Resolvin E1: A novel lipid mediator in the resolution of allergic airway inflammation

Expert Review of Clinical Immunology

Volumn 4, Issue 6, 2008, Pages 669-672

  Ishizuka, Tamotsu ^a   Hisada, Takeshi ^a   Aoki, Haruka ^a   Mori, Masatomo ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

Bronchial asthma; IL 17; IL 23; Resolvin E1; Th17 cell

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 6; LIPID MEDIATOR; LIPOXIN A; PROTEIN CHEMR23; RECEPTOR; REGULATOR PROTEIN; RESOLVIN E1; UNCLASSIFIED DRUG;

ASTHMA; DISEASE MODEL; DRUG EFFECT; DRUG MECHANISM; HUMAN; MEDIATOR; NONHUMAN; NOTE; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; TREATMENT OUTCOME;

EID: 77649086539     PISSN: 1744666X     EISSN: None     Source Type: Journal    
DOI: 10.1586/1744666X.4.6.669     Document Type: Note

References (14)

1. Serhan CN, Clish CB, Brannon J et al. Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from w-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. J. Exp. Med. 192(8), 1197-1204 (2000).
2. Arita M, Bianchini F, Aliberti J et al. Stereochemical assignment, anti- inflammatory properties, and receptor for the w-3 lipid mediator resolving E1. J. Exp. Med. 201(5), 713-722 (2005).
3. Hasturk H, Kantarci A, Ohira T et al. RvE1 protects from local inflammation and osteoclast-mediated bone destruction in periodontitis. FASEB J. 20(2), 401-403 (2006).
4. Arita M, Yoshida M, Hong S et al. Resolvin E1, an endogenous lipid mediator derived from w-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc. Natl Acad. Sci. USA 102(21), 7671-7676 (2005).
5. Levy BD, Kohli P, Gotlinger K et al. Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. J. Immunol. 178(1), 496-502 (2007).
6. Planaguma A, Kazani S, Marigowda G et al. Airway LXA4 generation and LXA4 receptor expression are decreased in severe asthma. Am. J. Respir. Crit. Care Med. 176(6), 574-582 (2008).
7. Haworth O, Cernadas M, Yong R, Serhan CN, Levy BD. Resolvin E1 regulates interleukin 23, interferon-γ and lipoxin A4 to promote the resolution of allergic airway inflammation. Nat. Immunol. 9(8), 873-879 (2008).
8. Aoki H, Hisada T, Ishizuka T et al. Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma. Biochem. Biophys. Res. Commun. 367(2), 509-515 (2008).
9. Arita M, Ohira T, Sun Y-P et al. Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. J. Immunol. 178(6), 3912-3917 (2007).
10. McGeachy MJ, Cua DJ. The link between IL-23 and Th17 cell-mediated immune pathologies. Semin. Immunol. 19(6), 372-376 (2007).
11. Maloy KJ. The interleukin-23/ interleukin-17 axis in intestinal inflammation. J. Intern. Med. 263(6), 584-590 (2008).
12. Oboki K, Ohno T, Saito H et al. Th17 and allergy. Allergol. Int. 57(2), 121-134 (2008).
13. McMahon B, Godson C. Lipoxins: endogenous regulators of inflammation. Am. J. Physiol. Renal Physiol. 286(2), F189-F201 (2004).
14. Arita M, Oh SF, Chonan T et al. Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions. J. Biol. Chem. 281(32), 22847-22854 (2006).