in pancreatic ductal adenocarcinoma
-
Kim, H. S., S. H. Lee, S. I. Do, S. J. Lim, Y. K. Park & Y. W. Kim: Clinicopathologic correlation of beclin-1 expression in pancreatic ductal adenocarcinoma. Pathol Res Pract, 207, 247-52 (2011)
-
(2011)
Pathol Res Pract
, vol.207
, pp. 247-252
-
-
Kim, H.S.1
Lee, S.H.2
Do, S.I.3
Lim, S.J.4
Park, Y.K.5
Kim, Y.W.6
-
25
-
-
77953708091
-
Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma
-
Wan, X. B., X. J. Fan, M. Y. Chen, J. Xiang, P. Y. Huang, L. Guo, X. Y. Wu, J. Xu, Z. J. Long, Y. Zhao, W. H. Zhou, H. Q. Mai, Q. Liu & M. H. Hong: Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma. Autophagy, 6, 395-404 (2010)
-
(2010)
Autophagy
, vol.6
, pp. 395-404
-
-
Wan, X.B.1
Fan, X.J.2
Chen, M.Y.3
Xiang, J.4
Huang, P.Y.5
Guo, L.6
Wu, X.Y.7
Xu, J.8
Long, Z.J.9
Zhao, Y.10
Zhou, W.H.11
Mai, H.Q.12
Liu, Q.13
Hong, M.H.14
-
26
-
-
9144240441
-
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
-
DOI 10.1172/JCI200320039
-
Qu, X., J. Yu, G. Bhagat, N. Furuya, H. Hibshoosh, A. Troxel, J. Rosen, E. L. Eskelinen, N. Mizushima, Y. Ohsumi, G. Cattoretti & B. Levine: Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest, 112, 1809-20 (2003) (Pubitemid 38063704)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.12
, pp. 1809-1820
-
-
Qu, X.1
Yu, J.2
Bhagat, G.3
Furuya, N.4
Hibshoosh, H.5
Troxel, A.6
Rosen, J.7
Eskelinen, E.-L.8
Mizushima, N.9
Ohsumi, Y.10
Cattoretti, G.11
Levine, B.12
-
27
-
-
0345166111
-
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
DOI 10.1073/pnas.2436255100
-
Yue, Z., S. Jin, C. Yang, A. J. Levine & N. Heintz: Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A, 100, 15077-82 (2003) (Pubitemid 37518019)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.25
, pp. 15077-15082
-
-
Yue, Z.1
Jin, S.2
Yang, C.3
Levine, A.J.4
Heintz, N.5
-
28
-
-
34547132328
-
Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3
-
DOI 10.1074/jbc.M701194200
-
Marino, G., N. Salvador-Montoliu, A. Fueyo, E. Knecht, N. Mizushima & C. Lopez-Otin: Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem, 282, 18573-83 (2007) (Pubitemid 47100226)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.25
, pp. 18573-18583
-
-
Marino, G.1
Salvador-Montoliu, N.2
Fueyo, A.3
Knecht, E.4
Mizushima, N.5
Lopez-Otin, C.6
-
29
-
-
65049086409
-
Embryonic stem cell markers expression in cancers
-
Schoenhals, M., A. Kassambara, J. De Vos, D. Hose, J. Moreaux & B. Klein: Embryonic stem cell markers expression in cancers. Biochem Biophys Res Commun, 383, 157-62 (2009)
-
(2009)
Biochem Biophys Res Commun
, vol.383
, pp. 157-162
-
-
Schoenhals, M.1
Kassambara, A.2
De Vos, J.3
Hose, D.4
Moreaux, J.5
Klein, B.6
-
30
-
-
0022380768
-
The c-myc malignancy in transgenic mice
-
Adams, J. M., A. W. Harris, C. A. Pinkert, L. M. Corcoran, W. S. Alexander, S. Cory, R. D. Palmiter & R. L. Brinster: The c-myc malignancy in transgenic mice. Nature, 318, 533-8 (1985)
-
(1985)
Nature
, vol.318
, pp. 533-538
-
-
Adams, J.M.1
Harris, A.W.2
Pinkert, C.A.3
Corcoran, L.M.4
Alexander, W.S.5
Cory, S.6
Palmiter, R.D.7
Brinster, R.L.8
-
31
-
-
69349098834
-
Stem cells: The promises and perils of p53
-
Krizhanovsky, V. & S. W. Lowe: Stem cells: The promises and perils of p53. Nature, 460, 1085-6 (2009)
-
(2009)
Nature
, vol.460
, pp. 1085-1086
-
-
Krizhanovsky, V.1
Lowe, S.W.2
-
32
-
-
78650015522
-
The role of mutant p53 in human cancer
-
Goh, A. M., C. R. Coffill & D. P. Lane: The role of mutant p53 in human cancer. J Pathol, 223, 116-26 (2011)
-
(2011)
J Pathol
, vol.223
, pp. 116-126
-
-
Goh, A.M.1
Coffill, C.R.2
Lane, D.P.3
-
33
-
-
78651100119
-
Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures
-
Mizuno, H., B. T. Spike, G. M. Wahl & A. J. Levine: Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. Proc Natl Acad Sci U S A, 107, 22745-50 (2010)
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 22745-22750
-
-
Mizuno, H.1
Spike, B.T.2
Wahl, G.M.3
Levine, A.J.4
-
34
-
-
51049098347
-
The Arf/p53 pathway in cancer and aging
-
Matheu, A., A. Maraver & M. Serrano: The Arf/p53 pathway in cancer and aging. Cancer Res, 68, 6031-4 (2008)
-
(2008)
Cancer Res
, vol.68
, pp. 6031-6034
-
-
Matheu, A.1
Maraver, A.2
Serrano, M.3
-
35
-
-
0028058712
-
Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer
-
Umbas, R., W. B. Isaacs, P. P. Bringuier, H. E. Schaafsma, H. F. Karthaus, G. O. Oosterhof, F. M. Debruyne & J. A. Schalken: Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res, 54, 3929-33 (1994) (Pubitemid 24241218)
