-
1
-
-
0021950948
-
Hypomethylation of dna from benign and malignant human colon neoplasms
-
Goelz SE, Vogelstein B, Hamilton SR, Feinberg AP. Hypomethylation of DNA from benign and malignant human colon neoplasms. Science. 1985;228(4696):187-90.
-
(1985)
Science.
, vol.228
, Issue.4696
, pp. 187-90
-
-
Goelz, S.E.1
Vogelstein, B.2
Hamilton, S.R.3
Feinberg, A.P.4
-
2
-
-
33644825262
-
Global dna demethylation in gastrointestinal cancer is age dependent and precedes genomic damage
-
Suzuki K, Suzuki I, Leodolter A, Alonso S, Horiuchi S, Yamashita K, et al. Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage. Cancer Cell. 2006;9 (3):199-207.
-
(2006)
Cancer Cell.
, vol.9
, Issue.3
, pp. 199-207
-
-
Suzuki, K.1
Suzuki, I.2
Leodolter, A.3
Alonso, S.4
Horiuchi, S.5
Yamashita, K.6
-
3
-
-
0037068353
-
Dna methylation in cancer: Too much, but also too little
-
Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene. 2002;21(35):5400-13.
-
(2002)
Oncogene.
, vol.21
, Issue.35
, pp. 5400-13
-
-
Ehrlich, M.1
-
4
-
-
59149084538
-
The human colon cancer methylome shows similar hypo-and hypermethylation at conserved tissue-specific cpg island shores
-
This aer mas DNA methylation hotsots using high-throughut analysis exanding the effect of methylation beyond the roximal romoter
-
Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, et al. The human colon cancer methylome shows similar hypo-and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet. 2009;41(2):178-86. This paper maps DNA methylation hotspots using high-throughput analysis, expanding the effect of methylation beyond the proximal promoter.
-
(2009)
Nat Genet.
, vol.41
, Issue.2
, pp. 178-86
-
-
Irizarry, R.A.1
Ladd-Acosta, C.2
Wen, B.3
Wu, Z.4
Montano, C.5
Onyango, P.6
-
5
-
-
1042278765
-
The history of cancer epigenetics
-
Feinberg AP, Tycko B. The history of cancer epigenetics. Nat Rev Cancer. 2004;4(2):143-53.
-
(2004)
Nat Rev Cancer.
, vol.4
, Issue.2
, pp. 143-53
-
-
Feinberg, A.P.1
Tycko, B.2
-
6
-
-
54249096084
-
Ectopic expression of p-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo
-
Milicic A, Harrison LA, Goodlad RA, Hardy RG, Nicholson AM, Presz M, et al. Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo. Cancer Res. 2008;68(19):7760-8.
-
(2008)
Cancer Res.
, vol.68
, Issue.19
, pp. 7760-8
-
-
Milicic, A.1
Harrison, L.A.2
Goodlad, R.A.3
Hardy, R.G.4
Nicholson, A.M.5
Presz, M.6
-
7
-
-
29344455676
-
The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer
-
Matsuzaki K, Deng G, Tanaka H, Kakar S, Miura S, Kim YS. The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer. Clin Cancer Res. 2005;11(24 Pt 1):8564-9.
-
(2005)
Clin Cancer Res.
, vol.11
, Issue.24 PART 1
, pp. 8564-9
-
-
Matsuzaki, K.1
Deng, G.2
Tanaka, H.3
Kakar, S.4
Miura, S.5
Kim, Y.S.6
-
8
-
-
33749037187
-
Chromosomal instability correlates with genome-wide dna demethylation in human primary colorectal cancers
-
Rodriguez J, Frigola J, Vendrell E, Risques RA, Fraga MF, Morales C, et al. Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers. Cancer Res. 2006;66(17):8462-9468.
-
(2006)
Cancer Res.
, vol.66
, Issue.17
, pp. 8462-9468
-
-
Rodriguez, J.1
Frigola, J.2
Vendrell, E.3
Risques, R.A.4
Fraga, M.F.5
Morales, C.6
-
9
-
-
36849059066
-
Line-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability
-
Estecio MR, Gharibyan V, Shen L, Ibrahim AE, Doshi K, He R, et al. LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. PLoS One. 2007;2(5):e399.
-
(2007)
PLoS One
, vol.2
, Issue.5
-
-
Estecio, M.R.1
Gharibyan, V.2
Shen, L.3
Ibrahim, A.E.4
Doshi, K.5
He, R.6
-
10
-
-
26444473234
-
Opposing effects of dna hypomethylation on intestinal and liver carcinogenesis
-
Yamada Y, Jackson-Grusby L, Linhart H, Meissner A, Eden A, Lin H, et al. Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc Natl Acad Sci USA. 2005;102(38):13580-5.
-
(2005)
Proc Natl Acad Sci US.A.
, vol.102
, Issue.38
, pp. 13580-5
-
-
Yamada, Y.1
Jackson-Grusby, L.2
Linhart, H.3
Meissner, A.4
Eden, A.5
Lin, H.6
-
11
-
-
0029001154
-
Suppression of intestinal neoplasia by dna hypomethylation
-
Laird PW, Jackson-Grusby L, Fazeli A, Dickinson SL, Jung WE, Li E, et al. Suppression of intestinal neoplasia by DNA hypomethylation. Cell. 1995;81(2):197-205.
-
(1995)
Cell.
, vol.81
, Issue.2
, pp. 197-205
-
-
Laird, P.W.1
Jackson-Grusby, L.2
Fazeli, A.3
Dickinson, S.L.4
Jung, W.E.5
Li, E.6
-
12
-
-
0034660686
-
Dnmt1n/+ reduces the net growth rate and multiplicity of intestinal adenomas in c57bl/6-multiple intestinal neoplasia (min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of min 1(akr) resistance allele
-
Cormier RT, Dove WF. Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele. Cancer Res. 2000;60(14):3965-70.
-
(2000)
Cancer Res.
, vol.60
, Issue.14
, pp. 3965-70
-
-
Cormier, R.T.1
Dove, W.F.2
-
13
-
-
0036494563
-
Complete genetic suppression of polyp formation and reduction of cpg-island hypermethylation in apc(min/+) dnmt1-hypomorphic mice
-
Eads CA, Nickel AE, Laird PW. Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice. Cancer Res. 2002;62 (5):1296-9.
-
(2002)
Cancer Res.
, vol.62
, Issue.5
, pp. 1296-9
-
-
Eads, C.A.1
Nickel, A.E.2
Laird, P.W.3
-
14
-
-
80052836966
-
Current findings for recurring mutations in acute myeloid leukemia
-
Takahashi S. Current findings for recurring mutations in acute myeloid leukemia. J Hematol Oncol. 2011;4:36.
