The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling

Journal of Endocrinology

Volumn 214, Issue 3, 2012, Pages 241-255

  Staines, Katherine A ^a   MacRae, Vicky E ^a   Farquharson, Colin ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BONE SIALOPROTEIN; DENTIN MATRIX PROTEIN 1; DENTIN SIALOPHOSPHOPROTEIN; GLYCOPROTEIN; MATRIX EXTRACELLULAR PHOSPHOGLYCOPROTEIN; OSTEOPONTIN; SIALOPROTEIN; SMALL ACIDIC SERINE AND ASPIRATE RICH MOTIF PEPTIDE; SMALL INTEGRIN BINDING LIGAND N LINKED GLYCOPROTEIN; UNCLASSIFIED DRUG;

BONE MINERALIZATION; BONE REMODELING; CARTILAGE CELL; HUMAN; HYPOPHOSPHATEMIA; NONHUMAN; OSTEOARTHRITIS; OSTEOBLAST; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROCESSING; REVIEW; SMALL ACIDIC SERINE AND ASPIRATE RICH MOTIF; WNT SIGNALING PATHWAY;

ANIMALS; BONE REMODELING; CALCIFICATION, PHYSIOLOGIC; EXTRACELLULAR MATRIX PROTEINS; GLYCOPROTEINS; HUMANS; INTEGRIN-BINDING SIALOPROTEIN; INTEGRINS; OSTEOPONTIN; PHOSPHOPROTEINS; SIALOGLYCOPROTEINS;

EID: 84866300463     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-12-0143     Document Type: Review

References (181)

1. Addison WN, Azari F, Sorensen ES, Kaartinen MT & McKee MD .2007 Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity. Journal of Biological Chemistry 282 15872-15883.
2. Addison WN, Nakano Y, Loisel T, Crine P & McKee MD .2008 MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM. Journal of Bone and Mineral Research 23 1638-1649.
3. Addison WN, Masica DL, Gray JJ & McKee MD. 2010 Phosphorylationdependent inhibition of mineralization by osteopontin ASARM peptides is regulated by PHEX cleavage. Journal of Bone and Mineral Research 25 695-705.
4. Alvares K, Kanwar YS & Veis A. 2006 Expression and potential role of dentin phosphophoryn (DPP) in mouse embryonic tissues involved in epithelial-mesenchymal interactions and branching morphogenesis. Developmental Dynamics 235 2980-2990.
5. Anderson HC .1995 Molecular biology of matrix vesicles. Clinical Orthopaedics and Related Research 314 266-280.
6. Anderson HC 2003 Matrix vesicles and calcification. Current Rheumatology Reports 5 222-226.
7. Argiro L, Desbarats M, Glorieux FH & Ecarot B 2001 Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. Genomics 74 342-351.
8. Aruffo A, Stamenkovic I, Melnick M, Underhill CB & Seed B 1990 CD44 is the principal cell surface receptor for hyaluronate. Cell 61 1303-1313.
9. Atkins GJ, Rowe PS, Lim HP, Welldon KJ, Ormsby R, Wijenayaka AR, Zelenchuk L, Evdokiou A & Findlay DM 2011 Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism. Journal of Bone and Mineral Research 26 1425-1436.
10. Baba O, Qin C, Brunn JC, Wygant JN, McIntyre BW & Butler WT 2004 Colocalization of dentin matrix protein 1 and dentin sialoprotein at late stages of rat molar development. Matrix Biology 23 371-379.
11. Baht GS, Hunter GK & Goldberg HA 2008 Bone sialoprotein-collagen interaction promotes hydroxyapatite nucleation. Matrix Biology 27 600-608.
12. Ballock RT & O'Keefe RJ 2003 The biology of the growth plate. Journal of Bone and Joint Surgery 85-A 715-726.
13. Beck GR Jr & Knecht N 2003 Osteopontin regulation by inorganic phosphate is ERK1/2-, protein kinase C-, and proteasome-dependent. Journal of Biological Chemistry 278 41921-41929.
