NAD + as a signaling molecule modulating metabolism

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 76, Issue , 2011, Pages 291-298

  Canto C ^a   Auwerx, J ^b  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

^b EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINAMIDE ADENINE DINUCLEOTIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; SILENT INFORMATION REGULATOR PROTEIN 2; SIRTUIN; HISTONE DEACETYLASE;

ARTICLE; BIOAVAILABILITY; BROWN ADIPOSE TISSUE; CALORIC RESTRICTION; CELL NUCLEUS; CELLULAR DISTRIBUTION; CHROMATIN STRUCTURE; CYTOPLASM; DEACETYLATION; ENZYME ACTIVITY; FATTY ACID METABOLISM; GENE EXPRESSION; GLUCOSE METABOLISM; HUMAN; IN VITRO STUDY; INTRACELLULAR SPACE; LIPID OXIDATION; LIPOPROTEIN SYNTHESIS; LONGEVITY; METABOLISM; MITOCHONDRIAL RESPIRATION; MITOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; BIOSYNTHESIS; HOMEOSTASIS; PROTEIN FUNCTION;

ANIMALS; HUMANS; METABOLISM; NAD; SIGNAL TRANSDUCTION; SIRTUINS;

EID: 84866545500     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2012.76.010439     Document Type: Article

References (97)

