MicroRNA in aging: From discovery to biology

Current Genomics

Volumn 13, Issue 7, 2012, Pages 548-557

  Jung, Hwa Jin ^a   Suh, Yousin ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Aging; Gene regulatory network; High throughput sequencing; Longevity; MicroRNAs; Target validation

Indexed keywords

MESSENGER RNA; MICRORNA;

AGING; CAENORHABDITIS ELEGANS; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENE TARGETING; GENE TECHNOLOGY; HIGH THROUGHPUT SEQUENCING; HOMEOSTASIS; HUMAN; LIFESPAN; LONGEVITY; NONHUMAN; PROTEIN FUNCTION; REVIEW;

EID: 84867810635     PISSN: 13892029     EISSN: 18755488     Source Type: Journal    
DOI: 10.2174/138920212803251436     Document Type: Review

References (129)

1. Lee, R.C.; Feinbaum, R.L.; Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 1993, 75(5), 843-54.
2. Bartel, D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 2004, 116(2), 281-97.
3. Creighton, C.J.; Reid, J.G.; Gunaratne, P.H. Expression profiling of microRNAs by deep sequencing. Brief Bioinform, 2009, 10(5), 490-7.
4. Okamura, K.; Phillips, M.D.; Tyler, D.M.; Duan, H.; Chou, Y.T.; Lai, E.C. The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolution. Nat Struct Mol Biol, 2008, 15(4), 354-63.
5. Ro, S.; Park, C.; Young, D.; Sanders, K.M.; Yan, W. Tissuedependent paired expression of miRNAs. Nucleic Acids Res, 2007, 35(17), 5944-53.
6. Filipowicz, W.; Bhattacharyya, S.N.; Sonenberg, N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet, 2008, 9(2), 102-14.
7. Du, T.; Zamore, P.D. microPrimer: the biogenesis and function of microRNA. Development, 2005, 132(21), 4645-52.
8. Llave, C.; Xie, Z.; Kasschau, K.D.; Carrington, J.C. Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA. Science, 2002, 297(5589), 2053-6.
9. Yekta, S.; Shih, I.H.; Bartel, D.P. MicroRNA-directed cleavage of HOXB8 mRNA. Science, 2004, 304(5670), 594-6.
10. Behm-Ansmant, I.; Rehwinkel, J.; Doerks, T.; Stark, A.; Bork, P.; Izaurralde, E. mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev, 2006, 20(14), 1885-98.
11. Braun, J.E.; Huntzinger, E.; Fauser, M.; Izaurralde, E. GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. Mol Cell, 2011, 44(1), 120-33.
12. Chekulaeva, M.; Mathys, H.; Zipprich, J.T.; Attig, J.; Colic, M.; Parker, R.; Filipowicz, W. miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved Wcontaining motifs. Nat Struct Mol Biol, 2011, 18(11), 1218-26.
13. Fabian, M.R.; Cieplak, M.K.; Frank, F.; Morita, M.; Green, J.; Srikumar, T.; Nagar, B.; Yamamoto, T.; Raught, B.; Duchaine, T.F.; Sonenberg, N. miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. Nat Struct Mol Biol, 2011, 19(3), 364.
14. Giraldez, A.J.; Mishima, Y.; Rihel, J.; Grocock, R.J.; Van Dongen, S.; Inoue, K.; Enright, A.J.; Schier, A.F. Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science, 2006, 312(5770), 75-9.
15. Wu, L.; Fan, J.; Belasco, J.G. MicroRNAs direct rapid deadenylation of mRNA. Proc Natl Acad Sci U S A, 2006, 103(11), 4034-9.
16. Humphreys, D.T.; Westman, B.J.; Martin, D.I.; Preiss, T. MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function. Proc Natl Acad Sci U S A, 2005, 102(47), 16961-6.
17. Maroney, P.A.; Yu, Y.; Fisher, J.; Nilsen, T.W. Evidence that microRNAs are associated with translating messenger RNAs in human cells. Nat Struct Mol Biol, 2006, 13(12), 1102-7.
18. Nottrott, S.; Simard, M.J.; Richter, J.D. Human let-7a miRNA blocks protein production on actively translating polyribosomes. Nat Struct Mol Biol, 2006, 13(12), 1108-14.