14. Beck GR Jr, Zerler B & Moran E 2000 Phosphate is a specific signal for induction of osteopontin gene expression. PNAS 97 8352-8357.
15. Bellahcene A, Castronovo V, Ogbureke KU, Fisher LW & Fedarko NS 2008 Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer. Nature Reviews. Cancer 8 212-226.
16. Bianco P, Fisher LW, Young MF, Termine JD & Robey PG 1991 Expression of bone sialoprotein (BSP) in developing human tissues. Calcified Tissue International 49 421-426.
17. Boskey AL, Maresca M, Doty S, Sabsay B & Veis A 1990 Concentrationdependent effects of dentin phosphophoryn in the regulation of in vitro hydroxyapatite formation and growth. Bone and Mineral 11 55-65.
18. Boskey AL, Maresca M, UllrichW, Doty SB, Butler WT & Prince CW 1993 Osteopontin-hydroxyapatite interactions in vitro: inhibition of hydroxyapatite formation and growth in a gelatingel. Bone and Mineral 22 147-159.
19. Boskey AL, Spevak L, Paschalis E, Doty SB & McKee MD 2002 Osteopontin deficiency increases mineral content and mineral crystallinity in mouse bone. Calcified Tissue International 71 145-154.
20. Boskey AL, Chiang P, Fermanis A, Brown J, Taleb H, David V & Rowe PS 2009 MEPE's diverse effects on mineralization. Calcified Tissue International 86 42-46.
21. Boskey AL, Christensen B, Taleb H & Sorensen ES 2012 Post-translational modification of osteopontin: effects on in vitro hydroxyapatite formation and growth. Biochemical and Biophysical Research Communications 419 333-338.
22. Boukpessi T, Gaucher C, Leger T, Salmon B, Le FJ, Willig C, Rowe PS, Garabedian M, Meilhac O & Chaussain C 2010 Abnormal presence of the matrix extracellular phosphoglycoprotein-derived acidic serine- and aspartate-rich motif peptide in human hypophosphatemic dentin. American Journal of Pathology 177 803-812.
23. Bowe AE, Finnegan R, Jan de Beur SM, Cho J, Levine MA, Kumar R & Schiavi SC 2001 FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate. Biochemical and Biophysical Research Communications 284 977-981.
24. Bresler D, Bruder J, Mohnike K, Fraser WD & Rowe PS 2004 Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets. Journal of Endocrinology 183 R1-R9.
25. Carpenter TO, Imel EA, Holm IA, Jan de Beur SM & Insogna KL 2011 A clinician's guide to X-linked hypophosphatemia. Journal of Bone and Mineral Research 26 1381-1388.
26. Castagnola P, Dozin B, Moro G & Cancedda R 1988 Changes in the expression of collagen genes show two stages in chondrocyte differentiation in vitro. Journal of Cell Biology 106 461-467.
27. Chan BY, Fuller ES, Russell AK, Smith SM, Smith MM, Jackson MT, Cake MA, Read RA, Bateman JF, Sambrook PN et al. 2011 Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis. Osteoarthritis and Cartilage 19 874-885.
28. Chellaiah MA, Kizer N, Biswas R, Alvarez U, Strauss-Schoenberger J, Rifas L, Rittling SR, Denhardt DT & Hruska KA 2003 Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression. Molecular Biology of the Cell 14 173-189.
29. Chen JK, Shapiro HS, Wrana JL, Reimers S, Heersche JN & Sodek J 1991 Localization of bone sialoprotein (BSP) expression to sites of mineralized tissue formation in fetal rat tissues by in situ hybridization. Matrix 11 133-143.
30. Chen J, Shapiro HS & Sodek J 1992 Development expression of bone sialoprotein mRNA in rat mineralized connective tissues. Journal of Bone and Mineral Research 7 987-997.
31. Chen S, Gluhak-Heinrich J, Martinez M, Li T, Wu Y, Chuang HH, Chen L, Dong J, Gay I & MacDougall M 2008 Bone morphogenetic protein 2 mediates dentin sialophosphoprotein expression and odontoblast differentiation via NF-Y signaling. Journal of Biological Chemistry 283 19359-19370.