1. Aksoy P, Escande C, White TA, Thompson M, Soares S, Benech JC, Chini EN. 2006a. Regulation of SIRT 1 mediated NAD dependent deacetylation: A novel role for the multifunctional enzyme CD38. Biochem Biophys Res Commun 349: 353-359.
2. Aksoy P, White TA, Thompson M, Chini EN. 2006b. Regulation of intracellular levels of NAD: A novel role for CD38. Biochem Biophys Res Commun 345: 1386-1392.
3. Altschul R, Hoffer A, Stephen JD. 1955. Influence of nicotinic acid on serum cholesterol in man. Arch Biochem Biophys 54: 558-559.
4. Ame JC, Rolli V, Schreiber V, Niedergang C, Apiou F, Decker P, Muller S, Hoger T, Menissier-de Murcia J, de Murcia G. 1999. PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. J Biol Chem 274: 17860-17868.
5. + levels. J Biol Chem 277: 18881-18890.
6. Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA. 2003. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423: 181-185.
7. Asher G, Reinke H, Altmeyer M, Gutierrez-Arcelus M, Hottiger MO, Schibler U. 2010. Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell 142: 943-953.
8. Bai P, Cantó C, Brunyanszki A, Huber A, Szanto M, Cen Y, Yamamoto H, Houten SM, Kiss B, Oudart H, et al. 2011a. PARP-2 regulates SIRT1 expression and whole-body energy expenditure. Cell Metab 13: 450-460.
9. Bai P, Cantó C, Oudart H, Brunyanszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper RH, et al. 2011b. PARP-1 inhibition increasesmitochondrialmetabolismthrough SIRT1 activation. Cell Metab 13: 461-468.
10. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, et al. 2006. Resveratrol improves health and survival of mice on a highcalorie diet. Nature 444: 337-342.
11. +. Cell 129: 473-484.
12. Benyo Z, Gille A, Kero J, Csiky M, Suchankova MC, Nusing RM, Moers A, Pfeffer K, Offermanns S. 2005. GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. J Clin Invest 115: 3634-3640.
13. Berger F, Ramirez-Hernandez MH, Ziegler M. 2004. The new life of a centenarian: Signalling functions of NAD(P). Trends Biochem Sci 29: 111-118.
14. + in fungi and humans. Cell 117: 495-502.
15. Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA. 2002. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J Biol Chem 277: 45099-45107.
16. + metabolism oxidative stress and sirt1 activity inWistar rats. PLoS One 6: e19194.
17. + glycohydrolase-catalysed reactions: Implication for CD38 signalling. Biochem J 358: 399-406.
18. Cantó C, Auwerx J. 2009. Caloric restriction, SIRT1 and longevity. Trends Endocrinol Metab 20: 325-331.
19. Cantó C, Auwerx J. 2011. Interference between PARPs and SIRT1: A novel approach to healthy ageing? Aging (Albany NY). 3: 543-547.
20. +? Pharmacol Rev 64: 166-187.
21. + metabolism and SIRT1 activity. Nature 458: 1056-1060.
22. Chambon P, Weill JD, Mandel P. 1963. Nicotinamide mononucleotide activation of new DNA-dependent polyadenylic acid synthesizing nuclear enzyme. Biochem Biophys Res Commun 11: 39-43.
23. Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente L. 2008. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev 22: 1753-1757.
24. Collins PB, Chaykin S. 1972. The management of nicotinamide and nicotinic acid in the mouse. J Biol Chem 247: 778-783.
25. Dali-Youcef N, Lagouge M, Froelich S, Koehl C, Schoonjans K, Auwerx J. 2007. Sirtuins: The "magnificent seven", function, metabolism and longevity. Ann Med 39: 335-345.
26. De Flora A, Guida L, Franco L, Zocchi E. 1997. The CD38/cyclic ADP-ribose system: A topological paradox. Int J Biochem Cell Biol 29: 1149-1166.
27. +) metabolism. FEBS Lett 492: 4-8.
28. + release. Am J Physiol 271: C1007-C1024.
29. DuJ, ZhouY, SuX, YuJJ, KhanS, Jiang H, KimJ, Woo J, KimJH, Choi BH, et al. 2011. Sirt5 is an NAD-dependent protein lysine demalonylase and desuccinylase. Science 334: 806-809.
30. + and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor. Proc Natl Acad Sci 100: 9202-9207.
31. Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA, Sartorelli V. 2008. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPKmediated regulation of Nampt. Dev Cell 14: 661-673.
32. Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P. 2007. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α. EMBO J 26: 1913-1923.
33. Goodwin PM, Lewis PJ, Davies MI, Skidmore CJ, Shall S. 1978. The effect of gamma radiation and neocarzinostatin on NAD and ATP levels in mouse leukaemia cells. Biochim Biophys Acta 543: 576-582.
34. Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, et al. 2006. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic β cells. Cell 126: 941-954.
