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Volumn 25, Issue 1, 2009, Pages 30-38

Co-evolution of tumor cells and their microenvironment

Author keywords

[No Author keywords available]

Indexed keywords

CANCER PREVENTION; CANCER THERAPY; CARCINOGENESIS; CELL COMPARTMENTALIZATION; EPIGENETICS; GENE EXPRESSION; GENOTYPE; MOLECULAR EVOLUTION; PRIORITY JOURNAL; REVIEW; STROMA CELL;

EID: 58149345546     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tig.2008.10.012     Document Type: Review
Times cited : (543)

References (75)
  • 1
    • 33845243362 scopus 로고    scopus 로고
    • Cancer as an evolutionary and ecological process
    • Merlo L.M., et al. Cancer as an evolutionary and ecological process. Nat. Rev. Cancer 6 (2006) 924-935
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 924-935
    • Merlo, L.M.1
  • 2
    • 33751217466 scopus 로고    scopus 로고
    • Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment
    • Anderson A.R., et al. Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Cell 127 (2006) 905-915
    • (2006) Cell , vol.127 , pp. 905-915
    • Anderson, A.R.1
  • 3
    • 9244227134 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer initiation and progression
    • Bhowmick N.A., et al. Stromal fibroblasts in cancer initiation and progression. Nature 432 (2004) 332-337
    • (2004) Nature , vol.432 , pp. 332-337
    • Bhowmick, N.A.1
  • 4
    • 43649085395 scopus 로고    scopus 로고
    • Microenvironmental regulation of cancer development
    • Hu M., and Polyak K. Microenvironmental regulation of cancer development. Curr. Opin. Genet. Dev. 18 (2008) 27-34
    • (2008) Curr. Opin. Genet. Dev. , vol.18 , pp. 27-34
    • Hu, M.1    Polyak, K.2
  • 5
    • 33748967069 scopus 로고    scopus 로고
    • Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer
    • Nelson C.M., and Bissell M.J. Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer. Annu. Rev. Cell Dev. Biol. 22 (2006) 287-309
    • (2006) Annu. Rev. Cell Dev. Biol. , vol.22 , pp. 287-309
    • Nelson, C.M.1    Bissell, M.J.2
  • 6
    • 33747859659 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer: a novel tumor-promoting cell type
    • Orimo A., and Weinberg R.A. Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle 5 (2006) 1597-1601
    • (2006) Cell Cycle , vol.5 , pp. 1597-1601
    • Orimo, A.1    Weinberg, R.A.2
  • 7
    • 33645739790 scopus 로고    scopus 로고
    • Tumor stroma and regulation of cancer development
    • Tlsty T.D., and Coussens L.M. Tumor stroma and regulation of cancer development. Annu. Rev. Pathol. 1 (2006) 119-150
    • (2006) Annu. Rev. Pathol. , vol.1 , pp. 119-150
    • Tlsty, T.D.1    Coussens, L.M.2
  • 8
    • 3142512612 scopus 로고    scopus 로고
    • Molecular characterization of the tumor microenvironment in breast cancer
    • Allinen M., et al. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 6 (2004) 17-32
    • (2004) Cancer Cell , vol.6 , pp. 17-32
    • Allinen, M.1
  • 9
    • 0036993579 scopus 로고    scopus 로고
    • Role of stroma in carcinogenesis of the prostate
    • Cunha G.R., et al. Role of stroma in carcinogenesis of the prostate. Differentiation 70 (2002) 473-485
    • (2002) Differentiation , vol.70 , pp. 473-485
    • Cunha, G.R.1
  • 10
    • 52149119128 scopus 로고    scopus 로고
    • A paracrine requirement for hedgehog signalling in cancer
    • Yauch R.L., et al. A paracrine requirement for hedgehog signalling in cancer. Nature 455 (2008) 406-410
    • (2008) Nature , vol.455 , pp. 406-410
    • Yauch, R.L.1
  • 11
    • 42949121126 scopus 로고    scopus 로고
    • Regulation of in situ to invasive breast carcinoma transition
    • Hu M., et al. Regulation of in situ to invasive breast carcinoma transition. Cancer Cell 13 (2008) 394-406
    • (2008) Cancer Cell , vol.13 , pp. 394-406
    • Hu, M.1
  • 12
    • 0032034449 scopus 로고    scopus 로고
    • The potential influence of radiation-induced microenvironments in neoplastic progression
    • Barcellos-Hoff M.H. The potential influence of radiation-induced microenvironments in neoplastic progression. J. Mammary Gland Biol. Neoplasia 3 (1998) 165-175
    • (1998) J. Mammary Gland Biol. Neoplasia , vol.3 , pp. 165-175