32. Cho YD, Yoon WJ, Woo KM, Baek JH, Park JC & Ryoo HM 2010 The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2. Journal of Biological Chemistry 285 36369-36376.
33. Cho YD, Kim WJ, Yoon WJ, Woo KM, Baek JH, Lee G, Kim GS & Ryoo HM 2011 Wnt3a stimulates Mepe, matrix extracellular phosphoglycoprotein, expression directly by the activation of the canonical Wnt signaling pathway and indirectly through the stimulation of autocrine Bmp-2 expression. Journal of Cellular Physiology 227 2287-2296.
34. Cooper LF, Yliheikkila PK, Felton DA & Whitson SW 1998 Spatiotemporal assessment of fetal bovine osteoblast culture differentiation indicates a role for BSP in promoting differentiation. Journal of Bone and Mineral Research 13 620-632.
35. David V, Martin A, Hedge AM & Rowe PS 2009 Matrix extracellular phosphoglycoprotein (MEPE) is a new bone renal hormone and vascularization modulator. Endocrinology 150 4012-4023.
36. David V, Martin AC, Hedge AM, Drezner MK & Rowe PS 2010 ASARM peptides: PHEX-dependent, independent regulation of serum phosphate. American Journal of Physiology - Renal Physiology 300 F783-F791.
37. Delgado-Calle J, Arozamena J, Garcia-Renedo R, Garcia-Ibarbia C, Pascual-Carra MA, Gonzalez-Macias J & Riancho JA 2011 Osteocyte deficiency in hip fractures. Calcified Tissue International 89 327-334.
38. Denhardt DT & Guo X 1993 Osteopontin: a protein with diverse functions. FASEB Journal 7 1475-1482.
39. Dobbie H, Unwin RJ, Faria NJ & Shirley DG 2008 Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption. Nephrology, Dialysis, Transplantation 23 730-733.
40. Dodds RA, Connor JR, James IE, Rykaczewski EL, Appelbaum E, Dul E & Gowen M 1995 Human osteoclasts, not osteoblasts, deposit osteopontin onto resorption surfaces: an in vitro and ex vivo study of remodeling bone. Journal of Bone and Mineral Research 10 1666-1680.
41. Eapen A, Ramachandran A, Pratap J & George A 2011 Activation of the ERK1/2 mitogen-activated protein kinase cascade by dentin matrix protein 1 promotes osteoblast differentiation. Cells, Tissues, Organs 194 255-260.
42. Ecarot B & Desbarats M 1999 1,25-(OH)2D3 down-regulates expression of Phex, a marker of the mature osteoblast. Endocrinology 140 1192-1199.
43. Ecarot B, Glorieux FH, Desbarats M, Travers R & Labelle L 1992 Effect of dietary phosphate deprivation and supplementation of recipient mice on bone formation by transplanted cells from normal and X-linked hypophosphatemic mice. Journal of Bone and Mineral Research 7 523-530.
44. Farrow EG, Davis SI,Ward LM, Summers LJ, Bubbear JS, Keen R, Stamp TC, Baker LR, Bonewald LF &White KE 2009 Molecular analysis of DMP1 mutants causing autosomal recessive hypophosphatemic rickets. Bone 44 287-294.
45. Fen JQ, Zhang J, Dallas SL, Lu Y, Chen S, Tan X, Owen M, Harris SE & MacDougall M 2002 Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene. Journal of Bone and Mineral Research 17 1822-1831.
46. Feng JQ, Huang H, Lu Y, Ye L, Xie Y, Tsutsui TW, Kunieda T, Castranio T, Scott G, Bonewald LB et al. 2003 The dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. Journal of Dental Research 82 776-780.
47. Feng JQ, Ward LM, Liu S, Lu Y, Xie Y, Yuan B, Yu X, Rauch F, Davis SI, Zhang S et al. 2006 Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nature Genetics 38 1310-1315.
48. Fisher LW& Fedarko NS 2003 Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins. Connective Tissue Research 44 (Suppl 1) 33-40.