35. Hara N, Yamada K, Shibata T, Osago H, Hashimoto T, Tsuchiya M. 2007. Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells. J Biol Chem 282: 24574-24582.
36. Herranz D, Serrano M. 2010. Impact of Sirt1 on mammalian aging. Aging (Albany NY) 2: 315-316.
37. +: An old metabolite controlling new metabolic signaling pathways. Endocr Rev 31: 194-223.
38. Imai S, Armstrong CM, Kaeberlein M, Guarente L. 2000a. Transcriptional silencing and longevity protein Sir2 is an NADdependent histone deacetylase. Nature 403: 795-800.
39. Imai S, Johnson FB, Marciniak RA, McVey M, Park PU, Guarente L. 2000b. Sir2: An NAD-dependent histone deacetylase that connects chromatin silencing, metabolism, and aging. Cold Spring Harb Symp Quant Biol 65: 297-302.
40. +) and AMPK/SIRT1. Nature 464: 1313-1319.
41. + and poly(ADP-ribose) levels but do not affect diethylnitrosamine-induced altered hepatic foci in Fischer-344 rats. J Nutr 125: 1455-1461.
42. Jager S, Handschin C, St-Pierre J, Spiegelman BM. 2007. AMPactivated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α. Proc Natl Acad Sci 104: 12017-12022.
43. Jin L, Galonek H, Israelian K, Choy W, Morrison M, Xia Y, Wang X, Xu Y, Yang Y, Smith JJ, et al. 2009. Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. Protein Sci 18: 514-525.
44. Jing E, Gesta S, Kahn CR. 2007. SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab 6: 105-114.
45. Kaeberlein M, McVey M, Guarente L. 1999. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13: 2570-2580.
46. Kamanna VS, Kashyap ML. 2008. Mechanism of action of niacin. Am J Cardiol 101: 20B-26B.
47. Karpe F, Frayn KN. 2004. The nicotinic acid receptor-A new mechanism for an old drug. Lancet 363: 1892-1894.
48. Kelly TJ, Lerin C, HaasW, Gygi SP, Puigserver P. 2009. GCN5- mediated transcriptional control of the metabolic coactivator PGC-1b through lysine acetylation. J Biol Chem 284: 19945-19952.
49. Kirkland JB. 2009. Niacin status, NAD distribution and ADPribose metabolism. Curr Pharm Des 15: 3-11.
50. Krishnakumar R, Kraus WL. 2010. The PARP side of the nucleus: Molecular actions, physiological outcomes, and clinical targets. Mol Cell 39: 8-24.
51. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, et al. 2006. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC- 1α. Cell 127: 1109-1122.
52. Lee HC. 2006. Structure and enzymatic functions of human CD38. Mol Med 12: 317-323.
53. Li X, Millar JS, Brownell N, Briand F, Rader DJ. 2010. Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes. Biochem Pharmacol 80: 1450-1457.
54. Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, Fink GR, Guarente L. 2002. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418: 344-348.
55. Liszt G, Ford E, Kurtev M, Guarente L. 2005. Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J Biol Chem 280: 21313-21320.
56. Mangerich A, Herbach N, Hanf B, Fischbach A, Popp O, Moreno- Villanueva M, Bruns OT, Burkle A. 2010. Inflammatoryand age-related pathologies in mice with ectopic expression of human PARP-1. Mech Ageing Dev 131: 389-404.
57. Mendoza-Alvarez H, Alvarez-Gonzalez R. 1993. Poly(ADP-ribose)polymerase is a catalytic dimer and the automodification reaction is intermolecular. J Biol Chem 268: 22575-22580.
58. Michan S, Sinclair D. 2007. Sirtuins in mammals: Insights into their biological function. Biochem J 404: 1-13.
59. Michishita E, Park JY, Burneskis JM, Barrett JC, Horikawa I. 2005. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell 16: 4623-4635.
60. Nakagawa T, Lomb DJ, Haigis MC, Guarente L. 2009. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 137: 560-570.
61. +-dependent tubulin deacetylase. Mol Cell 11: 437-444.
62. Onyango P, Celic I, McCaffery JM, Boeke JD, Feinberg AP. 2002. SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci 99: 13653-13658.
63. O'Reilly T, Niven DF. 2003. Levels of nicotinamide adenine dinucleotide in extracellular body fluids of pigs may be growth-limiting for Actinobacillus pleuropneumoniae and Haemophilus parasuis. Can J Vet Res 67: 229-231.
64. Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofalo RS, Griffith D, Griffor M, Loulakis P, Pabst B, et al. 2010. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem 285: 8340-8351.
65. Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L. 2004. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429: 771-776.
66. + depletion and reduced Sir2α deacetylase activity. J Biol Chem 280: 43121-43130.
67. Pittelli M, Formentini L, Faraco G, Lapucci A, Rapizzi E, Cialdai F, Romano G, Moneti G, Moroni F, Chiarugi A. 2010. Inhibition of nicotinamide phosphoribosyltransferase: Cellular bioenergetics reveals a mitochondrial insensitive NAD pool. J Biol Chem 285: 34106-34114.