-
(2011)
J Hematol Oncol.
, vol.4
, pp. 36
-
-
Takahashi, S.1
-
15
-
-
0034929515
-
Dna methylation: An alternative pathway to cancer
-
Wajed SA, Laird PW, DeMeester TR. DNA methylation: an alternative pathway to cancer. Ann Surg. 2001;234(1):10-20.
-
(2001)
Ann Surg.
, vol.234
, Issue.1
, pp. 10-20
-
-
Wajed, S.A.1
Laird, P.W.2
DeMeester, T.R.3
-
16
-
-
0345357773
-
Gene silencing in cancer in association with promoter hypermethylation
-
Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 2003;349 (21):2042-54.
-
(2003)
N Engl J Med.
, vol.349
, Issue.21
, pp. 2042-54
-
-
Herman, J.G.1
Baylin, S.B.2
-
17
-
-
13144266670
-
Incidence and functional consequences of hmlh1 promoter hypermethylation in colorectal carcinoma
-
Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP, et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA. 1998;95(12):6870-5.
-
(1998)
Proc Natl Acad Sci US.A.
, vol.95
, Issue.12
, pp. 6870-5
-
-
Herman, J.G.1
Umar, A.2
Polyak, K.3
Graff, J.R.4
Ahuja, N.5
Issa, J.P.6
-
18
-
-
77954720070
-
Clinical relevance of microsatellite instability in colorectal cancer
-
de la Chapelle A, Hampel H. Clinical relevance of microsatellite instability in colorectal cancer. J Clin Oncol. 2010;28(20):3380-7.
-
(2010)
J Clin Oncol.
, vol.28
, Issue.20
, pp. 3380-7
-
-
De La Chapelle, A.1
Hampel, H.2
-
19
-
-
0042440989
-
Association of the cpg island methylator phenotype with family history of cancer in patients with colorectal cancer
-
Frazier ML, Xi L, Zong J, Viscofsky N, Rashid A, Wu EF, et al. Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer. Cancer Res. 2003;63(16):4805-8.
-
(2003)
Cancer Res.
, vol.63
, Issue.16
, pp. 4805-8
-
-
Frazier, M.L.1
Xi, L.2
Zong, J.3
Viscofsky, N.4
Rashid, A.5
Wu, E.F.6
-
20
-
-
24144449572
-
Evaluation of a large, population-based sample supports a cpg island methylator phenotype in colon cancer
-
Samowitz WS, Albertsen H, Herrick J, Levin TR, Sweeney C, Murtaugh MA, et al. Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastroenterology. 2005;129(3):837-45.
-
(2005)
Gastroenterology.
, vol.129
, Issue.3
, pp. 837-45
-
-
Samowitz, W.S.1
Albertsen, H.2
Herrick, J.3
Levin, T.R.4
Sweeney, C.5
Murtaugh, M.A.6
-
21
-
-
34247570795
-
Evaluation of markers for cpg island methylator phenotype (cimp) in colorectal cancer by a large population-based sample
-
Ogino S, Kawasaki T, Kirkner GJ, Kraft P, Loda M, Fuchs CS. Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. J Mol Diagn. 2007;9(3):305-14.
-
(2007)
J Mol Diagn.
, vol.9
, Issue.3
, pp. 305-14
-
-
Ogino, S.1
Kawasaki, T.2
Kirkner, G.J.3
Kraft, P.4
Loda, M.5
Fuchs, C.S.6
-
22
-
-
33745541234
-
Cpg island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with braf mutation in colorectal cancer
-
Weisenberger DJ, Siegmund KD, Campan M, Young J, Long TI, Faasse MA, et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet. 2006;38(7):787-93.
-
(2006)
Nat Genet.
, vol.38
, Issue.7
, pp. 787-93
-
-
Weisenberger, D.J.1
Siegmund, K.D.2
Campan, M.3
Young, J.4
Long, T.I.5
Faasse, M.A.6
-
23
-
-
33846192840
-
The cpg island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer
-
Goel A, Nagasaka T,Arnold CN, Inoue T, Hamilton C,Niedzwiecki D, et al. The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. Gastroenterology. 2007;132(1):127-38.
-
(2007)
Gastroenterology.
, vol.132
, Issue.1
, pp. 127-38
-
-
Goel, A.1
Nagasaka, T.2
Arnold, C.N.3
Inoue, T.4
Hamilton, C.5
Niedzwiecki, D.6
-
24
-
-
44849132638
-
Mutations in both kras and braf may contribute to the methylator phenotype in colon cancer
-
60 e1
-
Nagasaka T, Koi M, Kloor M, Gebert J, Vilkin A, Nishida N, et al. Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer. Gastroenterology. 2008;134(7):1950-60. 60 e1.
-
(2008)
Gastroenterology.
, vol.134
, Issue.7
, pp. 1950-1960
-
-
Nagasaka, T.1
Koi, M.2
Kloor, M.3
Gebert, J.4
Vilkin, A.5
Nishida, N.6
-
25
-
-
56649084987
-
Comprehensive biostatistical analysis of cpg island methylator phenotype in colorectal cancer using a large population-based sample
-
Nosho K, Irahara N, Shima K, Kure S, Kirkner GJ, Schernhammer ES, et al. Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. PLoS One. 2008;3(11):e3698.
-
(2008)
PLoS One
, vol.3
, Issue.11
-
-
Nosho, K.1
Irahara, N.2
Shima, K.3
Kure, S.4
Kirkner, G.J.5
Schernhammer, E.S.6
-
26
-
-
10344260184
-
Cpg island methylator phenotype in cancer
-
Issa JP. CpG island methylator phenotype in cancer. Nat Rev Cancer. 2004;4(12):988-93.
-
(2004)
Nat Rev Cancer.
, vol.4
, Issue.12
, pp. 988-93
-
-
Issa, J.P.1
-
27
-
-
0041382819
-
Genetics supersedes epigenetics in colon cancer phenotype
-
Yamashita K, Dai T, Dai Y, Yamamoto F, Perucho M. Genetics supersedes epigenetics in colon cancer phenotype. Cancer Cell. 2003;4(2):121-31.
-
(2003)
Cancer Cell.
, vol.4
, Issue.2
, pp. 121-31
-
-
Yamashita, K.1
Dai, T.2
Dai, Y.3
Yamamoto, F.4
Perucho, M.5
-
28
-
-
35649014263
-
Cimp and colon cancer gets more complicated
-
Grady WM. CIMP and colon cancer gets more complicated. Gut. 2007;56(11):1498-500.