49. Fisher LW, Torchia DA, Fohr B, Young MF & Fedarko NS 2001 Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontin. Biochemical and Biophysical Research Communications 280 460-465.
50. Frost HM 1990 Skeletal structural adaptations to mechanical usage (SATMU): 1. Redefining Wolff 's law: the bone modeling problem. Anatomical Record 226 403-413.
51. Fujihara S, Yokozeki M, Oba Y, Higashibata Y, Nomura S & Moriyama K 2006 Function and regulation of osteopontin in response to mechanical stress. Journal of Bone and Mineral Research 21 956-964.
52. Ganss B, Kim RH & Sodek J 1999 Bone sialoprotein. Critical Reviews in Oral Biology and Medicine 10 79-98.
53. Gentili C & Cancedda R 2009 Cartilage and bone extracellular matrix. Current Pharmaceutical Design 15 1334-1348.
54. George A, Sabsay B, Simonian PA & Veis A 1993 Characterization of a novel dentin matrix acidic phosphoprotein, Implications for induction of biomineralization. Journal of Biological Chemistry 268 12624-12630.
55. Gericke A, Qin C, Sun Y, Redfern R, Redfern D, Fujimoto Y, Taleb H, Butler WT & Boskey AL 2010 Different forms of DMP1 play distinct roles in mineralization. Journal of Dental Research 89 355-359.
56. Gluhak-Heinrich J, Pavlin D, Yang W, MacDougall M & Harris SE 2007 MEPE expression in osteocytes during orthodontic tooth movement. Archives of Oral Biology 52 684-690.
57. Golub EE 2011 Biomineralization and matrix vesicles in biology and pathology. Seminars in Immunopathology 33 409-417.
58. Gordon JA, Tye CE, Sampaio AV, Underhill TM, Hunter GK & Goldberg HA 2007 Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralization in vitro. Bone 41 462-473.
59. Gowen LC, Petersen DN, Mansolf AL, Qi H, Stock JL, Tkalcevic GT, Simmons HA, Crawford DT, Chidsey-Frink KL, Ke HZ et al. 2003 Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass. Journal of Biological Chemistry 278 1998-2007.
60. Gross TS, King KA, Rabaia NA, Pathare P & Srinivasan S 2005 Upregulation of osteopontin by osteocytes deprived of mechanical loading or oxygen. Journal of Bone and Mineral Research 20 250-256.
61. Guo R, Rowe PS, Liu S, Simpson LG, Xiao ZS & Quarles LD 2002 Inhibition of MEPE cleavage by Phex. Biochemical and Biophysical Research Communications 297 38-45.
62. Hakim FT, Cranley R, Brown KS, Eanes ED, Harne L & Oppenheim JJ 1984 Hereditary joint disorder in progressive ankylosis (ank/ank) mice. I. Association of calcium hydroxyapatite deposition with inflammatory arthropathy. Arthritis and Rheumatism 27 1411-1420.
63. Harmey D, Johnson KA, Zelken J, Camacho NP, Hoylaerts MF, Noda M, Terkeltaub R & Millan JL 2006 Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice. Journal of Bone and Mineral Research 21 1377-1386.
64. Harris NL, Rattray KR, Tye CE, Underhill TM, Somerman MJ, D'Errico JA, Chambers AF, Hunter GK & Goldberg HA 2000 Functional analysis of bone sialoprotein: identification of the hydroxyapatite-nucleating and cellbinding domains by recombinant peptide expression and site-directed mutagenesis. Bone 27 795-802.
65. Hasegawa M, Segawa T, Maeda M, Yoshida T & Sudo A 2011 Thrombincleaved osteopontin levels in synovial fluid correlate with disease severity of knee osteoarthritis. Journal of Rheumatology 38 129-134.
66. Hayashibara T, Hiraga T, Yi B, Nomizu M, Kumagai Y, Nishimura R & Yoneda T 2004 A synthetic peptide fragment of human MEPE stimulates new bone formation in vitro and in vivo. Journal of Bone and Mineral Research 19 455-462.