    • Barcellos-Hoff, M.H.1
  • 13
    • 2342640981 scopus 로고    scopus 로고
    • Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions
    • Ohuchida K., et al. Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions. Cancer Res. 64 (2004) 3215-3222
    • (2004) Cancer Res. , vol.64 , pp. 3215-3222
    • Ohuchida, K.1
  • 14
    • 0036829090 scopus 로고    scopus 로고
    • Cancer and aging: a model for the cancer promoting effects of the aging stroma
    • Krtolica A., and Campisi J. Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int. J. Biochem. Cell Biol. 34 (2002) 1401-1414
    • (2002) Int. J. Biochem. Cell Biol. , vol.34 , pp. 1401-1414
    • Krtolica, A.1    Campisi, J.2
  • 15
    • 13944260728 scopus 로고    scopus 로고
    • Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation
    • Parrinello S., et al. Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J. Cell Sci. 118 (2005) 485-496
    • (2005) J. Cell Sci. , vol.118 , pp. 485-496
    • Parrinello, S.1
  • 16
    • 2342441403 scopus 로고    scopus 로고
    • The stroma as a crucial target in rat mammary gland carcinogenesis
    • Maffini M.V., et al. The stroma as a crucial target in rat mammary gland carcinogenesis. J. Cell Sci. 117 (2004) 1495-1502
    • (2004) J. Cell Sci. , vol.117 , pp. 1495-1502
    • Maffini, M.V.1
  • 17
    • 14044250003 scopus 로고    scopus 로고
    • Stroma is not a major target in DMBA-mediated tumorigenesis of mouse mammary preneoplasia
    • Medina D., and Kittrell F. Stroma is not a major target in DMBA-mediated tumorigenesis of mouse mammary preneoplasia. J. Cell Sci. 118 (2005) 123-127
    • (2005) J. Cell Sci. , vol.118 , pp. 123-127
    • Medina, D.1    Kittrell, F.2
  • 18
    • 0842288323 scopus 로고    scopus 로고
    • TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    • Bhowmick N.A., et al. TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303 (2004) 848-851
    • (2004) Science , vol.303 , pp. 848-851
    • Bhowmick, N.A.1
  • 19
    • 1842687362 scopus 로고    scopus 로고
    • Reconstruction of functionally normal and malignant human breast tissues in mice
    • Kuperwasser C., et al. Reconstruction of functionally normal and malignant human breast tissues in mice. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 4966-4971
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 4966-4971
    • Kuperwasser, C.1
  • 20
    • 21844432918 scopus 로고    scopus 로고
    • Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
    • Radisky D.C., et al. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 436 (2005) 123-127
    • (2005) Nature , vol.436 , pp. 123-127
    • Radisky, D.C.1
  • 21
    • 28944432805 scopus 로고    scopus 로고
    • Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis
    • Hill R., et al. Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Cell 123 (2005) 1001-1011
    • (2005) Cell , vol.123 , pp. 1001-1011
    • Hill, R.1
  • 22
    • 34548170996 scopus 로고    scopus 로고
    • The sonic hedgehog signaling network in development and neoplasia
    • Chari N.S., and McDonnell T.J. The sonic hedgehog signaling network in development and neoplasia. Adv. Anat. Pathol. 14 (2007) 344-352
    • (2007) Adv. Anat. Pathol. , vol.14 , pp. 344-352
    • Chari, N.S.1    McDonnell, T.J.2
  • 23
    • 0022891340 scopus 로고
    • Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak H.F. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315 (1986) 1650-1659
    • (1986) N. Engl. J. Med. , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 24
    • 47749139256 scopus 로고    scopus 로고
    • Cancer as an overhealing wound: an old hypothesis revisited
    • Schafer M., and Werner S. Cancer as an overhealing wound: an old hypothesis revisited. Nat. Rev. Mol. Cell Biol. 9 (2008) 628-638
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 628-638
    • Schafer, M.1    Werner, S.2
  • 25
    • 0036085164 scopus 로고    scopus 로고
    • Epidemiological and clinical aspects of nonsteroidal anti-inflammatory drugs and cancer risks
    • Moran E.M. Epidemiological and clinical aspects of nonsteroidal anti-inflammatory drugs and cancer risks. J. Environ. Pathol. Toxicol. Oncol. 21 (2002) 193-201