-
(2007)
Gut.
, vol.56
, Issue.11
, pp. 1498-500
-
-
Grady, W.M.1
-
29
-
-
80054790280
-
The roles of the methyl-cpg binding proteins in cancer
-
Parry L, Clarke AR. The roles of the Methyl-CpG binding proteins in cancer. Genes Cancer. 2011;2(6):618-30.
-
(2011)
Genes Cancer.
, vol.2
, Issue.6
, pp. 618-30
-
-
Parry, L.1
Clarke, A.R.2
-
30
-
-
32344449372
-
Kaiso-deficient mice show resistance to intestinal cancer
-
Prokhortchouk A, Sansom O, Selfridge J, Caballero IM, Salozhin S, Aithozhina D, et al. Kaiso-deficient mice show resistance to intestinal cancer. Mol Cell Biol. 2006;26(1):199-208.
-
(2006)
Mol Cell Biol.
, vol.26
, Issue.1
, pp. 199-208
-
-
Prokhortchouk, A.1
Sansom, O.2
Selfridge, J.3
Caballero, I.M.4
Salozhin, S.5
Aithozhina, D.6
-
31
-
-
0037603586
-
Deficiency of mbd2 suppresses intestinal tumorigenesis
-
Sansom OJ, Berger J, Bishop SM, Hendrich B, Bird A, Clarke AR. Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nat Genet. 2003;34(2):145-7.
-
(2003)
Nat Genet.
, vol.34
, Issue.2
, pp. 145-7
-
-
Sansom, O.J.1
Berger, J.2
Bishop, S.M.3
Hendrich, B.4
Bird, A.5
Clarke, A.R.6
-
32
-
-
33847076849
-
Chromatin modifications and their function
-
Kouzarides T. Chromatin modifications and their function. Cell. 2007;128(4):693-705.
-
(2007)
Cell.
, vol.128
, Issue.4
, pp. 693-705
-
-
Kouzarides, T.1
-
33
-
-
33750379420
-
Polycomb silencers control cell fate, development and cancer
-
Sparmann A, van LohuizenM. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer. 2006;6(11):846-56.
-
(2006)
Nat Rev Cancer.
, vol.6
, Issue.11
, pp. 846-56
-
-
Sparmann, A.1
Van Lohuizen, M.2
-
34
-
-
33846569960
-
A stem cell-like chromatin pattern may predispose tumor suppressor genes to dna hypermethylation and heritable silencing
-
Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet. 2007;39(2):237-42.
-
(2007)
Nat Genet.
, vol.39
, Issue.2
, pp. 237-42
-
-
Ohm, J.E.1
McGarvey, K.M.2
Yu, X.3
Cheng, L.4
Schuebel, K.E.5
Cope, L.6
-
35
-
-
33646870495
-
Genome-wide mapping of polycomb target genes unravels their roles in cell fate transitions
-
Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev. 2006;20(9):1123-36.
-
(2006)
Genes Dev.
, vol.20
, Issue.9
, pp. 1123-36
-
-
Bracken, A.P.1
Dietrich, N.2
Pasini, D.3
Hansen, K.H.4
Helin, K.5
-
36
-
-
11144356102
-
Loss of imprinting of insulin growth factor ii gene: A potential heritable biomarker for colon neoplasia predisposition
-
Cruz-Correa M, Cui H, Giardiello FM, Powe NR, Hylind L, Robinson A, et al. Loss of imprinting of insulin growth factor II gene: a potential heritable biomarker for colon neoplasia predisposition. Gastroenterology. 2004;126(4):964-70.
-
(2004)
Gastroenterology.
, vol.126
, Issue.4
, pp. 964-70
-
-
Cruz-Correa, M.1
Cui, H.2
Giardiello, F.M.3
Powe, N.R.4
Hylind, L.5
Robinson, A.6
-
37
-
-
1842479074
-
Igf2 loss of imprinting: A potential heritable risk factor for colorectal cancer
-
Jirtle RL. IGF2 loss of imprinting: a potential heritable risk factor for colorectal cancer. Gastroenterology. 2004;126(4):1190-3.
-
(2004)
Gastroenterology.
, vol.126
, Issue.4
, pp. 1190-3
-
-
Jirtle, R.L.1
-
38
-
-
38049170553
-
Enhanced sensitivity to igf-ii signaling links loss of imprinting of igf2 to increased cell proliferation and tumor risk
-
Kaneda A, Wang CJ, Cheong R, Timp W, Onyango P, Wen B, et al. Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci USA. 2007;104(52):20926- 31.
-
(2007)
Proc Natl Acad Sci US.A.
, vol.104
, Issue.52
, pp. 20926-31
-
-
Kaneda, A.1
Wang, C.J.2
Cheong, R.3
Timp, W.4
Onyango, P.5
Wen, B.6
-
39
-
-
26644444345
-
Global loss of imprinting leads to widespread tumorigenesis in adult mice
-
Holm TM, Jackson-Grusby L, Brambrink T, Yamada Y, Rideout 3rd WM, Jaenisch R. Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer Cell. 2005;8 (4):275-85.
-
(2005)
Cancer Cell.
, vol.8
, Issue.4
, pp. 275-85
-
-
Holm, T.M.1
Jackson-Grusby, L.2
Brambrink, T.3
Yamada, Y.4
Rideout III, W.M.5
Jaenisch, R.6
-
40
-
-
20144374299
-
Loss of imprinting of igf2 alters intestinal maturation and tumorigenesis in mice
-
Sakatani T, Kaneda A, Iacobuzio-Donahue CA, Carter MG, de Boom Witzel S, Okano H, et al. Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science. 2005;307(5717):1976-8.
-
(2005)
Science.
, vol.307
, Issue.5717
, pp. 1976-8
-
-
Sakatani, T.1
Kaneda, A.2
Iacobuzio-Donahue, C.A.3
Carter, M.G.4
De Boom Witzel, S.5
Okano, H.6
-
41
-
-
0037112364
-
Loss of imprinting in colorectal cancer linked to hypomethylation of h19 and igf2
-
Cui H, Onyango P, Brandenburg S, Wu Y, Hsieh CL, Feinberg AP. Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res. 2002;62(22):6442-6.
-
(2002)
Cancer Res.
, vol.62
, Issue.22
, pp. 6442-6
-
-
Cui, H.1
Onyango, P.2
Brandenburg, S.3
Wu, Y.4
Hsieh, C.L.5
Feinberg, A.P.6
-
42
-
-
0035895208
-
Loss of imprinting of the insulin-like growth factor ii gene occurs by biallelic methylation in a core region of h19-associated ctcf-binding sites in colorectal cancer
-
Nakagawa H, Chadwick RB, Peltomaki P, Plass C, Nakamura Y, de La Chapelle A. Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer. Proc Natl Acad Sci USA. 2001;98(2):591-6.