67. Hayashibara T, Hiraga T, Sugita A,Wang L, Hata K, Ooshima T & Yoneda T 2007 Regulation of osteoclast differentiation and function by phosphate: potential role of osteoclasts in the skeletal abnormalities in hypophosphatemic conditions. Journal of Bone and Mineral Research 22 1743-1751.
68. He G, Dahl T, Veis A & George A 2003 Dentin matrix protein 1 initiates hydroxyapatite formation in vitro. Connective Tissue Research 44 (Suppl 1) 240-245.
69. He G, Ramachandran A, Dahl T, George S, Schultz D, Cookson D, Veis A & George A 2005 Phosphorylation of phosphophoryn is crucial for its function as a mediator of biomineralization. Journal of Biological Chemistry 280 33109-33114.
70. Heinegard D 2009 Proteoglycans and more - from molecules to biology. International Journal of Experimental Pathology 90 575-586.
71. Henriksen K, Neutzsky-Wulff AV, Bonewald LF & Karsdal MA 2009 Local communication on and within bone controls bone remodeling. Bone 44 1026-1033.
72. Hessle L, Johnson KA, Anderson HC, Narisawa S, Sali A, Goding JW, Terkeltaub R & Millan JL 2002 Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. PNAS 99 9445-9449.
73. Hill PA 1998 Bone remodelling. British Journal of Orthodontics 25 101-107.
74. Ho AM, Johnson MD & Kingsley DM 2000 Role of the mouse ank gene in control of tissue calcification and arthritis. Science 289 265-270.
75. Holm IA, Huang X & Kunkel LM 1997 Mutational analysis of the PEX gene in patients with X-linked hypophosphatemic rickets. American Journal of Human Genetics 60 790-797.
76. Hopwood B, Tsykin A, Findlay DM & Fazzalari NL 2007 Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signalling. Arthritis Research and Therapy 9 R100.
77. Houston B, Paton IR, Burt DW & Farquharson C 2002 Chromosomal localization of the chicken and mammalian orthologues of the orphan phosphatase PHOSPHO1 gene. Animal Genetics 33 451-454.
78. Huang B, Maciejewska I, Sun Y, Peng T, Qin D, Lu Y, Bonewald L, Butler WT, Feng J & Qin C 2008 Identification of full-length dentin matrix protein 1 in dentin and bone. Calcified Tissue International 82 401-410.
79. Huesa C, Yadav MC, Finnila MA, Goodyear SR, Robins SP, Tanner KE, Aspden RM, Millan JL & Farquharson C 2011 PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures. Bone 48 1066-1074.
80. Hunter GK, Kyle CL & Goldberg HA 1994 Modulation of crystal formation by bone phosphoproteins: structural specificity of the osteopontinmediated inhibition of hydroxyapatite formation. Biochemical Journal 300 (pt 3) 723-728.
81. Hunter GK, Hauschka PV, Poole AR, Rosenberg LC & Goldberg HA 1996 Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins. Biochemical Journal 317 59-64.
82. Hunziker EB, Schenk RK & Cruz-Orive LM 1987 Quantitation of chondrocyte performance in growth-plate cartilage during longitudinal bone growth. Journal of Bone and Joint Surgery 69 162-173.
83. Huq NL, Cross KJ, Ung M & Reynolds EC 2005 A review of protein structure and gene organisation for proteins associated with mineralised tissue and calcium phosphate stabilisation encoded on human chromosome 4. Archives of Oral Biology 50 599-609.
84. Iohara K, Nakashima M, Ito M, Ishikawa M, Nakasima A & Akamine A 2004 Dentin regeneration by dental pulp stem cell therapy with recombinant human bone morphogenetic protein 2. Journal of Dental Research 83 590-595.
85. Johnson K, Goding J, van Etten D, Sali A, Hu SI, Farley D, Krug H, Hessle L, Millan JL & Terkeltaub R 2003 Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression. Journal of Bone and Mineral Research 18 994-1004.
86. Jono S, Peinado C & Giachelli CM 2000 Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification. Journal of Biological Chemistry 275 20197-20203.
87. Kawasaki K 2011 The SCPP gene family and the complexity of hard tissues in vertebrates. Cells, Tissues, Organs 194 108-112.
