NNeurocircuitry for modeling drug effects

Addiction Biology

Volumn 17, Issue 5, 2012, Pages 827-864

  Noori, Hamid R ^a   Spanagel, Rainer ^a   Hansson, Anita C ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Acetylcholine; addiction; alcoholism; corticotropin releasing hormone; dopamine; drug reinforcement; drugs of abuse; GABA; glutamate; in silico pharmacology; mathematical modelling; neuronal network; noradrenaline; serotonin; substance use disorders

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCHOLINE; CORTICOTROPIN RELEASING FACTOR; DOPAMINE; GLUTAMIC ACID; NEUROTRANSMITTER; NORADRENALIN; SEROTONIN; 4 AMINOBUTYRIC ACID RECEPTOR; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; GLUTAMINE;

ADDICTION; ALCOHOLISM; AMYGDALOID NUCLEUS; ARTICLE; BRAIN REGION; DRUG EFFECT; HUMAN; HYPOTHALAMUS; INSULA; MATHEMATICAL MODEL; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL NETWORK; NONHUMAN; NUCLEUS ACCUMBENS; PONS; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAPHE NUCLEUS; SUBSTANCE ABUSE; SUBSTANTIA NIGRA; THALAMUS; VENTRAL TEGMENTUM; ALGORITHM; ANIMAL; BRAIN; DISEASE MODEL; HISTOLOGY; NERVE TRACT; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; REINFORCEMENT; REVIEW; SYNAPTIC TRANSMISSION;

ALGORITHMS; ANIMALS; BEHAVIOR, ADDICTIVE; BRAIN; CORTICOTROPIN-RELEASING HORMONE; DISEASE MODELS, ANIMAL; GLUTAMINE; HUMANS; NEURAL PATHWAYS; NEUROTRANSMITTER AGENTS; NOREPINEPHRINE; RATS; RECEPTORS, GABA; REINFORCEMENT (PSYCHOLOGY); SEROTONIN; SUBSTANCE-RELATED DISORDERS; SYNAPTIC TRANSMISSION;

EID: 84866434088     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2012.00485.x     Document Type: Article

References (291)

1. Abrous DN, Koehl M, Le Moal M, (2005) Adult neurogenesis: from precursors to network and physiology. Physiol Rev 85: 523-569.
2. Adermark L, Clarke RB, Olsson T, Hansson E, Söderpalm B, Ericson M, (2011) Implications for glycine receptors and astrocytes in ethanol-induced elevation of dopamine levels in the nucleus accumbens. Addict Biol 16: 43-54.
3. Aguado T, Monory K, Palazuelos J, Stella N, Cravatt B, Lutz B, Marsicano G, Kokaia Z, Guzmán M, Galve-Roperh I, (2005) The endocannabinoid system drives neural progenitor proliferation. FASEB J 19: 1704-1706.
4. Aharonovich E, Hasin DS, Brooks AC, Liu X, Bisaga A, Nunes EV, (2006) Cognitive deficits predict low treatment retention in cocaine dependent patients. Drug Alcohol Depend 81: 313-322.
5. Ahlenius S, Carlsson A, Engel J, Svensson T, Sodersten P, (1973) Antagonism by alpha methyltyrosine of the ethanol-induced stimulation and euphoria in man. Clin Pharmacol Ther 14: 586-591.
6. Ahmed SH, Bobashev G, Gutkin BS, (2007) The simulation of addiction: pharmacological and neurocomputational models of drug self-administration. Drug Alcohol Depend 90: 304-311.
7. Ahmed SH, Koob GF, (2005) Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function. Psychopharmacology (Berl) 180: 473-490.
8. Asensio S, Romero MJ, Palau C, Sanchez A, Senabre I, Morales JL, Carcelen R, Romero FJ, (2010) Altered neural response of the appetitive emotional system in cocaine addiction: an fMRI Study. Addict Biol 15: 504-516.
9. Aston-Jones G, Delfs JM, Druhan J, Zhu Y, (1999) The bed nucleus of the stria terminalis. A target site for noradrenergic actions in opiate withdrawal. Ann N Y Acad Sci 877: 486-498.
10. Aston-Jones G, Harris GC, (2004) Brain substrates for increased drug seeking during protracted withdrawal. Neuropharmacology 47 (Suppl 1): 167-179.
11. Bachmanov AA, Kiefer SW, Molina JC, Tordoff MG, Duffy VB, Bartoshuk LM, Mennella JA, (2003) Chemosensory factors influencing alcohol perception, preferences, and consumption. Alcohol Clin Exp Res 27: 220-231.
12. Bäckström P, Bachteler D, Koch S, Hyytiä P, Spanagel R, (2004) mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 29: 921-928.
13. Baker TE, Stockwell T, Barnes G, Holroyd CB, (2011) Individual differences in substance dependence: at the intersection of brain, behaviour and cognition. Addict Biol 16: 458-466.
14. Barahona M, Pecora LM, (2002) Synchronization in small-world systems. Phys Rev Lett 89: 054101.
15. Barichella M, Marczewska AM, Mariani C, Landi A, Vairo A, Pezzoli G, (2003) Body weight gain rate in patients with Parkinson's disease and deep brain stimulation. Mov Disord 18: 1337-1340.
16. Barr CS, Dvoskin RL, Gupte M, Sommer W, Sun H, Schwandt ML, Lindell SG, Kasckow JW, Suomi SJ, Goldman D, Higley JD, Heilig M, (2009) Functional CRH variation increases stress-induced alcohol consumption in primates. Proc Natl Acad Sci USA 106: 14593-14598.
17. Barr CS, Dvoskin RL, Yuan Q, Lipsky RH, Gupte M, Hu X, Zhou Z, Schwandt ML, Lindell SG, McKee M, Becker ML, Kling MA, Gold PW, Higley D, Heilig M, Suomi SJ, Goldman D, (2008) CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques. Arch Gen Psychiatry 65: 934-944.
18. Barr CS, Newman TK, Lindell S, Shannon C, Champoux M, Lesch KP, Suomi SJ, Goldman D, Higley JD, (2004) Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates. Arch Gen Psychiatry 61: 1146-1152.
19. Baumgartner U, Buchholz HG, Bellosevich A, Magerl W, Siessmeier T, Rolke R, Hohnemann S, Piel M, Rosch F, Wester HJ, Henriksen G, Stoeter P, Bartenstein P, Treede RD, Schreckenberger M, (2006) High opiate receptor binding potential in the human lateral pain system. Neuroimage 30: 692-699.
20. Baunez C, Dias C, Cador M, Amalric M, (2005) The subthalamic nucleus exerts opposite control on cocaine and 'natural' rewards. Nat Neurosci 8: 484-489.
21. Bechtholt AJ, Cunningham CL, (2005) Ethanol-induced conditioned place preference is expressed through a ventral tegmental area dependent mechanism. Behav Neurosci 119: 213-223.
22. Beitner-Johnson D, Guitart X, Nestler EJ, (1992) Neurofilament proteins and the mesolimbic dopamine system: common regulation by chronic morphine and chronic cocaine in the rat ventral tegmental area. J Neurosci 12: 2165-2176.
23. Belin D, Mar AC, Dalley JW, Robbins TW, Everitt BJ, (2008) High impulsivity predicts the switch to compulsive cocaine-taking. Science 320: 1352-1355.
24. Belknap JK, Belknap ND, Berg JH, Coleman R, (1977) Preabsorptive vs. postabsorptive control of ethanol intake in C57BL/6J and DBA/2J mice. Behav Genet 7: 413-425.
25. Belujon P, Grace AA, (2011) Hippocampus, amygdala, and stress: interacting systems that affect susceptibility to addiction. Ann N Y Acad Sci 1216: 114-121.
