20-HETE mediates ozone-induced, neutrophil- independent airway hyper-responsiveness in mice

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Cooper, Philip R ^a   Mesaros, A Clementina ^a   Zhang, Jie ^a   Christmas, Peter ^b,c   Stark, Christopher M ^c   Douaidy, Karim ^c   Mittelman, Michael A ^a   Soberman, Roy J ^c   Blair, Ian A ^a   Panettieri Jr , Reynold A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b RADFORD UNIVERSITY   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINOBENZOTRIAZOLE; 20 HYDROXYICOSATETRAENOIC ACID; CARBACHOL; CYTOCHROME P450; DEXAMETHASONE; ICOSANOID; INDOMETACIN; INTERLEUKIN 6; LIPID; OZONE; PROSTAGLANDIN SYNTHASE; 1-AMINOBENZOTRIAZOLE; 20 HYDROXY 5,8,11,14 EICOSATETRAENOIC ACID; 20-HYDROXY-5,8,11,14-EICOSATETRAENOIC ACID; HYDROXYICOSATETRAENOIC ACID; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; CELL COUNT; CONTROLLED STUDY; ENZYME INHIBITION; IN VITRO STUDY; INCUBATION TIME; LIPID ANALYSIS; LIPID OXIDATION; LIQUID CHROMATOGRAPHY; LUNG LAVAGE; LUNG SLICE; MALE; MASS SPECTROMETRY; MOUSE; NEUTROPHIL COUNT; NONHUMAN; ANIMAL; BAGG ALBINO MOUSE; IMMUNOLOGY; LIPID PEROXIDATION; NEUTROPHIL; RESPIRATORY TRACT ALLERGY;

ANIMALIA; MURINAE; MUS;

ANIMALS; BRONCHIAL HYPERREACTIVITY; CARBACHOL; HYDROXYEICOSATETRAENOIC ACIDS; LIPID PEROXIDATION; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED BALB C; NEUTROPHILS; OZONE; RESPIRATORY HYPERSENSITIVITY; TRIAZOLES;

EID: 77953762076     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010235     Document Type: Article

References (44)

