Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases

Prostaglandins and Other Lipid Mediators

Volumn 99, Issue 3-4, 2012, Pages 57-67

  Giudetti, Anna Maria ^a   Cagnazzo, Raffaele ^b  

^a UNIVERSITY OF SALENTO   (Italy)

^b Pneumo Phthisiology Service USL   (Italy)

Author keywords

Acute respiratory distress syndrome; Asthma; Chronic obstructive pulmonary disease; Cystic fibrosis; n 3 polyunsaturated fatty acids; Respiratory diseases

Indexed keywords

ARACHIDONIC ACID; CD59 ANTIGEN; DOCOSAHEXAENOIC ACID; FISH OIL; G PROTEIN COUPLED RECEPTOR 120; ICOSAPENTAENOIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LINOLEIC ACID; LINOLENIC ACID; LIPOXIN A; STAT3 PROTEIN;

ANTIINFLAMMATORY ACTIVITY; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CYSTIC FIBROSIS; ELECTROPHILICITY; HUMAN; NONHUMAN; RESPIRATORY TRACT INFLAMMATION; REVIEW; SIGNAL TRANSDUCTION; VAGUS TONE;

ANIMALS; ANTIGENS, CD59; ARACHIDONIC ACID; ASTHMA; CHEMOKINES; CHRONIC DISEASE; CYSTIC FIBROSIS; DOCOSAHEXAENOIC ACIDS; EICOSANOIDS; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; HUMANS; INFLAMMATION; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY SYSTEM;

EID: 84869088760     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2012.09.006     Document Type: Review

References (141)