-
(1994)
Cancer Research
, vol.54
, Issue.14
, pp. 3929-3933
-
-
Umbas, R.1
Isaacs, W.B.2
Bringuier, P.P.3
Schaafsma, H.E.4
Karthaus, H.F.M.5
Oosterhof, G.O.N.6
Debruyne, F.M.J.7
Schalken, J.A.8
-
36
-
-
0027530351
-
Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis
-
Oka, H., H. Shiozaki, K. Kobayashi, M. Inoue, H. Tahara, T. Kobayashi, Y. Takatsuka, N. Matsuyoshi, S. Hirano, M. Takeichi & et al.: Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res, 53, 1696-701 (1993) (Pubitemid 23113254)
-
(1993)
Cancer Research
, vol.53
, Issue.7
, pp. 1696-1701
-
-
Oka, H.1
Shiozaki, H.2
Kobayashi, K.3
Inoue, M.4
Tahara, H.5
Kobayashi, T.6
Takatsuka, Y.7
Matsuyoshi, N.8
Hirano, S.9
Takeichi, M.10
Mori, T.11
-
37
-
-
44449111555
-
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
-
Onder, T. T., P. B. Gupta, S. A. Mani, J. Yang, E. S. Lander & R. A. Weinberg: Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res, 68, 3645-54 (2008)
-
(2008)
Cancer Res
, vol.68
, pp. 3645-3654
-
-
Onder, T.T.1
Gupta, P.B.2
Mani, S.A.3
Yang, J.4
Lander, E.S.5
Weinberg, R.A.6
-
38
-
-
79551602747
-
Metastamirs: A stepping stone towards improved cancer management
-
White, N. M., E. Fatoohi, M. Metias, K. Jung, C. Stephan & G. M. Yousef: Metastamirs: a stepping stone towards improved cancer management. Nat Rev Clin Oncol, 8, 75-84 (2011)
-
(2011)
Nat Rev Clin Oncol
, vol.8
, pp. 75-84
-
-
White, N.M.1
Fatoohi, E.2
Metias, M.3
Jung, K.4
Stephan, C.5
Yousef, G.M.6
-
39
-
-
70449718853
-
MicroRNAs: Crucial multi-tasking components in the complex circuitry of tumor metastasis
-
Valastyan, S. & R. A. Weinberg: MicroRNAs: Crucial multi-tasking components in the complex circuitry of tumor metastasis. Cell Cycle, 8, 3506-12 (2009)
-
(2009)
Cell Cycle
, vol.8
, pp. 3506-3512
-
-
Valastyan, S.1
Weinberg, R.A.2
-
40
-
-
66449095667
-
A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis
-
Valastyan, S., F. Reinhardt, N. Benaich, D. Calogrias, A. M. Szasz, Z. C. Wang, J. E. Brock, A. L. Richardson & R. A. Weinberg: A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell, 137, 1032-46 (2009)
-
(2009)
Cell
, vol.137
, pp. 1032-1046
-
-
Valastyan, S.1
Reinhardt, F.2
Benaich, N.3
Calogrias, D.4
Szasz, A.M.5
Wang, Z.C.6
Brock, J.E.7
Richardson, A.L.8
Weinberg, R.A.9
-
41
-
-
0036561909
-
AIDS-related malignancies
-
Boshoff, C. & R. Weiss: AIDS-related malignancies. Nat Rev Cancer, 2, 373-82 (2002) (Pubitemid 37328950)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.5
, pp. 373-382
-
-
Boshoff, C.1
Weiss, R.2
-
42
-
-
0025686979
-
Malignant lymphomas in cynomolgus monkeys infected with simian immunodeficiency virus
-
Feichtinger, H., P. Putkonen, C. Parravicini, S. L. Li, E. E. Kaaya, D. Bottiger, G. Biberfeld & P. Biberfeld: Malignant lymphomas in cynomolgus monkeys infected with simian immunodeficiency virus. Am J Pathol, 137, 1311-5 (1990)
-
(1990)
Am J Pathol
, vol.137
, pp. 1311-1315
-
-
Feichtinger, H.1
Putkonen, P.2
Parravicini, C.3
Li, S.L.4
Kaaya, E.E.5
Bottiger, D.6
Biberfeld, G.7
Biberfeld, P.8
-
43
-
-
33644924057
-
A population-based study of skin cancer incidence and prevalence in renal transplant recipients
-
DOI 10.1111/j.1365-2133.2005.07021.x
-
Moloney, F. J., H. Comber, P. O'Lorcain, P. O'Kelly, P. J. Conlon & G. M. Murphy: A population-based study of skin cancer incidence and prevalence in renal transplant recipients. Br J Dermatol, 154, 498-504 (2006) (Pubitemid 43382659)
-
(2006)
British Journal of Dermatology
, vol.154
, Issue.3
, pp. 498-504
-
-
Moloney, F.J.1
Comber, H.2
O'Lorcain, P.3
O'Kelly, P.4
Conlon, P.J.5
Murphy, G.M.6
-
44
-
-
0035953308
-
IFNγ, and lymphocytes prevent primary tumour development and shape tumour immunogenicity
-
DOI 10.1038/35074122
-
Shankaran, V., H. Ikeda, A. T. Bruce, J. M. White, P. E. Swanson, L. J. Old & R. D. Schreiber: IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature, 410, 1107-11 (2001) (Pubitemid 32391043)
-
(2001)
Nature
, vol.410
, Issue.6832
, pp. 1107-1111
-
-
Shankaran, V.1
Ikeda, H.2
Bruce, A.T.3
White, J.M.4
Swanson, P.E.5
Old, L.J.6
Schreiber, R.D.7
-
45
-
-
46449117415
-
Risk of cancer by ATM missense mutations in the general population
-
Dombernowsky, S. L., M. Weischer, K. H. Allin, S. E. Bojesen, A. Tybjaerg-Hansen & B. G. Nordestgaard: Risk of cancer by ATM missense mutations in the general population. J Clin Oncol, 26, 3057-62 (2008)
