메뉴 건너뛰기




Volumn 90, Issue 8, 2012, Pages 755-762

The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance

Author keywords

B cell; inflammation; insulin resistance; obesity; T cell; visceral adipose tissue

Indexed keywords

ADIPOCYTOKINE; GAMMA INTERFERON; GLUCOSE; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTION FACTOR GATA 3; TUMOR NECROSIS FACTOR ALPHA;

EID: 84866358717     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2011.110     Document Type: Review
Times cited : (111)

References (92)
  • 2
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 2010; 72: 219-246.
    • (2010) Annu Rev Physiol , Issue.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 3
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumorassociated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: Tumorassociated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 2002; 23: 549-555.
    • (2002) Trends Immunol , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 5
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112: 1821-1830.
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3    Tan, G.4    Yang, D.5    Chou, C.J.6
  • 6
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007; 117: 175-184.
    • (2007) J Clin Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 7
    • 0034029201 scopus 로고    scopus 로고
    • Immunohistochemical and ultrastructural localization of leptin and leptin receptor in human white adipose tissue and differentiating human adipose cells in primary culture
    • Bornstein SR, Abu-Asab M, Glasow A, Path G, Hauner H, Tsokos M et al. Immunohistochemical and ultrastructural localization of leptin and leptin receptor in human white adipose tissue and differentiating human adipose cells in primary culture. Diabetes 2000; 49: 532-538.
    • (2000) Diabetes , vol.49 , pp. 532-538
    • Bornstein, S.R.1    Abu-Asab, M.2    Glasow, A.3    Path, G.4    Hauner, H.5    Tsokos, M.6
  • 9
    • 33847280286 scopus 로고    scopus 로고
    • T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity
    • Wu H, Ghosh S, Perrard XD, Feng L, Garcia GE, Perrard JL et al. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation 2007; 115: 1029-1038.
    • (2007) Circulation , vol.115 , pp. 1029-1038
    • Wu, H.1    Ghosh, S.2    Perrard, X.D.3    Feng, L.4    Garcia, G.E.5    Perrard, J.L.6
  • 10
    • 38149142633 scopus 로고    scopus 로고
    • Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration
    • Rausch ME, Weisberg S, Vardhana P, Tortoriello DV. Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes (Lond) 2008; 32: 451-463.
    • (2008) Int J Obes (Lond) , vol.32 , pp. 451-463
    • Rausch, M.E.1    Weisberg, S.2    Vardhana, P.3    Tortoriello, D.V.4
  • 11
    • 65649117802 scopus 로고    scopus 로고
    • Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity
    • Duffaut C, Galitzky J, Lafontan M, Bouloumie A. Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity. Biochem Biophys Res Commun 2009; 384: 482-485.
    • (2009) Biochem Biophys Res Commun , vol.384 , pp. 482-485
    • Duffaut, C.1    Galitzky, J.2    Lafontan, M.3    Bouloumie, A.4
  • 12
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 2009; 15: 914-920.
    • (2009) Nat Med , vol.15 , pp. 914-920
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3    Eto, K.4    Yamashita, H.5    Ohsugi, M.6
  • 14
    • 85027938385 scopus 로고    scopus 로고
    • B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
    • Winer DA, Winer S, Shen L, Wadia PP, Yantha J, Paltser G et al. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med 2011; 17: 610-617.
    • (2011) Nat Med , Issue.17 , pp. 610-617
    • Winer, D.A.1    Winer, S.2    Shen, L.3    Wadia, P.P.4    Yantha, J.5    Paltser, G.6
  • 15
    • 53149119231 scopus 로고    scopus 로고
    • Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding
    • Elgazar-Carmon V, Rudich A, Hadad N, Levy R. Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding. J Lipid Res 2008; 49: 1894-1903.