1. P.J. Barnes, K.F. Chung, and C.P. Page Inflammatory mediators of asthma: an update Pharmacol Rev 50 1998 515 596 (Pubitemid 29028812)
2. J.H. Shelhamer, S.J. Levine, T. Wu, D.B. Jacoby, M.A. Kaliner, and S.I. Rennard NIH conference. Airway inflammation Ann Intern Med 123 1995 288 304
3. L.D. Martin, L.G. Rochelle, B.M. Fischer, T.M. Krunkosky, and K.B. Adler Airway epithelium as an effector of inflammation: molecular regulation of secondary mediators Eur Respir J 10 1997 2139 2146 (Pubitemid 27406456)
4. H. Kimata, A. Yoshida, C. Ishioka, I. Lindley, and H. Mikawa Interleukin 8 (IL-8) selectively inhibits immunoglobulin E production induced by IL-4 in human B cells J Exp Med 176 1992 1227 1231
5. K.F. Chung The role of airway smooth muscle in the pathogenesis of airway wall remodeling in chronic obstructive pulmonary disease Proc Am Thorac Soc 2 2005 347 354 (Pubitemid 41699695)
6. G.W. Canonica Treating asthma as an inflammatory disease Chest 130 2006 21S 28S (Pubitemid 44107233)
7. J. Bousquet, P.K. Jeffery, W.W. Busse, M. Johnson, and A.M. Vignola Asthma. From bronchoconstriction to airways inflammation and remodeling Am J Respir Crit Care Med 161 2000 1720 1745 (Pubitemid 30329053)
8. S. Turner, J. Paton, B. Higgins, and G. Douglas British guidelines on the management of asthma: what's new for 2011? Thorax 66 2011 1104 1105
9. T.M. Litchfield, and T.H. Lee Asthma: cells and cytokines J Asthma 29 1992 181 191
10. M.A. Gill The role of dendritic cells in asthma J Allergy Clin Immunol 129 2012 889 901
11. K. Bloemen, S. Verstraelen, R. Van Den Heuvel, H. Witters, I. Nelissen, and G. Schoeters The allergic cascade: review of the most important molecules in the asthmatic lung Immunol Lett 113 2007 6 18 (Pubitemid 47464616)
12. E.R. Walsh, K. Stokes, and A. August The role of eosinophils in allergic airway inflammation Discov Med 9 2010 357 362
13. K. Nakagome, and M. Nagata Pathogenesis of airway inflammation in bronchial asthma Auris Nasus Larynx 38 2011 555 563
14. A. Hill, and S.R. Gompertz Factors influencing airway inflammation in chronic obstructive pulmonary disease Thorax 55 2000 970 977
15. S. Saba, G. Soong, S. Greenberg, and A. Prince Bacterial stimulation of epithelial G-CSF and GM-CSF expression promotes PMN survival in CF airways Am J Respir Cell Mol Biol 27 2002 561 567 (Pubitemid 35301810)
16. G. Matute-Bello, W.C. Liles, and F. Radella II Neutrophil apoptosis in the acute respiratory distress syndrome Am J Respir Crit Care Med 156 1997 1969 1977 (Pubitemid 28011809)
17. R.A. Pauwels, A.S. Buist, P. Ma, C.R. Jenkins, S.S. Hurd, and GOLD Scientific Committee Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: National Heart, Lung, and Blood Institute and World Health Organization Global Initiative for Chronic Obstructive Lung Disease (GOLD): executive summary Respir Care 46 2001 798 825 (Pubitemid 33759920)
18. P.J. Barnes Mediators of chronic obstructive pulmonary disease Pharmacol Rev 56 2004 515 548 (Pubitemid 39658462)
19. R. O'Donnell, D. Breen, S. Wilson, and R. Djukanovic Inflammatory cells in the airways in COPD Thorax 61 2006 448 454 (Pubitemid 43723331)
20. V. Kumar, N. Fausto, and A. Abbas Pathological basis of disease 2004 W.B. Saunders Company Philadelphia
21. P.C. Calder n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases Am J Clin Nutr 83 2006 1505 1519
22. P. Benatti, G. Peluso, R. Nicolai, and M. Calvani Polyunsaturated fatty acids: biochemical, nutritional and epigenetic properties J Am Coll Nutr 23 2004 281 302 (Pubitemid 39096388)
23. I. Kudo, and M. Murakami Phospholipase A2 enzymes Prostaglandins Other Lipid Mediat 68-69 2002 3 58
24. R.A. Wolf, and R.W. Gross Identification of neutral active phospholipase C which hydrolyzes choline glycerophospholipids and plasmalogen selective phospholipase A2 in canine myocardium J Biol Chem 260 1985 7295 7303 (Pubitemid 15059367)
25. W. Busse, and M. Kraft Cysteinyl leukotrienes in allergic inflammation: strategic target for therapy Chest 127 2005 1312 1326 (Pubitemid 46224296)
26. T.S. Hallstrand, and W.R. Henderson Jr. An update on the role of leukotrienes in asthma Curr Opin Allergy Clin Immunol 10 2010 60 66