26. Benabid AL, (2003) Deep brain stimulation for Parkinson's disease. Curr Opin Neurobiol 13: 696-706.
27. Bevan MD, Magill PJ, Terman D, Bolam JP, Wilson CJ, (2002) Move to the rhythm: oscillations in the subthalamic nucleus-external globus pallidus network. Trends Neurosci 25: 525-531.
28. Björk K, Hansson AC, Sommer WH, (2010) Genetic variation and brain gene expression in rodent models of alcoholism. Int Rev Neurobiol 91: 129-171.
29. Bleier R, Cohn P, Siggelkow IR, (1979) A cytoarchitectonic atlas of the hypothalamus and hypothalamic third ventricle of the rat. In:, Morgane PJ, Panksepp J, eds. Anatomy of the Hypothalamus, pp. 137-220. New York: Marcel Dekker.
30. Bobashev G, Costenbader E, Gutkin B, (2007) Comprehensive mathematical modeling in drug addiction sciences. Drug Alcohol Depend 89: 102-106.
31. Boden JM, Fergusson DM, (2011) Alcohol and depression. Addiction 106: 906-914.
32. Brady JV, Nauta WJ, (1953) Subcortical mechanisms in emotional behavior: affective changes following septal forebrain lesions in the albino rat. J Comp Physiol Psychol 46: 339-346.
33. Brasser SM, Silbaugh BC, Ketchum MJ, Olney JJ, Lemon CH, (2012) Chemosensory responsiveness to ethanol and its individual sensory components in alcohol-preferring, alcohol-nonpreferring and genetically heterogeneous rats. Addict Biol 17: 423-436.
34. Brodie MS, Pesold C, Appel SB, (1999) Ethanol directly excites dopaminergic ventral tegmental area reward neurons. Alcohol Clin Exp Res 23: 1848-1852.
35. Brodie MS, Shefner SA, Dunwiddie TV, (1990) Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro. Brain Res 508: 65-69.
36. Budygin EA, Phillips PE, Robinson DL, Kennedy AP, Gainetdinov RR, Wightman RM, (2001) Effect of acute ethanol on striatal dopamine neurotransmission in ambulatory rats. J Pharmacol Exp Ther 297: 27-34.
37. Caine SB, Heinrichs SC, Coffin VL, Koob GF, (1995) Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat. Brain Res 692: 47-56.
38. Caine SB, Humby T, Robbins TW, Everitt BJ, (2001) Behavioral effects of psychomotor stimulants in rats with dorsal or ventral subiculum lesions: locomotion, cocaine self-administration, and prepulse inhibition of startle. Behav Neurosci 115: 880-894.
39. Cannon WB, Britton SW, (1925) Studies on the conditions of activity in endocrine glands: XV. Pseudaffective medulliadrenal secretion. Am J Physiol 72: 283-294.
40. Cervantes L, Fraguela Collar A, (2001) A mathematical model for the limbic system, Lecture Notes in Computer Science, Volume 1988/2001, 179-186.
41. Chang JY, Sawyer SF, Lee RS, Woodward DJ, (1994) Electrophysiological and pharmacological evidence for the role of the nucleus accumbens in cocaine self-administration in freely moving rats. J Neurosci 14: 1224-1244.
42. Chefer V, Meis J, Wang G, Kuzmin A, Bakalkin G, Shippenberg T, (2011) Repeated exposure to moderate doses of ethanol augments hippocampal glutamate neurotransmission by increasing release. Addict Biol 16: 229-237.
43. Chen EYH, (2003) A neurocomputational model of early psychosis. 1149-1155.
44. Chevillard L, Mégarbane B, Baud FJ, Risède P, Declèves X, Mager D, Milan N, Ricordel I, (2010) Mechanisms of respiratory insufficiency induced by methadone overdose in rats. Addict Biol 15: 62-80.
45. Chronister RB, Farnell KE, Marco LA, White LE, Jr, (1976) The rodent neostriatum: a Golgi analysis. Brain Res 108: 37-46.
46. Clark L, Bechara A, Damasio H, Aitken MR, Sahakian BJ, Robbins TW, (2008) Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making. Brain 131: 1311-1322.
47. Clark WE, (1932) The structure and connections of the thalamus. Brain 55: 406-470.
48. Cohen MX, Frank MJ, (2009) Neurocomputational models of basal ganglia function in learning, memory and choice. Behav Brain Res 199: 141-156.
49. Contoreggi C, Herning RI, Na P, Gold PW, Chrousos G, Negro PJ, Better W, Cadet JL, (2003) Stress hormone responses to corticotropin-releasing hormone in substance abusers without severe comorbid psychiatric disease. Biol Psychiatry 54: 873-878.
50. Contreras M, Ceric F, Torrealba F, (2007) Inactivation of the interoceptive insula disrupts drug craving and malaise induced by lithium. Science 318: 655-658.
51. Cowen MS, Djouma E, Lawrence AJ, (2005) The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems. J Pharmacol Exp Ther 315: 590-600.
52. Crews FT, Nixon K, (2003) Alcohol, neural stem cells, and adult neurogenesis. Alcohol Res Health 27: 197-204.
53. Cunningham KA, Lakoski JM, (1988) Electrophysiological effects of cocaine and procaine on dorsal raphe serotonin neurons. Eur J Pharmacol 148: 457-462.
54. Cunningham KA, Lakoski JM, (1990) The interaction of cocaine with serotonin dorsal raphe neurons. Single-unit extracellular recording studies. Neuropsychopharmacology 3: 41-50.
55. D'Souza DN, Harlan RE, Garcia MM, (1999) Sexual dimorphism in the response to N-methyl-D-aspartate receptor antagonists and morphine on behavior and c-Fos induction in the rat brain. Neuroscience 93: 1539-1547.
56. Dafny N, Dong WQ, Prieto-Gomez C, Reyes-Vazquez C, Stanford J, Qiao JT, (1996) Lateral hypothalamus: site involved in pain modulation. Neuroscience 70: 449-460.
57. Dahlstroem A, Fuxe K, (1964) Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol Scand Suppl 232: 231-255.
58. Davis M, Walker DL, Lee Y, (1997) Amygdala and bed nucleus of the stria terminalis: differential roles in fear and anxiety measured with the acoustic startle reflex. Philos Trans R Soc Lond B Biol Sci 352: 1675-1687.
59. De Biasi M, Salas R, (2008) Influence of neuronal nicotinic receptors over nicotine addiction and withdrawal. Exp Biol Med (Maywood) 233: 917-929.
60. Delfs JM, Zhu Y, Druhan JP, Aston-Jones G, (2000) Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion. Nature 403: 430-434.
61. Deurveilher S, Semba K, (2005) Indirect projections from the suprachiasmatic nucleus to major arousal-promoting cell groups in rat: implications for the circadian control of behavioural state. Neuroscience 130: 165-183.
62. Devan BD, (1997) Functional Organization of the Dorsal Striatum: Comparison to the Hippocampal System. PhD thesis, McGill University, Montreal, Canada.
63. Di Matteo V, Pierucci M, Benigno A, Esposito E, Crescimanno G, Di Giovanni G, (2010) Critical role of nitric oxide on nicotine-induced hyperactivation of dopaminergic nigrostriatal system: electrophysiological and neurochemical evidence in rats. CNS Neurosci Ther 16: 127-136.
64. Ding ZM, Rodd ZA, Engleman EA, McBride WJ, (2009) Sensitization of ventral tegmental area dopamine neurons to the stimulating effects of ethanol. Alcohol Clin Exp Res 33: 1571-1581.