    • (2008) J Lipid Res , vol.49 , pp. 1894-1903
    • Elgazar-Carmon, V.1    Rudich, A.2    Hadad, N.3    Levy, R.4
  • 16
    • 50249150303 scopus 로고    scopus 로고
    • FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice
    • Kendall MR, Hupfeld CJ. FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice. Diabetes Obes Metab 2008; 10: 802-805.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 802-805
    • Kendall, M.R.1    Hupfeld, C.J.2
  • 19
    • 54049086276 scopus 로고    scopus 로고
    • Interferongamma, a Th1 cytokine, regulates fat inflammation: A role for adaptive immunity in obesity
    • Rocha VZ, Folco EJ, Sukhova G, Shimizu K, Gotsman I, Vernon AH et al. Interferongamma, a Th1 cytokine, regulates fat inflammation: A role for adaptive immunity in obesity. Circ Res 2008; 103: 467-476.
    • (2008) Circ Res , vol.103 , pp. 467-476
    • Rocha, V.Z.1    Folco, E.J.2    Sukhova, G.3    Shimizu, K.4    Gotsman, I.5    Vernon, A.H.6
  • 20
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesityassociated insulin resistance through immunotherapy
    • Winer S, Chan Y, Paltser G, Truong D, Tsui H, Bahrami J et al. Normalization of obesityassociated insulin resistance through immunotherapy. Nat Med 2009; 15: 921-929.
    • (2009) Nat Med , vol.15 , pp. 921-929
    • Winer, S.1    Chan, Y.2    Paltser, G.3    Truong, D.4    Tsui, H.5    Bahrami, J.6
  • 21
    • 70349150518 scopus 로고    scopus 로고
    • Depotspecific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue
    • O'Rourke RW, Metcalf MD, White AE, Madala A, Winters BR, Maizlin et al. Depotspecific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue. Int J Obes (Lond) 2009; 33: 978-990.
    • (2009) Int J Obes (Lond) , vol.33 , pp. 978-990
    • O'Rourke, R.W.1    Metcalf, M.D.2    White, A.E.3    Madala, A.4    Winters, B.R.5    Maizlin6
  • 22
    • 68349160704 scopus 로고    scopus 로고
    • Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
    • Liu J, Divoux A, Sun J, Zhang J, Clement K, Glickman JN et al. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med 2009; 15: 940-945.
    • (2009) Nat Med , vol.15 , pp. 940-945
    • Liu, J.1    Divoux, A.2    Sun, J.3    Zhang, J.4    Clement, K.5    Glickman, J.N.6
  • 23
    • 0035831494 scopus 로고    scopus 로고
    • Interferon-gamma-induced regulation of peroxisome proliferator-activated receptor gamma and STATs in adipocytes
    • Waite KJ, Floyd ZE, Arbour-Reily P, Stephens JM. Interferon-gamma-induced regulation of peroxisome proliferator-activated receptor gamma and STATs in adipocytes. J Biol Chem 2001; 276: 7062-7068.
    • (2001) J Biol Chem , vol.276 , pp. 7062-7068
    • Waite, K.J.1    Floyd, Z.E.2    Arbour-Reily, P.3    Stephens, J.M.4
  • 24
    • 70450277113 scopus 로고    scopus 로고
    • Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway
    • McGillicuddy FC, Chiquoine EH, Hinkle CC, Kim RJ, Shah R, Roche HM et al. Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. J Biol Chem 2009; 284: 31936-31944.
    • (2009) J Biol Chem , vol.284 , pp. 31936-31944
    • McGillicuddy, F.C.1    Chiquoine, E.H.2    Hinkle, C.C.3    Kim, R.J.4    Shah, R.5    Roche, H.M.6
  • 25
    • 0036830636 scopus 로고    scopus 로고
    • SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
    • Rui L, Yuan M, Frantz D, Shoelson S, White MF. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem 2002; 277: 42394-42398.