19. Olsen, P.H.; Ambros, V. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev Biol, 1999, 216(2), 671-80.
20. Petersen, C.P.; Bordeleau, M.E.; Pelletier, J.; Sharp, P.A. Short RNAs repress translation after initiation in mammalian cells. Mol Cell, 2006, 21(4), 533-42.
21. Pillai, R.S.; Bhattacharyya, S.N.; Artus, C.G.; Zoller, T.; Cougot, N.; Basyuk, E.; Bertrand, E.; Filipowicz, W. Inhibition of translational initiation by Let-7 MicroRNA in human cells. Science, 2005, 309(5740), 1573-6.
22. Seggerson, K.; Tang, L.; Moss, E.G. Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation. Dev Biol, 2002, 243(2), 215-25.
23. Guo, H.; Ingolia, N.T.; Weissman, J.S.; Bartel, D.P. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature, 2010, 466(7308), 835-40.
24. Huntzinger, E.; Izaurralde, E. Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet, 2011, 12(2), 99-110.
25. Wang, X.H.; Qian, R.Z.; Zhang, W.; Chen, S.F.; Jin, H.M.; Hu, R.M. MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats. Clin Exp Pharmacol Physiol, 2009, 36(2), 181-8.
26. Saugstad, J.A. MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration. J Cereb Blood Flow Metab, 2010, 30(9), 1564-76.
27. Lewis, B.P.; Burge, C.B.; Bartel, D.P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell, 2005, 120(1), 15-20.
28. McCormick, K.P.; Willmann, M.R.; Meyers, B.C. Experimental design, preprocessing, normalization and differential expression analysis of small RNA sequencing experiments. Silence, 2011, 2(1), 2.
29. Wittmann, J.; Jack, H.M. New surprises from the deep--the family of small regulatory RNAs increases. ScientificWorldJournal, 2010, 10, 1239-43.
30. Valouev, A.; Ichikawa, J.; Tonthat, T.; Stuart, J.; Ranade, S.; Peckham, H.; Zeng, K.; Malek, J.A.; Costa, G.; McKernan, K.; Sidow, A.; Fire, A.; Johnson, S.M. A high-resolution, nucleosome position map of C. elegans reveals a lack of universal sequencedictated positioning. Genome Res, 2008, 18(7), 1051-63.
31. Binladen, J.; Gilbert, M.T.; Bollback, J.P.; Panitz, F.; Bendixen, C.; Nielsen, R.; Willerslev, E. The use of coded PCR primers enables high-throughput sequencing of multiple homolog amplification products by 454 parallel sequencing. PLoS One, 2007, 2(2), e197.
32. Craig, D.W.; Pearson, J.V.; Szelinger, S.; Sekar, A.; Redman, M.; Corneveaux, J.J.; Pawlowski, T.L.; Laub, T.; Nunn, G.; Stephan, D.A.; Homer, N.; Huentelman, M.J. Identification of genetic variants using bar-coded multiplexed sequencing. Nat Methods, 2008, 5(10), 887-93.
33. Hamady, M.; Walker, J.J.; Harris, J.K.; Gold, N.J.; Knight, R. Error-correcting barcoded primers for pyrosequencing hundreds of samples in multiplex. Nat Methods, 2008, 5(3), 235-7.
34. Kasschau, K.D.; Fahlgren, N.; Chapman, E.J.; Sullivan, C.M.; Cumbie, J.S.; Givan, S.A.; Carrington, J.C. Genome-wide profiling and analysis of Arabidopsis siRNAs. PLoS Biol, 2007, 5(3), e57.
35. Kim, J.B.; Porreca, G.J.; Song, L.; Greenway, S.C.; Gorham, J.M.; Church, G.M.; Seidman, C.E.; Seidman, J.G. Polony multiplex analysis of gene expression (PMAGE) in mouse hypertrophic cardiomyopathy. Science, 2007, 316(5830), 1481-4.
36. Meyer, M.; Stenzel, U.; Myles, S.; Prufer, K.; Hofreiter, M. Targeted high-throughput sequencing of tagged nucleic acid samples. Nucleic Acids Res, 2007, 35(15), e97.
37. Smith, A.M.; Heisler, L.E.; St Onge, R.P.; Farias-Hesson, E.; Wallace, I.M.; Bodeau, J.; Harris, A.N.; Perry, K.M.; Giaever, G.; Pourmand, N.; Nislow, C. Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples. Nucleic Acids Res, 2010, 38(13), e142.