65. Dong HW, Swanson LW, (2003) Projections from the rhomboid nucleus of the bed nuclei of the stria terminalis: implications for cerebral hemisphere regulation of ingestive behaviors. J Comp Neurol 463: 434-472.
66. Dong HW, Swanson LW, (2004) Projections from bed nuclei of the stria terminalis, posterior division: implications for cerebral hemisphere regulation of defensive and reproductive behaviors. J Comp Neurol 471: 396-433.
67. Dong HW, Swanson LW, (2006a) Projections from bed nuclei of the stria terminalis, anteromedial area: cerebral hemisphere integration of neuroendocrine, autonomic, and behavioral aspects of energy balance. J Comp Neurol 494: 142-178.
68. Dong HW, Swanson LW, (2006b) Projections from bed nuclei of the stria terminalis, dorsomedial nucleus: implications for cerebral hemisphere integration of neuroendocrine, autonomic, and drinking responses. J Comp Neurol 494: 75-107.
69. Dumont EC, Mark GP, Mader S, Williams JT, (2005) Self-administration enhances excitatory synaptic transmission in the bed nucleus of the stria terminalis. Nat Neurosci 8: 413-414.
70. Dunn AJ, Berridge CW, (1990) Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Res Brain Res Rev 15: 71-100.
71. DuPont RL, (1995) Anxiety and addiction: a clinical perspective on comorbidity. Bull Menninger Clin 59: A53-A72.
72. Durstewitz D, Kelc M, Güntürkün O, (1999) A neurocomputational theory of the dopaminergic modulation of working memory function. J Neurosci 19: 2807-2822.
73. Dyr W, Kostowski W, (1995) Evidence that the amygdala is involved in the inhibitory effects of 5-HT3 receptor antagonists on alcohol drinking in rats. Alcohol 12: 387-391.
74. Economidou D, Hansson AC, Weiss F, Terasmaa A, Sommer WH, Cippitelli A, Fedeli A, Martin-Fardon R, Massi M, Ciccocioppo R, Heilig M, (2008) Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat. Biol Psychiatry 64: 211-218.
75. Edwards S, Bachtell RK, Guzman D, Whisler KN, Self DW, (2011) Emergence of context-associated GluR(1) and ERK phosphorylation in the nucleus accumbens core during withdrawal from cocaine self-administration. Addict Biol 16: 450-457.
76. Eisch AJ, Barrot M, Schad CA, Self DW, Nestler EJ, (2000) Opiates inhibit neurogenesis in the adult rat hippocampus. Proc Natl Acad Sci USA 97: 7579-7584.
77. Eisch AJ, Harburg GC, (2006) Opiates, psychostimulants, and adult hippocampal neurogenesis: insights for addiction and stem cell biology. Hippocampus 16: 271-286.
78. Ellen P, Powell EW, (1962) Effects of septal lesions on behavior generated by positive reinforcement. Exp Neurol 6: 1-11.
79. Erb S, Salmaso N, Rodaros D, Stewart J, (2001) A role for the CRF-containing pathway from central nucleus of the amygdala to bed nucleus of the stria terminalis in the stress-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl) 158: 360-365.
80. Erb S, Stewart J, (1999) A role for the bed nucleus of the stria terminalis, but not the amygdala, in the effects of corticotropin-releasing factor on stress-induced reinstatement of cocaine seeking. J Neurosci 19: RC35.
81. Ericson M, Chau P, Clarke RB, Adermark L, Söderpalm B, (2011) Rising taurine and ethanol concentrations in nucleus accumbens interact to produce dopamine release after ethanol administration. Addict Biol 16: 377-385.
82. Everitt BJ, Robbins TW, (2005) Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 8: 1481-1489.
83. Farrar AM, Font L, Pereira M, Mingote S, Bunce JG, Chrobak JJ, Salamone JD, (2008) Forebrain circuitry involved in effort-related choice: injections of the GABAA agonist muscimol into ventral pallidum alter response allocation in food-seeking behavior. Neuroscience 152: 321-330.
84. Foddai M, Dosia G, Spiga S, Diana M, (2004) Acetaldehyde increases dopaminergic neuronal activity in the VTA. Neuropsychopharmacology 29: 530-536.
85. Frank ST, Krumm B, Spanagel R, (2008) Cocaine-induced dopamine overflow within the nucleus accumbens measured by in vivo microdialysis: a meta-analysis. Synapse 62: 243-252.
86. Franklin TR, Wang Z, Li Y, Suh JJ, Goldman M, Lohoff FW, Cruz J, Hazan R, Jens W, Detre JA, Berrettini W, O'Brien CP, Childress AR, (2011) Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort. Addict Biol 16: 308-322.
87. Fritz M, El Rawas R, Salti A, Klement S, Bardo MT, Kemmler G, Dechant G, Saria A, Zernig G, (2011) Reversal of cocaine-conditioned place preference and mesocorticolimbic Zif268 expression by social interaction in rats. Addict Biol 16: 273-284.
88. Fuller TA, Russchen FT, Price JL, (1987) Sources of presumptive glutamergic/aspartergic afferents to the rat ventral striatopallidal region. J Comp Neurol 258: 317-338.
89. Funk CK, O'Dell LE, Crawford EF, Koob GF, (2006) Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats. J Neurosci 26: 11324-11332.
90. Gardner EL, (2011) Addiction and brain reward and antireward pathways. Adv Psychosom Med 30: 22-60.
91. Gardner EL, Lowinson JH, (1993) Drug craving and positive/negative hedonic brain substrates activated by addicting drugs. Semin Neurosci 5: 359-368.
92. Gaspar P, Berger B, Febvret A, Vigny A, Henry JP, (1989) Catecholamine innervation of the human cerebral cortex as revealed by comparative immunohistochemistry of tyrosine hydroxylase and dopamine-beta-hydroxylase. J Comp Neurol 279: 249-271.
93. Gatto GJ, McBride WJ, Murphy JM, Lumeng L, Li TK, (1994) Ethanol self-infusion into the ventral tegmental area by alcohol-preferring rats. Alcohol 11: 557-564.
94. Gehlert DR, Cippitelli A, Thorsell A, Le AD, Hipskind PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, Ciccocioppo R, Heilig M, (2007) 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6- dimethyl- imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism. J Neurosci 27: 2718-2726.
95. George DT, Nutt DJ, Dwyer BA, Linnoila M, (1990) Alcoholism and panic disorder: is the comorbidity more than coincidence? Acta Psychiatr Scand 81: 97-107.
96. Gessa GL, Muntoni F, Collu M, Vargiu L, Mereu G, (1985) Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area. Brain Res 348: 201-203.
97. Gilman JM, Hommer DW, (2008) Modulation of brain response to emotional images by alcohol cues in alcohol-dependent patients. Addict Biol 13: 423-434.
98. Goldman-Rakic PS, (1982) Cytoarchitectonic heterogeneity of the primate neostriatum: subdivision into Island and Matrix cellular compartments. J Comp Neurol 205: 398-413.
99. Goldstein RZ, Volkow ND, (2011) Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci 12: 652-669.
100. Goudriaan AE, de Ruiter MB, van den Brink W, Oosterlaan J, Veltman DJ, (2010) Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study. Addict Biol 15: 491-503.
101. Gutkin BS, Dehaene S, Changeux JP, (2006) A neurocomputational hypothesis for nicotine addiction. Proc Natl Acad Sci USA 103: 1106-1111.
102. Haber SN, Knutson B, (2010) The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacology 35: 4-26.
103. Hansson AC, Cippitelli A, Sommer W, Ciccocioppo R, Heilig M, (2007) Region-specific down regulation of Crhr1 gene expression in alcohol preferring msP rats following ad lib access to alcohol. Addict Biol 12: 30-34.
