Treating asthma as an inflammatory disease

Chest

Volumn 130, Issue 1 SUPPL., 2006, Pages 21S-28S

  Canonica, G Walter ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Allergic rhinitis; Asthma; Corticosteroids; Inflammation; Remodeling

Indexed keywords

ANTIHISTAMINIC AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; CYTOKINE; FLUTICASONE; HISTAMINE; IMMUNOGLOBULIN E; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 13; INTERLEUKIN 4; LEUKOTRIENE RECEPTOR BLOCKING AGENT; METHACHOLINE;

ALLERGIC ASTHMA; ALLERGIC RHINITIS; ASTHMA; BRONCHUS HYPERREACTIVITY; CHRONIC DISEASE; CLINICAL PRACTICE; CONFERENCE PAPER; CORTICOSTEROID THERAPY; DISEASE COURSE; DISEASE EXACERBATION; DRUG EFFICACY; FAMILY HISTORY; FOLLOW UP; FORCED EXPIRATORY VOLUME; HUMAN; INFLAMMATION; INFLAMMATORY DISEASE; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MONOTHERAPY; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROVOCATION TEST; RESPIRATORY TRACT ALLERGY; SKIN TEST; TREATMENT OUTCOME;

EID: 33746323435     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.130.1_suppl.21S     Document Type: Conference Paper

References (60)