    • (2002) J. Environ. Pathol. Toxicol. Oncol. , vol.21 , pp. 193-201
    • Moran, E.M.1
  • 26
    • 0036513029 scopus 로고    scopus 로고
    • Oncogenic resistance to growth-limiting conditions
    • Blagosklonny M.V. Oncogenic resistance to growth-limiting conditions. Nat. Rev. Cancer 2 (2002) 221-225
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 221-225
    • Blagosklonny, M.V.1
  • 27
    • 36549083391 scopus 로고    scopus 로고
    • Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations
    • Marusyk A., and DeGregori J. Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations. Biochim. Biophys. Acta 1785 (2008) 1-11
    • (2008) Biochim. Biophys. Acta , vol.1785 , pp. 1-11
    • Marusyk, A.1    DeGregori, J.2
  • 28
    • 52049083887 scopus 로고    scopus 로고
    • Nitric oxide is a key component in inflammation-accelerated tumorigenesis
    • Hussain S.P., et al. Nitric oxide is a key component in inflammation-accelerated tumorigenesis. Cancer Res. 68 (2008) 7130-7136
    • (2008) Cancer Res. , vol.68 , pp. 7130-7136
    • Hussain, S.P.1
  • 29
    • 48949119478 scopus 로고    scopus 로고
    • Tissue factor, angiogenesis and tumour progression
    • Bluff J.E., et al. Tissue factor, angiogenesis and tumour progression. Breast Cancer Res. 10 (2008) 204
    • (2008) Breast Cancer Res. , vol.10 , pp. 204
    • Bluff, J.E.1
  • 30
    • 28644432204 scopus 로고    scopus 로고
    • VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    • Kaplan R.N., et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438 (2005) 820-827
    • (2005) Nature , vol.438 , pp. 820-827
    • Kaplan, R.N.1
  • 31
    • 50449085139 scopus 로고    scopus 로고
    • Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas
    • Kerbel R.S., et al. Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) E54
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105
    • Kerbel, R.S.1
  • 32
    • 50349097617 scopus 로고    scopus 로고
    • Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents
    • Shaked Y., et al. Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents. Cancer Cell 14 (2008) 263-273
    • (2008) Cancer Cell , vol.14 , pp. 263-273
    • Shaked, Y.1
  • 33
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A., et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121 (2005) 335-348
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1
  • 34
    • 34948896045 scopus 로고    scopus 로고
    • Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    • Karnoub A.E., et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449 (2007) 557-563
    • (2007) Nature , vol.449 , pp. 557-563
    • Karnoub, A.E.1
  • 35
    • 44649088833 scopus 로고    scopus 로고
    • Systemic endocrine instigation of indolent tumor growth requires osteopontin
    • McAllister S.S., et al. Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell 133 (2008) 994-1005
    • (2008) Cell , vol.133 , pp. 994-1005
    • McAllister, S.S.1
  • 36
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B., and Kinzler K.W. Cancer genes and the pathways they control. Nat. Med. 10 (2004) 789-799
    • (2004) Nat. Med. , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 37
    • 0025221197 scopus 로고
    • Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro
    • Bartek J., et al. Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro. Int. J. Cancer 46 (1990) 839-844
    • (1990) Int. J. Cancer , vol.46 , pp. 839-844
    • Bartek, J.1
  • 38
    • 0033966575 scopus 로고    scopus 로고
    • Genetic progression and clonal relationship of recurrent premalignant head and neck lesions
    • Califano J., et al. Genetic progression and clonal relationship of recurrent premalignant head and neck lesions. Clin. Cancer Res. 6 (2000) 347-352
    • (2000) Clin. Cancer Res. , vol.6 , pp. 347-352
    • Califano, J.1
  • 39
    • 40349100163 scopus 로고    scopus 로고
    • BRCA1 regulates human mammary stem/progenitor cell fate
    • Liu S., et al. BRCA1 regulates human mammary stem/progenitor cell fate. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 1680-1685
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 1680-1685
    • Liu, S.1
  • 40
    • 0342264492 scopus 로고    scopus 로고
    • Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis
    • Moinfar F., et al. Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. Cancer Res. 60 (2000) 2562-2566
    • (2000) Cancer Res. , vol.60 , pp. 2562-2566
    • Moinfar, F.1
  • 41
    • 0036843937 scopus 로고    scopus 로고
    • Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas
    • Kurose K., et al. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat. Genet. 32 (2002) 355-357
    • (2002) Nat. Genet. , vol.32 , pp. 355-357
    • Kurose, K.1
  • 42
    • 20344393370 scopus 로고    scopus 로고
    • Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors
    • Weber F., et al. Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors. Br. J. Cancer 92 (2005) 1922-1926
    • (2005) Br. J. Cancer , vol.92 , pp. 1922-1926
    • Weber, F.1
  • 43
    • 33646885230 scopus 로고    scopus 로고
    • Total-genome analysis of BRCA1/2-related invasive carcinomas of the breast identifies tumor stroma as potential landscaper for neoplastic initiation
    • Weber F., et al. Total-genome analysis of BRCA1/2-related invasive carcinomas of the breast identifies tumor stroma as potential landscaper for neoplastic initiation. Am. J. Hum. Genet. 78 (2006) 961-972
    • (2006) Am. J. Hum. Genet. , vol.78 , pp. 961-972
    • Weber, F.1
  • 44
    • 37349101054 scopus 로고    scopus 로고
    • Breast-cancer stromal cells with TP53 mutations and nodal metastases
    • Patocs A., et al. Breast-cancer stromal cells with TP53 mutations and nodal metastases. N. Engl. J. Med. 357 (2007) 2543-2551
    • (2007) N. Engl. J. Med. , vol.357 , pp. 2543-2551
    • Patocs, A.1
  • 45
    • 42549152045 scopus 로고    scopus 로고
    • No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
    • Qiu W., et al. No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas. Nat. Genet. 40 (2008) 650-655
    • (2008) Nat. Genet. , vol.40 , pp. 650-655
    • Qiu, W.1
  • 46
    • 55149113365 scopus 로고    scopus 로고
    • Pancreatic cancer associated fibroblasts display normal allelotypes
    • Walter K., et al. Pancreatic cancer associated fibroblasts display normal allelotypes. Cancer Biol. Ther. 7 (2008) 882-888
    • (2008) Cancer Biol. Ther. , vol.7 , pp. 882-888
    • Walter, K.1
  • 47
    • 33646415964 scopus 로고    scopus 로고
    • Multiple-criterion evaluation of reported mutations: a proposed scoring system for the intragenic somatic mutation literature
    • Winter J.M., et al. Multiple-criterion evaluation of reported mutations: a proposed scoring system for the intragenic somatic mutation literature. Cancer Biol. Ther. 5 (2006) 360-370
    • (2006) Cancer Biol. Ther. , vol.5 , pp. 360-370
    • Winter, J.M.1
  • 48
    • 33847419142 scopus 로고    scopus 로고
    • Molecular definition of breast tumor heterogeneity
    • Shipitsin M., et al. Molecular definition of breast tumor heterogeneity. Cancer Cell 11 (2007) 259-273
    • (2007) Cancer Cell , vol.11 , pp. 259-273
    • Shipitsin, M.1
  • 49
    • 3242668449 scopus 로고    scopus 로고
    • Progressive genetic abnormalities in human cancer
    • Mendelsohn J., et al. (Eds), W.B. Saunders Co.
    • Kern S.E. Progressive genetic abnormalities in human cancer. In: Mendelsohn J., et al. (Eds). Molecular Basis of Cancer (2001), W.B. Saunders Co. 41-69
    • (2001) Molecular Basis of Cancer , pp. 41-69
    • Kern, S.E.1
  • 50
    • 0035282432 scopus 로고    scopus 로고
    • Involvement of chemokine receptors in breast cancer metastasis
    • Muller A., et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 410 (2001) 50-56
    • (2001) Nature , vol.410 , pp. 50-56
    • Muller, A.1
  • 51
    • 23044499067 scopus 로고    scopus 로고
    • Distinct epigenetic changes in the stromal cells of breast cancers
    • Hu M., et al. Distinct epigenetic changes in the stromal cells of breast cancers. Nat. Genet. 37 (2005) 899-905
    • (2005) Nat. Genet. , vol.37 , pp. 899-905
    • Hu, M.1
  • 52
    • 31544435739 scopus 로고    scopus 로고
    • Breast cancer DNA methylation profiles in cancer cells and tumor stroma: association with HER-2/neu status in primary breast cancer
    • Fiegl H., et al. Breast cancer DNA methylation profiles in cancer cells and tumor stroma: association with HER-2/neu status in primary breast cancer. Cancer Res. 66 (2006) 29-33