    • (2002) J Biol Chem , vol.277 , pp. 42394-42398
    • Rui, L.1    Yuan, M.2    Frantz, D.3    Shoelson, S.4    White, M.F.5
  • 26
    • 0035930605 scopus 로고    scopus 로고
    • SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice
    • Emanuelli B, Peraldi P, Filloux C, Chavey C, Freidinger K, Hilton DJ et al. SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. J Biol Chem 2001; 276: 47944-47949.
    • (2001) J Biol Chem , vol.276 , pp. 47944-47949
    • Emanuelli, B.1    Peraldi, P.2    Filloux, C.3    Chavey, C.4    Freidinger, K.5    Hilton, D.J.6
  • 28
    • 0020502358 scopus 로고
    • Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity
    • Nathan CF, Murray HW, Wiebe ME, Rubin BY. Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med 1983; 158: 670-689.
    • (1983) J Exp Med , vol.158 , pp. 670-689
    • Nathan, C.F.1    Murray, H.W.2    Wiebe, M.E.3    Rubin, B.Y.4
  • 30
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity 2004; 21: 467-476.
    • (2004) Immunity , vol.21 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 31
    • 79251589063 scopus 로고    scopus 로고
    • Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes
    • Jagannathan-Bogdan M, McDonnell ME, Shin H, Rehman Q, Hasturk H, Apovian CM et al. Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes. J Immunol 2011; 186: 1162-1172.
    • (2011) J Immunol , vol.186 , pp. 1162-1172
    • Jagannathan-Bogdan, M.1    McDonnell, M.E.2    Shin, H.3    Rehman, Q.4    Hasturk, H.5    Apovian, C.M.6
  • 32
    • 79957987902 scopus 로고    scopus 로고
    • State of the union between metabolism and the immune system in type 2 diabetes
    • Nikolajczyk BS, Jagannathan-Bogdan M, Shin H, Gyurko R. State of the union between metabolism and the immune system in type 2 diabetes. Genes Immun 2011; 12: 239-250.
    • (2011) Genes Immun , vol.12 , pp. 239-250
    • Nikolajczyk, B.S.1    Jagannathan-Bogdan, M.2    Shin, H.3    Gyurko, R.4
  • 34
    • 78650310810 scopus 로고    scopus 로고
    • The expanding family of innate lymphoid cells: Regulators and effectors of immunity and tissue remodeling
    • Spits H, Di Santo JP. The expanding family of innate lymphoid cells: Regulators and effectors of immunity and tissue remodeling. Nat Immunol 2011; 12: 21-27.
    • (2011) Nat Immunol , vol.12 , pp. 21-27
    • Spits, H.1    Di Santo, J.P.2
  • 35
    • 75149169811 scopus 로고    scopus 로고
    • Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in dietinduced obese mice
    • Ohmura K, Ishimori N, Ohmura Y, Tokuhara S, Nozawa A, Horii S et al. Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in dietinduced obese mice. Arterioscler Thromb Vasc Biol 2010; 30: 193-199.
    • (2010) Arterioscler Thromb Vasc Biol , Issue.30 , pp. 193-199
    • Ohmura, K.1    Ishimori, N.2    Ohmura, Y.3    Tokuhara, S.4    Nozawa, A.5    Horii, S.6
  • 36
    • 79958022995 scopus 로고    scopus 로고
    • Mice lacking NKT cells but with a complete complement of CD8+ T-cells are not protected against the metabolic abnormalities of diet-induced obesity
    • Mantell BS, Stefanovic-Racic M, Yang X, Dedousis N, Sipula IJ, O'Doherty RM. Mice lacking NKT cells but with a complete complement of CD8+ T-cells are not protected against the metabolic abnormalities of diet-induced obesity. PLoS One 2011; 6: E19831.
    • (2011) PLoS One , Issue.6
    • Mantell, B.S.1    Stefanovic-Racic, M.2    Yang, X.3    Dedousis, N.4    Sipula, I.J.5    O'Doherty, R.M.6
  • 37
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 2009; 15: 930-939.