27. P. Montuschi, and M.L. Peters-Golden Leukotriene modifiers for asthma treatment Clin Exp Allergy 40 2010 1732 1741
28. W. Szczeklik, M. Sanak, and L. Mastalerz 12-Hydroxy-eicosatetraenoic acid (12-HETE): a biomarker of Churg-Strauss syndrome Clin Exp Allergy 42 2012 513 522
29. L.C. His, L.C. Wilson, and T.E. Eling Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate J Biol Chem 277 2002 40549 40556
30. H.W. Chu, S. Balzar, and J.Y. Westcott Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition Clin Exp Allergy 32 2002 1558 1565 (Pubitemid 35370530)
31. P. Bradding, A.E. Redington, R. Djukanovic, D.J. Conrad, and S.T. Holgate 15-Lipoxygenase immunoreactivity in normal and in asthmatic airways Am J Respir Crit Care Med 151 1995 1201 1204
32. D.E. Griswold, and J.L. Adams Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): rationale for selective inhibition and progress to date Med Res Rev 16 1996 181 206 (Pubitemid 26099988)
33. W.S. Powell Eicosanoids and the lung. Physiological basis of respiratory disease 2005 BC Decker Inc. USA
34. P.C. Calder Dietary modification of inflammation with lipids Proc Nutr Soc 61 2002 345 358 (Pubitemid 34982924)
35. P.N. Black, and S. Sharpe Dietary fat and asthma: is there a connection? Eur Respir J 10 1997 6 12 (Pubitemid 27047172)
36. K.T. Moreland, J.D. Procknow, R.S. Sprague, J.L. Iverson, A.J. Lonigro, and A.H. Stephenson Cyclooxygenase (COX)-1 and COX-2 participate in 5,6-epoxyeicosatrienoic acid-induced contraction of rabbit intralobar pulmonary arteries J Pharmacol Exp Ther 321 2007 446 454 (Pubitemid 46624502)
37. C. Morin, M. Sirois, V. Echave, M.M. Gomes, and E. Rousseau Functional effects of 20-HETE on human bronchi: hyperpolarization and relaxation due to BKCa channel activation Am J Physiol Lung Cell Mol Physiol 293 2007 L1037 L1044
38. E.K. Birks, M. Bousamra, K. Presberg, J.A. Marsh, R.M. Effros, and E.R. Jacobs Human pulmonary arteries dilate to 20-HETE, an endogenous eicosanoid of lung tissue Am J Physiol 272 1997 L823 L829
39. M.I. Townsley, C. Morisseau, B. Hammock, and J.A. King Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury Microcirculation 17 2010 137 146
40. P.R. Cooper, A.C. Mesaros, and J. Zhang 20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice PLoS One 5 2010 e10235
41. J.A. Lawson, J. Rokach, and G.A. FitzGerald Isoprostanes: formation, analysis and use as indices of lipid peroxidation in vivo J Biol Chem 274 1999 24441 24444
42. H.K. Dutt, S. Gaur, A. Kumar, and S. Goswami Oxidative stress in bronchial asthma: a clinical study J Appl Pharm Sci 1 2011 145 149
43. E. Baraldi, S. Carraro, and R. Alinovi Cysteinyl leukotrienes and 8-isoprostane in exhaled breath condensate of children with asthma exacerbations Thorax 58 2003 505 509 (Pubitemid 36714012)
44. S.P. Tull, C.M. Yates, and B.H. Maskrey Omega-3 fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment PLoS Biol 7 2009 e1000177
45. D.W. Goldman, W.C. Pickett, and E.J. Goetzl Human neutrophil chemotactic and degranulating activities of leukotriene B5 (LTB5) derived from eicosapentaenoic acid Biochem Biophys Res Commun 117 1983 282 288 (Pubitemid 14216878)
46. C. Morin, S. Fortin, A.M. Cantin, and E. Rousseau Docosahexaenoic acid derivative prevents inflammation and hyperreactivity in lung: implication of PKC-potentiated inhibitory protein for heterotrimeric myosin light chain phosphatase of 17 kD in asthma Am J Respir Cell Mol Biol 45 2011 366 375
47. S.D. Freedman, P.G. Blanco, and M.M. Zaman Association of cystic fibrosis with abnormalities in fatty acid metabolism N Engl J Med 350 2004 560 569 (Pubitemid 38160786)
48. P.C. Calder Polyunsaturated fatty acids and inflammatory processes: new twists in an old tale Biochimie 91 2009 791 795
49. P.C. Calder Fatty acids and inflammation: the cutting edge between food and pharma Eur J Pharmacol 668 2011 S50 S58
50. B.D. Levy, C.B. Clish, B. Schmidt, K. Gronert, and C.N. Serhan Lipid mediator class switching during acute inflammation: signals in resolution Nat Immunol 2 2001 612 619 (Pubitemid 32677628)
