MicroRNAs in the cardiovascular system

Current Opinion in Cardiology

Volumn 26, Issue 3, 2011, Pages 181-189

  Han, Mingyue ^a   Toli, Jessica ^a   Abdellatif, Maha ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

failure; hypertrophy; ischemia; microRNA

Indexed keywords

MICRORNA; MICRORNA 1; MICRORNA 133; MICRORNA 199A; MICRORNA 199B; MICRORNA 208; MICRORNA 21; MICRORNA 210; MICRORNA 23A; MICRORNA 494; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; CELL VIABILITY; DOWN REGULATION; GENE EXPRESSION; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HUMAN; ISCHEMIC HEART DISEASE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

CARDIOMEGALY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; GENE EXPRESSION; HEART FAILURE; HUMANS; MICRORNAS; MUSCLE CELLS; MYOCARDIAL ISCHEMIA;

EID: 79955070159     PISSN: 02684705     EISSN: None     Source Type: Journal    
DOI: 10.1097/HCO.0b013e328345983d     Document Type: Article

References (105)

1. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993; 75:843-854. (Pubitemid 24014542)
2. Olsen PH, Ambros V. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev Biol 1999; 216:671-680. (Pubitemid 30013313)
3. Reinhart BJ, Slack FJ, Basson M, et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 2000; 403:901-906. (Pubitemid 30130993)
4. Boutet SC, Disatnik MH, Chan LS, et al. Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors. Cell 2007; 130:349-362. (Pubitemid 47081135)
5. Cheng LC, Pastrana E, Tavazoie M, Doetsch F. MiR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nat Neurosci 2009; 12:399-408.
6. Zhao C, Sun G, Li S, Shi Y. A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination. Nat Struct Mol Biol 2009; 16:365-371.
7. Shibata M, Kurokawa D, Nakao H, et al. MicroRNA-9 modulates Cajal- Retzius cell differentiation by suppressing Foxg1 expression in mouse medial pallium. J Neurosci 2008; 28:10415-10421.
8. Agrawal R, Tran U, Wessely O. The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xlim1/Lhx1. Development 2009; 136:3927-3936.
9. Lu Y, Thomson JM, Wong HY, et al. Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Dev Biol 2007; 310:442-453. (Pubitemid 47483685)
10. Yi R, Poy MN, Stoffel M, Fuchs E. A skin microRNA promotes differentiation by repressing 'stemness'. Nature 2008; 452:225-229. (Pubitemid 351380241)
11. Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and downregulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2002; 99:15524-15529. (Pubitemid 35403967)
12. Sayed D, Hong C, Chen IY, et al. MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res 2007; 100:416-424.
13. Van Rooij E, Sutherland LB, Liu N, et al. A signature pattern of stressresponsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci USA 2006; 103:18255-18260. (Pubitemid 44871645)
14. Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A. Identification of mammalian microRNA host genes and transcription units. Genome Res 2004; 14:1902-1910. (Pubitemid 39386503)
15. Van Rooij E, Quiat D, Johnson BA, et al. A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell 2009; 17:662-673.
16. Jegga AG, Chen J, Gowrisankar S, et al. GenomeTrafac: a whole genome resource for the detection of transcription factor binding site clusters associated with conventional and microRNA encoding genes conserved between mouse and human gene orthologs. Nucleic Acids Res 2007; 35:D116-D121. (Pubitemid 46056181)
17. Zhou X, Ruan J, Wang G, Zhang W. Characterization and identification of microRNA core promoters in four model species. PLoS Comput Biol 2007; 3:0412-0423. (Pubitemid 46535734)
18. Lee Y, Ahn C, Han J, et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003; 425:415-419. (Pubitemid 37187272)
19. Denli AM, Tops BB, Plasterk RH, et al. Processing of primary microRNAs by the microprocessor complex. Nature 2004; 432:231-235. (Pubitemid 39545854)
20. Gregory RI, Yan KP, Amuthan G, et al. The microprocessor complex mediates the genesis of microRNAs. Nature 2004; 432:235-240. (Pubitemid 39545855)
21. Han J, Lee Y, Yeom KH, et al. The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev 2004; 18:3016-3027. (Pubitemid 39658171)