    • (2009) Nat Med , vol.15 , pp. 930-939
    • Feuerer, M.1    Herrero, L.2    Cipolletta, D.3    Naaz, A.4    Wong, J.5    Nayer, A.6
  • 38
    • 79551529432 scopus 로고    scopus 로고
    • Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers
    • Deiuliis J, Shah Z, Shah N, Needleman B, Mikami D, Narula V et al. Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers. PLoS One 2011; 6: E16376.
    • (2011) PLoS One , vol.6
    • Deiuliis, J.1    Shah, Z.2    Shah, N.3    Needleman, B.4    Mikami, D.5    Narula, V.6
  • 39
    • 79953204947 scopus 로고    scopus 로고
    • Inflammation correlates with markers of T-cell subsets including regulatory T cells in adipose tissue from obese patients
    • Zeyda M, Huber J, Prager G, Stulnig TM. Inflammation correlates with markers of T-cell subsets including regulatory T cells in adipose tissue from obese patients. Obesity (Silver Spring) 2011; 19: 743-748.
    • (2011) Obesity (Silver Spring) , vol.19 , pp. 743-748
    • Zeyda, M.1    Huber, J.2    Prager, G.3    Stulnig, T.M.4
  • 40
    • 79959782887 scopus 로고    scopus 로고
    • Regulatory T cell plasticity: Beyond the controversies
    • Hori S. Regulatory T cell plasticity: Beyond the controversies. Trends Immunol 2011; 32: 295-300.
    • (2011) Trends Immunol , Issue.32 , pp. 295-300
    • Hori, S.1
  • 42
    • 80052277906 scopus 로고    scopus 로고
    • Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
    • Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y et al. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell 2011; 146: 772-784.
    • (2011) Cell , vol.146 , pp. 772-784
    • Dang, E.V.1    Barbi, J.2    Yang, H.Y.3    Jinasena, D.4    Yu, H.5    Zheng, Y.6
  • 43
    • 77953110535 scopus 로고    scopus 로고
    • Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice
    • Ilan Y, Maron R, Tukpah AM, Maioli TU, Murugaiyan G, Yang K et al. Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice. Proc Natl Acad Sci USA 2010; 107: 9765-9770.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 9765-9770
    • Ilan, Y.1    Maron, R.2    Tukpah, A.M.3    Maioli, T.U.4    Murugaiyan, G.5    Yang, K.6
  • 44
  • 45
    • 80053130719 scopus 로고    scopus 로고
    • An essential role of the transcription factor GATA-3 for the function of regulatory T cells
    • Wang Y, Su MA, Wan YY. An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity 2011; 35: 337-348.
    • (2011) Immunity , vol.35 , pp. 337-348
    • Wang, Y.1    Su, M.A.2    Wan, Y.Y.3
  • 46
    • 44349112305 scopus 로고    scopus 로고
    • Adipocytederived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
    • Kang K, Reilly SM, Karabacak V, Gangl MR, Fitzgerald K, Hatano B et al. Adipocytederived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab 2008; 7: 485-495.
    • (2008) Cell Metab , vol.7 , pp. 485-495
    • Kang, K.1    Reilly, S.M.2    Karabacak, V.3    Gangl, M.R.4    Fitzgerald, K.5    Hatano, B.6
  • 47
    • 0033595261 scopus 로고    scopus 로고
    • Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase
    • Huang JT, Welch JS, Ricote M, Binder CJ, Willson TM, Kelly C et al. Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. Nature 1999; 400: 378-382.
    • (1999) Nature , vol.400 , pp. 378-382
    • Huang, J.T.1    Welch, J.S.2    Ricote, M.3    Binder, C.J.4    Willson, T.M.5    Kelly, C.6
  • 50
    • 79953815551 scopus 로고    scopus 로고
    • Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
    • Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK et al. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 2011; 332: 243-247.