104. Hansson AC, Cippitelli A, Sommer WH, Fedeli A, Bjork K, Soverchia L, Terasmaa A, Massi M, Heilig M, Ciccocioppo R, (2006) Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress. Proc Natl Acad Sci USA 103: 15236-15241.
105. Hansson AC, Nixon K, Rimondini R, Damadzic R, Sommer WH, Eskay R, Crews FT, Heilig M, (2010) Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats. Int J Neuropsychopharmacol 13: 583-593.
106. Hartley CA, Phelps EA, (2010) Changing fear: the neurocircuitry of emotion regulation. Neuropsychopharmacology 35: 136-146.
107. Hartwell KJ, Johnson KA, Li X, Myrick H, LeMatty T, George MS, Brady KT, (2011) Neural correlates of craving and resisting craving for tobacco in nicotine dependent smokers. Addict Biol 16: 654-666.
108. Heidbreder CA, Groenewegen HJ, (2003) The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics. Neurosci Biobehav Rev 27: 555-579.
109. Heilig M, Koob GF, (2007) A key role for corticotropin-releasing factor in alcohol dependence. Trends Neurosci 30: 399-406.
110. Heilig M, Thorsell A, Sommer WH, Hansson AC, Ramchandani VA, George DT, Hommer D, Barr CS, (2009) Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues. Neurosci Biobehav Rev 35: 334-344.
111. Helinski S, Spanagel R, (2011) Publication trends in addiction research. Addict Biol 16: 532-539.
112. Henry B, Vale W, Markou A, (2006) The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J Neurosci 26: 9142-9152.
113. Herkenham M, Edley SM, Stuart J, (1984) Cell clusters in the nucleus accumbens of the rat, and the mosaic relationship of opiate receptors, acetylcholinesterase and subcortical afferent terminations. Neuroscience 11: 561-593.
114. Heyser CJ, Roberts AJ, Schulteis G, Koob GF, (1999) Central administration of an opiate antagonist decreases oral ethanol self-administration in rats. Alcohol Clin Exp Res 23: 1468-1476.
115. Hikida T, Kimura K, Wada N, Funabiki K, Nakanishi S, (2010) Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behavior. Neuron 66: 896-907.
116. Hikosaka O, (2010) The habenula: from stress evasion to value-based decision-making. Nat Rev Neurosci 11: 503-513.
117. Hodge CW, Haraguchi M, Erickson H, Samson HH, (1993) Ventral tegmental microinjections of quinpirole decrease ethanol and sucrose-reinforced responding. Alcohol Clin Exp Res 17: 370-375.
118. Hong S, Hikosaka O, (2008) The globus pallidus sends reward-related signals to the lateral habenula. Neuron 60: 720-729.
119. Hubner CB, Koob GF, (1990) The ventral pallidum plays a role in mediating cocaine and heroin self-administration in the rat. Brain Res 508: 20-29.
120. Hurd YL, Suzuki M, Sedvall GC, (2001) D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain. J Chem Neuroanat 22: 127-137.
121. Hyytia P, Koob GF, (1995) GABAA receptor antagonism in the extended amygdala decreases ethanol self-administration in rats. Eur J Pharmacol 283: 151-159.
122. Imperato A, Di Chiara G, (1986) Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J Pharmacol Exp Ther 239: 219-228.
123. Jackson EA, Kelly PH, (1983a) Nigral dopaminergic mechanisms in drug-induced circling. Brain Res Bull 11: 605-611.
124. Jackson EA, Kelly PH, (1983b) Role of nigral dopamine in amphetamine-induced locomotor activity. Brain Res 278: 366-369.
125. Jarrard LE, (1993) On the role of the hippocampus in learning and memory in the rat. Behav Neural Biol 60: 9-26.
126. Ji H, Shepard PD, (2007) Lateral habenula stimulation inhibits rat midbrain dopamine neurons through a GABA(A) receptor-mediated mechanism. J Neurosci 27: 6923-6930.
127. Jones EG, (1983) The thalamus. In:, Emson PC, ed. Chemical Neuroanatomy, pp. 257-293. New York: Raven Press.
128. Jongen-Relo AL, Voorn P, Groenewegen HJ, (1994) Immunohistochemical characterization of the shell and core territories of the nucleus accumbens in the rat. Eur J Neurosci 6: 1255-1264.
129. Kahn L, Alonso G, Normand E, Manzoni OJ, (2005) Repeated morphine treatment alters polysialylated neural cell adhesion molecule, glutamate decarboxylase-67 expression and cell proliferation in the adult rat hippocampus. Eur J Neurosci 21: 493-500.
130. Kakko J, von Wachenfeldt J, Svanborg KD, Lidstrom J, Barr CS, Heilig M, (2008) Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence. Biol Psychiatry 63: 172-177.
131. Kalivas PW, (2009) The glutamate homeostasis hypothesis of addiction. Nat Rev Neurosci 10: 561-572.
132. Kampov-Polevoy AB, Kasheffskaya OP, Sinclair JD, (1990) Initial acceptance of ethanol: gustatory factors and patterns of alcohol drinking. Alcohol 7: 83-85.
133. Kelai S, Maussion G, Noble F, Boni C, Ramoz N, Moalic JM, Peuchmaur M, Gorwood P, Simonneau M, (2008) Nrxn3 upregulation in the globus pallidus of mice developing cocaine addiction. Neuroreport 19: 751-755.
134. Kelly E, Jenner P, Marsden CD, (1987) Comparison of changes in locomotor activity with striatal homovanillic acid and 3,4-dihydroxyphenylacetic acid concentrations following the bilateral intranigral injection of dopamine agonist drugs in rats. J Pharm Pharmacol 39: 196-202.
135. Kilts CD, Schweitzer JB, Quinn CK, Gross RE, Faber TL, Muhammad F, Ely TD, Hoffman JM, Drexler KP, (2001) Neural activity related to drug craving in cocaine addiction. Arch Gen Psychiatry 58: 334-341.
136. Kirby LG, Zeeb FD, Winstanley CA, (2011) Contributions of serotonin in addiction vulnerability. Neuropharmacology 61: 421-432.
137. Klitenick MA, Deutch AY, Churchill L, Kalivas PW, (1992) Topography and functional role of dopaminergic projections from the ventral mesencephalic tegmentum to the ventral pallidum. Neuroscience 50: 371-386.
138. Kobayashi S, Schultz W, (2008) Influence of reward delays on responses of dopamine neurons. J Neurosci 28: 7837-7846.
139. Kochman LJ, dos Santos AA, Fornal CA, Jacobs BL, (2006) Despite strong behavioral disruption, Delta9-tetrahydrocannabinol does not affect cell proliferation in the adult mouse dentate gyrus. Brain Res 1113: 86-93.
140. Kolb B, (1974a) Dissociation of the effects of lesions of the orbital or medial aspect of the prefrontal cortex of the rat with respect to activity. Behav Biol 10: 329-343.
141. Kolb B, (1974b) Prefrontal lesions alter eating and hoarding behavior in rats. Physiol Behav 12: 507-511.
142. Kolb B, (1984) Functions of the frontal cortex of the rat: a comparative review. Brain Res 320: 65-98.
143. Koob GF, (2010) The role of CRF and CRF-related peptides in the dark side of addiction. Brain Res 1314: 3-14.
144. Koob GF, Heinrichs SC, (1999) A role for corticotropin releasing factor and urocortin in behavioral responses to stressors. Brain Res 848: 141-152.
