A genetic switch for long-term memory

Comptes Rendus de l'Academie des Sciences - Serie III

Volumn 321, Issue 2-3, 1998, Pages 91-96

  Pittenger, Chris ^a   Kandel, Eric ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Aplysia; CREB; Gene regulation; LTP; Memory; Synaptic plasticity

Indexed keywords

APLYSIA; BRAIN FUNCTION; GENE ACTIVATION; GENE CONTROL; GENETIC TRANSCRIPTION; HIPPOCAMPUS; LONG TERM MEMORY; MAMMAL; NERVE CELL PLASTICITY; NONHUMAN; PROTEIN SYNTHESIS; REPRESSOR GENE; REVIEW;

EID: 0032005107     PISSN: 07644469     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0764-4469(97)89807-1     Document Type: Article

References (36)

1. Polster M.R., Nadel L., Schacter D.L. 1991. Cognitive neuroscience analyses of memory: a historical perspective. / Cognitive Neurosci. 3(2), 95-116.
2. Schachter D.L. 1996. Searching for Memory. Basic Books, New York.
3. Müller G.E., Pilzecker 1900. A. Experimentelle Beitrage zur Lehre vom Gedachtniss. Psychol. 1, 1-288.
4. Zubin J., Barrera S.E. 1941. Effect of electric convulsive therapy on memory. Proc. Society of Experimental Biology and Medicin 48, 596597,
5. Flexner L.B., Flexner J.B., De La Haba G., Roberts R.B. 1965. Loss of memory as related to inhibition of cerebral protein synthesis. J. Neurochem. 12(7), 535-541.
6. Kandel E.R. 1979. Behavioral Biology of Aplysia. W.H. Freeman & Co.
7. Castellucci V., Kandel E. 1976. Presynaptic facilitation as a mechanism for behavioral sensitization in Aplysia. Science 194, 1176-1178.
8. Schwartz J.H.; Castellucci V.F., Kandel E.R. 1971. Functioning of identified neurons and synapses in abdominal ganglion of Aplysia in absence of protein synthesis. J. Neurophysiol. 34(6), 939-953.
9. Castellucci V.F., Frost W.N., Goelet P., Montarolo P.C., Schacher S., Morgan J.A., Blumenfeld H., Kandel E.R. 1986. Cell and molecular analysis of long-term sensitization in Aplysia. J. Physiol. 81 (4), 349-357.
10. Brunelli M., Castellucci V., Kandel E.R. 1976. Synaptic facilitation and behavioral sensitization in Aplysia: possible role of serotonin and cyclinc AMP. Science 194, 1178-1181.
11. Klein M., Kandel E.R. 1980. Mechanism of calcium current modulation underlying presynaptic facilitation and behavioral sensitization in Aplysia. Proc. NatJ. Acad. Sei. USA 77(11), 6912-6916.
12. Braha O., Dale N., Hochner B., Klein M., Abrams T.W., Kandel E.R. (1990). Second messengers involved in the two processes of presynaptic facilitation that contribute to sensitization and dishabituation in Aplysia sensory neurons. Proc. Natl. Acad. Sei. USA 87, 2040-2044.
13. Sacktor T.C., Schwartz J.H. 1990. Sensitizing stimuli cause translocation of protein kinase C in Aplysia sensory neurons. Proc. Natl. Acad. Sei. USA 87, 2036-2039.
14. Schacher S., Castellucci V.F., Kandel E.R. 1988. cAMP evokes longterm facilitation in Aplysia sensory neurons that requires new protein synthesis. Science 240, 1667-1669.
15. Rayport S.G., Schacher S. 1986. Synaptic plasticity in vitro: cell culture of identified Aplysia neurons mediating short-term habituation and sensitization.J. Neurosci. 6, 759-763.
16. Montarolo P.C., Goelet P., Castellucci V.F., Morgan J., Kandel E.R., Schacher S. 1986. A critical period for macromolecular synthesis in longterm heterosynaptic facilitation in Aplysia. Science 234, 1249-1254.
17. Shuster M.J., Camardo J.S., Siegelbaum S.A., Kandel E.R. 1985. Cyclic Amp-dependent protein kinase closes the serotonin-sensitive K+ channels of Aplysia sensory neurones in cell-free membrane patches. Nature 313, 392-395.
18. Bacskai B.J., Hochner B., Mahaut-Smith M., Adams S.R., Kaang B.K., Kandel E.R., Tsien R.Y. 1993. Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science 260, 222226.
19. Bergold P.J., Beushausen S.A., Sacktor T.C., Cheley S., Bayley H., SchwartzJ.H. 1992. A regulatory subunit of the cAMP-dependent protein kinase down-regulated in Aplysia sensory neurons during long-term sensitization. Neuron 8, 387-397.
20. Kaang B.K., Kandel E.R., Grant S.G. 1993. Activation of cAMPresponsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons. Neuron 10, 427-435.
21. Dash P.K., Hochner B., Kandel E.R. 1990. Injection of the cAMPresponsivc element into the nucleus of Aplysia sensory neurons blocks long-term facilitation. Nature 345, 718-721.
22. Bartsch et al. 1996.5oc. NeuroseJ.; Bartsch et al., in preparation.
23. Bartsch D., Ghirardi M., Skehel P.A., Karl K.A., Herder S.P., Chen M., Bailey C.H., Kandel E.R. 1995. Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change. Ce//83, 979-992.
24. Hegde A.N., Inokushi K., Pei W., Casadio A., Ghirardi M., Chain D.G., Martin K.C, Kandel E.R., SchwartzJ.H. 1997. Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia. Cell 89, 115-126.
25. Mayford M., Barzilai A., Keller F., Schacher S., Kandel E.R. 1992. Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in Aplysia. Science 256, 638-644.
26. Alberini CM., Ghirardi M., Metz R., Kandel E.R. 1994. OEBP is an immediate-early gene required fo rthe consolidation of long-term facilitation in Aplysia. Cell 76, 1099-1114.
27. Frey U., Krug M., Reymann K.G., Matthies H. 1988. Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro. Brain Res. 542, 57-65.
28. Abel T., Nguyen P.V., Barad M., Deuel T.A., Kandel E.R., Bourtchouladze R. 1997. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell 88, 615-626.
29. YinJ.C, Del VecchioM., Zhou.H., TullyT. 1995. CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Ce//81, 107-115.
30. Yin J.C., Wallach J.S., Del Vecchio M., Wilder E.L., Zhou H., Quinn W.G., Tully T. 1994. Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell 79, 49-58.
31. Bourtchuladze R., Frenguelli B., Blendy J., Cioffi D., Schutz G., Suva A.J. 1994. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 79, 59-68.
32. Qian Z., Gilbert M.E., Colicos M.A., Kandel E.R., Kühl D. 1993. Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation. Nature 361, 453-457.
33. Hughes P., Beilharz E., Gluckman'P., Dragunow M. 1993. Brainderived neurotrophic factor is induced as an immediate early gene following N-methyl-D-aspartate receptor activation. Neurosci. 57, 319328.
34. Davis G.W., Schuster CM., Goodman C.S. 1996. Genetic dissection of structural and functional components of synaptic plasticity. III. CREB is necessary for presynaptic functional plasticity. Neuron 17, 669-679.
35. Nibuya M., Nestler E.)., Duman R.S. 1996. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J. Neurosci. 16, 2365-2372.
36. Huang Y.Y., Kandel E.R., Varshavsky L, Brandon E.P., Qi M., Idzerda R.L., McKnight G.S., Bourtchouladze R. 1995. A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning. Cell83, 1211-1222.