-
(2008)
J Clin Oncol
, vol.26
, pp. 3057-3062
-
-
Dombernowsky, S.L.1
Weischer, M.2
Allin, K.H.3
Bojesen, S.E.4
Tybjaerg-Hansen, A.5
Nordestgaard, B.G.6
-
46
-
-
42149116279
-
Cancer risks in Fanconi anemia: Findings from the German Fanconi Anemia Registry
-
DOI 10.3324/haematol.12234
-
Rosenberg, P. S., B. P. Alter & W. Ebell: Cancer risks in Fanconi anemia: findings from the German Fanconi Anemia Registry. Haematologica, 93, 511-7 (2008) (Pubitemid 351536378)
-
(2008)
Haematologica
, vol.93
, Issue.4
, pp. 511-517
-
-
Rosenberg, P.S.1
Alter, B.P.2
Ebell, W.3
-
47
-
-
18444362122
-
Biallelic inactivation of BRCA2 in Fanconi anemia
-
DOI 10.1126/science.1073834
-
Howlett, N. G., T. Taniguchi, S. Olson, B. Cox, Q. Waisfisz, C. De Die-Smulders, N. Persky, M. Grompe, H. Joenje, G. Pals, H. Ikeda, E. A. Fox & A. D. D'Andrea: Biallelic inactivation of BRCA2 in Fanconi anemia. Science, 297, 606-9 (2002) (Pubitemid 34815345)
-
(2002)
Science
, vol.297
, Issue.5581
, pp. 606-609
-
-
Howlett, N.G.1
Taniguchi, T.2
Olson, S.3
Cox, B.4
Waisfisz, Q.5
De Die-Smulders, C.6
Persky, N.7
Grompe, M.8
Joenje, H.9
Pals, G.10
Ikeda, H.11
Fox, E.A.12
D'Andrea, A.D.13
-
48
-
-
0033740880
-
Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases. Anglian Breast Cancer Study Group
-
Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases. Anglian Breast Cancer Study Group. Br J Cancer, 83, 1301-8 (2000)
-
(2000)
Br J Cancer
, vol.83
, pp. 1301-1308
-
-
-
49
-
-
34547496282
-
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer
-
DOI 10.1073/pnas.0702969104
-
Liu, X., H. Holstege, H. van der Gulden, M. Treur-Mulder, J. Zevenhoven, A. Velds, R. M. Kerkhoven, M. H. van Vliet, L. F. Wessels, J. L. Peterse, A. Berns & J. Jonkers: Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc Natl Acad Sci U S A, 104, 12111-6 (2007) (Pubitemid 47185638)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.29
, pp. 12111-12116
-
-
Liu, X.1
Holstege, H.2
Van Der Gulden, H.3
Treur-Mulder, M.4
Zevenhoven, J.5
Velds, A.6
Kerkhoven, R.M.7
Van Vliet, M.H.8
Wessels, L.F.A.9
Petersen, J.L.10
Berns, A.11
Jonkers, J.12
-
50
-
-
0025196019
-
Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents
-
Dolan, M. E., R. C. Moschel & A. E. Pegg: Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc Natl Acad Sci U S A, 87, 5368-72 (1990)
-
(1990)
Proc Natl Acad Sci U S A
, vol.87
, pp. 5368-5372
-
-
Dolan, M.E.1
Moschel, R.C.2
Pegg, A.E.3
-
51
-
-
77956234314
-
Novel smallmolecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells
-
Bapat, A., L. S. Glass, M. Luo, M. L. Fishel, E. C. Long, M. M. Georgiadis & M. R. Kelley: Novel smallmolecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells. J Pharmacol Exp Ther, 334, 988-98 (2010)
-
(2010)
J Pharmacol Exp Ther
, vol.334
, pp. 988-998
-
-
Bapat, A.1
Glass, L.S.2
Luo, M.3
Fishel, M.L.4
Long, E.C.5
Georgiadis, M.M.6
Kelley, M.R.7
-
52
-
-
38849199681
-
Visualizing spatiotemporal dynamics of multicellular cell-cycle progression
-
DOI 10.1016/j.cell.2007.12.033, PII S0092867408000548
-
Sakaue-Sawano, A., H. Kurokawa, T. Morimura, A. Hanyu, H. Hama, H. Osawa, S. Kashiwagi, K. Fukami, T. Miyata, H. Miyoshi, T. Imamura, M. Ogawa, H. Masai & A. Miyawaki: Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell, 132, 487-98 (2008) (Pubitemid 351191996)
-
(2008)
Cell
, vol.132
, Issue.3
, pp. 487-498
-
-
Sakaue-Sawano, A.1
Kurokawa, H.2
Morimura, T.3
Hanyu, A.4
Hama, H.5
Osawa, H.6
Kashiwagi, S.7
Fukami, K.8
Miyata, T.9
Miyoshi, H.10
Imamura, T.11
Ogawa, M.12
Masai, H.13
Miyawaki, A.14
-
53
-
-
0033564697
-
1-phase progression
-
Sherr, C. J. & J. M. Roberts: CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev, 13, 1501-12 (1999) (Pubitemid 29297917)
-
(1999)
Genes and Development
, vol.13
, Issue.12
, pp. 1501-1512
-
-
Sherr, C.J.1
Roberts, J.M.2
-
54
-
-
0038052805
-
The cell cycle: A review of regulation, deregulation and therapeutic targets in cancer
-
DOI 10.1046/j.1365-2184.2003.00266.x
-
Vermeulen, K., D. R. Van Bockstaele & Z. N. Berneman: The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif, 36, 131-49 (2003) (Pubitemid 36808270)
-
(2003)
Cell Proliferation
, vol.36
, Issue.3
, pp. 131-149
-
-
Vermeulen, K.1
Van Bockstaele, D.R.2
Berneman, Z.N.3
-
55
-
-
1942438028
-
Microtubules as a target for anticancer drugs
-
Jordan, M. A. & L. Wilson: Microtubules as a target for anticancer drugs. Nat Rev Cancer, 4, 253-65 (2004) (Pubitemid 38525281)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.4