145. Koob GF, Le Moal M, (1997) Drug abuse: hedonic homeostatic dysregulation. Science 278: 52-58.
146. Koob GF, Le Moal M, (2008) Addiction and the brain antireward system. Annu Rev Psychol 59: 29-53.
147. Koob GF, Rassnick S, Heinrichs S, Weiss F, (1994) Alcohol, the reward system and dependence. EXS 71: 103-114.
148. Koob GF, Volkow ND, (2010) Neurocircuitry of addiction. Neuropsychopharmacology 35: 217-238.
149. Kozink RV, Lutz AM, Rose JE, Froeliger B, McClernon FJ, (2010) Smoking withdrawal shifts the spatiotemporal dynamics of neurocognition. Addict Biol 15: 480-490.
150. Krettek JE, Price JL, (1977) Projections from the amygdaloid complex to the cerebral cortex and thalamus in the rat and cat. J Comp Neurol 172: 687-722.
151. Krystal JH, Webb E, Grillon C, Cooney N, Casal L, Morgan CA, Southwick SM, Davis M, Charney DS, (1997) Evidence of acoustic startle hyperreflexia in recently detoxified early onset male alcoholics: modulation by yohimbine and m-chlorophenylpiperazine (mCPP). Psychopharmacology 131: 207-215.
152. Kuczenski R, Segal DS, (2001) Caudate-putamen and nucleus accumbens extracellular acetylcholine responses to methamphetamine binges. Brain Res 923: 32-38.
153. LaLumiere RT, Kalivas PW, (2008) Glutamate release in the nucleus accumbens core is necessary for heroin seeking. J Neurosci 28: 3170-3177.
154. Lardeux S, Pernaud R, Paleressompoulle D, Baunez C, (2009) Beyond the reward pathway: coding reward magnitude and error in the rat subthalamic nucleus. J Neurophysiol 102: 2526-2537.
155. Lazarini F, Lledo PM, (2011) Is adult neurogenesis essential for olfaction? Trends Neurosci 34: 20-30.
156. LeDoux JE, (2000) Emotion circuits in the brain. Annu Rev Neurosci 23: 155-184.
157. Lee CY, Double KL, Crocker AD, (1995) Expression of stereotyped behaviour requires stimulation of nigral D1 dopamine receptors. Brain Res 681: 205-208.
158. Lee RS, Criado JR, Koob GF, Henriksen SJ, (1999) Cellular responses of nucleus accumbens neurons to opiate-seeking behavior: I. Sustained responding during heroin self-administration. Synapse 33: 49-58.
159. Lee S, Selvage D, Hansen K, Rivier C, (2004) Site of action of acute alcohol administration in stimulating the rat hypothalamic-pituitary-adrenal axis: comparison between the effect of systemic and intracerebroventricular injection of this drug on pituitary and hypothalamic responses. Endocrinology 145: 4470-4479.
160. Leggio L, Addolorato G, Cippitelli A, Jerlhag E, Kampov-Polevoy AB, Swift RM, (2011) Role of feeding-related pathways in alcohol dependence: a focus on sweet preference, NPY, and ghrelin. Alcohol Clin Exp Res 35: 194-202.
161. Letchworth SR, Nader MA, Smith HR, Friedman DP, Porrino LJ, (2001) Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. J Neurosci 21: 2799-2807.
162. Limousin P, Pollak P, Benazzouz A, Hoffmann D, Le Bas JF, Broussolle E, Perret JE, Benabid AL, (1995) Effect of parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation. Lancet 345: 91-95.
163. Liu J, Yu B, Orozco-Cabal L, Grigoriadis DE, Rivier J, Vale WW, Shinnick-Gallagher P, Gallagher JP, (2005) Chronic cocaine administration switches corticotropin-releasing factor2 receptor-mediated depression to facilitation of glutamatergic transmission in the lateral septum. J Neurosci 25: 577-583.
164. Lozano AM, Mayberg HS, Giacobbe P, Hamani C, Craddock RC, Kennedy SH, (2008) Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression. Biol Psychiatry 64: 461-467.
165. Lum JT, Piercey MF, (1988) Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. Eur J Pharmacol 149: 9-15.
166. Maccioni P, Orru A, Korkosz A, Gessa GL, Carai MA, Colombo G, Bienkowski P, (2007) Cue-induced reinstatement of ethanol seeking in Sardinian alcohol-preferring rats. Alcohol 41: 31-39.
167. Mallet L, Polosan M, Jaafari N, Baup N, Welter ML, Fontaine D, du, Montcel ST, Yelnik J, Chereau I, Arbus C, Raoul S, Aouizerate B, Damier P, Chabardes S, Czernecki V, Ardouin C, Krebs MO, Bardinet E, Chaynes P, Burbaud P, Cornu P, Derost P, Bougerol T, Bataille B, Mattei V, Dormont D, Devaux B, Verin M, Houeto JL, Pollak P, Benabid AL, Agid Y, Krack P, Millet B, Pelissolo A, (2008) Subthalamic nucleus stimulation in severe obsessive-compulsive disorder. N Engl J Med 359: 2121-2134.
168. Mark GP, Shabani S, Dobbs LK, Hansen ST, (2011) Cholinergic modulation of mesolimbic dopamine function and reward. Physiol Behav 104: 76-81.
169. Matsumoto M, (2009) Role of the lateral habenula and dopamine neurons in reward processing. Brain Nerve 61: 389-396.
170. Matsumoto M, Hikosaka O, (2007) Lateral habenula as a source of negative reward signals in dopamine neurons. Nature 447: 1111-1115.
171. McAlonan GM, Robbins TW, Everitt BJ, (1993) Effects of medial dorsal thalamic and ventral pallidal lesions on the acquisition of a conditioned place preference: further evidence for the involvement of the ventral striatopallidal system in reward-related processes. Neuroscience 52: 605-620.
172. McFarland K, Davidge SB, Lapish CC, Kalivas PW, (2004) Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior. J Neurosci 24: 1551-1560.
173. McFarland K, Kalivas PW, (2001) The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior. J Neurosci 21: 8655-8663.
174. McGregor A, Roberts DC, (1993) Dopaminergic antagonism within the nucleus accumbens or the amygdala produces differential effects on intravenous cocaine self-administration under fixed and progressive ratio schedules of reinforcement. Brain Res 624: 245-252.
175. Meloni EG, Davis M, (2004) The substantia nigra pars reticulata mediates the enhancement of startle by the dopamine D1 receptor agonist SKF 82958 in rats. Psychopharmacology (Berl) 174: 228-236.
176. Mensah PL, (1977) The internal organization of the mouse caudate nucleus: evidence for cell clustering and regional variation. Brain Res 137: 53-66.
177. Mensah PL, (1980) Distribution of the largest neuron in mouse caudate-putamen nucleus: its position in large-cell-medium-cell clusters. Exp Brain Res 38: 267-271.
178. Mereu G, Fadda F, Gessa GL, (1984) Ethanol stimulates the firing rate of nigral dopaminergic neurons in unanesthetized rats. Brain Res 292: 63-69.
179. Metaxas A, Bailey A, Barbano MF, Galeote L, Maldonado R, Kitchen I, (2010) Differential region-specific regulation of α4β2* nAChRs by self-administered and non-contingent nicotine in C57BL/6J mice. Addict Biol 15: 464-479.
180. Mickiewicz AL, Dallimore JE, Napier TC, (2009) The ventral pallidum is critically involved in the development and expression of morphine-induced sensitization. Neuropsychopharmacology 34: 874-886.
181. Miller EK, (2000) The prefrontal cortex and cognitive control. Nat Rev Neurosci 1: 59-65.
182. Miller JM, Vorel SR, Tranguch AJ, Kenny ET, Mazzoni P, van, Gorp WG, Kleber HD, (2006) Anhedonia after a selective bilateral lesion of the globus pallidus. Am J Psychiatry 163: 786-788.
