메뉴 건너뛰기




Volumn 292, Issue 5519, 2001, Pages 1175-1178

Relapse to cocaine-seeking after hippocampal theta burst stimulation

Author keywords

[No Author keywords available]

Indexed keywords

FIBERS; NEUROLOGY; PHARMACODYNAMICS;

EID: 0035843905     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1058043     Document Type: Article
Times cited : (428)

References (67)
  • 3
    • 9844233166 scopus 로고    scopus 로고
    • H. C. Breiter et al., Neuron 19, 591 (1997).
    • (1997) Neuron , vol.19 , pp. 591
    • Breiter, H.C.1
  • 5
    • 0033593639 scopus 로고    scopus 로고
    • G. J. Wang et al., Life Sci. 64, 775 (1999).
    • (1999) Life Sci. , vol.64 , pp. 775
    • Wang, G.J.1
  • 28
    • 0343720456 scopus 로고    scopus 로고
    • note
    • Before surgery, rats were trained to self-administer food. A monopolar electrode was implanted in the MFB (AP + 5.4, ML ± 1.6, DV +1.6), VSUB (AP + 2.7, ML ± 5.2, DV + 2.4), or CBL (AP - 2.6, ML ± 2.5, DV + 5.0); coordinates relative to interaural line (65). Electrical stimulations were constant-current injections administered by pulse generator and stimulus isolation unit. Currents were square, cathodal, pulse width 0.4 ms, intensity 400 μA 200 pulses per stimulation. Stimulation patterns were "sham": The rat was connected to the stimulation apparatus, but no actual electrical stimulation was delivered; 2-Hz repetitive; "theta burst": 40 trains of five pulses, frequency of trains 5 Hz, frequency of pulses within train 100 Hz. Means and variances of the number of lever presses of different treatment groups were compared with one-way analysis of variance and post-hoc Tukey tests.
  • 30
    • 0343284917 scopus 로고    scopus 로고
    • note
    • Bilateral guide cannulae (22 gauge) were implanted into VTA: AP + 4.2; ML ± 1.0; DV + 1.7. NMDA and KYN were dissolved in saline and the pH adjusted to 7.0 to 8.0 with NaOH. NMDA, KYN, and VEH were injected manually through inner cannulae (28 gauge) over 30 s in 0.5 μl; inner cannulae were left in place for 60 s after the injection. KYN or VEH were microinjected 15 min before electrical stimulation.
  • 41
    • 0343284910 scopus 로고    scopus 로고
    • note
    • "Intrinsic burst" stimulation: 67 trains of three pulses, frequency of trains 2 Hz, duration between first and second pulse within each train 60 ms, duration between second and third pulse 160 ms. Intracranial self-stimulation was done as described (66). During MFB self-stimulation, optimal stimulation intensity was determined for each rat and varied between -251 and -158 μA. Using this intensity, we applied "ICSS" priming stimulation: pulse width 0.1 ms, 20 trains of 64 pulses, interval between trains 1.0 s, interval between pulses within train 5.0 ms.
  • 67
    • 0343284901 scopus 로고    scopus 로고
    • note
    • We thank L. Brown, P. K. Stanton, and M. Makman for helpful suggestions; D. Colon for administrative assistance; and W. Paredes for technical support. Supported by the New York State Office of Mental Health, the New York State Office of Alcoholism and Substance Abuse Services, and the Julia Sullivan Medical Research Fund.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.