51. G.M. Gauvreau, R.M. Watson, and P.M. O'Byrne Protective effects of inhaled PGE2 on allergen-induced airway responses and airway inflammation Am J Respir Crit Care Med 159 1999 31 36 (Pubitemid 29036499)
52. O. Haworth, and B.D. Levy Endogenous lipid mediators in the resolution of airway inflammation Eur Respir J 30 2007 980 992 (Pubitemid 351194804)
53. C. Bonnans, I. Vachier, C. Chavis, P. Godard, J. Bousquet, and P. Chanez Lipoxins are potential endogenous antiinflammatory mediators in asthma Am J Respir Crit Care Med 165 June (11) 2002 1531 1535 (Pubitemid 34606669)
54. C.L. Karp, L.M. Flick, and K.W. Park Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway Nat Immunol 5 2004 388 392 (Pubitemid 38500087)
55. C.N. Serhan Novel chemical mediators in the resolution of inflammation: resolvins and protectins Anesthesiol Clin 24 2006 341 364
56. C.N. Serhan, S. Yacoubian, and R. Yang Anti-inflammatory and proresolving lipid mediators Annu Rev Pathol 3 2008 279 312 (Pubitemid 351488283)
57. C.N. Serhan, N. Chiang, and T.E. Van Dyke Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators Nat Rev Immunol 8 2008 349 361 (Pubitemid 351595216)
58. M. Spite, and C.N. Serhan Novel lipid mediators promote resolution of acute inflammation impact of aspirin and statins Circ Res 107 2010 1170 1184
59. M. Arita, F. Bianchini, and J. Aliberti Stereochemical assignment, anti-inflammatory properties, and receptor for the omega-3 lipid mediator resolvin E J Exp Med 201 2005 713 722 (Pubitemid 40395117)
60. H. Seki, K. Fukunaga, and M. Arita The anti-inflammatory and proresolving mediator resolvin E1 protects mice from bacterial pneumonia and acute lung injury J Immunol 184 2010 836 843
61. T. Ishizuka, T. Hisada, H. Aoki, and M. Mori Resolvin E1: a novel lipid mediator in the resolution of allergic airway inflammation Expert Rev Clin Immunol 4 2008 669 672
62. B.L. Levy, P. Kohli, and K. Gotlinger Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness J Immunol 178 2007 496 502 (Pubitemid 46039663)
63. A. Groeger, C. Cipollina, and M.P. Cole Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids Nat Chem Biol 6 2010 433 441
64. C. Cipollina, S. Salvatore, B.A. Freeman, and F.J. Schopfer Late-breaking abstract: cyclooxygenase- and lypoxigenase-dependent generation of omega-3 electrophilic fatty acid-derivatives with anti-inflammatory properties Eur Respir Soc 2011 P763
65. A. Matsumori The role of NF-kappaB in the pathogenesis of heart failure and endotoxemia Drugs Fut 29 2004 733
66. J.Y. Lee, K.H. Sohn, S.H. Rhee, and D. Hwang Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4 J Biol Chem 276 2001 16683 16689
67. A.R. Weatherill, J.Y. Lee, L. Zhao, D.G. Lemay, H.S. Youn, and D.H. Hwang Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4 J Immunol 174 2005 5390 5397 (Pubitemid 40593178)
68. S. Camandola, G. Leonarduzzi, and T. Musso Nuclear factor kB is activated by arachidonic acid but not by eicosapentaenoic acid Biochem Biophys Res Commun 229 1996 643 647 (Pubitemid 27029084)
69. J.Y. Lee, A. Plakidas, and W.H. Lee Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids J Lipid Res 44 2003 479 486 (Pubitemid 37279695)
70. A. Dunne, and L.A. O'Neill The interleukin-1 receptor/Toll-Like receptor superfamily: signal transduction during inflammation and host defense Sci STKE 25 2003 re3
71. M. Massaro, A. Habib, and L. Lubrano The omega-3 fatty acid docosahexaenoate attenuates endothelial cyclooxygenase-2 induction through both NADP(H) oxidase and PKC inhibition Proc Natl Acad Sci USA 103 2006 15184 15189 (Pubitemid 44583185)
72. K.A. Zarember, and P.J. Godowski Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines J Immunol 168 2002 554 561 (Pubitemid 34049553)
73. K. Karimi, H. Sarir, and E. Mortaz Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages Respir Res 7 2006 66
74. M.A. Birrell, E. Hardaker, and S. Wong Iκ-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma Am J Respir Crit Care Med 172 2005 962 971 (Pubitemid 41476532)
75. J. Xu, Y. Du, D. Li, and Y. Xu Nuclear factor-kappa B and intercellular adhesion molecule-1 expression in airway epithelial cells from smoking rats Zhonghua Jie He He Hu Xi Za Zhi 25 2002 493 496