183. Mitrano DA, Pare JF, Smith Y, (2010) Ultrastructural relationships between cortical, thalamic, and amygdala glutamatergic inputs and group I metabotropic glutamate receptors in the rat accumbens. J Comp Neurol 518: 1315-1329.
184. Moller C, Wiklund L, Sommer W, Thorsell A, Heilig M, (1997) Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions. Brain Res 760: 94-101.
185. Morgan MA, LeDoux JE, (1995) Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats. Behav Neurosci 109: 681-688.
186. Moro E, Lang AE, Strafella AP, Poon YY, Arango PM, Dagher A, Hutchison WD, Lozano AM, (2004) Bilateral globus pallidus stimulation for Huntington's disease. Ann Neurol 56: 290-294.
187. Muir JL, Everitt BJ, Robbins TW, (1996) The cerebral cortex of the rat and visual attentional function: dissociable effects of mediofrontal, cingulate, anterior dorsolateral, and parietal cortex lesions on a five-choice serial reaction time task. Cereb Cortex 6: 470-481.
188. Muller CP, Carey RJ, Huston JP, De Souza Silva MA, (2007) Serotonin and psychostimulant addiction: focus on 5-HT1A-receptors. Prog Neurobiol 81: 133-178.
189. Nakagawa T, Yamamoto R, Fujio M, Suzuki Y, Minami M, Satoh M, Kaneko S, (2005) Involvement of the bed nucleus of the stria terminalis activated by the central nucleus of the amygdala in the negative affective component of morphine withdrawal in rats. Neuroscience 134: 9-19.
190. Napier TC, Mickiewicz AL, (2010) The role of the ventral pallidum in psychiatric disorders. Neuropsychopharmacology 35: 337.
191. Naqvi NH, Bechara A, (2009) The hidden island of addiction: the insula. Trends Neurosci 32: 56-67.
192. Narabayashi H, (1997) Pallidotomy revisited. Analysis of posteroventral pallidotomy. Stereotact Funct Neurosurg 69: 54-61.
193. Newlin DB, Hotchkiss B, Cox WM, Rauscher F, Li TK, (1989) Autonomic and subjective responses to alcohol stimuli with appropriate control stimuli. Addict Behav 14: 625-630.
194. Nikolaus S, Huston JP, Hasenohrl RU, (2000) Anxiolytic-like effects in rats produced by ventral pallidal injection of both N- and C-terminal fragments of substance P. Neurosci Lett 283: 37-40.
195. Noori HR, (2011) The effects of the acute administration of low-dosage ethanol on the phasic neurochemical oscillations of the basal ganglia. Math Med Biol (in press).
196. Noori HR, (2012) Multi-scale modeling of complex neuronal networks: a view towards striatal cholinergic pattern formations. J Biol Phys (in press).
197. Noori HR, Jäger W, (2010) Neurochemical oscillations in the basal ganglia. Bull Math Biol 72: 133-147.
198. Nowak KL, McBride WJ, Lumeng L, Li TK, Murphy JM, (2000) Involvement of dopamine D2 autoreceptors in the ventral tegmental area on alcohol and saccharin intake of the alcohol-preferring P rat. Alcohol Clin Exp Res 24: 476-483.
199. Olds J, Milner P, (1954) Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. J Comp Physiol Psychol 47: 419-427.
200. Pan ZZ, Williams JT, (1989) Differential actions of cocaine and amphetamine on dorsal raphe neurons in vitro. J Pharmacol Exp Ther 251: 56-62.
201. Parent A, Hazrati LN, (1995) Functional anatomy of the basal ganglia. II. The place of subthalamic nucleus and external pallidum in basal ganglia circuitry. Brain Res Brain Res Rev 20: 128-154.
202. Parsons LH, Justice JB, Jr, (1993) Serotonin and dopamine sensitization in the nucleus accumbens, ventral tegmental area, and dorsal raphe nucleus following repeated cocaine administration. J Neurochem 61: 1611-1619.
203. Peoples LL, Cavanaugh D, (2003) Differential changes in signal and background firing of accumbal neurons during cocaine self-administration. J Neurophysiol 90: 993-1010.
204. Peoples LL, Uzwiak AJ, Gee F, Fabbricatore AT, Muccino KJ, Mohta BD, West MO, (1999) Phasic accumbal firing may contribute to the regulation of drug taking during intravenous cocaine self-administration sessions. Ann N Y Acad Sci 877: 781-787.
205. Peters J, Kalivas PW, Quirk GJ, (2009) Extinction circuits for fear and addiction overlap in prefrontal cortex. Learn Mem 16: 279-288.
206. Pitts DK, Marwah J, (1987) Cocaine modulation of central monoaminergic neurotransmission. Pharmacol Biochem Behav 26: 453-461.
207. Pontieri FE, Mainero C, La Riccia M, Passarelli F, Orzi F, (1995) Functional correlates of repeated administration of cocaine and apomorphine in the rat. Eur J Pharmacol 284: 205-209.
208. Porrino LJ, Daunais JB, Smith HR, Nader MA, (2004) The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administration. Neurosci Biobehav Rev 27: 813-820.
209. Prado-Alcala R, Streather A, Wise RA, (1984) Brain stimulation reward and dopamine terminal fields. II. Septal and cortical projections. Brain Res 301: 209-219.
210. Prado-Alcala R, Wise RA, (1984) Brain stimulation reward and dopamine terminal fields. I. Caudate-putamen, nucleus accumbens and amygdala. Brain Res 297: 265-273.
211. Price JL, Drevets WC, (2010) Neurocircuitry of mood disorders. Neuropsychopharmacology 35: 192-216.
212. Quinlan MG, Sharf R, Lee DY, Wise RA, Ranaldi R, (2004) Blockade of substantia nigra dopamine D1 receptors reduces intravenous cocaine reward in rats. Psychopharmacology (Berl) 175: 53-59.
213. Rademacher DJ, Rosenkranz JA, Morshedi MM, Sullivan EM, Meredith GE, (2010) Amphetamine-associated contextual learning is accompanied by structural and functional plasticity in the basolateral amygdala. J Neurosci 30: 4676-4686.
214. Reid MS, Flammino F, Starosta A, Palamar J, Franck J, (2006) Physiological and subjective responding to alcohol cue exposure in alcoholics and control subjects: evidence for appetitive responding. J Neural Transm 113: 1519-1535.
215. Risbrough VB, Hauger RL, Roberts AL, Vale WW, Geyer MA, (2004) Corticotropin-releasing factor receptors CRF1 and CRF2 exert both additive and opposing influences on defensive startle behavior. J Neurosci 24: 6545-6552.
216. Robbins TW, Everitt BJ, (2002) Limbic-striatal memory systems and drug addiction. Neurobiol Learn Mem 78: 625-636.
217. Robledo P, Koob GF, (1993) Two discrete nucleus accumbens projection areas differentially mediate cocaine self-administration in the rat. Behav Brain Res 55: 159-166.
218. Rocha BA, Scearce-Levie K, Lucas JJ, Hiroi N, Castanon N, Crabbe JC, Nestler EJ, Hen R, (1998) Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. Nature 393: 175-178.
219. Rodd ZA, Bell RL, Melendez RI, Kuc KA, Lumeng L, Li TK, Murphy JM, McBride WJ, (2004a) Comparison of intracranial self-administration of ethanol within the posterior ventral tegmental area between alcohol-preferring and Wistar rats. Alcohol Clin Exp Res 28: 1212-1219.
220. Rodd ZA, Bell RL, Zhang Y, Murphy JM, Goldstein A, Zaffaroni A, Li TK, McBride WJ, (2005) Regional heterogeneity for the intracranial self-administration of ethanol and acetaldehyde within the ventral tegmental area of alcohol-preferring (P) rats: involvement of dopamine and serotonin. Neuropsychopharmacology 30: 330-338.