, pp. 253-265
-
-
Jordan, M.A.1
Wilson, L.2
-
56
-
-
33644830944
-
Targeting the cell cycle: A new approach to cancer therapy
-
Schwartz, G. K. & M. A. Shah: Targeting the cell cycle: a new approach to cancer therapy. J Clin Oncol, 23, 9408-21 (2005)
-
(2005)
J Clin Oncol
, vol.23
, pp. 9408-9421
-
-
Schwartz, G.K.1
Shah, M.A.2
-
57
-
-
70450280886
-
Cyclin-dependent kinase inhibitors as potential targeted anticancer agents
-
Diaz-Padilla, I., L. L. Siu & I. Duran: Cyclin-dependent kinase inhibitors as potential targeted anticancer agents. Invest New Drugs (2009)
-
(2009)
Invest New Drugs
-
-
Diaz-Padilla, I.1
Siu, L.L.2
Duran, I.3
-
58
-
-
72949096792
-
Senescence in tumours: Evidence from mice and humans
-
Collado, M. & M. Serrano: Senescence in tumours: evidence from mice and humans. Nat Rev Cancer, 10, 51-7 (2010)
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 51-57
-
-
Collado, M.1
Serrano, M.2
-
59
-
-
74049111326
-
Telomeres and telomerase in cancer
-
Artandi, S. E. & R. A. DePinho: Telomeres and telomerase in cancer. Carcinogenesis, 31, 9-18 (2010)
-
(2010)
Carcinogenesis
, vol.31
, pp. 9-18
-
-
Artandi, S.E.1
De Pinho, R.A.2
-
60
-
-
78349257844
-
The essence of senescence
-
Kuilman, T., C. Michaloglou, W. J. Mooi & D. S. Peeper: The essence of senescence. Genes Dev, 24, 2463-79 (2010)
-
(2010)
Genes Dev
, vol.24
, pp. 2463-2479
-
-
Kuilman, T.1
Michaloglou, C.2
Mooi, W.J.3
Peeper, D.S.4
-
61
-
-
77957757037
-
Jailbreak: Oncogeneinduced senescence and its evasion
-
McDuff, F. K. & S. D. Turner: Jailbreak: oncogeneinduced senescence and its evasion. Cell Signal, 23, 6-13 (2011)
-
(2011)
Cell Signal
, vol.23
, pp. 6-13
-
-
McDuff, F.K.1
Turner, S.D.2
-
62
-
-
4344703317
-
Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions
-
DOI 10.1038/sj.onc.1207834
-
Zhang, H., B. S. Herbert, K. H. Pan, J. W. Shay & S. N. Cohen: Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions. Oncogene, 23, 6193-8 (2004) (Pubitemid 39215289)
-
(2004)
Oncogene
, vol.23
, Issue.37
, pp. 6193-6198
-
-
Zhang, H.1
Herbert, B.-S.2
Pan, K.-H.3
Shay, J.W.4
Cohen, S.N.5
-
63
-
-
0038277105
-
Tumor cell senescence in cancer treatment
-
Roninson, I. B.: Tumor cell senescence in cancer treatment. Cancer Res, 63, 2705-15 (2003) (Pubitemid 36667137)
-
(2003)
Cancer Research
, vol.63
, Issue.11
, pp. 2705-2715
-
-
Roninson, I.B.1
-
64
-
-
70149104225
-
Resveratrol and quercetin cooperate to induce senescence-like growth arrest in C6 rat glioma cells
-
Zamin, L. L., E. C. Filippi-Chiela, P. Dillenburg-Pilla, F. Horn, C. Salbego & G. Lenz: Resveratrol and quercetin cooperate to induce senescence-like growth arrest in C6 rat glioma cells. Cancer Sci, 100, 1655-62 (2009)
-
(2009)
Cancer Sci
, vol.100
, pp. 1655-1662
-
-
Zamin, L.L.1
Filippi-Chiela, E.C.2
Dillenburg-Pilla, P.3
Horn, F.4
Salbego, C.5
Lenz, G.6
-
65
-
-
42949129074
-
Many roads lead to oncogene-induced senescence
-
DOI 10.1038/sj.onc.1210950, PII 1210950
-
Courtois-Cox, S., S. L. Jones & K. Cichowski: Many roads lead to oncogene-induced senescence. Oncogene, 27, 2801-9 (2008) (Pubitemid 351620451)
-
(2008)
Oncogene
, vol.27
, Issue.20
, pp. 2801-2809
-
-
Courtois-Cox, S.1
Jones, S.L.2
Cichowski, K.3
-
66
-
-
33846282393
-
PRAK Is Essential for ras-Induced Senescence and Tumor Suppression
-
DOI 10.1016/j.cell.2006.11.050, PII S0092867407000049
-
Sun, P., N. Yoshizuka, L. New, B. A. Moser, Y. Li, R. Liao, C. Xie, J. Chen, Q. Deng, M. Yamout, M. Q. Dong, C. G. Frangou, J. R. Yates, 3rd, P. E. Wright & J. Han: PRAK is essential for ras-induced senescence and tumor suppression. Cell, 128, 295-308 (2007) (Pubitemid 46123511)
-
(2007)
Cell
, vol.128
, Issue.2
, pp. 295-308
-
-
Sun, P.1
Yoshizuka, N.2
New, L.3
Moser, B.A.4
Li, Y.5
Liao, R.6
Xie, C.7
Chen, J.8
Deng, Q.9
Yamout, M.10
Dong, M.-Q.11
Frangou, C.G.12
Yates III, J.R.13
Wright, P.E.14
Han, J.15
-
67
-
-
33845269825
-
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
-
DOI 10.1038/nature05327, PII NATURE05327
-
D. Micco, R., M. Fumagalli, A. Cicalese, S. Piccinin, P. Gasparini, C. Luise, C. Schurra, M. Garre, P. G. Nuciforo, A. Bensimon, R. Maestro, P. G. Pelicci & F. d'Adda di Fagagna: Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature, 444, 638-42 (2006) (Pubitemid 44864443)
-
(2006)
Nature
, vol.444
, Issue.7119
, pp. 638-642
-
-
Di Micco, R.1
Fumagalli, M.2