22. Landthaler M, Yalcin A, Tuschl T. The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis. Curr Biol 2004; 14:2162-2167. (Pubitemid 39623200)
23. Han J, Lee Y, Yeom KH, et al. Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell 2006; 125:887-901. (Pubitemid 43810154)
24. Thomson JM, Newman M, Parker JS, et al. Extensive posttranscriptional regulation of microRNAs and its implications for cancer. Genes Dev 2006; 20:2202-2207.
25. Newman MA, Thomson JM, Hammond SM. Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA 2008; 14:1539-1549.
26. Viswanathan SR, Daley GQ, Gregory RI. Selective blockade of microRNA processing by Lin28. Science 2008; 320:97-100. (Pubitemid 351490762)
27. Rybak A, Fuchs H, Smirnova L, et al. A feedback loop comprising lin-28 and let-7 controls prelet-7 maturation during neural stem-cell commitment. Nat Cell Biol 2008; 10:987-993.
28. Michlewski G,Guil S,Semple CA,Caceres JF. Posttranscriptional regulation of miRNAs harboring conserved terminal loops. Mol Cell 2008; 32:383-393.
29. Bohnsack MT, Czaplinski K, Gorlich D. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of premiRNAs. RNA 2004; 10:185-191. (Pubitemid 38129823)
30. Lund E,Guttinger S, Calado A, et al. Nuclear export of microRNA precursors. Science 2004; 303:95-98. (Pubitemid 38055779)
31. Yi R, Qin Y, Macara IG, Cullen BR. Exportin-5 mediates the nuclear export of premicroRNAs and short hairpin RNAs. Genes Dev 2003; 17:3011-3016. (Pubitemid 38040764)
32. Hutvagner G, Zamore PD. A microRNA in a multiple-turnover RNAi enzyme complex. Science 2002; 297:2056-2060.
33. O'Carroll D, Mecklenbrauker I, Das PP, et al. A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev 2007; 21:1999-2004. (Pubitemid 47267286)
34. Meister G, Landthaler M, Patkaniowska A, et al. Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell 2004; 15:185-197. (Pubitemid 38950966)
35. Liu J, Rivas FV, Wohlschlegel J, et al. A role for the P-body component GW182 in microRNA function. Nat Cell Biol 2005; 7:1261-1266.
36. Chendrimada TP, Gregory RI, Kumaraswamy E, et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 2005; 436:740-744. (Pubitemid 41117280)
37. Jin P, Zarnescu DC, Ceman S, et al. Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nat Neurosci 2004; 7:113-117. (Pubitemid 38129786)
38. Feng Y, Gutekunst CA, Eberhart DE, et al. Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes. J Neurosci 1997; 17:1539-1547. (Pubitemid 27089800)
39. Hock J, Weinmann L, Ender C, et al. Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. EMBO Rep 2007; 8:1052-1060. (Pubitemid 350042341)
40. Humphreys DT, Westman BJ, Martin DI, Preiss T. MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function. Proc Natl Acad Sci USA 2005; 102:16961-16966. (Pubitemid 41692666)
41. Pillai RS, Bhattacharyya SN, Artus CG, et al. Inhibition of translational initiation by Let-7 MicroRNA in human cells. Science 2005; 309:1573-1576. (Pubitemid 41266485)
42. Thermann R, Hentze MW. Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation. Nature 2007; 447:875-878. (Pubitemid 46920140)
43. Wu L, Fan J, Belasco JG. MicroRNAs direct rapid deadenylation of mRNA. Proc Natl Acad Sci USA 2006; 103:4034-4039.
44. Behm-Ansmant I, Rehwinkel J, Doerks T, et al. mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev 2006; 20:1885-1898. (Pubitemid 44079326)
45. Wakiyama M, Takimoto K, Ohara O, Yokoyama S. Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. Genes Dev 2007; 21:1857-1862. (Pubitemid 47204925)
46. Cheng Y, Ji R, Yue J, et al. MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy? Am J Pathol 2007; 170:1831-1840. (Pubitemid 47339258)
47. Ikeda S, Kong SW, Lu J, et al. Altered microRNA expression in human heart disease. Physiol Genomics 2007; 31:367-373. (Pubitemid 350127777)
48. Matkovich SJ, Van Booven DJ, Youker KA, et al. Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support. Circulation 2009; 119:1263-1271.
49. Naga Prasad SV, Duan ZH, Gupta MK, et al. Unique microRNA profile in endstage heart failure indicates alterations in specific cardiovascular signaling networks. J Biol Chem 2009; 284:27487-27499.