-
(2001)
Proc Natl Acad Sci US.A.
, vol.98
, Issue.2
, pp. 591-6
-
-
Nakagawa, H.1
Chadwick, R.B.2
Peltomaki, P.3
Plass, C.4
Nakamura, Y.5
De La Chapelle, A.6
-
43
-
-
0030031360
-
Loss of h19 imprinting in esophageal cancer
-
Hibi K, Nakamura H, Hirai A, Fujikake Y, Kasai Y, Akiyama S, et al. Loss of H19 imprinting in esophageal cancer. Cancer Res. 1996;56(3):480-2.
-
(1996)
Cancer Res.
, vol.56
, Issue.3
, pp. 480-2
-
-
Hibi, K.1
Nakamura, H.2
Hirai, A.3
Fujikake, Y.4
Kasai, Y.5
Akiyama, S.6
-
44
-
-
79960309513
-
Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinoma
-
Vincent A, Omura N, Hong SM, Jaffe A, Eshleman J, Goggins M. Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinoma. Clin Cancer Res. 2011;17(13):4341-54.
-
(2011)
Clin Cancer Res.
, vol.17
, Issue.13
, pp. 4341-54
-
-
Vincent, A.1
Omura, N.2
Hong, S.M.3
Jaffe, A.4
Eshleman, J.5
Goggins, M.6
-
45
-
-
67149130222
-
Epigenetics and epigenetic alterations in pancreatic cancer
-
Omura N, Goggins M. Epigenetics and epigenetic alterations in pancreatic cancer. Int J Clin Exp Pathol. 2009;2(4):310-26.
-
(2009)
Int J Clin Exp Pathol.
, vol.2
, Issue.4
, pp. 310-26
-
-
Omura, N.1
Goggins, M.2
-
46
-
-
16944367477
-
Abrogation of the rb/p16 tumorsuppressive pathway in virtually all pancreatic carcinomas
-
Schutte M, Hruban RH, Geradts J, Maynard R, Hilgers W, Rabindran SK, et al. Abrogation of the Rb/p16 tumorsuppressive pathway in virtually all pancreatic carcinomas. Cancer Res. 1997;57(15):3126-30.
-
(1997)
Cancer Res.
, vol.57
, Issue.15
, pp. 3126-30
-
-
Schutte, M.1
Hruban, R.H.2
Geradts, J.3
Maynard, R.4
Hilgers, W.5
Rabindran, S.K.6
-
47
-
-
0034662626
-
Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer
-
Esteller M, Sparks A, Toyota M, Sanchez-Cespedes M, Capella G, Peinado MA, et al. Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res. 2000;60(16):4366-71.
-
(2000)
Cancer Res.
, vol.60
, Issue.16
, pp. 4366-71
-
-
Esteller, M.1
Sparks, A.2
Toyota, M.3
Sanchez-Cespedes, M.4
Capella, G.5
Peinado, M.A.6
-
48
-
-
0041559969
-
Aberrant methylation of the 5′ cpg island of tslc1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade panlns
-
Jansen M, Fukushima N, Rosty C, Walter K, Altink R, Heek TV, et al. Aberrant methylation of the 5′ CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs. Cancer Biol Ther. 2002;1(3):293-6.
-
(2002)
Cancer Biol Ther.
, vol.1
, Issue.3
, pp. 293-6
-
-
Jansen, M.1
Fukushima, N.2
Rosty, C.3
Walter, K.4
Altink, R.5
Heek, T.V.6
-
49
-
-
79956201806
-
Epigenetic silencing of tumor suppressor genes in pancreatic cancer
-
Lomberk GA. Epigenetic silencing of tumor suppressor genes in pancreatic cancer. J Gastrointest Cancer. 2011;42 (2):93-9.
-
(2011)
J Gastrointest Cancer.
, vol.42
, Issue.2
, pp. 93-9
-
-
Lomberk, G.A.1
-
50
-
-
0036598992
-
Targeting death and decoy receptors of the tumournecrosis factor superfamily
-
Ashkenazi A. Targeting death and decoy receptors of the tumournecrosis factor superfamily. Nat Rev Cancer. 2002;2(6):420-30.
-
(2002)
Nat Rev Cancer.
, vol.2
, Issue.6
, pp. 420-30
-
-
Ashkenazi, A.1
-
51
-
-
79952060606
-
Aberrant methylation frequency of tnfrsf10c promoter in pancreatic cancer cell lines
-
Cai HH, Sun YM, Miao Y, GaoWT, Peng Q, Yao J, et al. Aberrant methylation frequency of TNFRSF10C promoter in pancreatic cancer cell lines. Hepatobiliary Pancreat Dis Int. 2011;10(1):95-100.
-
(2011)
Hepatobiliary Pancreat Dis Int.
, vol.10
, Issue.1
, pp. 95-100
-
-
Cai, H.H.1
Sun, Y.M.2
Miao, Y.3
Gao, W.T.4
Peng, Q.5
Yao, J.6
-
52
-
-
77953571951
-
Pancreatic cancer dnmt1 expression and sensitivity to dnmt1 inhibitors
-
Li A, Omura N, Hong SM, Goggins M. Pancreatic cancer DNMT1 expression and sensitivity to DNMT1 inhibitors. Cancer Biol Ther. 2010;25:9(4).
-
(2010)
Cancer Biol Ther.
, vol.25
, Issue.9
, pp. 4
-
-
Li, A.1
Omura, N.2
Hong, S.M.3
Goggins, M.4
-
53
-
-
81055124827
-
Expression of dnmt1 and dnmt3a are regulated by gli1 in human pancreatic cancer
-
He S, Wang F, Yang L, Guo C, Wan R, Ke A, et al. Expression of DNMT1 and DNMT3a are regulated by GLI1 in human pancreatic cancer. PLoS One. 2011;6(11):e27684.
-
(2011)
PLoS One
, vol.6
, Issue.11
-
-
He, S.1
Wang, F.2
Yang, L.3
Guo, C.4
Wan, R.5
Ke, A.6
-
54
-
-
39749128967
-
Cpg island methylation profile of pancreatic intraepithelial neoplasia
-
Sato N, Fukushima N, Hruban RH, Goggins M. CpG island methylation profile of pancreatic intraepithelial neoplasia. Mod Pathol. 2008;21(3):238-44.