68. Revollo JR, Grimm AA, Imai S. 2004. The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J Biol Chem 279: 50754-50763.
69. Revollo JR, Korner A, Mills KF, Satoh A, Wang T, Garten A, Dasgupta B, Sasaki Y, Wolberger C, Townsend RR, et al. 2007. Nampt/PBEF/Visfatin regulates insulin secretion in b cells as a systemic NAD biosynthetic enzyme. Cell Metab 6: 363-375.
70. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. 2005. Nutrient control of glucosehomeostasis through a complex of PGC-1α and SIRT1. Nature 434: 113-118.
71. Rongvaux A, Andris F, Van Gool F, Leo O. 2003. Reconstructing eukaryotic NAD metabolism. Bioessays 25: 683-690.
72. Rongvaux A, Galli M, Denanglaire S, Van Gool F, Dreze PL, Szpirer C, Bureau F, Andris F, Leo O. 2008. Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress. J Immunol 181: 4685-4695.
73. + and vitamin B3: From metabolism to therapies. J Pharmacol Exp Ther 324: 883-893.
74. Sauve AA, Wolberger C, Schramm VL, Boeke JD. 2006. The biochemistry of sirtuins. Annu Rev Biochem 75: 435-465.
75. Schwer B, North BJ, Frye RA, Ott M, Verdin E. 2002. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol 158: 647-657.
76. Shi T, Wang F, Stieren E, Tong Q. 2005. SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem 280: 13560-13567.
77. Shieh WM, Ame JC, Wilson MV, Wang ZQ, KohDW, Jacobson MK, Jacobson EL. 1998. Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers. J Biol Chem 273: 30069-30072.
78. Skidmore CJ, Davies MI, Goodwin PM, Halldorsson H, Lewis PJ, Shall S, Zia'ee AA. 1979. The involvement of poly(ADPribose) polymerase in the degradation of NAD caused by gamma-radiation and N-methyl-N-nitrosourea. Eur J Biochem 101: 135-142.
79. Smith BC, Hallows WC, Denu JM. 2009. A continuous microplate assay for sirtuins and nicotinamide-producing enzymes. Anal Biochem 394: 101-109.
80. +-dependent histone deacetylase SIRT1. J Biol Chem 282: 6823-6832.
81. Tischler ME, Friedrichs D, Coll K, Williamson JR. 1977. Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats. Arch Biochem Biophys 184: 222-236.
82. Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, Offermanns S. 2003. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat Med 9: 352-355.
83. Vaccari CS, Nagamia S, Thoenes M, Oguchi A, Hammoud R, Khan BV. 2007. Efficacy of controlled-release niacin in treatment of metabolic syndrome: Correlation to surrogate markers of atherosclerosis, vascular reactivity, and inflammation. J Clin Lipidol 1: 605-613.
84. Vakhrusheva O, Smolka C, Gajawada P, Kostin S, Boettger T, Kubin T, Braun T, Bober E. 2008. Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res 102: 703-710.
85. +-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation. Circ Res 97: 25-34.
86. van der Veer E, Ho C, O'Neil C, Barbosa N, Scott R, Cregan SP, Pickering JG. 2007. Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. J Biol Chem 282: 10841-10845.
87. van Roermund CW, Elgersma Y, Singh N, Wanders RJ, Tabak HF. 1995. The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions. EMBO J 14: 3480-3486.
88. Vaquero A, Scher MB, Lee DH, Sutton A, Cheng HL, Alt FW, Serrano L, Sternglanz R, Reinberg D. 2006. SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev 20: 1256-1261.
89. Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA. 2001. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107: 149-159.
90. Verdin E, Hirschey MD, Finley LW, Haigis MC. 2010. Sirtuin regulation of mitochondria: Energy production, apoptosis, and signaling. Trends Biochem Sci 35: 669-675.
91. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, et al. 2010. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev 24: 1403-1417.
92. Westphal S, Borucki K, Taneva E, Makarova R, Luley C. 2007. Extended-release niacin raises adiponectin and leptin. Atherosclerosis 193: 361-365.
93. Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D. 2004. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430: 686-689.
94. Yamada K, Hara N, Shibata T, Osago H, Tsuchiya M. 2006. The simultaneous measurement of nicotinamide adenine dinucleotide and related compounds by liquid chromatography/electrospray ionization tandem mass spectrometry. Anal Biochem 352: 282-285.
95. Yamamoto H, Schoonjans K, Auwerx J. 2007. Sirtuin functions in health and disease. Mol Endocrinol 21: 1745-1755.
96. + levels dictate cell survival. Cell 130: 1095-1107.
97. Yang T, Chan NY, Sauve AA. 2007b. Syntheses of nicotinamide riboside and derivatives: Effective agents for increasing nicotinamide adenine dinucleotide concentrations in mammalian cells. J Med Chem 50: 6458-6461.