Cicalese, A.3
Piccinin, S.4
Gasparini, P.5
Luise, C.6
Schurra, C.7
Garre, M.8
Giovanni Nuciforo, P.9
Bensimon, A.10
Maestro, R.11
Giuseppe Pelicci, P.12
D'Adda Di Fagagna, F.13
-
68
-
-
33845235459
-
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
-
DOI 10.1038/nature05268, PII NATURE05268
-
Bartkova, J., N. Rezaei, M. Liontos, P. Karakaidos, D. Kletsas, N. Issaeva, L. V. Vassiliou, E. Kolettas, K. Niforou, V. C. Zoumpourlis, M. Takaoka, H. Nakagawa, F. Tort, K. Fugger, F. Johansson, M. Sehested, C. L. Andersen, L. Dyrskjot, T. Orntoft, J. Lukas, C. Kittas, T. Helleday, T. D. Halazonetis, J. Bartek & V. G. Gorgoulis: Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature, 444, 633-7 (2006) (Pubitemid 44864442)
-
(2006)
Nature
, vol.444
, Issue.7119
, pp. 633-637
-
-
Bartkova, J.1
Rezaei, N.2
Liontos, M.3
Karakaidos, P.4
Kletsas, D.5
Issaeva, N.6
Vassiliou, L.-V.F.7
Kolettas, E.8
Niforou, K.9
Zoumpourlis, V.C.10
Takaoka, M.11
Nakagawa, H.12
Tort, F.13
Fugger, K.14
Johansson, F.15
Sehested, M.16
Andersen, C.L.17
Dyrskjot, L.18
Orntoft, T.19
Lukas, J.20
Kittas, C.21
Helleday, T.22
Halazonetis, T.D.23
Bartek, J.24
Gorgoulis, V.G.25
more..
-
69
-
-
58849154235
-
Senescence-messaging secretome: SMS-ing cellular stress
-
Kuilman, T. & D. S. Peeper: Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer, 9, 81-94 (2009)
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 81-94
-
-
Kuilman, T.1
Peeper, D.S.2
-
70
-
-
38849168162
-
Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
-
DOI 10.1016/j.cell.2007.12.032, PII S0092867408000536
-
Wajapeyee, N., R. W. Serra, X. Zhu, M. Mahalingam & M. R. Green: Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell, 132, 363-74 (2008) (Pubitemid 351191995)
-
(2008)
Cell
, vol.132
, Issue.3
, pp. 363-374
-
-
Wajapeyee, N.1
Serra, R.W.2
Zhu, X.3
Mahalingam, M.4
Green, M.R.5
-
71
-
-
0242410719
-
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
-
DOI 10.1126/science.1090072
-
Villunger, A., E. M. Michalak, L. Coultas, F. Mullauer, G. Bock, M. J. Ausserlechner, J. M. Adams & A. Strasser: p53-and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science, 302, 1036-8 (2003) (Pubitemid 37386194)
-
(2003)
Science
, vol.302
, Issue.5647
, pp. 1036-1038
-
-
Villunger, A.1
Michalak, E.M.2
Coultas, L.3
Mullauer, F.4
Bock, G.5
Ausserlechner, M.J.6
Adams, J.M.7
Strasser, A.8
-
72
-
-
79955485120
-
Apoptosis promotes early tumorigenesis
-
Tang, D., M. T. Lotze, R. Kang & H. J. Zeh: Apoptosis promotes early tumorigenesis. Oncogene, 30, 1851-4 (2011)
-
(2011)
Oncogene
, vol.30
, pp. 1851-1854
-
-
Tang, D.1
Lotze, M.T.2
Kang, R.3
Zeh, H.J.4
-
73
-
-
54249123632
-
IAP-targeted therapies for cancer
-
LaCasse, E. C., D. J. Mahoney, H. H. Cheung, S. Plenchette, S. Baird & R. G. Korneluk: IAP-targeted therapies for cancer. Oncogene, 27, 6252-75 (2008)
-
(2008)
Oncogene
, vol.27
, pp. 6252-6275
-
-
La Casse, E.C.1
Mahoney, D.J.2
Cheung, H.H.3
Plenchette, S.4
Baird, S.5
Korneluk, R.G.6
-
74
-
-
28544443984
-
Promoting apoptosis as a strategy for cancer drug discovery
-
DOI 10.1038/nrc1736
-
Fesik, S. W.: Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer, 5, 876-85 (2005) (Pubitemid 41746032)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.11
, pp. 876-885
-
-
Fesik, S.W.1
-
75
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
DOI 10.1038/nature03579
-
Oltersdorf, T., S. W. Elmore, A. R. Shoemaker, R. C. Armstrong, D. J. Augeri, B. A. Belli, M. Bruncko, T. L. Deckwerth, J. Dinges, P. J. Hajduk, M. K. Joseph, S. Kitada, S. J. Korsmeyer, A. R. Kunzer, A. Letai, C. Li, M. J. Mitten, D. G. Nettesheim, S. Ng, P. M. Nimmer, J. M. O'Connor, A. Oleksijew, A. M. Petros, J. C. Reed, W. Shen, S. K. Tahir, C. B. Thompson, K. J. Tomaselli, B. Wang, M. D. Wendt, H. Zhang, S. W. Fesik & S. H. Rosenberg: An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature, 435, 677-81 (2005) (Pubitemid 40825512)
-
(2005)
Nature
, vol.435
, Issue.7042
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
Armstrong, R.C.4
Augeri, D.J.5
Belli, B.A.6
Bruncko, M.7
Deckwerth, T.L.8
Dinges, J.9
Hajduk, P.J.10
Joseph, M.K.11
Kitada, S.12
Korsmeyer, S.J.13
Kunzer, A.R.14
Letai, A.15
Li, C.16
Mitten, M.J.17
Nettesheim, D.G.18
Ng, S.19
Nimmer, P.M.20
O'Connor, J.M.21
Oleksijew, A.22
Petros, A.M.23
Reed, J.C.24
Shen, W.25
Tahir, S.K.26
Thompson, C.B.27
Tomaselli, K.J.28
Wang, B.29
Wendt, M.D.30
Zhang, H.31
Fesik, S.W.32
Rosenberg, S.H.33
more..
