Lipoxins are potential endogenous antiinflammatory mediators in asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 165, Issue 11, 2002, Pages 1531-1535

  Bonnans, Caroline ^a   Vachier, Isabelle ^a   Chavis, Claude ^a   Godard, Philippe ^a   Bousquet, Jean ^a   Chanez, Pascal ^a,b  

^a INSERM   (France)

^b HÔPITAL ARNAUD DE VILLENEUVE   (France)

Author keywords

Asthma; Inflammation; Interleukin 8; Lipoxins; Peripheral blood mononuclear cells

Indexed keywords

ANTIINFLAMMATORY AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; FLUTICASONE; GLUCOCORTICOID; ICOSANOID; INTERLEUKIN 8; LIPOXIN; LIPOXIN A; LIPOXIN B; MESSENGER RNA; PERTUSSIS TOXIN; PREDNISONE; RECEPTOR;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BIOSYNTHESIS; CHRONIC INFLAMMATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CYTOKINE RELEASE; DISEASE SEVERITY; FATTY ACID SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LONG TERM CARE; MALE; MEDIATOR; MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPUTUM ANALYSIS; SUPERNATANT;

ASTHMA; BASE SEQUENCE; BIOLOGICAL MARKERS; BRONCHIAL PROVOCATION TESTS; FEMALE; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; INFLAMMATION MEDIATORS; INTERLEUKIN-8; LIPOXINS; MALE; MOLECULAR SEQUENCE DATA; PROBABILITY; PROSPECTIVE STUDIES; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SAMPLING STUDIES; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; SPUTUM; STATISTICS, NONPARAMETRIC;

EID: 0036606481     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200201-053OC     Document Type: Article

References (40)

1. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes
2. Mechanisms in anti-inflammation and resolution: The role of lipoxins and aspirin-triggered lipoxins
3. Formation of lipoxins and leukotrienes by human alveolar macrophages incubated with 15(S)-HETE: A model for cellular cooperation between macrophages and airway epithelial cells
4. Lipoxin formation during human neutrophil-platelet interactions: Evidence for the transformation of leukotriene A4 by platelet 12- lipoxygenase in vitro
5. Human alveolar macrophages have 15-lipoxygenase and generate15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins
6. Cutting edge: Lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages
7. Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers
8. Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells
9. Lipoxin (LX) A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1α-initiated neutrophil responses and trafficking: Regulators of a cytokine-chemokine axis
10. Endogenous antiinflammatory mediators from arachidonate in human neutrophils
11. Lipoxin A4 inhibits IL-1β-induced IL-6, IL-8 and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases
12. Induction of functional lipoxin A4 receptors in HL-60 cells
13. Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor
14. Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor
15. Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells: Differential activation of MAP kinases through distinct receptors
16. Antiinflammatory actions of glucocorticoids: Molecular mechanisms
17. Natural history of asthma in patients requiring long-term systemic corticosteroids
18. Bronchoscopic evaluation of severe asthma: Persistent inflammation associated with high dose glucocorticoids
19. Prednisone-dependent asthma: Inflammatory indices in induced sputum
20. Neutrophilic inflammation in severe persistent asthma
21. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
22. Identification of lipoxin A4 and its relationship to the sulfidopeptide leukotrienes C4, D4, and E4 in the bronchoalveolar lavage fluids obtained from patients with selected pulmonary diseases
23. 5(S),15(S)-dihydroxyeicosatetraenoic acid and lipoxin generation in human polymorphonuclear cells: Dual specificity of 5-lipoxygenase towards endogenous and exogenous precursors
24. Leukocyte recruitment after local endobronchial allergen challenge in asthma: Relationship to procedure and to airway interleukin-8 release
25. Modulation and induction of eosinophil chemotaxis by granulocyte-macrophage colony-stimulating factor and interleukin-3
26. Expression of the potent inflammatory cytokines granulocyte-macrophage colony stimulating factor, interleukin-6 and interleukin-8 in bronchial epithelial cells of patients with asthma
27. Glucocorticoid receptor alpha and beta in glucocorticoid-dependent asthma
28. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma: This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986
29. Superoxide anion production by monocytes of corticosteroid-treated asthmatics patients
30. Glucocorticoid receptors in bronchial epithelial cells in asthma
31. Methods for sputum induction and analysis of induced sputum: A method for assessing airway inflammation in asthma
32. Eosinophilic inflammation assessed by induceds sputum in corticosteroid-dependent asthma
33. Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase
34. Lipoxin A4 metabolism by differentiated HL-60 cells and human monocytes: Conversion to novel 15-oxo and dihydro products
35. Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils
36. Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: Selective inactivation by dehydrogenation and reduction
37. Lipoxin B4 regulates human monocyte/neutrophil adherence and motility: Design of stable lipoxin B4 analogs with increased biologic activity
38. Lipoxin A4 receptor activation is distinct from that of the formyl peptide receptor in myeloid cells: Inhibition of CD11/18 expression by lipoxin A4-Lipoxin A4 receptor interaction
39. Lipoxin recognition sites: Specific binding of labeled lipoxin A4 with human neutrophils