    • (2011) Science , vol.332 , pp. 243-247
    • Wu, D.1    Molofsky, A.B.2    Liang, H.E.3    Ricardo-Gonzalez, R.R.4    Jouihan, H.A.5    Bando, J.K.6
  • 51
    • 75749122181 scopus 로고    scopus 로고
    • Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    • Moro K, Yamada T, Tanabe M, Takeuchi T, Ikawa T, Kawamoto H et al. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 2010; 463: 540-544.
    • (2010) Nature , vol.463 , pp. 540-544
    • Moro, K.1    Yamada, T.2    Tanabe, M.3    Takeuchi, T.4    Ikawa, T.5    Kawamoto, H.6
  • 52
    • 67349103904 scopus 로고    scopus 로고
    • The inflammatory receptor CD40 is expressed on human adipocytes: Contribution to crosstalk between lymphocytes and adipocytes
    • Poggi M, Jager J, Paulmyer-Lacroix O, Peiretti F, Gremeaux T, Verdier M et al. The inflammatory receptor CD40 is expressed on human adipocytes: Contribution to crosstalk between lymphocytes and adipocytes. Diabetologia 2009; 52: 1152-1163.
    • (2009) Diabetologia , vol.52 , pp. 1152-1163
    • Poggi, M.1    Jager, J.2    Paulmyer-Lacroix, O.3    Peiretti, F.4    Gremeaux, T.5    Verdier, M.6
  • 53
    • 80052971178 scopus 로고    scopus 로고
    • CD40L deficiency ameliorates adipose tissue inflammation and metabolic manifestations of obesity in mice
    • Poggi M, Engel D, Christ A, Beckers L, Wijnands E, Boon L et al. CD40L deficiency ameliorates adipose tissue inflammation and metabolic manifestations of obesity in mice. Arterioscler Thromb Vasc Biol 2011; 31: 2251-2260.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 2251-2260
    • Poggi, M.1    Engel, D.2    Christ, A.3    Beckers, L.4    Wijnands, E.5    Boon, L.6
  • 54
    • 44749092181 scopus 로고    scopus 로고
    • Peripheral B cell subsets
    • Allman D, Pillai S. Peripheral B cell subsets. Curr Opin Immunol 2008; 20: 149-157.
    • (2008) Curr Opin Immunol , vol.20 , pp. 149-157
    • Allman, D.1    Pillai, S.2
  • 55
    • 22544470027 scopus 로고    scopus 로고
    • B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae
    • Haas KM, Poe JC, Steeber DA, Tedder TF. B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae. Immunity 2005; 23: 7-18.
    • (2005) Immunity , vol.23 , pp. 7-18
    • Haas, K.M.1    Poe, J.C.2    Steeber, D.A.3    Tedder, T.F.4
  • 56
    • 30744458329 scopus 로고    scopus 로고
    • A case for regulatory B cells
    • Mizoguchi A, Bhan AK. A case for regulatory B cells. J Immunol 2006; 176: 705-710.
    • (2006) J Immunol , vol.176 , pp. 705-710
    • Mizoguchi, A.1    Bhan, A.K.2
  • 57
    • 43049156086 scopus 로고    scopus 로고
    • A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses
    • Yanaba K, Bouaziz JD, Haas KM, Poe JC, Fujimoto M, Tedder TF. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 2008; 28: 639-650.
    • (2008) Immunity , vol.28 , pp. 639-650
    • Yanaba, K.1    Bouaziz, J.D.2    Haas, K.M.3    Poe, J.C.4    Fujimoto, M.5    Tedder, T.F.6
  • 58
    • 78751469622 scopus 로고    scopus 로고
    • Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells
    • Iwata Y, Matsushita T, Horikawa M, Dilillo DJ, Yanaba K, Venturi GM et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 2011; 117: 530-541.
    • (2011) Blood , vol.117 , pp. 530-541
    • Iwata, Y.1    Matsushita, T.2    Horikawa, M.3    Dilillo, D.J.4    Yanaba, K.5    Venturi, G.M.6
  • 59
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010; 140: 900-917.