38. Stiller, M.; Knapp, M.; Stenzel, U.; Hofreiter, M.; Meyer, M. Direct multiplex sequencing (DMPS)--a novel method for targeted high-throughput sequencing of ancient and highly degraded DNA. Genome Res, 2009, 19(10), 1843-8.
39. Meyer, M.; Stenzel, U.; Hofreiter, M. Parallel tagged sequencing on the 454 platform. Nat Protoc, 2008, 3(2), 267-78.
40. Gunaratne, P.H.; Coarfa, C.; Soibam, B.; Tandon, A. miRNA data analysis: next-gen sequencing. Methods Mol Biol, 2012, 822, 273-88.
41. Griffiths-Jones, S.; Moxon, S.; Marshall, M.; Khanna, A.; Eddy, S.R.; Bateman, A. Rfam: annotating non-coding RNAs in complete genomes. Nucleic Acids Res, 2005, 33(Database issue), D121-4.
42. Xiao, F.; Zuo, Z.; Cai, G.; Kang, S.; Gao, X.; Li, T. miRecords: an integrated resource for microRNA-target interactions. Nucleic Acids Res, 2009, 37(Database issue), D105-10.
43. Roubelakis, M.G.; Zotos, P.; Papachristoudis, G.; Michalopoulos, I.; Pappa, K.I.; Anagnou, N.P.; Kossida, S. Human microRNA target analysis and gene ontology clustering by GOmir, a novel stand-alone application. BMC Bioinformatics, 2009, 10 Suppl 6, S20.
44. Sethupathy, P.; Corda, B.; Hatzigeorgiou, A.G. TarBase: A comprehensive database of experimentally supported animal microRNA targets. Rna, 2006, 12(2), 192-7.
45. Nam, S.; Kim, B.; Shin, S.; Lee, S. miRGator: an integrated system for functional annotation of microRNAs. Nucleic Acids Res, 2008, 36(Database issue), D159-64.
46. Subramanian, A.; Tamayo, P.; Mootha, V.K.; Mukherjee, S.; Ebert, B.L.; Gillette, M.A.; Paulovich, A.; Pomeroy, S.L.; Golub, T.R.; Lander, E.S.; Mesirov, J.P. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A, 2005, 102(43), 15545-50.
47. Kaya, K.D.; Karakulah, G.; Yakicier, C.M.; Acar, A.C.; Konu, O. mESAdb: microRNA expression and sequence analysis database. Nucleic Acids Res, 2011, 39(Database issue), D170-80.
48. Long, J.M.; Lahiri, D.K. Advances in microRNA experimental approaches to study physiological regulation of gene products implicated in CNS disorders. Exp Neurol, 2012.
49. Yang, J.H.; Li, J.H.; Shao, P.; Zhou, H.; Chen, Y.Q.; Qu, L.H. starBase: a database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Res, 2010, 39(Database issue), D202-9.
50. Zisoulis, D.G.; Lovci, M.T.; Wilbert, M.L.; Hutt, K.R.; Liang, T.Y.; Pasquinelli, A.E.; Yeo, G.W. Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans. Nat Struct Mol Biol, 2010, 17(2), 173-9.
51. Leung, A.K.; Young, A.G.; Bhutkar, A.; Zheng, G.X.; Bosson, A.D.; Nielsen, C.B.; Sharp, P.A. Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs. Nat Struct Mol Biol, 2011, 18(2), 237-44.
52. Zhang, C.; Darnell, R.B. Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data. Nat Biotechnol, 2011, 29(7), 607-14.
53. Hafner, M.; Landthaler, M.; Burger, L.; Khorshid, M.; Hausser, J.; Berninger, P.; Rothballer, A.; Ascano, M.; Jungkamp, A.C.; Munschauer, M.; Ulrich, A.; Wardle, G.S.; Dewell, S.; Zavolan, M.; Tuschl, T. PAR-CliP--a method to identify transcriptome-wide the binding sites of RNA binding proteins. J Vis Exp, 2010(41).
54. Pasquinelli, A.E. MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet, 2012, 13(4), 271-82.
55. Lanceta, J.; Prough, R.A.; Liang, R.; Wang, E. MicroRNA group disorganization in aging. Exp Gerontol, 2010, 45(4), 269-78.