-
(2008)
Mod Pathol.
, vol.21
, Issue.3
, pp. 238-44
-
-
Sato, N.1
Fukushima, N.2
Hruban, R.H.3
Goggins, M.4
-
55
-
-
38449100788
-
Expression profile of class i histone deacetylases in human cancer tissues
-
Nakagawa M, Oda Y, Eguchi T, Aishima S, Yao T, Hosoi F, et al. Expression profile of class I histone deacetylases in human cancer tissues. Oncol Rep. 2007;18(4):769-74.
-
(2007)
Oncol Rep.
, vol.18
, Issue.4
, pp. 769-74
-
-
Nakagawa, M.1
Oda, Y.2
Eguchi, T.3
Aishima, S.4
Yao, T.5
Hosoi, F.6
-
56
-
-
67649965963
-
Significance of dna methyltransferase-1 and histone deacetylase-1 in pancreatic cancer
-
Wang W, Gao J, Man XH, Li ZS, Gong YF. Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer. Oncol Rep. 2009;21(6):1439-47.
-
(2009)
Oncol Rep.
, vol.21
, Issue.6
, pp. 1439-47
-
-
Wang, W.1
Gao, J.2
Man, X.H.3
Li, Z.S.4
Gong, Y.F.5
-
57
-
-
79953304257
-
Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer
-
Zhou W, Liang IC, Yee NS. Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer. Cancer Biol Ther. 2011;11(7):659-70.
-
(2011)
Cancer Biol Ther.
, vol.11
, Issue.7
, pp. 659-70
-
-
Zhou, W.1
Liang, I.C.2
Yee, N.S.3
-
58
-
-
67649200336
-
E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a snailhdac1hdac2 repressor complex
-
e1-5. This study provides an interesting look at epigenetic pathways downstream of a well known participant in colorectal cancer Jul
-
von Burstin J, Eser S, Paul MC, Seidler B, Brandl M, Messer M, et al. E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex. Gastroenterology. 2009 Jul; 137(1):361-71, 71 e1-5. This study provides an interesting look at epigenetic pathways downstream of a well known participant in colorectal cancer.
-
(2009)
Gastroenterology.
, vol.137
, Issue.1
, pp. 361-71
-
-
Von Burstin, J.1
Eser, S.2
Paul, M.C.3
Seidler, B.4
Brandl, M.5
Messer, M.6
-
59
-
-
24644480749
-
Molecular requirements for epithelial-mesenchymal transition during tumor progression
-
Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol. 2005;17(5):548-58.
-
(2005)
Curr Opin Cell Biol.
, vol.17
, Issue.5
, pp. 548-58
-
-
Huber, M.A.1
Kraut, N.2
Beug, H.3
-
60
-
-
0033789680
-
The transcription factor snail is a repressor of e-cadherin gene expression in epithelial tumour cells
-
Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, et al. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol. 2000;2 (2):84-9.
-
(2000)
Nat Cell Biol.
, vol.2
, Issue.2
, pp. 84-9
-
-
Batlle, E.1
Sancho, E.2
Franci, C.3
Dominguez, D.4
Monfar, M.5
Baulida, J.6
-
61
-
-
0035920152
-
A new role for e12/e47 in the repression of ecadherin expression and epithelial-mesenchymal transitions
-
Perez-Moreno MA, Locascio A, Rodrigo I, Dhondt G, Portillo F, Nieto MA, et al. A new role for E12/E47 in the repression of Ecadherin expression and epithelial-mesenchymal transitions. J Biol Chem. 2001;276(29):27424-31.
-
(2001)
J Biol Chem.
, vol.276
, Issue.29
, pp. 27424-31
-
-
Perez-Moreno, M.A.1
Locascio, A.2
Rodrigo, I.3
Dhondt, G.4
Portillo, F.5
Nieto, M.A.6
-
62
-
-
84857055686
-
Recruitment of histone deacetylases hdac1 and hdac2 by the transcriptional repressor zeb1 downregulates e-cadherin expression in pancreatic cancer
-
Aghdassi A, Sendler M, Guenther A, Mayerle J, Behn CO, Heidecke CD, et al. Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer. Gut. 2012;61 (3):439-48.
-
(2012)
Gut.
, vol.61
, Issue.3
, pp. 439-48
-
-
Aghdassi, A.1
Sendler, M.2
Guenther, A.3
Mayerle, J.4
Behn, C.O.5
Heidecke, C.D.6
-
63
-
-
41149162821
-
Expression of hypoxia-inducible factor-1alpha, histone deacetylase 1, and metastasis-associated protein 1 in pancreatic carcinoma: Correlation with poor prognosis with possible regulation
-
Miyake K, Yoshizumi T, Imura S, Sugimoto K, Batmunkh E, Kanemura H, et al. Expression of hypoxia-inducible factor-1alpha, histone deacetylase 1, and metastasis-associated protein 1 in pancreatic carcinoma: correlation with poor prognosis with possible regulation. Pancreas. 2008;36(3):e1-9.
-
(2008)
Pancreas.
, vol.36
, Issue.3
-
-
Miyake, K.1
Yoshizumi, T.2
Imura, S.3
Sugimoto, K.4
Batmunkh, E.5
Kanemura, H.6
-
64
-
-
34247862190
-
Microrna expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis
-
Bloomston M, Frankel WL, Petrocca F, Volinia S, Alder H, Hagan JP, et al. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA. 2007;297(17):1901-8.
-
(2007)
JAMA
, vol.297
, Issue.17
, pp. 1901-8
-
-
Bloomston, M.1
Frankel, W.L.2
Petrocca, F.3
Volinia, S.4
Alder, H.5
Hagan, J.P.6
-
65
-
-
54049115957
-
Analysis of micrornas in pancreatic fineneedle aspirates can classify benign and malignant tissues
-
Szafranska AE, Doleshal M, Edmunds HS, Gordon S, Luttges J, Munding JB, et al. Analysis of microRNAs in pancreatic fineneedle aspirates can classify benign and malignant tissues. Clin Chem. 2008;54(10):1716-24.
-
(2008)
Clin Chem.
, vol.54
, Issue.10
, pp. 1716-24
-
-
Szafranska, A.E.1
Doleshal, M.2
Edmunds, H.S.3
Gordon, S.4
Luttges, J.5
Munding, J.B.6
-
66
-
-
73549106305
-
A resource for analysis of microrna expression and function in pancreatic ductal adenocarcinoma cells
-
Kent OA, Mullendore M,Wentzel EA, Lopez-Romero P, Tan AC, Alvarez H, et al. A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells. Cancer Biol Ther. 2009;8(21):2013-24.