    • (2010) Cell , Issue.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 61
    • 0037327274 scopus 로고    scopus 로고
    • Autoimmune islet destruction in spontaneous type 1 diabetes is not beta-cell exclusive
    • Winer S, Tsui H, Lau A, Song A, Li X, Cheung RK et al. Autoimmune islet destruction in spontaneous type 1 diabetes is not beta-cell exclusive. Nat Med 2003; 9: 198-205.
    • (2003) Nat Med , vol.9 , pp. 198-205
    • Winer, S.1    Tsui, H.2    Lau, A.3    Song, A.4    Li, X.5    Cheung, R.K.6
  • 62
    • 67349151367 scopus 로고    scopus 로고
    • Associations between autoantibodies against apolipoprotein B-100 peptides and vascular complications in patients with type 2 diabetes
    • Fredrikson GN, Anand DV, Hopkins D, Corder R, Alm R, Bengtsson E et al. Associations between autoantibodies against apolipoprotein B-100 peptides and vascular complications in patients with type 2 diabetes. Diabetologia 2009; 52: 1426-1433.
    • (2009) Diabetologia , vol.52 , pp. 1426-1433
    • Fredrikson, G.N.1    Anand, D.V.2    Hopkins, D.3    Corder, R.4    Alm, R.5    Bengtsson, E.6
  • 63
    • 66749138197 scopus 로고    scopus 로고
    • Autoantibodies in type 2 diabetes induce stress fiber formation and apoptosis in endothelial cells
    • Zimering MB, Pan Z. Autoantibodies in type 2 diabetes induce stress fiber formation and apoptosis in endothelial cells. J Clin Endocrinol Metab 2009; 94: 2171-2177.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 2171-2177
    • Zimering, M.B.1    Pan, Z.2
  • 64
    • 67651246858 scopus 로고    scopus 로고
    • Sera from patients with type 2 diabetes contain agonistic autoantibodies against G proteincoupled receptors
    • Hempel P, Karczewski P, Kohnert KD, Raabe J, Lemke B, Kunze R et al. Sera from patients with type 2 diabetes contain agonistic autoantibodies against G proteincoupled receptors. Scand J Immunol 2009; 70: 159-160.
    • (2009) Scand J Immunol , vol.70 , pp. 159-160
    • Hempel, P.1    Karczewski, P.2    Kohnert, K.D.3    Raabe, J.4    Lemke, B.5    Kunze, R.6
  • 65
    • 77958537881 scopus 로고    scopus 로고
    • Post-streptococcal autoantibodies inhibit protein disulfide isomerase and are associated with insulin resistance
    • Aran A, Weiner K, Lin L, Finn LA, Greco MA, Peppard P et al. Post-streptococcal autoantibodies inhibit protein disulfide isomerase and are associated with insulin resistance. PLoS One 2010; 5: E12875.
    • (2010) PLoS One , vol.5
    • Aran, A.1    Weiner, K.2    Lin, L.3    Finn, L.A.4    Greco, M.A.5    Peppard, P.6
  • 67
    • 77955653584 scopus 로고    scopus 로고
    • Toll-like receptors regulate B cell cytokine production in patients with diabetes
    • Jagannathan M, McDonnell M, Liang Y, Hasturk H, Hetzel J, Rubin D et al. Toll-like receptors regulate B cell cytokine production in patients with diabetes. Diabetologia 2010; 53: 1461-1471.
    • (2010) Diabetologia , Issue.53 , pp. 1461-1471
    • Jagannathan, M.1    McDonnell, M.2    Liang, Y.3    Hasturk, H.4    Hetzel, J.5    Rubin, D.6
  • 69
    • 69949150673 scopus 로고    scopus 로고
    • A crucial role for adipose tissue p53 in the regulation of insulin resistance
    • Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, Ito T et al. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med 2009; 15: 1082-1087.