56. Vidal, M.; Cusick, M.E.; Barabasi, A.L. Interactome networks and human disease. Cell, 2011, 144(6), 986-98.
57. Boehm, M.; Slack, F. A developmental timing microRNA and its target regulate life span in C. elegans. Science, 2005, 310(5756), 1954-7.
58. de Lencastre, A.; Pincus, Z.; Zhou, K.; Kato, M.; Lee, S.S.; Slack, F.J. MicroRNAs Both Promote and Antagonize Longevity in Celegans. Current Biology, 2010, 20(24), 2159-2168.
59. Pincus, Z., Smith-Vikos, T., Slack, F.J. MicroRNA Predictors of Longevity in Caenorhabditis elegans. PLoS Genet, 2011, 7(9), e1002306.
60. Ibanez-Ventoso, C.; Driscoll, M. MicroRNAs in C. elegans Aging: Molecular Insurance for Robustness? Curr Genomics, 2009, 10(3), 144-53.
61. de Lencastre, A.; Pincus, Z.; Zhou, K.; Kato, M.; Lee, S.S.; Slack, F.J. MicroRNAs both promote and antagonize longevity in C. elegans. Curr Biol, 2010, 20(24), 2159-68.
62. Ibanez-Ventoso, C.; Yang, M.; Guo, S.; Robins, H.; Padgett, R.W.; Driscoll, M. Modulated microRNA expression during adult lifespan in Caenorhabditis elegans. Aging Cell, 2006, 5(3), 235-46.
63. Kato, M.; Chen, X.; Inukai, S.; Zhao, H.; Slack, F.J. Ageassociated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans. RNA, 2011, 17(10), 1804-20.
64. Ibanez-Ventoso, C.; Vora, M.; Driscoll, M. Sequence relationships among C. elegans, D. melanogaster and human microRNAs highlight the extensive conservation of microRNAs in biology. PLoS One, 2008, 3(7), e2818.
65. Wang, D.E. MicroRNA Regulation and its Biological Significance in Personalized Medicine and Aging. Curr Genomics, 2009, 10(3), 143.
66. Bates, D.J.; Li, N.; Liang, R.; Sarojini, H.; An, J.; Masternak, M.M.; Bartke, A.; Wang, E. MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging. Aging Cell, 2010, 9(1), 1-18.
67. Kozomara, A.; Griffiths-Jones, S. miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res, 2011, 39(Database issue), D152-7.
68. Smith-Vikos, T.; Slack, F.J. MicroRNAs and their roles in aging. J Cell Sci, 2012, 125(Pt 1), 7-17.
69. Williams, A.E.; Perry, M.M.; Moschos, S.A.; Lindsay, M.A. microRNA expression in the aging mouse lung. BMC Genomics, 2007, 8, 172.
70. Li, N.; Bates, D.J.; An, J.; Terry, D.A.; Wang, E. Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain. Neurobiol Aging, 2009, 32(5), 944-55.
71. Zhang, J.; Liu, Q.; Zhang, W.; Li, J.; Li, Z.; Tang, Z.; Li, Y.; Han, C.; Hall, S.H.; Zhang, Y. Comparative profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides. Acta Biochim Biophys Sin (Shanghai), 2010, 42(2), 145-53.
72. Noren Hooten, N.; Abdelmohsen, K.; Gorospe, M.; Ejiogu, N.; Zonderman, A.B.; Evans, M.K. microRNA expression patterns reveal differential expression of target genes with age. PLoS One, 2010, 5(5), e10724.
73. Vijg, J.; Campisi, J. Puzzles, promises and a cure for ageing. Nature, 2008, 454(7208), 1065-71.
74. Fontana, L.; Partridge, L.; Longo, V.D. Extending healthy life span--from yeast to humans. Science, 2010, 328(5976), 321-6.
75. Kimura, K.D.; Tissenbaum, H.A.; Liu, Y.; Ruvkun, G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science, 1997, 277(5328), 942-6.
76. Tatar, M.; Kopelman, A.; Epstein, D.; Tu, M.P.; Yin, C.M.; Garofalo, R.S. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science, 2001, 292(5514), 107-10.
77. Bluher, M.; Kahn, B.B.; Kahn, C.R. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science, 2003, 299(5606), 572-4.