221. Rodd ZA, Melendez RI, Bell RL, Kuc KA, Zhang Y, Murphy JM, McBride WJ, (2004b) Intracranial self-administration of ethanol within the ventral tegmental area of male Wistar rats: evidence for involvement of dopamine neurons. J Neurosci 24: 1050-1057.
222. Rodd-Henricks ZA, McKinzie DL, Melendez RI, Berry N, Murphy JM, McBride WJ, (2003) Effects of serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats. Psychopharmacology (Berl) 165: 252-259.
223. Rogers JL, Ghee S, See RE, (2008) The neural circuitry underlying reinstatement of heroin-seeking behavior in an animal model of relapse. Neuroscience 151: 579-588.
224. Rose M, (1928) Gyrus limbicus anterior und regio retrosplenialis (cortex holorotoptychos quinquenstraficatus). Vergleichende Architektonik bei Tier und Mensch. J Psychol. Neurol 35: 65-173.
225. Rouaud T, Lardeux S, Panayotis N, Paleressompoulle D, Cador M, Baunez C, (2010) Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation. Proc Natl Acad Sci USA 107: 1196-1200.
226. Rubin JE, Terman D, (2004) High frequency stimulation of the subthalamic nucleus eliminates pathological thalamic rhythmicity in a computational model. J Comput Neurosci 16: 211-235.
227. Ryabinin AE, Criado JR, Henriksen SJ, Bloom FE, Wilson MC, (1997) Differential sensitivity of c-Fos expression in hippocampus and other brain regions to moderate and low doses of alcohol. Mol Psychiatry 2: 32-43.
228. Sanchez MM, Young LJ, Plotsky PM, Insel TR, (1999) Autoradiographic and in situ hybridization localization of corticotropin-releasing factor 1 and 2 receptors in nonhuman primate brain. J Comp Neurol 408: 365-377.
229. Saper CB, (1982) Convergence of autonomic and limbic connections in the insular cortex of the rat. J Comp Neurol 210: 163-173.
230. Sarnyai Z, Shaham Y, Heinrichs SC, (2001) The role of corticotropin-releasing factor in drug addiction. Pharmacol Rev 53: 209-243.
231. Sartorius A, Henn FA, (2007) Deep brain stimulation of the lateral habenula in treatment resistant major depression. Med Hypotheses 69: 1305-1308.
232. Sartorius A, Kiening KL, Kirsch P, von, Gall CC, Haberkorn U, Unterberg AW, Henn FA, Meyer-Lindenberg A, (2010) Remission of major depression under deep brain stimulation of the lateral habenula in a therapy-refractory patient. Biol Psychiatry 67: 9-11.
233. Schultz W, (1998) Predictive reward signal of dopamine neurons. J Neurophysiol 80: 1-27.
234. Schumann G, Loth E, Banaschewski T, Barbot A, Barker G, Büchel C, Conrod PJ, Dalley JW, Flor H, Gallinat J, Garavan H, Heinz A, Itterman B, Lathrop M, Mallik C, Mann K, Martinot JL, Paus T, Poline JB, Robbins TW, Rietschel M, Reed L, Smolka M, Spanagel R, Speiser C, Stephens DN, Ströhle A, Struve M, IMAGEN Consortium (2010) The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology. Mol Psychiatry 15: 1128-1139.
235. Sesack SR, Deutch AY, Roth RH, Bunney BS, (1989) Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin. J Comp Neurol 290: 213-242.
236. Sesack SR, Grace AA, (2010) Cortico-Basal Ganglia reward network: microcircuitry. Neuropsychopharmacology 35: 27-47.
237. Sharma A, Brody AL, (2009) In vivo brain imaging of human exposure to nicotine and tobacco. Handb Exp Pharmacol 192: 145-171.
238. Shin LM, Liberzon I, (2010) The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology 35: 169-191.
239. Sommer WH, Rimondini R, Hansson AC, Hipskind PA, Gehlert DR, Barr CS, Heilig M, (2008) Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence. Biol Psychiatry 63: 139-145.
240. Sora I, Hall FS, Andrews AM, Itokawa M, Li XF, Wei HB, Wichems C, Lesch KP, Murphy DL, Uhl GR, (2001) Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proc Natl Acad Sci USA 98: 5300-5305.
241. Sora I, Wichems C, Takahashi N, Li XF, Zeng Z, Revay R, Lesch KP, Murphy DL, Uhl GR, (1998) Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. Proc Natl Acad Sci USA 95: 7699-7704.
242. Sotomayor R, Forray MI, Gysling K, (2005) Acute morphine administration increases extracellular DA levels in the rat lateral septum by decreasing the GABAergic inhibitory tone in the ventral tegmental area. J Neurosci Res 81: 132-139.
243. Spanagel R, (2009) Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiol Rev 89: 649-705.
244. Spanagel R, Bartsch D, Brors B, Dahmen N, Deussing J, Eils R, Ende G, Gallinat J, Gebicke-Haerter P, Heinz A, Kiefer F, Jager W, Mann K, Matthaus F, Nothen M, Rietschel M, Sartorius A, Schutz G, Sommer WH, Sprengel R, Walter H, Wichmann E, Wienker T, Wurst W, Zimmer A, (2010) An integrated genome research network for studying the genetics of alcohol addiction. Addict Biol 15: 369-379.
245. Spiga S, Lintas A, Migliore M, Diana M, (2010) Altered architecture and functional consequences of the mesolimbic dopamine system in cannabis dependence. Addict Biol 15: 266-276.
246. Sudai E, Croitoru O, Shaldubina A, Abraham L, Gispan I, Flaumenhaft Y, Roth-Deri I, Kinor N, Aharoni S, Ben-Tzion M, Yadid G, (2011) High cocaine dosage decreases neurogenesis in the hippocampus and impairs working memory. Addict Biol 16: 251-260.
247. Swanson LW, Cowan WM, (1979) The connections of the septal region in the rat. J Comp Neurol 186: 621-655.
248. Tabakoff B, Saba L, Kechris K, Hu W, Bhave SV, Finn DA, Grahame NJ, Hoffman PL, (2008) The genomic determinants of alcohol preference in mice. Mamm Genome 19: 352-365.
249. Takahashi Y, Roesch MR, Stalnaker TA, Schoenbaum G, (2007) Cocaine exposure shifts the balance of associative encoding from ventral to dorsolateral striatum. Front Integr Neurosci 1: 11.
250. Taraschenko OD, Shulan JM, Maisonneuve IM, Glick SD, (2007) 18-MC acts in the medial habenula and interpeduncular nucleus to attenuate dopamine sensitization to morphine in the nucleus accumbens. Synapse 61: 547-560.
251. Teuchert-Noodt G, Dawirs RR, Hildebrandt K, (2000) Adult treatment with methamphetamine transiently decreases dentate granule cell proliferation in the gerbil hippocampus. J Neural Transm 107: 133-143.
252. Timmerman W, Abercrombie ED, (1996) Amphetamine-induced release of dendritic dopamine in substantia nigra pars reticulata: D1-mediated behavioral and electrophysiological effects. Synapse 23: 280-291.
253. Tomasi D, Goldstein RZ, Telang F, Maloney T, Alia-Klein N, Caparelli EC, Volkow ND, (2007) Thalamo-cortical dysfunction in cocaine abusers: implications in attention and perception. Psychiatry Res 155: 189-201.
254. Trevitt T, Carlson B, Correa M, Keene A, Morales M, Salamone JD, (2002) Interactions between dopamine D1 receptors and gamma-aminobutyric acid mechanisms in substantia nigra pars reticulata of the rat: neurochemical and behavioral studies. Psychopharmacology (Berl) 159: 229-237.