88. Kawasaki K & Weiss KM 2006 Evolutionary genetics of vertebrate tissue mineralization: the origin and evolution of the secretory calcium-binding phosphoprotein family. Journal of Experimental Zoology. Part B, Molecular Development and Evolution 306 295-316.
89. Kawasaki K, Buchanan AV & Weiss KM 2007 Gene duplication and the evolution of vertebrate skeletal mineralization. Cells, Tissues, Organs 186 7-24.
90. Kim JW, Hu JC, Lee JI, Moon SK, Kim YJ, Jang KT, Lee SH, Kim CC, Hahn SH & Simmer JP 2005 Mutational hot spot in the DSPP gene causing dentinogenesis imperfecta type II. Human Genetics 116 186-191.
91. King KB, Opel CF & Rempel DM 2005 Cyclical articular joint loading leads to cartilage thinning and osteopontin production in a novel in vivo rabbit model of repetitive finger flexion. Osteoarthritis and Cartilage 13 971-978.
92. Klein-Nulend J, Roelofsen J, Semeins CM, Bronckers AL & Burger EH 1997 Mechanical stimulation of osteopontin mRNA expression and synthesis in bone cell cultures. Journal of Cellular Physiology 170 174-181.
93. Landis WJ, Jacquet R, Hillyer J & Zhang J 2003 Analysis of osteopontin in mouse growth plate cartilage by application of laser capture microdissection and RT-PCR. Connective Tissue Research 44 (Suppl 1) 28-32.
94. Li X, Ominsky MS, Warmington KS, Morony S, Gong J, Cao J, Gao Y, Shalhoub V, Tipton B, Haldankar R et al. 2009 Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. Journal of Bone and Mineral Research 24 578-588.
95. Li X, Warmington KS, Niu QT, Asuncion FJ, Barrero M, Grisanti M, Dwyer D, Stouch B, Thway TM, Stolina M et al. 2010 Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats. Journal of Bone and Mineral Research 25 2647-2656.
96. Ling Y, Rios HF, Myers ER, Lu Y, Feng JQ & Boskey AL 2005 DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis. Journal of Bone and Mineral Research 20 2169-2177.
97. Liu S, Zhou J, Tang W, Jiang X, Rowe DW & Quarles LD 2006 Pathogenic role of Fgf23 in Hyp mice. American Journal of Physiology. Endocrinology and Metabolism 291 E38-E49.
98. Liu S, Rowe PS, Vierthaler L, Zhou J & Quarles LD 2007 Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity. Journal of Endocrinology 192 261-267.
99. Liu S, Zhou J, Tang W, Menard R, Feng JQ & Quarles LD 2008 Pathogenic role of Fgf23 in Dmp1-null mice. American Journal of Physiology. Endocrinology and Metabolism 295 E254-E261.
100. Lorenz-Depiereux B, Bastepe M, Benet-Pages A, Amyere M, Wagenstaller J, Muller-Barth U, Badenhoop K, Kaiser SM, Rittmaster RS, Shlossberg AH et al. 2006 DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Nature Genetics 38 1248-1250.
101. Lu C, Huang S, Miclau T, Helms JA & Colnot C 2004 Mepe is expressed during skeletal development and regeneration. Histochemistry and Cell Biology 121 493-499.
102. Lu Y, Yuan B, Qin C, Cao Z, Xie Y, Dallas SL, McKee MD, Drezner MK, Bonewald LF & Feng JQ 2011 The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment. Journal of Bone and Mineral Research 26 331-340.
103. MacDougall M, Gu TT, Luan X, Simmons D & Chen J 1998 Identification of a novel isoform of mouse dentin matrix protein 1: spatial expression in mineralized tissues. Journal of Bone and Mineral Research 13 422-431.
104. Maciejewska I, Cowan C, Svoboda K, Butler WT, D'Souza R & Qin C 2008 The NH2-terminal and COOH-terminal fragments of dentin matrix protein 1 (DMP1) localize differently in the compartments of dentin and growth plate of bone. Journal of Histochemistry and Cytochemistry 57 155-156.