-
76
-
-
33745713171
-
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
-
Degenhardt, K., R. Mathew, B. Beaudoin, K. Bray, D. Anderson, G. Chen, C. Mukherjee, Y. Shi, C. Gelinas, Y. Fan, D. A. Nelson, S. Jin & E. White: Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell, 10, 51-64 (2006)
-
(2006)
Cancer Cell
, vol.10
, pp. 51-64
-
-
Degenhardt, K.1
Mathew, R.2
Beaudoin, B.3
Bray, K.4
Anderson, D.5
Chen, G.6
Mukherjee, C.7
Shi, Y.8
Gelinas, C.9
Fan, Y.10
Nelson, D.A.11
Jin, S.12
White, E.13
-
77
-
-
67650095390
-
The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells
-
Lomonaco, S. L., S. Finniss, C. Xiang, A. Decarvalho, F. Umansky, S. N. Kalkanis, T. Mikkelsen & C. Brodie: The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells. Int J Cancer, 125, 717-22 (2009)
-
(2009)
Int J Cancer
, vol.125
, pp. 717-722
-
-
Lomonaco, S.L.1
Finniss, S.2
Xiang, C.3
Decarvalho, A.4
Umansky, F.5
Kalkanis, S.N.6
Mikkelsen, T.7
Brodie, C.8
-
78
-
-
67549142261
-
Life and death partners: Apoptosis, autophagy and the cross-talk between them
-
Eisenberg-Lerner, A., S. Bialik, H. U. Simon & A. Kimchi: Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ, 16, 966-75 (2009)
-
(2009)
Cell Death Differ
, vol.16
, pp. 966-975
-
-
Eisenberg-Lerner, A.1
Bialik, S.2
Simon, H.U.3
Kimchi, A.4
-
79
-
-
77950509348
-
Autophagy and tumorigenesis
-
Chen, N. & J. Debnath: Autophagy and tumorigenesis. FEBS Lett, 584, 1427-35 (2010)
-
(2010)
FEBS Lett
, vol.584
, pp. 1427-1435
-
-
Chen, N.1
Debnath, J.2
-
80
-
-
79955606244
-
Beclin-1 and LC3A expression in cutaneous malignant melanomas: A biphasic survival pattern for beclin-1
-
Sivridis, E., M. I. Koukourakis, S. E. Mendrinos, A. Karpouzis, A. Fiska, C. Kouskoukis & A. Giatromanolaki: Beclin-1 and LC3A expression in cutaneous malignant melanomas: a biphasic survival pattern for beclin-1. Melanoma Res, 21, 188-95 (2011)
-
(2011)
Melanoma Res
, vol.21
, pp. 188-195
-
-
Sivridis, E.1
Koukourakis, M.I.2
Mendrinos, S.E.3
Karpouzis, A.4
Fiska, A.5
Kouskoukis, C.6
Giatromanolaki, A.7
-
81
-
-
64349123107
-
Autophagy mediates the mitotic senescence transition
-
Young, A. R., M. Narita, M. Ferreira, K. Kirschner, M. Sadaie, J. F. Darot, S. Tavare, S. Arakawa, S. Shimizu, F. M. Watt & M. Narita: Autophagy mediates the mitotic senescence transition. Genes Dev, 23, 798-803 (2009)
-
(2009)
Genes Dev
, vol.23
, pp. 798-803
-
-
Young, A.R.1
Narita, M.2
Ferreira, M.3
Kirschner, K.4
Sadaie, M.5
Darot, J.F.6
Tavare, S.7
Arakawa, S.8
Shimizu, S.9
Watt, F.M.10
Narita, M.11
-
82
-
-
34147193472
-
Cell biology: Autophagy and cancer
-
DOI 10.1038/446745a, PII 446745A
-
Levine, B.: Cell biology: autophagy and cancer. Nature, 446, 745-7 (2007) (Pubitemid 46582063)
-
(2007)
Nature
, vol.446
, Issue.7137
, pp. 745-747
-
-
Levine, B.1
-
83
-
-
33747195353
-
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
-
DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
-
Takahashi, K. & S. Yamanaka: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126, 663-76 (2006) (Pubitemid 44233629)
-
(2006)
Cell
, vol.126
, Issue.4
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
84
-
-
77958450786
-
Transient oncogenes
-
Lenz, G.: Transient oncogenes. Med Hypotheses, 75, 660-2 (2010)
-
(2010)
Med Hypotheses
, vol.75
, pp. 660-662
-
-
Lenz, G.1
-
85
-
-
33845317573
-
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
-
DOI 10.1038/nature05236, PII NATURE05236
-
Bao, S., Q. Wu, R. E. McLendon, Y. Hao, Q. Shi, A. B. Hjelmeland, M. W. Dewhirst, D. D. Bigner & J. N. Rich: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature, 444, 756-60 (2006) (Pubitemid 44949604)
-
(2006)
Nature
, vol.444
, Issue.7120
, pp. 756-760
-
-
Bao, S.1
Wu, Q.2
McLendon, R.E.3
Hao, Y.4
Shi, Q.5
Hjelmeland, A.B.6
Dewhirst, M.W.7
Bigner, D.D.8
Rich, J.N.9
-
86
-
-
77958501473
-
DNA damagemediated induction of a chemoresistant niche
-
Gilbert, L. A. & M. T. Hemann: DNA damagemediated induction of a chemoresistant niche. Cell, 143, 355-66 (2010)
-
(2010)
Cell
, vol.143
, pp. 355-366
-
-
Gilbert, L.A.1
Hemann, M.T.2
-
87
-
-
34247217907
-
Chemical genetics reveals a complex functional ground state of neural stem cells
-
DOI 10.1038/nchembio873, PII NCHEMBIO873
-