    • (2006) Cancer Res. , vol.66 , pp. 29-33
    • Fiegl, H.1
  • 53
    • 33144465069 scopus 로고    scopus 로고
    • Gene promoter methylation in prostate tumor-associated stromal cells
    • Hanson J.A., et al. Gene promoter methylation in prostate tumor-associated stromal cells. J. Natl. Cancer Inst. 98 (2006) 255-261
    • (2006) J. Natl. Cancer Inst. , vol.98 , pp. 255-261
    • Hanson, J.A.1
  • 54
    • 57149111920 scopus 로고    scopus 로고
    • Global hypomethylation of genomic DNA in cancer-associated myofibroblasts
    • Jiang L., et al. Global hypomethylation of genomic DNA in cancer-associated myofibroblasts. Cancer Res. 68 (2008) 9900-9908
    • (2008) Cancer Res. , vol.68 , pp. 9900-9908
    • Jiang, L.1
  • 55
    • 49649096347 scopus 로고    scopus 로고
    • Calcification of multipotent prostate tumor endothelium
    • Dudley A.C., et al. Calcification of multipotent prostate tumor endothelium. Cancer Cell 14 (2008) 201-211
    • (2008) Cancer Cell , vol.14 , pp. 201-211
    • Dudley, A.C.1
  • 56
    • 0036289709 scopus 로고    scopus 로고
    • Gene expression profile analysis of rheumatoid synovial fibroblast cultures revealing the overexpression of genes responsible for tumor-like growth of rheumatoid synovium
    • Watanabe N., et al. Gene expression profile analysis of rheumatoid synovial fibroblast cultures revealing the overexpression of genes responsible for tumor-like growth of rheumatoid synovium. Biochem. Biophys. Res. Commun. 294 (2002) 1121-1129
    • (2002) Biochem. Biophys. Res. Commun. , vol.294 , pp. 1121-1129
    • Watanabe, N.1
  • 57
    • 0036726312 scopus 로고    scopus 로고
    • β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
    • Weaver V.M., et al. β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2 (2002) 205-216
    • (2002) Cancer Cell , vol.2 , pp. 205-216
    • Weaver, V.M.1
  • 58
    • 51449108974 scopus 로고    scopus 로고
    • A novel 3D in vitro culture model to study stromal-epithelial interactions in the mammary gland
    • Krause S., et al. A novel 3D in vitro culture model to study stromal-epithelial interactions in the mammary gland. Tissue Eng. Part C Methods 14 (2008) 261-271
    • (2008) Tissue Eng. Part C Methods , vol.14 , pp. 261-271
    • Krause, S.1
  • 59
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: mechanisms of anti-tumour activity
    • Ellis L.M., and Hicklin D.J. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat. Rev. Cancer 8 (2008) 579-591
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 60
    • 0035445625 scopus 로고    scopus 로고
    • Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour-microenvironment interactions
    • Kurose K., et al. Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour-microenvironment interactions. Hum. Mol. Genet. 10 (2001) 1907-1913
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1907-1913
    • Kurose, K.1
  • 61
    • 0035153878 scopus 로고    scopus 로고
    • Presence of genetic alterations in microdissected stroma of human colon and breast cancers
    • Wernert N., et al. Presence of genetic alterations in microdissected stroma of human colon and breast cancers. Anticancer Res. 21 (2001) 2259-2264
    • (2001) Anticancer Res. , vol.21 , pp. 2259-2264
    • Wernert, N.1
  • 62
    • 0034566319 scopus 로고    scopus 로고
    • Presence of genetic alterations in microdissected stroma of human colon and breast cancers
    • Wernert N., et al. Presence of genetic alterations in microdissected stroma of human colon and breast cancers. J. Mol. Med. 78 (2000) B30
    • (2000) J. Mol. Med. , vol.78
    • Wernert, N.1
  • 63
    • 0142243215 scopus 로고    scopus 로고
    • Molecular genetic alterations in the laser-capture-microdissected stroma adjacent to bladder carcinoma
    • Paterson R.F., et al. Molecular genetic alterations in the laser-capture-microdissected stroma adjacent to bladder carcinoma. Cancer 98 (2003) 1830-1836
    • (2003) Cancer , vol.98 , pp. 1830-1836
    • Paterson, R.F.1
  • 64
    • 10744226105 scopus 로고    scopus 로고
    • Genetic alterations in the peritumoral stromal cells of malignant and borderline epithelial ovarian tumors as indicated by allelic imbalance on chromosome 3p