50. Sucharov C, Bristow MR, Port JD. miRNA expression in the failing human heart: functional correlates. J Mol Cell Cardiol 2008; 45:185-192.
51. Tatsuguchi M, Seok HY, Callis TE, et al. Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell Cardiol 2007; 42:1137-1141. (Pubitemid 46829201)
52. Thum T, Galuppo P, Wolf C, et al. MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation 2007; 116:258-267. (Pubitemid 47196561)
53. Izumo S, Nadal-Ginard B, Mahdavi V. Protooncogene induction and reprogramming of cardiac gene expression produced in pressure overload. Proc Natl Acad Sci USA 1988; 85:339-343.
54. Mahdavi V, Lompre AM, Chambers AP, Nadal-Ginard B. Cardiac myosin heavy chain isozymic transitions during development and under pathological conditions are regulated at the level of mRNA availability. Eur Heart J 1984; 5 (Suppl. F):181-191. (Pubitemid 15118575)
55. Johnatty SE, Dyck JR, Michael LH, et al. Identification of genes regulated during mechanical load-induced cardiac hypertrophy. J Mol Cell Cardiol 2000; 32:805-815. (Pubitemid 30658917)
56. Rane S, Sayed D, Abdellatif M. MicroRNA with a MacroFunction. Cell Cycle 2007; 6:1850-1855. (Pubitemid 47327902)
57. Ikeda S, He A, Kong SW, et al. MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes. Mol Cell Biol 2009; 29:2193-2204.
58. Care A, Catalucci D, Felicetti F, et al. MicroRNA-133 controls cardiac hypertrophy. Nat Med 2007; 13:613-618. (Pubitemid 46828487)
59. Elia L, Contu R, Quintavalle M, et al. Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions. Circulation 2009; 120:2377-2385.
60. Liu N, Bezprozvannaya S, Williams AH, et al. MicroRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev 2008; 22:3242-3254.
61. Matkovich SJ, Wang W, Tu Y, et al. MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts. Circ Res 2009; 106:166-175.
62. Beuvink I, Kolb FA, Budach W, et al. A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian micro- RNAs. Nucleic Acids Res 2007; 35:e52.
63. Van Rooij E, Sutherland LB, Qi X, et al. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 2007; 316:575-579. (Pubitemid 46683138)
64. Callis TE, Pandya K, Seok HY, et al. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest 2009; 119:2772-2786.
65. Morissette MR, Cook SA, Foo S, et al. Myostatin regulates cardiomyocyte growth through modulation of Akt signaling. Circ Res 2006; 99:15-24. (Pubitemid 44297051)
66. Linhares VL, Almeida NA, Menezes DC, et al. Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5, GATA4 and Tbx5. Cardiovasc Res 2004; 64:402-411. (Pubitemid 39505419)
67. Sayed D, He M, Hong C, et al. MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand. J Biol Chem 2010; 285:20281-20290.
68. Thum T, Gross C, Fiedler J, et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008; 456:980-984.
69. Patrick DM, Montgomery RL, Qi X, et al. Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice. J Clin Invest 2010; 120:3912-3916.
70. Dong S, Cheng Y, Yang J, et al. MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction. J Biol Chem 2009; 284:29514-29525.
71. Sayed D, Rane S, Lypowy J, et al. MicroRNA-21 targets sprouty2 and promotes cellular outgrowths. Mol Biol Cell 2008; 18:3272-3282.
72. Lin Z, Murtaza I, Wang K, et al. MiR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy. Proc Natl Acad Sci USA 2009; 106:12103-12108.
73. Willis MS, Ike C, Li L, et al. Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo. Circ Res 2007; 100:456-459. (Pubitemid 46673255)
74. Da Costa Martins PA, Salic K, Gladka MM, et al. MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/ NFAT signalling. Nat Cell Biol 2010; 12:1220-1227.
75. Xu C, Lu Y, Pan Z, et al. The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. J Cell Sci 2007; 120:3045-3052. (Pubitemid 47517087)
76. Ren XP, Wu J, Wang X, et al. MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. Circulation 2009; 119:2357-2366.
77. Cheng Y, Liu X, Zhang S, et al. MicroRNA-21 protects against the H(2)O(2)- induced injury on cardiac myocytes via its target gene PDCD4. J Mol Cell Cardiol 2009; 47:5-14.