-
(2009)
Cancer Biol Ther.
, vol.8
, Issue.21
, pp. 2013-24
-
-
Kent, O.A.1
Mullendore, M.2
Wentzel, E.A.3
Lopez-Romero, P.4
Tan, A.C.5
Alvarez, H.6
-
67
-
-
34249817549
-
Transactivation of mir-34a by p53 broadly influences gene expression and promotes apoptosis
-
Chang TC,Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, et al. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell. 2007;26(5):745-52.
-
(2007)
Mol Cell.
, vol.26
, Issue.5
, pp. 745-52
-
-
Chang, T.C.1
Wentzel, E.A.2
Kent, O.A.3
Ramachandran, K.4
Mullendore, M.5
Lee, K.H.6
-
68
-
-
34249822779
-
Transcriptional activation of mir-34a contributes to p53-mediated apoptosis
-
Raver-Shapira N, Marciano E, Meiri E, Spector Y, Rosenfeld N, Moskovits N, et al. Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell. 2007;26 (5):731-43.
-
(2007)
Mol Cell.
, vol.26
, Issue.5
, pp. 731-43
-
-
Raver-Shapira, N.1
Marciano, E.2
Meiri, E.3
Spector, Y.4
Rosenfeld, N.5
Moskovits, N.6
-
69
-
-
80052316514
-
Targeting epigenetic regulation of mir-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells
-
Nalls D, Tang SN, Rodova M, Srivastava RK, Shankar S. Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells. PLoS One. 2011;6(8):e24099.
-
(2011)
PLoS One
, vol.6
, Issue.8
-
-
Nalls, D.1
Tang, S.N.2
Rodova, M.3
Srivastava, R.K.4
Shankar, S.5
-
70
-
-
84864604837
-
Loss of mir-126 is crucial to pancreatic cancer progression
-
Frampton AE, Krell J, Jacob J, Stebbing J, Castellano L, Jiao LR. Loss of miR-126 is crucial to pancreatic cancer progression. Expert Rev Anticancer Ther. 2012;12(7):881-4.
-
(2012)
Expert Rev Anticancer Ther.
, vol.12
, Issue.7
, pp. 881-4
-
-
Frampton, A.E.1
Krell, J.2
Jacob, J.3
Stebbing, J.4
Castellano, L.5
Jiao, L.R.6
-
71
-
-
0030049705
-
Mdc9, a widely expressed cellular disintegrin containing cytoplasmic sh3 ligand domains
-
Weskamp G, Kratzschmar J, Reid MS, Blobel CP. MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. J Cell Biol. 1996;132(4):717-26.
-
(1996)
J Cell Biol.
, vol.132
, Issue.4
, pp. 717-26
-
-
Weskamp, G.1
Kratzschmar, J.2
Reid, M.S.3
Blobel, C.P.4
-
72
-
-
11144356553
-
Adam9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma
-
Grutzmann R, Luttges J, Sipos B, Ammerpohl O, Dobrowolski F, Alldinger I, et al. ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma. Br J Cancer. 2004;90(5):1053-8.
-
(2004)
Br J Cancer.
, vol.90
, Issue.5
, pp. 1053-8
-
-
Grutzmann, R.1
Luttges, J.2
Sipos, B.3
Ammerpohl, O.4
Dobrowolski, F.5
Alldinger, I.6
-
73
-
-
84857049876
-
A microrna that limits metastatic colonisation and endothelial recruitment
-
Khew-Goodall Y, Goodall GJ. A microRNA that limits metastatic colonisation and endothelial recruitment. EMBO J. 2012;31 (4):786-7.
-
(2012)
EMBO J.
, vol.31
, Issue.4
, pp. 786-7
-
-
Khew-Goodall, Y.1
Goodall, G.J.2
-
74
-
-
79953211498
-
Ezh2 regulates neuronal differentiation of mesenchymal stem cells through pip5k1c-dependent calcium signaling
-
Yu YL, Chou RH, Chen LT, Shyu WC, Hsieh SC, Wu CS, et al. EZH2 regulates neuronal differentiation of mesenchymal stem cells through PIP5K1C-dependent calcium signaling. J Biol Chem. 2011;286(11):9657-67.
-
(2011)
J Biol Chem.
, vol.286
, Issue.11
, pp. 9657-67
-
-
Yu, Y.L.1
Chou, R.H.2
Chen, L.T.3
Shyu, W.C.4
Hsieh, S.C.5
Wu, C.S.6
-
75
-
-
50249175130
-
Loss of trimethylation at lysine 27 of histone h3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers
-
Wei Y, Xia W, Zhang Z, Liu J, Wang H, Adsay NV, et al. Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers. Mol Carcinog. 2008;47(9):701-6.
-
(2008)
Mol Carcinog.
, vol.47
, Issue.9
, pp. 701-6
-
-
Wei, Y.1
Xia, W.2
Zhang, Z.3
Liu, J.4
Wang, H.5
Adsay, N.V.6
-
76
-
-
84855405573
-
Curcumin analogue cdf inhibits pancreatic tumor growth by switching on suppressor micrornas and attenuating ezh2 expression
-
Bao B, Ali S, Banerjee S, Wang Z, Logna F, Azmi AS, et al. Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression. Cancer Res. 2012;72(1):335-45.
-
(2012)
Cancer Res.
, vol.72
, Issue.1
, pp. 335-45
-
-
Bao, B.1
Ali, S.2
Banerjee, S.3
Wang, Z.4
Logna, F.5
Azmi, A.S.6
-
77
-
-
68349160654
-
Epigenetic events in gastrointestinal cancer
-
Selaru FM, David S, Meltzer SJ, Hamilton JP. Epigenetic events in gastrointestinal cancer. Am J Gastroenterol. 2009;104 (8):1910-2.
-
(2009)
Am J Gastroenterol.
, vol.104
, Issue.8
, pp. 1910-2
-
-
Selaru, F.M.1
David, S.2
Meltzer, S.J.3
Hamilton, J.P.4
-
78
-
-
84863230017
-
Analysis of the runx3 gene methylation in serum dna from esophagus squamous cell carcinoma, gastric and colorectal adenocarcinoma patients
-
Zheng Y, Zhang Y, Huang X, Chen L. Analysis of the RUNX3 gene methylation in serum DNA from esophagus squamous cell carcinoma, gastric and colorectal adenocarcinoma patients. Hepatogastroenterology. 2011;58(112):2007-11.