    • (2009) Nat Med , vol.15 , pp. 1082-1087
    • Minamino, T.1    Orimo, M.2    Shimizu, I.3    Kunieda, T.4    Yokoyama, M.5    Ito, T.6
  • 71
    • 34047119110 scopus 로고    scopus 로고
    • Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation
    • Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S, Segawa K et al. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 2007; 56: 901-911.
    • (2007) Diabetes , vol.56 , pp. 901-911
    • Hosogai, N.1    Fukuhara, A.2    Oshima, K.3    Miyata, Y.4    Tanaka, S.5    Segawa, K.6
  • 73
    • 77449083262 scopus 로고    scopus 로고
    • Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis
    • Alkhouri N, Gornicka A, Berk MP, Thapaliya S, Dixon LJ, Kashyap S et al. Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis. J Biol Chem 2010; 285: 3428-3438.
    • (2010) J Biol Chem , vol.285 , pp. 3428-3438
    • Alkhouri, N.1    Gornicka, A.2    Berk, M.P.3    Thapaliya, S.4    Dixon, L.J.5    Kashyap, S.6
  • 74
    • 74949138985 scopus 로고    scopus 로고
    • Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice
    • Wueest S, Rapold RA, Schumann DM, Rytka JM, Schildknecht A, Nov O et al. Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. J Clin Invest 2010; 120: 191-202.
    • (2010) J Clin Invest , vol.120 , pp. 191-202
    • Wueest, S.1    Rapold, R.A.2    Schumann, D.M.3    Rytka, J.M.4    Schildknecht, A.5    Nov, O.6
  • 75
    • 27444437321 scopus 로고    scopus 로고
    • Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    • Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 2005; 46: 2347-2355.
    • (2005) J Lipid Res , vol.46 , pp. 2347-2355
    • Cinti, S.1    Mitchell, G.2    Barbatelli, G.3    Murano, I.4    Ceresi, E.5    Faloia, E.6
  • 76
    • 0035907302 scopus 로고    scopus 로고
    • Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
    • Lee JY, Sohn KH, Rhee SH, Hwang D. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem 2001; 276: 16683-16689.
    • (2001) J Biol Chem , vol.276 , pp. 16683-16689
    • Lee, J.Y.1    Sohn, K.H.2    Rhee, S.H.3    Hwang, D.4
  • 77
    • 36849005372 scopus 로고    scopus 로고
    • A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
    • Nguyen MT, Favelyukis S, Nguyen AK, Reichart D, Scott PA, Jenn A et al. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem 2007; 282: 35279-35292.
    • (2007) J Biol Chem , vol.282 , pp. 35279-35292
    • Nguyen, M.T.1    Favelyukis, S.2    Nguyen, A.K.3    Reichart, D.4    Scott, P.A.5    Jenn, A.6
  • 78
    • 67949091182 scopus 로고    scopus 로고
    • Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated fatty acid/toll-like receptor 4 signaling and macrophage activation in obese adipose tissue
    • Suganami T, Yuan X, Shimoda Y, Uchio-Yamada K, Nakagawa N, Shirakawa I et al. Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated fatty acid/toll-like receptor 4 signaling and macrophage activation in obese adipose tissue. Circ Res 2009; 105: 25-32.
    • (2009) Circ Res , vol.105 , pp. 25-32
    • Suganami, T.1    Yuan, X.2    Shimoda, Y.3    Uchio-Yamada, K.4    Nakagawa, N.5    Shirakawa, I.6
  • 80
    • 70350389389 scopus 로고    scopus 로고
    • Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice
    • Saberi M, Woods NB, de Luca C, Schenk S, Lu JC, Bandyopadhyay G et al. Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab 2009; 10: 419-429.
    • (2009) Cell Metab , vol.10 , pp. 419-429
    • Saberi, M.1    Woods, N.B.2    De Luca, C.3    Schenk, S.4    Lu, J.C.5    Bandyopadhyay, G.6
  • 82
    • 79955038882 scopus 로고    scopus 로고
    • Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
    • Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 2011; 12: 408-415.