1. Global Initiative for Asthma (GINA). Available at http:// www.ginasthma.com. Accessed June 21, 2006
2. Spallarossa D, Battistini E, Silvestri M, et al. Steroid-naïve adolescents with mild intermittent allergic asthma have airway hyperresponsiveness and elevated exhaled nitric oxide levels. J Asthma 2003; 40:301-310
3. Tashkin DP. The role of small airway inflammation in asthma. Allergy Asthma Proc 2002; 23:233-242
4. Van den Burgt JA, Busse WW, Martin RJ, et al. Efficacy and safety overview of a new inhaled corticosteroid, QVAR (hydrofluoroalkane-beclomethasone extrafine inhalation aerosol) in asthma. J Allergy Clin Immunol 2000; 106:1209-1226
5. Lange P, Parner J, Vestbo J, et al. A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med 1998; 339:1194-1200
6. National Asthma Education and Prevention Program. Expert panel report 2. Guidelines for the diagnosis and management of asthma. Bethesda (MD): National Institutes of Health, National Heart, Lung and Blood Institute; 1997. NIH Publication No. 97-4051. Available at: http://www.nhlbi.nih.gov/ guidelines/asthma/asthgdln.pdf. Accessed June 21, 2006
7. Brightling CE, Bradding P, Symon FA, et al. Mast cell infiltration of airway smooth muscle in asthma. N Engl J Med 2002; 346:1699-1705
8. Carroll NG, Mutavdzic S, James AL. Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J 2002; 19:879-885
9. Busse WW, Lemarskie RF Jr. Asthma. N Engl J Med 2001; 344, 350-362
10. Elias J, Lee CG, Sheng T, et al. New insights into the pathogenesis of asthma. J Clin Invest 2003; 111:291-297
11. Bacon AS, Ahluwalia P, Irani AM, et al. Tear and conjunctival changes during the allergen-induced early- and late-phase responses. J Allergy Clin Immunol 2000; 106:948-954
12. Passalacqua G, Ciprandi G, Canonica GW. The nose-lung interaction in allergic rhinitis and asthma: united airways disease. Curr Opin Allergy Clin Immunol 2001; 1:7-13
13. Ciprandi G, Buscaglia S, Pesce G, et al. Minimal persistent inflammation is present at mucosal level in patients with asymptomatic rhinitis and mite allergy. J Allergy Clin Immunol 1995; 96:971-979
14. Ricca V, Landi M, Ferrero P, et al. Minimal persistent inflammation is also present in patients with seasonal allergic rhinitis. J Allergy Clin Immunol 2000; 105:54-57
15. Bagnasco M, Pesce G, Fiorino N, et al. In situ hybridization analysis of ICAM-1 (CD54) mRNA on conjunctival epithelium during allergic inflammation. Clin Exp Allergy 1997; 27:737-743
16. Jeffery PK, Laitinen A, Venge P Biopsy markers of airway inflammation and remodelling. Respir Med 2000; 94(Suppl F):S9-S15
17. Beasley R, Roche WR, Roberts JA, et al. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 1989; 139:806-817
18. Payne D, McKenzie SA, Stacey S, et al. Safety and ethics of bronchoscopy and endobronchial biopsy in difficult asthma. Arch Dis Child 2001; 84:423-426
19. Dinakar C. Exhaled nitric oxide in the clinical management of asthma. Curr Allergy Asthma Rep 2004; 4:454-459
20. Brightling CE, Green RH, Pavord ID. Biomarkers predicting response to corticosteroid therapy in asthma. Treat Respir Med 2005; 4:309-316
21. Zitt M. Clinical applications of exhaled nitric oxide for the diagnosis and management of asthma: a consensus report. Clin Ther 2005; 27:1238-1250
22. Bousquet J, Van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. Allergy Clin Immunol 2001; 108:S147-S334
23. Ciprandi G, Vizzaccaro A, Cirillo I, et al. Increase of asthma and allergic rhinitis prevalence in young Italian men. Int Arch Allergy Immunol 1996; 111:278-283
24. Spector SL. Overview of comorbid associations of allergic rhinitis. J Allergy Clin Immunol 1997; 99:S773-S780
25. Lombardi C, Passalacqua G, Gargioni S, et al. The natural history of respiratory allergy: a follow-up study of 99 patients up to 10 years. Respir Med 2001; 95:9-12
26. Adams RJ, Fuhlbrigge AL, Finkelstein JA, et al. Intranasal steroids and the risk of emergency department visits for asthma. J Allergy Clin Immunol 2002; 109:436-442
27. British Medical Association, Royal Pharmaceutical Society of Great Britain. British National Formulary. No. 48. London, UK: British Medical Association, 2004
28. Gotwals PJ, Chi-Rosso G, Lidner V, et al. The α1β1 integrin is expressed during neointima formation in rat arteries and mediates collagen matrix reorganisation. J Clin Invest 1996; 97:2469-2477
29. Lorimier S, Gillery P, Hornebeck W, et al. Tissue origin and extracellular matrix control neutral proteinase activity in human fibroblast three-dimensional cultures. J Cell Physiol 1996; 168:188-198
30. Ashcroft GS, Horan MA, Ferguson MW. The effects of ageing on cutaneous wound healing in mammals. J Anat 1995; 187:1-26
31. McParland BE, Macklem PT, Pare PD Airway remodeling: friend or foe? J Appl Physiol 2003; 95:426-434
32. Tattersfield AE, Knox AJ, Britton JR, et al. Asthma. Lancet 2002; 360:1313-1322
33. Elias JA, Zhu Z, Chupp G, et al. Airway remodeling in asthma. J Clin Invest 1999; 104:1001-1006
34. Schmidt M, Sun G, Stacey MA, et al. Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol 2003; 170:380-389
35. Gizycki MJ, Adelroth E, Rogers AV, et al. Myofibroblast involvement in the allergen-induced late response in mild atopic asthma. Am J Respir Cell Mol Biol 1997; 16:664-673
36. Johnson PR, Roth M, Tamm M, et al. Airway smooth muscle proliferation is increased in asthma. Am J Respir Crit Care Med 2001; 164:474-477
37. Benayoun L, Druilhe A, Dombret M-C, et al. Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med 2003; 167:1360-1368
38. Woodruff PG, Dolganov GM, Ferrando RE, et al. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med 2004; 169:1001-1006
39. Carroll N, Elliot J, Morton A, et al. The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis 1993; 147:405-410
40. Doucet C, Brouty-Boye D, Pottin-Clemenceau C, et al. Interleukin (IL) 4 and IL-13 act on human lung fibroblasts: implication in asthma. J Clin Invest 1998; 101:2129-2139
41. Davies DE, Wicks J, Powell RM, et al. Airway remodeling in asthma: new insights. J Allergy Clin Immunol 2003; 111:215-225
42. Jarjour NN, Kelly EA. Pathogenesis of asthma. Med Clin North Am 2002; 86:925-936
43. Hoshino M, Takahashi M, Takai Y, et al. Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthma. J Allergy Clin Immunol 1999; 104:356-363
44. Cazes E, Giron-Michel J, Baouz S, et al. Novel anti-inflammatory effects of the inhaled corticosteroid fluticasone propionate during lung fibroblastic differentiation. J Immunol 2001; 167:5329-5337
45. Agertoft L, Pedersen S. Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function. Respir Med 1994; 88:373-381
46. Barnes PJ, Adcock IM. How do corticosteroids work in asthma? Ann Intern Med 2003; 139:359-370
47. Wark PA, Gibson PG. Clinical usefulness of inflammatory markers in asthma. Am J Respir Med 2003; 2:11-19
48. Kharitonov SA, Barnes PJ. Effects of corticosteroids on noninvasive biomarkers of inflammation in asthma and COPD. Proc Am Thorac Soc 2004; 1:191-199
49. Remington TL, Digiovine B. Long-acting β-agonists: antiinflammatory properties and synergy with corticosteroids in asthma. Curr Opin Pulm Med 2005; 11:74-78
50. Simons FR. A comparison of beclomethasone, salmeterol and placebo in children with asthma: Canadian Beclomethasone Dipropionate-Salmeterol Xinafoate Study Group. N Engl J Med 1997; 337,1659-1665
51. Tinkelman DG, Reed CE, Nelson HS, et al. Aerosol beclomethasone dipropionate compared with theophylline as primary treatment of chronic, mild to moderately severe asthma in children. Pediatrics 1993; 92:64-77
52. Walker S, Monteil M, Phelan K, et al. Anti-IgE for chronic-asthma in adults and children. Cochrane Database Syst Rev 2004; CD003559
53. Holgate ST, Djukanovic R, Casale T, et al. Antiimmunoglobulin E treatment with omalizumab in allergic diseases: an update on anti-inflammatory activity and clinical efficacy. Clin Exp Allergy 2005; 35:408-416
54. Wenzel SE. The role of leukotrienes in asthma. Prostaglandins Leukot Essent Fatty Acids 2003; 69:145-155
55. Menzies-Gow A, Flood-Page P, Sehmi R, et al. Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics. J Allergy Clin Immunol 2003; 111:714-719
56. Flood-Page P, Menzies-Gow A, Phipps S, et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest 2003; 112:1029-1036
57. Emerman CL, Cydulka RK. Effect of pulmonary function testing on the management of acute asthma. Arch Intern Med 1995; 155:2225-2228
58. Joseph-Bowen J, de Klerk NH, Firth MJ, et al. Lung function, bronchial responsiveness, and asthma in a community cohort of 6-year-old children. Am J Respir Crit Care Med 2004; 169:850-854
59. Lombardi C, Gani F, Landi M, et al. Clinical and therapeutic aspects of allergic asthma in adolescents. Pediatr Allergy Immunol 2003; 14:453-457
60. Ward C, Johns DP, Bish R, et al. Reduced airway distensibility, fixed airflow limitation, and airway wall remodeling in asthma. Am J Respir Crit Care Med 2001; 164:1718-1721