-
(2011)
Hepatogastroenterology
, vol.58
, Issue.112
, pp. 2007-2011
-
-
Zheng, Y.1
Zhang, Y.2
Huang, X.3
Chen, L.4
-
79
-
-
83155177127
-
Plasma dna methylation of wnt antagonists predicts recurrence of esophageal squamous cell carcinoma
-
Liu JB, Qiang FL, Dong J, Cai J, Zhou SH, Shi MX, et al. Plasma DNA methylation of Wnt antagonists predicts recurrence of esophageal squamous cell carcinoma. World J Gastroenterol. 2011;17(44):4917-21.
-
(2011)
World J Gastroenterol.
, vol.17
, Issue.44
, pp. 4917-21
-
-
Liu, J.B.1
Qiang, F.L.2
Dong, J.3
Cai, J.4
Zhou, S.H.5
Shi, M.X.6
-
80
-
-
54149111724
-
Similarity of aberrant dna methylation in barrett's esophagus and esophageal adenocarcinoma
-
Smith E, De Young NJ, Pavey SJ, Hayward NK, Nancarrow DJ, Whiteman DC, et al. Similarity of aberrant DNA methylation in Barrett's esophagus and esophageal adenocarcinoma. Mol Cancer. 2008;7:75.
-
(2008)
Mol Cancer
, vol.7
, pp. 75
-
-
Smith, E.1
De Young, N.J.2
Pavey, S.J.3
Hayward, N.K.4
Nancarrow, D.J.5
Whiteman, D.C.6
-
81
-
-
33744745285
-
Promoter methylation and response to chemotherapy and radiation in esophageal cancer
-
Hamilton JP, Sato F, Greenwald BD, Suntharalingam M, Krasna MJ, Edelman MJ, et al. Promoter methylation and response to chemotherapy and radiation in esophageal cancer. Clin Gastroenterol Hepatol. 2006;4(6):701-8.
-
(2006)
Clin Gastroenterol Hepatol.
, vol.4
, Issue.6
, pp. 701-8
-
-
Hamilton, J.P.1
Sato, F.2
Greenwald, B.D.3
Suntharalingam, M.4
Krasna, M.J.5
Edelman, M.J.6
-
82
-
-
84859940334
-
Multifactorial etiology of gastric cancer
-
Zabaleta J. Multifactorial etiology of gastric cancer. Methods Mol Biol. 2012;863:411-35.
-
(2012)
Methods Mol Biol.
, vol.863
, pp. 411-35
-
-
Zabaleta, J.1
-
83
-
-
0036724347
-
Distinct promoter hypermethylation of p16ink4a, cdh1, and rar-beta in intestinal, diffuse-adherent, and diffuse-scattered type gastric carcinomas
-
Oue N, Motoshita J, Yokozaki H, Hayashi K, Tahara E, Taniyama K, et al. Distinct promoter hypermethylation of p16INK4a, CDH1, and RAR-beta in intestinal, diffuse-adherent, and diffuse-scattered type gastric carcinomas. J Pathol. 2002;198 (1):55-9.
-
(2002)
J Pathol.
, vol.198
, Issue.1
, pp. 55-9
-
-
Oue, N.1
Motoshita, J.2
Yokozaki, H.3
Hayashi, K.4
Tahara, E.5
Taniyama, K.6
-
84
-
-
79952705527
-
Aberrant dna methylation distinguishes hepatocellular carcinoma associated with hbv and hcv infection and alcohol intake
-
LambertMP, Paliwal A,Vaissiere T, Chemin I, Zoulim F, Tommasino M, et al. Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake. J Hepatol. 2011;54(4):705-15.
-
(2011)
J Hepatol.
, vol.54
, Issue.4
, pp. 705-15
-
-
Lambert, M.P.1
Paliwal, A.2
Vaissiere, T.3
Chemin, I.4
Zoulim, F.5
Tommasino, M.6
-
85
-
-
0024376173
-
Ras oncogenes in human cancer: A review
-
Bos JL. Ras oncogenes in human cancer: a review. Cancer Res. 1989;49(17):4682-9.
-
(1989)
Cancer Res.
, vol.49
, Issue.17
, pp. 4682-9
-
-
Bos, J.L.1
-
86
-
-
52749099497
-
Assessment of somatic k-ras mutations as a mechanism associated with resistance to egfr-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
-
Linardou H, Dahabreh IJ, Kanaloupiti D, Siannis F, Bafaloukos D, Kosmidis P, et al. Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. Lancet Oncol. 2008;9(10):962-72.
-
(2008)
Lancet Oncol.
, vol.9
, Issue.10
, pp. 962-72
-
-
Linardou, H.1
Dahabreh, I.J.2
Kanaloupiti, D.3
Siannis, F.4
Bafaloukos, D.5
Kosmidis, P.6
-
87
-
-
0037264633
-
Signalling pathways in cancer therapy
-
Downward J. Targeting RAS, signalling pathways in cancer therapy. Nat Rev Cancer. 2003;3(1):11-22.
-
(2003)
Nat Rev Cancer.
, vol.3
, Issue.1
, pp. 11-22
-
-
Downward, J.1
Targeting, R.A.S.2
-
88
-
-
0032937784
-
Association of k-ras mutations with p16 methylation in human colon cancer
-
Guan RJ, Fu Y, Holt PR, Pardee AB. Association of K-ras mutations with p16 methylation in human colon cancer. Gastroenterology. 1999;116(5):1063-71.
-
(1999)
Gastroenterology.
, vol.116
, Issue.5
, pp. 1063-71
-
-
Guan, R.J.1
Fu, Y.2
Holt, P.R.3
Pardee, A.B.4
-
89
-
-
0037038684
-
Farnesyltransferase inhibitor (l-744,832) restores tgfbeta type ii receptor expression and enhances radiation sensitivity in k-ras mutant pancreatic cancer cell line mia paca-2
-
Alcock RA, Dey S, Chendil D, InayatMS,Mohiuddin M, Hartman G, et al. Farnesyltransferase inhibitor (L-744,832) restores TGFbeta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2. Oncogene. 2002;21(51):7883-90.
-
(2002)
Oncogene.
, vol.21
, Issue.51
, pp. 7883-90
-
-
Alcock, R.A.1
Dey, S.2
Chendil, D.3
Inayat, M.S.4
Mohiuddin, M.5
Hartman, G.6
-
90
-
-
0345148793
-
Oncogenic ras inhibits fas ligand-mediated apoptosis by downregulating the expression of fas
-
Peli J, Schroter M, Rudaz C, Hahne M, Meyer C, Reichmann E, et al. Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas. EMBO J. 1999;18(7):1824-31.
-
(1999)
EMBO J.