78. van Heemst, D.; Beekman, M.; Mooijaart, S.P.; Heijmans, B.T.; Brandt, B.W.; Zwaan, B.J.; Slagboom, P.E.; Westendorp, R.G. Reduced insulin/IGF-1 signalling and human longevity. Aging Cell, 2005, 4(2), 79-85.
79. Murphy, C.T. The search for DAF-16/FOXO transcriptional targets: approaches and discoveries. Experimental gerontology, 2006, 41(10), 910-21.
80. Greer, E.L.; Brunet, A. FOXO transcription factors in ageing and cancer. Acta physiologica, 2008, 192(1), 19-28.
81. Shan, Z.X.; Lin, Q.X.; Fu, Y.H.; Deng, C.Y.; Zhou, Z.L.; Zhu, J.N.; Liu, X.Y.; Zhang, Y.Y.; Li, Y.; Lin, S.G.; Yu, X.Y. Upregulated expression of miR-1/miR-206 in a rat model of myocardial infarction. Biochem Biophys Res Commun, 2009, 381(4), 597-601.
82. Kato, M.; Putta, S.; Wang, M.; Yuan, H.; Lanting, L.; Nair, I.; Gunn, A.; Nakagawa, Y.; Shimano, H.; Todorov, I.; Rossi, J.J.; Natarajan, R. TGF-beta activates Akt kinase through a microRNAdependent amplifying circuit targeting PTEN. Nat Cell Biol, 2009, 11(7), 881-9.
83. Sayed, D.; Abdellatif, M. AKT-ing via microRNA. Cell Cycle, 2010, 9(16), 3213-7.
84. Kenyon, C.J. The genetics of ageing. Nature, 2010, 464(7288), 504-12.
85. Harrison, D.E.; Strong, R.; Sharp, Z.D.; Nelson, J.F.; Astle, C.M.; Flurkey, K.; Nadon, N.L.; Wilkinson, J.E.; Frenkel, K.; Carter, C.S.; Pahor, M.; Javors, M.A.; Fernandez, E.; Miller, R.A. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature, 2009, 460(7253), 392-5.
86. Jia, K.; Chen, D.; Riddle, D.L. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development, 2004, 131(16), 3897-906.
87. Kaeberlein, M.; Powers, R.W., 3rd; Steffen, K.K.; Westman, E.A.; Hu, D.; Dang, N.; Kerr, E.O.; Kirkland, K.T.; Fields, S.; Kennedy, B.K. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science, 2005, 310(5751), 1193-6.
88. Kapahi, P.; Zid, B.M.; Harper, T.; Koslover, D.; Sapin, V.; Benzer, S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol, 2004, 14(10), 885-90.
89. Vellai, T.; Takacs-Vellai, K.; Zhang, Y.; Kovacs, A.L.; Orosz, L.; Muller, F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature, 2003, 426(6967), 620.
90. Nagaraja, A.K.; Creighton, C.J.; Yu, Z.; Zhu, H.; Gunaratne, P.H.; Reid, J.G.; Olokpa, E.; Itamochi, H.; Ueno, N.T.; Hawkins, S.M.; Anderson, M.L.; Matzuk, M.M. A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer. Mol Endocrinol, 2010, 24(2), 447-63.
91. Zhu, H.; Wu, H.; Liu, X.; Li, B.; Chen, Y.; Ren, X.; Liu, C.G.; Yang, J.M. Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy, 2009, 5(6), 816-23.
92. Kennedy, B.K.; Smith, E.D.; Kaeberlein, M. The enigmatic role of Sir2 in aging. Cell, 2005, 123(4), 548-50.
93. Michan, S.; Sinclair, D. Sirtuins in mammals: insights into their biological function. Biochem J, 2007, 404(1), 1-13.
94. Menghini, R.; Casagrande, V.; Cardellini, M.; Martelli, E.; Terrinoni, A.; Amati, F.; Vasa-Nicotera, M.; Ippoliti, A.; Novelli, G.; Melino, G.; Lauro, R.; Federici, M. MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation, 2009, 120(15), 1524-32.
95. Lee, J.; Padhye, A.; Sharma, A.; Song, G.; Miao, J.; Mo, Y.Y.; Wang, L.; Kemper, J.K. A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition. J Biol Chem, 2010, 285(17), 12604-11.