76. T.D. Mickleborough, M.R. Lindley, A.A. Ionescu, and A.D. Fly Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma Chest 129 2006 39 49 (Pubitemid 43265241)
77. A. Agustí, M. Morlá, J. Sauleda, C. Saus, and X. Busquets NF-kappaB activation and iNOS upregulation in skeletal muscle of patients with COPD and low body weight Thorax 59 2004 483 487 (Pubitemid 38797520)
78. M.M. Zaman, A. Gelrud, and O. Junaidi Interleukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered Clin Diagn Lab Immunol 11 2004 819 824 (Pubitemid 39280584)
79. A. Hirasawa, T. Hara, S. Katsuma, T. Adachi, and G. Tsujimoto Free fatty acid receptors and drug discovery Biol Pharm Bull 31 2008 1847 1851
80. P. Singer, H. Shapiro, M. Theilla, R. Anbar, J. Singer, and J. Cohen Anti-inflammatory properties of omega-3 fatty acids in critical illness: novel mechanisms and an integrative perspective Intensive Care Med 34 2008 1580 1592
81. H. Yoshikawa, M. Kurokawa, and N. Ozaki Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7 Clin Exp Immunol 146 2006 116 123 (Pubitemid 44393846)
82. K.J. Tracey The inflammatory reflex Nature 420 2002 853 859 (Pubitemid 36019638)
83. K. Pollock, and M.T. Withnall Protein tyrosine kinase but not protein kinase C inhibition blocks receptor induced alveolar macrophage activation Mediators Inflamm 2 1993 373 377 (Pubitemid 23323361)
84. O. Haworth, M. Cernadas, R. Yang, C.N. Serhan, and B.D. Levy Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxins A4 to promote the resolution of allergic airway inflammation Nat Immunol 9 2008 873 879
85. H. Aoki, T. Hisada, and T. Ishizuka Protective effect of resolvin E1 on the development of asthmatic airway inflammation Biochem Biophys Res Commun 400 2010 128 133
86. H. Aoki, T. Hisada, and T. Ishizuka Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma Biochem Biophys Res Commun 367 2008 509 515
87. A. Yokoyama, T. Hamazaki, and A. Ohshita Effect of aerosolized docosahexaenoic acid in a mouse model of atopic asthma Int Arch Allergy Immunol 123 2000 327 332 (Pubitemid 32037612)
88. L.G. Wood, L.C. Hazlewood, P.S. Foster, and P.M. Hansbro Lyprinol reduces inflammation and improves lung function in a mouse model of allergic airways disease Clin Exp Allergy 40 2010 1785 1793
89. S. Johansson, A. Lönnqvist, S. Ostman, A.S. Sandberg, and A.E. Wold Long-chain polyunsaturated fatty acids are consumed during allergic inflammation and affect T helper type 1 (Th1)- and Th2-mediated hypersensitivity differently Clin Exp Immunol 160 2010 411 419
90. S. Bilal, O. Haworth, L. Wu, K.H. Weylandt, B.D. Levy, and J.X. Kang Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses Biochim Biophys Acta 1812 2011 1164 1169
91. B. Wang, X. Gong, and J.Y. Wan Resolvin D1 protects mice from LPS-induced acute lung injury Pulm Pharmacol Ther 24 2011 434 441
92. K. Mayer, A. Kiessling, and J. Ott Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids Am J Respir Crit Care Med 179 2009 474 483
93. D. Tetaert, M. Pierre, and D. Demeyer Dietary n-3 fatty acids have suppressive effects on mucin upregulation in mice infected with Pseudomonas aeruginosa Respir Res 8 2007 39
94. C. Andersson, M.M. Zaman, A.B. Jones, and S.D. Freedman Alterations in immune response and PPAR/LXR regulation in cystic fibrosis macrophages J Cyst Fibros 7 2008 68 78
95. S.E. Wenzel Arachidonic acid metabolites: mediators of inflammation in asthma Pharmacotherapy 17 1997 3S 12S (Pubitemid 27057108)
96. D.F. Horrobin Low prevalences of coronary heart disease (CHD), psoriasis, asthma and rheumatoid arthritis in Eskimos: are they caused by high dietary intake of eicosapentaenoic acid (EPA), a genetic variation of essential fatty acid (EFA) metabolism or a combination of both? Med Hypotheses 22 1987 421 428 (Pubitemid 17140104)
97. R. Schubert, R. Kitz, and C. Beermann Effect of n-3 polyunsaturated fatty acids in asthma after low-dose allergen challenge Int Arch Allergy Immunol 148 2009 321 329
98. J.P. Arm, C.E. Horton, B.W. Spur, J.M. Mencia-Huerta, and T.H. Lee The effects of dietary supplementation with fish oil lipids on the airways response to inhaled allergen in bronchial asthma Am Rev Respir Dis 139 1989 1395 1400 (Pubitemid 19155496)