, vol.18
, Issue.7
, pp. 1824-31
-
-
Peli, J.1
Schroter, M.2
Rudaz, C.3
Hahne, M.4
Meyer, C.5
Reichmann, E.6
-
91
-
-
35548953686
-
An elaborate pathway required for ras-mediated epigenetic silencing
-
This study elegantly inoints an effector mediated by mutant Ras signaling resonsible for the downregulation of FAS
-
Gazin C, Wajapeyee N, Gobeil S, Virbasius CM, Green MR. An elaborate pathway required for Ras-mediated epigenetic silencing. Nature. 2007;449(7165):1073-7. This study elegantly pinpoints an effector mediated by mutant Ras signaling responsible for the downregulation of FA.S.
-
(2007)
Nature.
, vol.449
, Issue.7165
, pp. 1073-7
-
-
Gazin, C.1
Wajapeyee, N.2
Gobeil, S.3
Virbasius, C.M.4
Green, M.R.5
-
92
-
-
0029046134
-
Regulation of dna methylation by the ras signaling pathway
-
MacLeod AR, Rouleau J, Szyf M. Regulation of DNA methylation by the Ras signaling pathway. J Biol Chem. 1995;270(19):11327-37.
-
(1995)
J Biol Chem.
, vol.270
, Issue.19
, pp. 11327-37
-
-
MacLeod, A.R.1
Rouleau, J.2
Szyf, M.3
-
93
-
-
32844459336
-
The polycomb group protein ezh2 directly controls dna methylation
-
Vire E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, et al. The Polycomb group protein EZH2 directly controls DNA methylation. Nature. 2006;439(7078):871-4.
-
(2006)
Nature.
, vol.439
, Issue.7078
, pp. 871-4
-
-
Vire, E.1
Brenner, C.2
Deplus, R.3
Blanchon, L.4
Fraga, M.5
Didelot, C.6
-
94
-
-
79960400013
-
Cladribine plus rituximab is an effective therapy for newly diagnosed mantle cell lymphoma
-
Spurgeon SE, Pindyck T, Okada C, Chen Y, Chen Z, Mater E, et al. Cladribine plus rituximab is an effective therapy for newly diagnosed mantle cell lymphoma. Leuk Lymphoma. 2011;52(8):1488-94.
-
(2011)
Leuk Lymphoma.
, vol.52
, Issue.8
, pp. 1488-94
-
-
Spurgeon, S.E.1
Pindyck, T.2
Okada, C.3
Chen, Y.4
Chen, Z.5
Mater, E.6
-
95
-
-
22144461094
-
Mechanism of inhibition of dna methyltransferases by cytidine analogs in cancer therapy
-
This may serve as a model for eigenetic theray combined with monoclonal antibody treatments
-
Gowher H, Jeltsch A. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004;3(11):1062-8. This may serve as a model for epigenetic therapy combined with monoclonal antibody treatments.
-
(2004)
Cancer Biol Ther.
, vol.3
, Issue.11
, pp. 1062-8
-
-
Gowher, H.1
Jeltsch, A.2
-
96
-
-
0028151343
-
Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of dna methyltransferase rather than dna demethylation
-
Juttermann R, Li E, Jaenisch R. Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci USA. 1994;91(25):11797-801.
-
(1994)
Proc Natl Acad Sci US.A.
, vol.91
, Issue.25
, pp. 11797-801
-
-
Juttermann, R.1
Li, E.2
Jaenisch, R.3
-
97
-
-
0037437788
-
The effects of cladribine and fludarabine on dna methylation in k562 cells
-
Wyczechowska D, Fabianowska-Majewska K. The effects of cladribine and fludarabine on DNA methylation in K562 cells. Biochem Pharmacol. 2003;65(2):219-25.
-
(2003)
Biochem Pharmacol.
, vol.65
, Issue.2
, pp. 219-25
-
-
Wyczechowska, D.1
Fabianowska-Majewska, K.2
-
98
-
-
79959261552
-
Vorinostat-induced apoptosis in mantle cell lymphoma is mediated by acetylation of proapoptotic bh3-only gene promoters
-
Xargay-Torrent S, Lopez-Guerra M, Saborit-Villarroya I, Rosich L, Campo E, Roue G, et al. Vorinostat-induced apoptosis in mantle cell lymphoma is mediated by acetylation of proapoptotic BH3-only gene promoters. Clin Cancer Res. 2011;17(12):3956-68.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.12
, pp. 3956-3968
-
-
Xargay-Torrent, S.1
Lopez-Guerra, M.2
Saborit-Villarroya, I.3
Rosich, L.4
Campo, E.5
Roue, G.6
-
99
-
-
33846122993
-
Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug
-
Marks PA, Breslow R. Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat Biotechnol. 2007;25(1):84-90.
-
(2007)
Nat Biotechnol.
, vol.25
, Issue.1
, pp. 84-90
-
-
Marks, P.A.1
Breslow, R.2
-
100
-
-
33644697486
-
Cetuximab and irinotecan/5-fluorouracil/folinic acid is a safe combination for the first-line treatment of patients with epidermal growth factor receptor expressing metastatic colorectal carcinoma
-
Folprecht G, Lutz MP, Schoffski P, Seufferlein T, Nolting A, Pollert P, et al. Cetuximab and irinotecan/5-fluorouracil/folinic acid is a safe combination for the first-line treatment of patients with epidermal growth factor receptor expressing metastatic colorectal carcinoma. Ann Oncol. 2006;17 (3):450-6.
-
(2006)
Ann Oncol.
, vol.17
, Issue.3
, pp. 450-6
-
-
Folprecht, G.1
Lutz, M.P.2
Schoffski, P.3
Seufferlein, T.4
Nolting, A.5
Pollert, P.6
-
101
-
-
13644259457
-
A cpg island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines
-
Lind GE, Thorstensen L, Lovig T, Meling GI, Hamelin R, Rognum TO, et al. A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines. Mol Cancer. 2004;3:28.
-
(2004)
Mol Cancer.
, vol.3
, pp. 28
-
-
Lind, G.E.1
Thorstensen, L.2
Lovig, T.3
Meling, G.I.4
Hamelin, R.5
Rognum, T.O.6
-
102
-
-
33646369393
-
Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band
-
Frigola J, Song J, Stirzaker C, Hinshelwood RA, Peinado MA, Clark SJ. Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nat Genet. 2006;38(5):540-9.
-
(2006)
Nat Genet.
, vol.38
, Issue.5
, pp. 540-9
-
-
Frigola, J.1
Song, J.2
Stirzaker, C.3
Hinshelwood, R.A.4
Peinado, M.A.5
Clark, S.J.6
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