Diamandis, P., J. Wildenhain, I. D. Clarke, A. G. Sacher, J. Graham, D. S. Bellows, E. K. Ling, R. J. Ward, L. G. Jamieson, M. Tyers & P. B. Dirks: Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol, 3, 268-73 (2007) (Pubitemid 46625832)
-
(2007)
Nature Chemical Biology
, vol.3
, Issue.5
, pp. 268-273
-
-
Diamandis, P.1
Wildenhain, J.2
Clarke, I.D.3
Sacher, A.G.4
Graham, J.5
Bellows, D.S.6
Ling, E.K.M.7
Ward, R.J.8
Jamieson, L.G.9
Tyers, M.10
Dirks, P.B.11
-
88
-
-
77955015464
-
AACR centennial series: The biology of cancer metastasis: Historical perspective
-
Talmadge, J. E. & I. J. Fidler: AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Res, 70, 5649-69 (2010)
-
(2010)
Cancer Res
, vol.70
, pp. 5649-5669
-
-
Talmadge, J.E.1
Fidler, I.J.2
-
89
-
-
70450198396
-
Epithelial-mesenchymal transitions in development and disease
-
Thiery, J. P., H. Acloque, R. Y. Huang & M. A. Nieto: Epithelial-mesenchymal transitions in development and disease. Cell, 139, 871-90 (2009)
-
(2009)
Cell
, vol.139
, pp. 871-890
-
-
Thiery, J.P.1
Acloque, H.2
Huang, R.Y.3
Nieto, M.A.4
-
91
-
-
61649113720
-
Endogenous inhibitors of angiogenesis: A historical review
-
Ribatti, D.: Endogenous inhibitors of angiogenesis: a historical review. Leuk Res, 33, 638-44 (2009)
-
(2009)
Leuk Res
, vol.33
, pp. 638-644
-
-
Ribatti, D.1
-
92
-
-
58149345546
-
Co-evolution of tumor cells and their microenvironment
-
Polyak, K., I. Haviv & I. G. Campbell: Co-evolution of tumor cells and their microenvironment. Trends Genet, 25, 30-8 (2009)
-
(2009)
Trends Genet
, vol.25
, pp. 30-38
-
-
Polyak, K.1
Haviv, I.2
Campbell, I.G.3
-
94
-
-
41149097574
-
Adoptive cell transfer: A clinical path to effective cancer immunotherapy
-
DOI 10.1038/nrc2355, PII NRC2355
-
Rosenberg, S. A., N. P. Restifo, J. C. Yang, R. A. Morgan & M. E. Dudley: Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Nat Rev Cancer, 8, 299-308 (2008) (Pubitemid 351430867)
-
(2008)
Nature Reviews Cancer
, vol.8
, Issue.4
, pp. 299-308
-
-
Rosenberg, S.A.1
Restifo, N.P.2
Yang, J.C.3
Morgan, R.A.4
Dudley, M.E.5
-
95
-
-
0037362790
-
Cancer selection
-
DOI 10.1038/nrc1016
-
Leroi, A. M., V. Koufopanou & A. Burt: Cancer selection. Nat Rev Cancer, 3, 226-31 (2003) (Pubitemid 37328874)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.3
, pp. 226-231
-
-
Leroi, A.M.1
Koufopanou, V.2
Burt, A.3
-
96
-
-
0029804029
-
A CDKN2-like polymorphism in Xiphophorus LG V is associated with UV-B-induced melanoma formation in platyfish-swordtail hybrids
-
Nairn, R. S., S. Kazianis, B. B. McEntire, L. Della Coletta, R. B. Walter & D. C. Morizot: A CDKN2-like polymorphism in Xiphophorus LG V is associated with UV-B-induced melanoma formation in platyfish-swordtail hybrids. Proc Natl Acad Sci U S A, 93, 13042-7 (1996)
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 13042-13047
-
-
Nairn, R.S.1
Kazianis, S.2
McEntire, B.B.3
Della Coletta, L.4
Walter, R.B.5
Morizot, D.C.6
-
97
-
-
0031927348
-
The macromelanophore locus and the melanoma oncogene Xmrk are separate genetic entities in the genome of Xiphophorus
-
Weis, S. & M. Schartl: The macromelanophore locus and the melanoma oncogene Xmrk are separate genetic entities in the genome of Xiphophorus. Genetics, 149, 1909-20 (1998) (Pubitemid 28375960)
-
(1998)
Genetics
, vol.149
, Issue.4
, pp. 1909-1920
-
-
Weis, S.1
Schartl, M.2
-
98
-
-
34548186667
-
Cellular senescence: When bad things happen to good cells
-
DOI 10.1038/nrm2233, PII NRM2233
-
Campisi, J. & F. d'Adda di Fagagna: Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol, 8, 729-40 (2007) (Pubitemid 47312822)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.9
, pp. 729-740
-
-
Campisi, J.1
D'Adda Di Fagagna, F.2
-
99
-
-
0034641980
-
Apoptosis in development
-
Meier, P., A. Finch & G. Evan: Apoptosis in development. Nature, 407, 796-801 (2000)
-
(2000)
Nature
, vol.407
, pp. 796-801
-
-
Meier, P.1
Finch, A.2
Evan, G.3
-
100
-
-
0036791348
-
How death shapes life during development
-
Baehrecke, E. H.: How death shapes life during development. Nat Rev Mol Cell Biol, 3, 779-87 (2002)
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 779-787
-
-
Baehrecke, E.H.1
-
101
-
-
34547952048
-
Cdk1 is sufficient to drive the mammalian cell cycle
-
DOI 10.1038/nature06046, PII NATURE06046
-
Santamaria, D., C. Barriere, A. Cerqueira, S. Hunt, C. Tardy, K. Newton, J. F. Caceres, P. Dubus, M. Malumbres & M. Barbacid: Cdk1 is sufficient to drive the mammalian cell cycle. Nature, 448, 811-5 (2007) (Pubitemid 47266342)