96. Strum, J.C.; Johnson, J.H.; Ward, J.; Xie, H.; Feild, J.; Hester, A.; Alford, A.; Waters, K.M. MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1. Mol Endocrinol, 2009, 23(11), 1876-84.
97. Rane, S.; He, M.; Sayed, D.; Vashistha, H.; Malhotra, A.; Sadoshima, J.; Vatner, D.E.; Vatner, S.F.; Abdellatif, M. Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res, 2009, 104(7), 879-86.
98. Andersen, R.V.; Wittrup, H.H.; Tybjaerg-Hansen, A.; Steffensen, R.; Schnohr, P.; Nordestgaard, B.G. Hepatic lipase mutations, elevated high-density lipoprotein cholesterol, and increased risk of ischemic heart disease: the Copenhagen City Heart Study. J Am Coll Cardiol, 2003, 41(11), 1972-82.
99. Cheng, Y.; Ji, R.; Yue, J.; Yang, J.; Liu, X.; Chen, H.; Dean, D.B.; Zhang, C. MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy? Am J Pathol, 2007, 170(6), 1831-40.
100. Cheng, Y.; Liu, X.; Zhang, S.; Lin, Y.; Yang, J.; Zhang, C. MicroRNA-21 protects against the H(2)O(2)-induced injury on cardiac myocytes via its target gene PDCD4. J Mol Cell Cardiol, 2009, 47(1), 5-14.
101. Cheng, Y.; Tan, N.; Yang, J.; Liu, X.; Cao, X.; He, P.; Dong, X.; Qin, S.; Zhang, C. A translational study of circulating cell-free microRNA-1 in acute myocardial infarction. Clin Sci (Lond), 2010, 119(2), 87-95.
102. D'Alessandra, Y.; Devanna, P.; Limana, F.; Straino, S.; Di Carlo, A.; Brambilla, P.G.; Rubino, M.; Carena, M.C.; Spazzafumo, L.; De Simone, M.; Micheli, B.; Biglioli, P.; Achilli, F.; Martelli, F.; Maggiolini, S.; Marenzi, G.; Pompilio, G.; Capogrossi, M.C. Circulating microRNAs are new and sensitive biomarkers of myocardial infarction. Eur Heart J, 2010, 31(22), 2765-73.
103. Han, M.; Toli, J.; Abdellatif, M. MicroRNAs in the cardiovascular system. Curr Opin Cardiol, 2011, 26(3), 181-9.
104. Hulsmans, M.; De Keyzer, D.; Holvoet, P. MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis. Faseb J, 2011.
105. Sayed, D.; He, M.; Hong, C.; Gao, S.; Rane, S.; Yang, Z.; Abdellatif, M. MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand. J Biol Chem, 2010, 285(26), 20281-90.
106. Sayed, D.; Hong, C.; Chen, I.Y.; Lypowy, J.; Abdellatif, M. MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res, 2007, 100(3), 416-24.
107. Tatsuguchi, M.; Seok, H.Y.; Callis, T.E.; Thomson, J.M.; Chen, J.F.; Newman, M.; Rojas, M.; Hammond, S.M.; Wang, D.Z. Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell Cardiol, 2007, 42(6), 1137-41.
108. van Rooij, E.; Sutherland, L.B.; Liu, N.; Williams, A.H.; McAnally, J.; Gerard, R.D.; Richardson, J.A.; Olson, E.N. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A, 2006, 103(48), 18255-60.
109. Hamrick, M.W.; Herberg, S.; Arounleut, P.; He, H.Z.; Shiver, A.; Qi, R.Q.; Zhou, L.; Isales, C.M.; Mi, Q.S. The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice. Biochem Biophys Res Commun, 2010, 400(3), 379-83.
110. Guller, I.; Russell, A.P. MicroRNAs in skeletal muscle: their role and regulation in development, disease and function. J Physiol, 2010, 588(Pt 21), 4075-87.
111. Niwa, R.; Zhou, F.; Li, C.; Slack, F.J. The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans. Dev Biol, 2008, 315(2), 418-25.
112. Provost, P. MicroRNAs as a molecular basis for mental retardation, Alzheimer's and prion diseases. Brain Res, 2010, 1338, 58-66.