    • Tuhkanen H., et al. Genetic alterations in the peritumoral stromal cells of malignant and borderline epithelial ovarian tumors as indicated by allelic imbalance on chromosome 3p. Int. J. Cancer 109 (2004) 247-252
    • (2004) Int. J. Cancer , vol.109 , pp. 247-252
    • Tuhkanen, H.1
  • 65
    • 33845931347 scopus 로고    scopus 로고
    • Identification of alterations in DNA copy number in host stromal cells during tumor progression
    • Pelham R.J., et al. Identification of alterations in DNA copy number in host stromal cells during tumor progression. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 19848-19853
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 19848-19853
    • Pelham, R.J.1
  • 66
    • 42549109044 scopus 로고    scopus 로고
    • Macro-environment of breast carcinoma: frequent genetic alterations in the normal appearing skins of patients with breast cancer
    • Moinfar F., et al. Macro-environment of breast carcinoma: frequent genetic alterations in the normal appearing skins of patients with breast cancer. Mod. Pathol. 21 (2008) 639-646
    • (2008) Mod. Pathol. , vol.21 , pp. 639-646
    • Moinfar, F.1
  • 67
    • 0033931246 scopus 로고    scopus 로고
    • Genomic alterations associated with loss of heterozygosity for TP53 in Li-Fraumeni syndrome fibroblasts
    • Burt E.C., et al. Genomic alterations associated with loss of heterozygosity for TP53 in Li-Fraumeni syndrome fibroblasts. Br. J. Cancer 83 (2000) 467-472
    • (2000) Br. J. Cancer , vol.83 , pp. 467-472
    • Burt, E.C.1
  • 68
    • 42049091225 scopus 로고    scopus 로고
    • Breast-cancer stromal cells with TP53 mutations
    • Campbell I.G., et al. Breast-cancer stromal cells with TP53 mutations. N. Engl. J. Med. 358 (2008) 1634-1635
    • (2008) N. Engl. J. Med. , vol.358 , pp. 1634-1635
    • Campbell, I.G.1
  • 69
    • 0025351937 scopus 로고
    • Altered expression of chondroitin sulfate proteoglycan in the stroma of human colon carcinoma. Hypomethylation of PG-40 gene correlates with increased PG-40 content and mRNA levels
    • Adany R., et al. Altered expression of chondroitin sulfate proteoglycan in the stroma of human colon carcinoma. Hypomethylation of PG-40 gene correlates with increased PG-40 content and mRNA levels. J. Biol. Chem. 265 (1990) 11389-11396
    • (1990) J. Biol. Chem. , vol.265 , pp. 11389-11396
    • Adany, R.1
  • 70
    • 0025761007 scopus 로고
    • Hypomethylation of the dEcoRIn proteoglycan gene in human colon cancer
    • Adany R., and Iozzo R.V. Hypomethylation of the dEcoRIn proteoglycan gene in human colon cancer. Biochem. J. 276 (1991) 301-306
    • (1991) Biochem. J. , vol.276 , pp. 301-306
    • Adany, R.1    Iozzo, R.V.2
  • 71
    • 21344440015 scopus 로고    scopus 로고
    • X-linked dominant growth suppression of transplanted tumors in C57BL/6J-scid mice
    • Wood M., et al. X-linked dominant growth suppression of transplanted tumors in C57BL/6J-scid mice. Cancer Res. 65 (2005) 5690-5695
    • (2005) Cancer Res. , vol.65 , pp. 5690-5695
    • Wood, M.1
  • 72
    • 1642391048 scopus 로고    scopus 로고
    • Host genetics and tumour metastasis
    • Hunter K.W. Host genetics and tumour metastasis. Br. J. Cancer 90 (2004) 752-755
    • (2004) Br. J. Cancer , vol.90 , pp. 752-755
    • Hunter, K.W.1
  • 73
    • 33744960226 scopus 로고    scopus 로고
    • Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
    • Carey L.A., et al. Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA 295 (2006) 2492-2502
    • (2006) JAMA , vol.295 , pp. 2492-2502
    • Carey, L.A.1
  • 74
    • 0034194138 scopus 로고    scopus 로고
    • Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium
    • Woodford-Richens K., et al. Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium. Cancer Res. 60 (2000) 2477-2482
    • (2000) Cancer Res. , vol.60 , pp. 2477-2482
    • Woodford-Richens, K.1
  • 75
    • 33745578957 scopus 로고    scopus 로고
    • Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
    • Kim B.G., et al. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Nature 441 (2006) 1015-1019
    • (2006) Nature , vol.441 , pp. 1015-1019
    • Kim, B.G.1


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