-
(2007)
Nature
, vol.448
, Issue.7155
, pp. 811-815
-
-
Santamaria, D.1
Barriere, C.2
Cerqueira, A.3
Hunt, S.4
Tardy, C.5
Newton, K.6
Caceres, J.F.7
Dubus, P.8
Malumbres, M.9
Barbacid, M.10
-
102
-
-
77249119762
-
The landscape of somatic copy-number alteration across human cancers
-
Beroukhim, R., C. H. Mermel, D. Porter, G. Wei, S. Raychaudhuri, J. Donovan, J. Barretina, J. S. Boehm, J. Dobson, M. Urashima, K. T. Mc Henry, R. M. Pinchback, A. H. Ligon, Y. J. Cho, L. Haery, H. Greulich, M. Reich, W. Winckler, M. S. Lawrence, B. A. Weir, K. E. Tanaka, D. Y. Chiang, A. J. Bass, A. Loo, C. Hoffman, J. Prensner, T. Liefeld, Q. Gao, D. Yecies, S. Signoretti, E. Maher, F. J. Kaye, H. Sasaki, J. E. Tepper, J. A. Fletcher, J. Tabernero, J. Baselga, M. S. Tsao, F. Demichelis, M. A. Rubin, P. A. Janne, M. J. Daly, C. Nucera, R. L. Levine, B. L. Ebert, S. Gabriel, A. K. Rustgi, C. R. Antonescu, M. Ladanyi, A. Letai, L. A. Garraway, M. Loda, D. G. Beer, L. D. True, A. Okamoto, S. L. Pomeroy, S. Singer, T. R. Golub, E. S. Lander, G. Getz, W. R. Sellers & M. Meyerson: The landscape of somatic copy-number alteration across human cancers. Nature, 463, 899-905
-
Nature
, vol.463
, pp. 899-905
-
-
Beroukhim, R.1
Mermel, C.H.2
Porter, D.3
Wei, G.4
Raychaudhuri, S.5
Donovan, J.6
Barretina, J.7
Boehm, J.S.8
Dobson, J.9
Urashima, M.10
McHenry, K.T.11
Pinchback, R.M.12
Ligon, A.H.13
Cho, Y.J.14
Haery, L.15
Greulich, H.16
Reich, M.17
Winckler, W.18
Lawrence, M.S.19
Weir, B.A.20
Tanaka, K.E.21
Chiang, D.Y.22
Bass, A.J.23
Loo, A.24
Hoffman, C.25
Prensner, J.26
Liefeld, T.27
Gao, Q.28
Yecies, D.29
Signoretti, S.30
Maher, E.31
Kaye, F.J.32
Sasaki, H.33
Tepper, J.E.34
Fletcher, J.A.35
Tabernero, J.36
Baselga, J.37
Tsao, M.S.38
Demichelis, F.39
Rubin, M.A.40
Janne, P.A.41
Daly, M.J.42
Nucera, C.43
Levine, R.L.44
Ebert, B.L.45
Gabriel, S.46
Rustgi, A.K.47
Antonescu, C.R.48
Ladanyi, M.49
Letai, A.50
Garraway, L.A.51
Loda, M.52
Beer, D.G.53
True, L.D.54
Okamoto, A.55
Pomeroy, S.L.56
Singer, S.57
Golub, T.R.58
Lander, E.S.59
Getz, G.60
Sellers, W.R.61
Meyerson, M.62
more..
-
103
-
-
0037112844
-
'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally
-
DOI 10.1093/emboj/cdf595
-
Garcia-Cao, I., M. Garcia-Cao, J. Martin-Caballero, L. M. Criado, P. Klatt, J. M. Flores, J. C. Weill, M. A. Blasco & M. Serrano: "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. Embo J, 21, 6225-35 (2002) (Pubitemid 35415339)
-
(2002)
EMBO Journal
, vol.21
, Issue.22
, pp. 6225-6235
-
-
Garcia-Cao, I.1
Garcia-Cao, M.2
Martin-Caballero, J.3
Criado, L.M.4
Klatt, P.5
Flores, J.M.6
Weill, J.-C.7
Blasco, M.A.8
Serrano, M.9
-
104
-
-
67650261911
-
Cell death: A dynamic response concept
-
Loos, B. & A. M. Engelbrecht: Cell death: a dynamic response concept. Autophagy, 5, 590-603 (2009)
-
(2009)
Autophagy
, vol.5
, pp. 590-603
-
-
Loos, B.1
Engelbrecht, A.M.2
-
105
-
-
62349116134
-
In vivo imaging, tracking, and targeting of cancer stem cells
-
Vlashi, E., K. Kim, C. Lagadec, L. D. Donna, J. T. McDonald, M. Eghbali, J. W. Sayre, E. Stefani, W. McBride & F. Pajonk: In vivo imaging, tracking, and targeting of cancer stem cells. J Natl Cancer Inst, 101, 350-9 (2009)
-
(2009)
J Natl Cancer Inst
, vol.101
, pp. 350-359
-
-
Vlashi, E.1
Kim, K.2
Lagadec, C.3
Donna, L.D.4
McDonald, J.T.5
Eghbali, M.6
Sayre, J.W.7
Stefani, E.8
McBride, W.9
Pajonk, F.10
-
106
-
-
3543092021
-
Pathways of apoptotic and non-apoptotic death in tumour cells
-
Okada, H. & T. W. Mak: Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer, 4, 592-603 (2004) (Pubitemid 39025054)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.8
, pp. 592-603
-
-
Okada, H.1
Mak, T.W.2
-
107
-
-
0347601880
-
A decade of caspases
-
DOI 10.1038/sj.onc.1207107
-
Degterev, A., M. Boyce & J. Yuan: A decade of caspases. Oncogene, 22, 8543-67 (2003) (Pubitemid 38028527)
-
(2003)
Oncogene
, vol.22
, Issue.53 REV. ISS. 7
, pp. 8543-8567
-
-
Degterev, A.1
Boyce, M.2
Yuan, J.3
-
108
-
-
37549048249
-
The BCL-2 protein family: Opposing activities that mediate cell death
-
Youle, R. J. & A. Strasser: The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol, 9, 47-59 (2008)
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 47-59
-
-
Youle, R.J.1
Strasser, A.2
|