78. Wang X, Zhang X, Ren XP, et al. MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury. Circulation 2010; 122:1308-1318.
79. Roy S, Khanna S, Hussain SR, et al. MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. Cardiovasc Res 2009; 82:21-29.
80. Van Rooij E, Sutherland LB, Thatcher JE, et al. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci USA 2008; 105:13027-13032.
81. Ye Y, Hu Z, Lin Y, et al. Downregulation of microRNA-29 by antisense inhibitors and a PPAR-gamma agonist protects against myocardial ischaemia- reperfusion injury. Cardiovasc Res 2010; 87:535-544.
82. Hausenloy DJ, Tsang A, Mocanu MM, Yellon DM. Ischemic preconditioning protects by activating prosurvival kinases at reperfusion. Am J Physiol Heart Circ Physiol 2005; 288:H971-H976. (Pubitemid 40139686)
83. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986; 74:1124-1136. (Pubitemid 17174962)
84. Rowland RT, Meng X, Cleveland JC, et al. Cardioadaptation induced by cyclic ischemic preconditioning is mediated by translational regulation of de novo protein synthesis. J Surg Res 1997; 71:155-160. (Pubitemid 27400957)
85. Cai Z, Zhong H, Bosch-Marce M, et al. Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1{alpha}. Cardiovasc Res 2008; 77:463-470. (Pubitemid 351197653)
86. Eckle T, Kohler D, Lehmann R, et al. Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning. Circulation 2008; 118:166-175.
87. Rane S, He M, Sayed D, et al. Downregulation of MiR-199a derepresses hypoxia-inducible factor-1{alpha} and sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res 2009; 104:879-886.
88. Rane S, He M, Sayed D, et al. An antagonism between the AKT and betaadrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p. Cell Signal 2010; 22:1054-1062.
89. Yin C, Salloum FN, Kukreja RC. A novel role of microRNA in late preconditioning. Upregulation of endothelial nitric oxide synthase and heat shock protein 70. Circ Res 2009; 104:572-575.
90. Cheng Y, Zhu P, Yang J, et al. Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via antiapoptosis through its target PDCD4. Cardiovasc Res 2010; 87:431-439.
91. Harris TA, YamakuchiM, Ferlito M, et al. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci USA 2008; 105:1516-1521. (Pubitemid 351346546)
92. Guo C, Sah JF, Beard L, et al. The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosomes Cancer 2008; 47:939-946.
93. Kuhnert F, Mancuso MR, Hampton J, et al. Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Development 2008; 135:3989-3993.
94. Wang S, Aurora AB, Johnson BA, et al. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell 2008; 15:261-271.
95. Camps C, Buffa FM, Colella S, et al. hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer. Clin Cancer Res 2008; 14:1340-1348. (Pubitemid 351413913)
96. Fasanaro P, D'Alessandra Y, Di Stefano V, et al. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. J Biol Chem 2008; 283:15878-15883.
97. Hu S, Huang M, Li Z, et al. MicroRNA-210 as a novel therapy for treatment of ischemic heart disease. Circulation 2010; 122:S124-S131.
98. Ji X, Takahashi R, Hiura Y, et al. Plasma miR-208 as a biomarker of myocardial injury. Clin Chem 2009; 55:1944-1949.
99. Ai J, Zhang R, Li Y, et al. Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction. Biochem Biophys Res Commun 2009; 391:73-77.
100. Cheng Y, Tan N, Yang J, et al. A translational study of circulating cell-free microRNA-1 in acute myocardial infarction. Clin Sci 2010; 119:87-95.
101. Wang GK, Zhu JQ, Zhang JT, et al. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J 2010; 31:659-666.
102. D'Alessandra Y, Devanna P, Limana F, et al. Circulating microRNAs are new and sensitive biomarkers of myocardial infarction. Eur Heart J 2010; 2010:2705-2707.
103. Tijsen AJ, Creemers EE, Moerland PD, et al. MiR423-5p as a circulating biomarker for heart failure. Circ Res 2010; 106:1035-1039.
104. Fichtlscherer S, De Rosa S, Fox H, et al. Circulating microRNAs in patients with coronary artery disease. Circ Res 2010; 107:573-574.
105. Kumarswamy R, Anker SD, Thum T. MicroRNAs as circulating biomarkers for heart failure: questions about MiR-423-5p. Circ Res 2010; 106:e8.