113. Nakasa, T.; Ishikawa, M.; Shi, M.; Shibuya, H.; Adachi, N.; Ochi, M. Acceleration of muscle regeneration by local injection of muscle-specific microRNAs in rat skeletal muscle injury model. J Cell Mol Med, 2010, 14(10), 2495-505.
114. Koutsoulidou, A.; Mastroyiannopoulos, N.P.; Furling, D.; Uney, J.B.; Phylactou, L.A. Expression of miR-1, miR-133a, miR-133b and miR-206 increases during development of human skeletal muscle. BMC Dev Biol, 2011, 11, 34.
115. Chen, J.F.; Callis, T.E.; Wang, D.Z. microRNAs and muscle disorders. J Cell Sci, 2009, 122(Pt 1), 13-20.
116. McCarthy, J.J.; Esser, K.A. MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy. J Appl Physiol, 2007, 102(1), 306-13.
117. Rottiers, V.; Naar, A.M. MicroRNAs in metabolism and metabolic disorders. Nat Rev Mol Cell Biol, 2012, 13(4), 239-50.
118. Vinciguerra, M.; Sgroi, A.; Veyrat-Durebex, C.; Rubbia-Brandt, L.; Buhler, L.H.; Foti, M. Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes. Hepatology, 2009, 49(4), 1176-84.
119. Bork, S.; Horn, P.; Castoldi, M.; Hellwig, I.; Ho, A.D.; Wagner, W. Adipogenic differentiation of human mesenchymal stromal cells is down-regulated by microRNA-369-5p and up-regulated by microRNA-371. J Cell Physiol, 2010, 226(9), 2226-34.
120. Kinoshita, M.; Ono, K.; Horie, T.; Nagao, K.; Nishi, H.; Kuwabara, Y.; Takanabe-Mori, R.; Hasegawa, K.; Kita, T.; Kimura, T. Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5. Mol Endocrinol, 2010, 24(10), 1978-87.
121. Lee, E.K.; Lee, M.J.; Abdelmohsen, K.; Kim, W.; Kim, M.M.; Srikantan, S.; Martindale, J.L.; Hutchison, E.R.; Kim, H.H.; Marasa, B.S.; Selimyan, R.; Egan, J.M.; Smith, S.R.; Fried, S.K.; Gorospe, M. miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol, 2010, 31(4), 626-38.
122. Lin, Q.; Gao, Z.; Alarcon, R.M.; Ye, J.; Yun, Z. A role of miR-27 in the regulation of adipogenesis. Febs J, 2009, 276(8), 2348-58.
123. Sun, T.; Fu, M.; Bookout, A.L.; Kliewer, S.A.; Mangelsdorf, D.J. MicroRNA let-7 regulates 3T3-L1 adipogenesis. Mol Endocrinol, 2009, 23(6), 925-31.
124. Yang, Z.; Bian, C.; Zhou, H.; Huang, S.; Wang, S.; Liao, L.; Zhao, R.C. MicroRNA hsa-miR-138 inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells through adenovirus EID-1. Stem Cells Dev, 2010, 20(2), 259-67.
125. Zhu, H.; Shyh-Chang, N.; Segre, A.V.; Shinoda, G.; Shah, S.P.; Einhorn, W.S.; Takeuchi, A.; Engreitz, J.M.; Hagan, J.P.; Kharas, M.G.; Urbach, A.; Thornton, J.E.; Triboulet, R.; Gregory, R.I.; Consortium, D.; Investigators, M.; Altshuler, D.; Daley, G.Q. The Lin28/let-7 axis regulates glucose metabolism. Cell, 2011, 147(1), 81-94.
126. Junn, E.; Mouradian, M.M. MicroRNAs in neurodegenerative diseases and their therapeutic potential. Pharmacol Ther, 2012, 133(2), 142-50.
127. Grillari, J.; Grillari-Voglauer, R. Novel modulators of senescence, aging, and longevity: Small non-coding RNAs enter the stage. Exp Gerontol, 2010, 45(4), 302-11.
128. Baek, D.; Villen, J.; Shin, C.; Camargo, F.D.; Gygi, S.P.; Bartel, D.P. The impact of microRNAs on protein output. Nature, 2008, 455(7209), 64-71.
129. Saba, R.; Goodman, C.D.; Huzarewich, R.L.; Robertson, C.; Booth, S.A. A miRNA signature of prion induced neurodegeneration. PLoS One, 2008, 3(11), e3652.