    • (2011) Nat Immunol , vol.12 , pp. 408-415
    • Wen, H.1    Gris, D.2    Lei, Y.3    Jha, S.4    Zhang, L.5    Huang, M.T.6
  • 83
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar B, Youm YH, Ravussin A, Galgani JE, Stadler K, Mynatt RL et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 2011; 17: 179-188.
    • (2011) Nat Med , vol.17 , pp. 179-188
    • Vandanmagsar, B.1    Youm, Y.H.2    Ravussin, A.3    Galgani, J.E.4    Stadler, K.5    Mynatt, R.L.6
  • 84
    • 75649096002 scopus 로고    scopus 로고
    • Thioredoxin-interacting protein links oxidative stress to inflammasome activation
    • Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol 2010; 11: 136-140.
    • (2010) Nat Immunol , vol.11 , pp. 136-140
    • Zhou, R.1    Tardivel, A.2    Thorens, B.3    Choi, I.4    Tschopp, J.5
  • 85
    • 60749104683 scopus 로고    scopus 로고
    • The inflammasome: A caspase-1-activation platform that regulates immune responses and disease pathogenesis
    • Franchi L, Eigenbrod T, Munoz-Planillo R, Nunez G. The inflammasome: A caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 2009; 10: 241-247.
    • (2009) Nat Immunol , vol.10 , pp. 241-247
    • Franchi, L.1    Eigenbrod, T.2    Munoz-Planillo, R.3    Nunez, G.4
  • 86
    • 77951800951 scopus 로고    scopus 로고
    • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    • Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 2010; 464: 1357-1361.
    • (2010) Nature , vol.464 , pp. 1357-1361
    • Duewell, P.1    Kono, H.2    Rayner, K.J.3    Sirois, C.M.4    Vladimer, G.5    Bauernfeind, F.G.6
  • 87
    • 82255164680 scopus 로고    scopus 로고
    • Deficiency for costimulatory receptor 4-1BB protects against obesity-induced inflammation and metabolic disorders
    • Kim CS, Kim JG, Lee BJ, Choi MS, Choi HS, Kawada T et al. Deficiency for costimulatory receptor 4-1BB protects against obesity-induced inflammation and metabolic disorders. Diabetes 2011; 60: 3159-3168.
    • (2011) Diabetes , vol.60 , pp. 3159-3168
    • Kim, C.S.1    Kim, J.G.2    Lee, B.J.3    Choi, M.S.4    Choi, H.S.5    Kawada, T.6
  • 88
    • 77956396699 scopus 로고    scopus 로고
    • Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: Implications for systemic inflammation and insulin resistance
    • Yang H, Youm YH, Vandanmagsar B, Ravussin A, Gimble JM, Greenway F et al. Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: Implications for systemic inflammation and insulin resistance. J Immunol 2010; 185: 1836-1845.
    • (2010) J Immunol , vol.185 , pp. 1836-1845
    • Yang, H.1    Youm, Y.H.2    Vandanmagsar, B.3    Ravussin, A.4    Gimble, J.M.5    Greenway, F.6
  • 90
  • 91
    • 80052021813 scopus 로고    scopus 로고
    • Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases
    • Talukdar S, Olefsky JM, Osborn O. Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases. Trends Pharmacol Sci 2011; 32: 543-550.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 543-550
    • Talukdar, S.1    Olefsky, J.M.2    Osborn, O.3
  • 92
    • 80052157340 scopus 로고    scopus 로고
    • Bariatric surgery reduces visceral adipose inflammation and improves endothelial function in type 2 diabetic mice
    • Zhang H, Wang Y, Zhang J, Potter BJ, Sowers JR, Zhang C. Bariatric surgery reduces visceral adipose inflammation and improves endothelial function in type 2 diabetic mice. Arterioscler Thromb Vasc Biol 2011; 31: 2063-2069.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 2063-2069
    • Zhang, H.1    Wang, Y.2    Zhang, J.3    Potter, B.J.4    Sowers, J.R.5    Zhang, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.