99. F.C. Thien, J.M. Mencia-Huerta, and T.H. Lee Dietary fish oil effects on seasonal hay fever and asthma in pollen-sensitive subjects Am Rev Respir Dis 147 1993 1138 1143 (Pubitemid 23149869)
100. K.S. Broughton, C.S. Johnson, B.K. Pace, M. Liebman, and K.M. Kleppinger Reduced asthma symptoms with n-3 fatty acid ingestion are related to 5-series leukotriene production Am J Clin Nutr 65 1997 1011 1017 (Pubitemid 27152619)
101. T.D. Mickleborough, S.L. Tecklenburg, G.S. Montgomery, and M.R. Lindley Eicosapentaenoic acid is more effective than docosahexaenoic acid in inhibiting proinflammatory mediator production and transcription from LPS-induced human asthmatic alveolar macrophage cells Clin Nutr 28 2009 71 77
102. S. Tecklenburg-Lund, T.D. Mickleborough, L.A. Turner, A.D. Fly, J.M. Stager, and G.S. Montgomery Randomized controlled trial of fish oil and montelukast and their combination on airway inflammation and hyperpnea-induced bronchoconstriction PLoS One 5 2010 e13487
103. J. Dry, and D. Vincent Effect of a fish oil diet on asthma: results of a 1-y double-blind study Int Arch Allergy Appl Immunol 95 1991 156 157
104. A. Emelyanov, G. Fedoseev, O. Krasnoschekova, A. Abulimity, T. Trendeleva, and P.J. Barnes Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomized clinical trial Eur Respir J 20 2002 596 600
105. M. SalLam, F. Motaleb, M. Ahmed, and A. Mahmoud Anti-inflammatory effect of Omega-3 polyunsaturated fatty acids in children with bronchial asthma; relation to nuclear factor-kappa B (NF-κB) and inflammatory cytokines il-12 and il-13 Egypt J Biochem Mol Biol 2010 28
106. T. Nagakura, S. Matsuda, K. Shichijyo, H. Sugimoto, and K. Hata Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma Eur Respir J 16 2000 861 865 (Pubitemid 32049372)
107. M.A. Biltagi, A.A. Baset, M. Bassiouny, M.A. Kasrawi, and M. Attia Omega-3 fatty acids, vitamin C and Zn supplementation in asthmatic children: a randomized self-controlled study Acta Paediatr 98 2009 737 742
108. S. Mihrshahi, J.K. Peat, and G.B. Marks Eighteen-month outcomes of house dust mite avoidance and dietary fatty acid modification in the childhood asthma prevention study (CAPS) J Allergy Clin Immunol 111 2003 162 166
109. P.J. Barmes Mediators of chronic obstructive pulmonary disease Pharmacol Rev 56 2004 515 548
110. W. Matsuyama, H. Mitsuyama, and M. Watanabe Effects of omega-3 polyunsaturated fatty acids on inflammatory markers in COPD Chest 128 2005 3817 3827 (Pubitemid 43062641)
111. R. Broekhuizen, E.F. Wouters, E.C. Creutzberg, C.A. Weling-Scheepers, and A.M. Schols Polyunsaturated fatty acids improve exercise capacity in chronic obstructive pulmonary disease Thorax 60 2005 376 382 (Pubitemid 40685819)
112. C. Delacourt Inflammation and cystic fibrosis Arch Pediatr 10 2003 338s 341s
113. D.S. Armstrong, K. Grimwood, R. Carzino, J.B. Carlin, A. Olinsky, and P.D. Phelan Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis BMJ 310 1995 1571 1572
114. J.L. Taylor-Cousar, K.A. Von Kessel, R. Young, and D.P. Nichols Potential of anti-inflammatory treatment for cystic fibrosis lung disease J Inflamm Res 3 2010 61 74
115. J.K. Ichikawa, A. Norris, and M.G. Bangera Interaction of Pseudomonas aeruginosa with epithelial cells: identification of differentially regulated genes by expression microarray analysis of human cDNAs Proc Natl Acad Sci USA 97 2000 9659 9664 (Pubitemid 30650832)
116. N. Aldallal, E.E. McNaughton, and L.J. Manzel Inflammatory response in airway epithelial cells isolated from patients with cystic fibrosis Am J Respir Crit Care Med 166 2002 1248 1256 (Pubitemid 35222603)
117. R. Lawrence, and T. Sorrell Eicosapentaenoic acid in cystic fibrosis: evidence of a pathogenetic role for leukotriene B4 Lancet 342 1993 465 469 (Pubitemid 23240311)
118. R. Lawrence, and T. Sorrell Eicosapentaenoic acid modulates neutrophil leukotriene B4 receptor expression in cystic fibrosis Clin Exp Immunol 98 1994 12 16 (Pubitemid 24315444)