1. Galan I, Tobias A, Banegas JR, Aranguez E (2003) Short-term effects of air pollution on daily asthma emergency room admissions. Eur Respir J 22: 802-808.
2. Medina-Ramon M, Zanobetti A, Schwartz J (2006) The effect of ozone and PM10 on hospital admissions for pneumonia and chronic obstructive pulmonary disease: a national multicity study. Am J Epidemiol 163: 579-588.
3. Stokstad E (2008) Air-quality standards. EPA adjusts a smog standard to White House preference. Science 319: 1602-1603.
4. Ratto J, Wong H, Liu J, Fahy J, Boushey H, et al. (2006) Effects of multiday exposure to ozone on airway inflammation as determined using sputum induction. Environ Health Perspect 114: 209-212.
5. Jorres RA, Holz O, Zachgo W, Timm P, Koschyk S, et al. (2000) The effect of repeated ozone exposures on inflammatory markers in bronchoalveolar lavage fluid and mucosal biopsies. Am J Respir Crit Care Med 161: 1855-1861.
6. Seltzer J, Bigby BG, Stulbarg M, Holtzman MJ, Nadel JA, et al. (1986) O3- induced change in bronchial reactivity to methacholine and airway inflammation in humans. J Appl Physiol 60: 1321-1326.
7. Arjomandi M, Witten A, Abbritti E, Reintjes K, Schmidlin I, et al. (2005) Repeated exposure to ozone increases alveolar macrophage recruitment into asthmatic airways. Am J Respir Crit Care Med 172: 427-432.
8. Blomberg A, Mudway IS, Nordenhall C, Hedenstrom H, Kelly FJ, et al. (1999) Ozone-induced lung function decrements do not correlate with early airway inflammatory or antioxidant responses. Eur Respir J 13: 1418-1428.
9. Schelegle ES, Siefkin AD, McDonald RJ (1991) Time course of ozone-induced neutrophilia in normal humans. Am Rev Respir Dis 143: 1353-1358.
10. Balmes JR, Chen LL, Scannell C, Tager I, Christian D, et al. (1996) Ozoneinduced decrements in FEV1 and FVC do not correlate with measures of inflammation. Am J Respir Crit Care Med 153: 904-909.
11. Williams AS, Issa R, Leung SY, Nath P, Ferguson GD, et al. (2007) Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125. J Pharmacol Exp Ther 322: 351-359.
12. Williams AS, Leung SY, Nath P, Khorasani NM, Bhavsar P, et al. (2007) Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia. J Appl Physiol 103: 1189-1195.
13. Jang AS, Choi IS, Lee JH, Park CS, Park CS (2006) Prolonged ozone exposure in an allergic airway disease model: adaptation of airway responsiveness and airway remodeling. Respir Res 7: 24.
14. Bascom R, Bromberg P, Costa D (1996) Health effects of outdoor air pollution. Committee of the Environmental and Occupational Health Assembly of the American Thoracic Society. Am J Respir Crit Care Med 153: 3-50.
15. Chen C, Arjomandi M, Balmes J, Tager I, Holland N (2007) Effects of chronic and acute ozone exposure on lipid peroxidation and antioxidant capacity in healthy young adults. Environ Health Perspect 115: 1732-1737.
16. Alfaro MF, Walby WF, Adams WC, Schelegle ES (2007) Breath condensate levels of 8-isoprostane and leukotriene B4 after ozone inhalation are greater in sensitive versus nonsensitive subjects. Exp Lung Res 33: 115-133.
17. Prakash C, Zhang JY, Falck JR, Chauhan K, Blair IA (1992) 20-Hydroxyeicosatetraenoic acid is excreted as a glucuronide conjugate in human urine. Biochem Biophys Res Commun 185: 728-733.
18. Wu S, Chen W, Murphy E, Gabel S, Tomer KB, et al. (1997) Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes. J Biol Chem 272: 12551-12559.
19. Zhu D, Effros RM, Harder DR, Roman RJ, Jacobs ER (1998) Tissue sources of cytochrome P450 4A and 20-HETE synthesis in rabbit lungs. Am J Respir Cell Mol Biol 19: 121-128.
20. Imig JD, Zou AP, Stec DE, Harder DR, Falck JR, et al. (1996) Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. Am J Physiol 270: R217-227.
21. Le Bouquin R, Lugnier A, Frossard N, Pons F (2004) Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta. Fundam Clin Pharmacol 18: 181-186.
22. Zhu D, Zhang C, Medhora M, Jacobs ER (2002) CYP4A mRNA, protein, and product in rat lungs: novel localization in vascular endothelium. J Appl Physiol 93: 330-337.
23. Kierstein S, Krytska K, Sharma S, Amrani Y, Salmon M, et al. (2008) Ozone inhalation induces exacerbation of eosinophilic airway inflammation and hyperresponsiveness in allergen-sensitized mice. Allergy 63: 438-446.
24. Held HD, Martin C, Uhlig S (1999) Characterization of airway and vascular responses in murine lungs. BrJPharmacol 126: 1191-1199.
25. Henjakovic M, Martin C, Hoymann HG, Sewald K, Ressmeyer AR, et al. (2008) Ex vivo lung function measurements in precision-cut lung slices (PCLS) from chemical allergen-sensitized mice represent a suitable alternative to in vivo studies. Toxicol Sci 106: 444-453.
26. Lee SH, Blair IA (2007) Targeted chiral lipidomics analysis by liquid chromatography electron capture atmospheric pressure chemical ionization mass spectrometry (LC-ECAPCI/MS). Methods Enzymol 433: 159-174.
27. Mesaros C, Lee SH, Blair IA (2009) Targeted quantitative analysis of eicosanoid lipids in biological samples using liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci.
28. Christmas P, Tolentino K, Primo V, Berry KZ, Murphy RC, et al. (2006) Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4. J Biol Chem 281: 7189-7196.
29. Depuydt P, Joos GF, Pauwels RA (1999) Ambient ozone concentrations induce airway hyperresponsiveness in some rat strains. Eur Respir J 14: 125-131.
30. Evans TW, Brokaw JJ, Chung KF, Nadel JA, McDonald DM (1988) Ozoneinduced bronchial hyperresponsiveness in the rat is not accompanied by neutrophil influx or increased vascular permeability in the trachea. Am Rev Respir Dis 138: 140-144.
31. Pino MV, Stovall MY, Levin JR, Devlin RB, Koren HS, et al. (1992) Acute ozone-induced lung injury in neutrophil-depleted rats. Toxicol Appl Pharmacol 114: 268-276.
32. Schlesinger RB, Driscoll KE, Gunnison AF, Zelikoff JT (1990) Pulmonary arachidonic acid metabolism following acute exposures to ozone and nitrogen dioxide. J Toxicol Environ Health 31: 275-290.
33. Kroetz DL, Xu F (2005) Regulation and inhibition of arachidonic acid omegahydroxylases and 20-HETE formation. Annu Rev Pharmacol Toxicol 45: 413-438.
34. Su P, Kaushal KM, Kroetz DL (1998) Inhibition of renal arachidonic acid omega-hydroxylase activity with ABT reduces blood pressure in the SHR. Am J Physiol 275: R426-438.
35. Miyata N, Taniguchi K, Seki T, Ishimoto T, Sato-Watanabe M, et al. (2001) HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme. Br J Pharmacol 133: 325-329.
36. Nakano H, Aizawa H, Matsumoto K, Fukuyama S, Inoue H, et al. (2000) Cyclooxygenase-2 participates in the late phase of airway hyperresponsiveness after ozone exposure in guinea pigs. Eur J Pharmacol 403: 267-275.
37. Lee HK, Murlas C (1985) Ozone-induced bronchial hyperreactivity in guinea pigs is abolished by BW 755C or FPL 55712 but not by indomethacin. Am Rev Respir Dis 132: 1005-1009.
38. Hazucha MJ, Madden M, Pape G, Becker S, Devlin R, et al. (1996) Effects of cyclo-oxygenase inhibition on ozone-induced respiratory inflammation and lung function changes. Eur J Appl Physiol Occup Physiol 73: 17-27.
39. Marwick JA, Ito K, Adcock IM, Kirkham PA (2007) Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy. Expert Opin Ther Targets 11: 745-755.
40. Ito K, Herbert C, Siegle JS, Vuppusetty C, Hansbro N, et al. (2008) Steroidresistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma. Am J Respir Cell Mol Biol 39: 543-550.
41. Cloutier M, Campbell S, Basora N, Proteau S, Payet MD, et al. (2003) 20- HETE inotropic effects involve the activation of a nonselective cationic current in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 285: L560-568.
42. Morin C, Sirois M, Echave V, Gomes MM, Rousseau E (2007) Functional effects of 20-HETE on human bronchi: hyperpolarization and relaxation due to BKCa channel activation. Am J Physiol Lung Cell Mol Physiol 293: L1037-1044.
43. Muller DN, Schmidt C, Barbosa-Sicard E, Wellner M, Gross V, et al. (2007) Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation. Biochem J 403: 109-118.
44. Kafoury RM, Pryor WA, Squadrito GL, Salgo MG, Zou X, et al. (1998) Lipid ozonation products activate phospholipases A2, C, and D. Toxicol Appl Pharmacol 150: 338-349.