255. Uhart M, Wand GS, (2009) Stress, alcohol and drug interaction: an update of human research. Addict Biol 14: 43-64.
256. Uslaner JM, Crombag HS, Ferguson SM, Robinson TE, (2003) Cocaine-induced psychomotor activity is associated with its ability to induce c-fos mRNA expression in the subthalamic nucleus: effects of dose and repeated treatment. Eur J Neurosci 17: 2180-2186.
257. Uylings HB, Groenewegen HJ, Kolb B, (2003) Do rats have a prefrontal cortex? Behav Brain Res 146: 3-17.
258. Valdez GR, Zorrilla EP, Roberts AJ, Koob GF, (2003) Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence. Alcohol 29: 55-60.
259. Varshavsky R, Horn D, Linial M, (2008) Global considerations in hierarchial clustering reveal meaningful patterns in data. PLoS ONE 3: e2247.
260. Vengeliene V, Celerier E, Chaskiel L, Penzo F, Spanagel R, (2009) Compulsive alcohol drinking in rodents. Addict Biol 14: 384-396.
261. Versace F, Minnix JA, Robinson JD, Lam CY, Brown VL, Cinciripini PM, (2011) Brain reactivity to emotional, neutral and cigarette-related stimuli in smokers. Addict Biol 16: 296-307.
262. Villegas E, Estruch R, Mengod G, Cortés R, (2011) NMDA receptors in frontal cortex and hippocampus of alcohol consumers. Addict Biol 16: 163-165.
263. Volkow ND, Fowler JS, Wang GJ, Swanson JM, (2004) Dopamine in drug abuse and addiction: results from imaging studies and treatment implications. Mol Psychiatry 9: 557-569.
264. Volkow ND, Tomasi D, Wang GJ, Fowler JS, Telang F, Goldstein RZ, Alia-Klein N, Wong C, (2011) Reduced metabolism in brain 'control networks' following cocaine-cues exposure in female cocaine abusers. PLoS ONE 6: e16573.
265. Volkow ND, Wang GJ, Fowler JS, Logan J, Gatley SJ, Hitzemann R, Chen AD, Dewey SL, Pappas N, (1997) Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects. Nature 386: 830-833.
266. Volkow ND, Wang GJ, Telang F, Fowler JS, Logan J, Childress AR, Jayne M, Ma Y, Wong C, (2006) Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction. J Neurosci 26: 6583-6588.
267. Vollstädt-Klein S, Kobiella A, Bühler M, Graf C, Fehr C, Mann K, Smolka MN, (2011) Severity of dependence modulates smokers' neuronal cue reactivity and cigarette craving elicited by tobacco advertisement. Addict Biol 16: 166-175.
268. Vorel SR, Liu X, Hayes RJ, Spector JA, Gardner EL, (2001) Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science 292: 1175-1178.
269. Vrana SL, Vrana KE, Koves TR, Smith JE, Dworkin SI, (1993) Chronic cocaine administration increases CNS tyrosine hydroxylase enzyme activity and mRNA levels and tryptophan hydroxylase enzyme activity levels. J Neurochem 61: 2262-2268.
270. Walaas I, (1983) The hippocampus. In:, Emson PC, ed. Chemical Neuroanatomy, pp. 337-358. New York: Raven Press.
271. Walker DL, Miles LA, Davis M, (2009) Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses. Prog Neuropsychopharmacol Biol Psychiatry 33: 1291-1308.
272. Walker JR, Ahmed SH, Gracy KN, Koob GF, (2000) Microinjections of an opiate receptor antagonist into the bed nucleus of the stria terminalis suppress heroin self-administration in dependent rats. Brain Res 854: 85-92.
273. Wang X, Cen X, Lu L, (2001) Noradrenaline in the bed nucleus of the stria terminalis is critical for stress-induced reactivation of morphine-conditioned place preference in rats. Eur J Pharmacol 432: 153-161.
274. Weber RJ, Gomez-Flores R, Smith JE, Martin TJ, (2009) Neuronal adaptations, neuroendocrine and immune correlates of heroin self-administration. Brain Behav Immun 23: 993-1002.
275. Weinshenker D, Schroeder JP, (2007) There and back again: a tale of norepinephrine and drug addiction. Neuropsychopharmacology 32: 1433-1451.
276. Weiss F, Lorang MT, Bloom FE, Koob GF, (1993) Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants. J Pharmacol Exp Ther 267: 250-258.
277. Whitelaw RB, Markou A, Robbins TW, Everitt BJ, (1996) Excitotoxic lesions of the basolateral amygdala impair the acquisition of cocaine-seeking behaviour under a second-order schedule of reinforcement. Psychopharmacology (Berl) 127: 213-224.
278. Wise RA, (2009) Roles for nigrostriatal-not just mesocorticolimbic- dopamine in reward and addiction. Trends Neurosci 32: 517-524.
279. Witjas T, Baunez C, Henry JM, Delfini M, Regis J, Cherif AA, Peragut JC, Azulay JP, (2005) Addiction in Parkinson's disease: impact of subthalamic nucleus deep brain stimulation. Mov Disord 20: 1052-1055.
280. Wu CW, Chua LO, (1995) Synchronization in an array of linearly coupled dynamical systems. IEEE Trans Circuits Syst 42: 430-447.
281. Yamamoto T, Takemura M, Inui T, Torii K, Maeda N, Ohmoto M, Matsumoto I, Abe K, (2009) Functional organization of the rodent parabrachial nucleus. Ann N Y Acad Sci 1170: 378-382.
282. Yim HJ, Gonzales RA, (2000) Ethanol-induced increases in dopamine extracellular concentration in rat nucleus accumbens are accounted for by increased release and not uptake inhibition. Alcohol 22: 107-115.
283. Yin HH, Mulcare SP, Hilario MR, Clouse E, Holloway T, Davis MI, Hansson AC, Lovinger DM, Costa RM, (2009) Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill. Nat Neurosci 12: 333-341.
284. Yokoi M, Mori K, Nakanishi S, (1995) Refinement of odor molecule tuning by dendrodendritic synaptic inhibition in the olfactory bulb. Proc Natl Acad Sci USA 92: 3371-3375.
285. You ZB, Wang B, Zitzman D, Azari S, Wise RA, (2007) A role for conditioned ventral tegmental glutamate release in cocaine seeking. J Neurosci 27: 10546-10555.
286. You ZB, Wang B, Zitzman D, Wise RA, (2008) Acetylcholine release in the mesocorticolimbic dopamine system during cocaine seeking: conditioned and unconditioned contributions to reward and motivation. J Neurosci 28: 9021-9029.
287. Yurek DM, Hipkens SB, (1993) Intranigral injections of SCH 23390 inhibit amphetamine-induced rotational behavior. Brain Res 623: 56-64.
288. Zahm DS, Brog JS, (1992) On the significance of subterritories in the 'accumbens' part of the rat ventral striatum. Neuroscience 50: 751-767.
289. Zahm DS, Heimer L, (1990) Two transpallidal pathways originating in the rat nucleus accumbens. J Comp Neurol 302: 437-446.
290. Zahm DS, Heimer L, (1993) Specificity in the efferent projections of the nucleus accumbens in the rat: comparison of the rostral pole projection patterns with those of the core and shell. J Comp Neurol 327: 220-232.
291. Zhang F, Zhou W, Liu H, Zhu H, Tang S, Lai M, Yang G, (2005) Increased c-Fos expression in the medial part of the lateral habenula during cue-evoked heroin-seeking in rats. Neurosci Lett 386: 133-137.