119. G. Olveira, C. Olveira, and E. Acosta Fatty acid supplements improve respiratory, inflammatory and nutritional parameters in adults with cystic fibrosis Arch Bronconeumol 46 2010 70 77
120. A. Panchaud, A. Sauty, and Y. Kernen Biological effects of a dietary omega-3 polyunsaturated fatty acids supplementation in cystic fibrosis patients: a randomized, crossover placebo-controlled trial Clin Nutr 25 2006 418 427 (Pubitemid 43843016)
121. B. De Vizia, V. Raia, C. Spano, C. Pavlidis, A. Coruzzo, and M. Alessio Effect of an 8-month treatment with omega-3 fatty acids (eicosapentaenoic and docosahexaenoic) in patients with cystic fibrosis JPEN J Parenter Enteral Nutr 27 2003 52 57 (Pubitemid 36105644)
122. L.E. Kurlandsky, M.R. Bennink, P.M. Webb, P.J. Ulrich, and L.J. Baer The absorption and effect of dietary supplementation with omega-3 fatty acids on serum leukotriene B4 in patients with cystic fibrosis Pediatr Pulmonol 18 1994 211 217 (Pubitemid 2161378)
123. P. Singer, and H. Shapiro Enteral omega-3 in acute respiratory distress syndrome Curr Opin Clin Nutr Metab Care 12 2009 123 128
124. J. Grommes, and O. Soehnlein Contribution of neutrophils to acute lung injury Mol Med 17 2011 293 307
125. J.E. Gadek, S.J. De Michele, and M.D. Karlstad Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Enteral Nutrition in ARDS Study Group Crit Care Med 27 1999 1409 1420 (Pubitemid 29406926)
126. P. Singer, M. Theilla, H. Fisher, L. Gibstein, E. Grozovski, and J. Cohen Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury Crit Care Med 34 2006 1033 1038
127. A. Pontes-Arruda, A.M. Aragão, and J.D. Albuquerque Effects of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in mechanically ventilated patients with severe sepsis and septic shock Crit Care Med 34 2006 2325 2333 (Pubitemid 44260016)
128. A. Pontes-Arruda, L.F. Martins, and S.M. de Lima Enteral nutrition with eicosapentaenoic acid, γ-linolenic acid and antioxidants in the early treatment of sepsis: results from a multicenter, prospective, randomized, double-blinded, controlled study: the INTERSEPT study Crit Care 15 2011 R144
129. J.W. Fetterman Jr., and M.M. Zdanowicz Therapeutic potential of n-3 polyunsaturated fatty acids in disease Am J Health Syst Pharm 66 2009 1169 1179
130. H.O. Bang, and J. Dyerberg Plasma lipids and lipoproteins in Greenlandic west coast Eskimos Acta Med Scand 192 1972 85 94
131. C.B. Stephensen Fish oil and inflammatory disease: is asthma the next target for n-3 fatty acid supplements? Nutr Rev 62 2004 486 489 (Pubitemid 39658306)
132. W.W. Busse, and R.F. Lemanske Jr. Asthma N Engl J Med 344 2001 350 362 (Pubitemid 32107645)
133. T.D. Mickleborough, and K.W. Rundell Dietary polyunsaturated fatty acids in asthma- and exercise-induced bronchoconstriction Eur J Clin Nutr 59 2005 1335 1346 (Pubitemid 43135148)
134. J.A. Dustan, and S.L. Prescott Does fish oil supplementation in pregnancy reduce the risk of allergic disease in infants? Curr Opin Allergy Clin Immunol 5 2005 215 221 (Pubitemid 40694985)
135. T.W. Rice, A.P. Wheeler, B.T. Thompson, B.P. deBoisblanc, J. Steingrub, and P. Rock Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury JAMA 306 2011 1574 1581
136. R.D. Stapleton, T.R. Martin, and N.S. Weiss A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury Crit Care Med 39 2011 1655 1662
137. A. Gupta, D. Govil, and S. Bhatnagar Efficacy and safety of parenteral omega 3 fatty acids in ventilated patients with acute lung injury Indian J Crit Care Med 15 2011 108 113
138. D.J. Cook, and D.K. Heyland Pharmaconutrition in acute lung injury JAMA 306 2011 1599 1600
139. C. Alberda, L. Gramlich, and N. Jones The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study Intensive Care Med 35 2009 1728 1737
140. E.C. Broadfield, T.M. McKeever, and A. Whitehurst A case-control study of dietary and erythrocyte membrane fatty acids in asthma Clin Exp Allergy 34 2004 1232 1236 (Pubitemid 39093062)
141. A.S. Kenler, W.S. Swails, and D.F. Driscoll Early enteral feeding in postsurgical cancer patients. Fish oil structured lipid-based polymeric formula versus a standard polymeric formula Ann Surg 223 1996 316 333 (Pubitemid 26086724)