105. Maciejewska I, Qin D, Huang B, Sun Y, Mues G, Svoboda K, Bonewald L, Butler WT, Feng JQ & Qin C 2009 Distinct compartmentalization of dentin matrix protein 1 fragments in mineralized tissues and cells. Cells, Tissues, Organs 189 186-191.
106. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS & Mirams M 2008 Endochondral ossification: how cartilage is converted into bone in the developing skeleton. International Journal of Biochemistry and Cell Biology 40 46-62.
107. Mackie EJ, Tatarczuch L & Mirams M 2011 The growth plate chondrocyte and endochondral ossification. Journal of Endocrinology 211 109-121.
108. MacRae VE, Davey MG, McTeir L, Narisawa S, Yadav MC, Millan JL & Farquharson C 2010 Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick. Bone 46 1146-1155.
109. Majeska RJ &Wuthier RE 1975 Studies on matrix vesicles isolated from chick epiphyseal cartilage. Association of pyrophosphatase and ATPase activities with alkaline phosphatase. Biochimica et Biophysica Acta 391 51-60.
110. Malaval L, Wade-Gueye NM, Boudiffa M, Fei J, Zirngibl R, Chen F, Laroche N, Roux JP, Burt-Pichat B, Duboeuf F et al. 2008 Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis. Journal of Experimental Medicine 205 1145-1153.
111. Manolagas SC 2000 Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocrine Reviews 21 115-137.
112. Marks J, Churchill LJ, Debnam ES & Unwin RJ 2008 Matrix extracellular phosphoglycoprotein inhibits phosphate transport. Journal of the American Society of Nephrology 19 2313-2320.
113. Martin A, David V, Laurence JS, Schwarz PM, Lafer EM, Hedge AM & Rowe PS 2008 Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP. Endocrinology 149 1757-1772.
114. Martin A, Liu S, David V, Li H, Karydis A, Feng JQ & Quarles LD 2011 Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling. FASEB Journal 25 2551-2562.
115. Mellis DJ, Itzstein C, Helfrich MH & Crockett JC 2011 The skeleton: a multifunctional complex organ: the role of key signalling pathways in osteoclast differentiation and in bone resorption. Journal of Endocrinology 211 131-143.
116. Meyer JL 1984 Can biological calcification occur in the presence of pyrophosphate? Archives of Biochemistry and Biophysics 231 1-8
117. Mizuno M, Imai T, Fujisawa R, Tani H & Kuboki Y 2000 Bone sialoprotein (BSP) is a crucial factor for the expression of osteoblastic phenotypes of bone marrow cells cultured on type I collagen matrix. Calcified Tissue International 66 388-396.
118. Morinobu M, Ishijima M, Rittling SR, Tsuji K, Yamamoto H, Nifuji A, Denhardt DT & Noda M 2003 Osteopontin expression in osteoblasts and osteocytes during bone formation under mechanical stress in the calvarial suture in vivo. Journal of Bone and Mineral Research 18 1706-1715.
119. Moss DW, Eaton RH, Smith JK &Whitby LG 1967 Association of inorganicpyrophosphatase activity with human alkaline-phosphatase preparations. Biochemical Journal 102 53-57.
120. Nahar NN, Missana LR, Garimella R, Tague SE & Anderson HC 2008 Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins. Journal of Bone and Mineral Metabolism 26 514-519.
121. Nampei A, Hashimoto J, Hayashida K, Tsuboi H, Shi K, Tsuji I, Miyashita H, Yamada T, Matsukawa N, Matsumoto M et al. 2004 Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone. Journal of Bone Mineral and Metabolism 22 176-184.
122. Narayanan K, Srinivas R, Ramachandran A, Hao J, Quinn B & George A 2001 Differentiation of embryonic mesenchymal cells to odontoblast-like cells by overexpression of dentin matrix protein 1. PNAS 98 4516-4521.
123. Ogbureke KU & Fisher LW 2007 SIBLING expression patterns in duct epithelia reflect the degree of metabolic activity. Journal of Histochemistry and Cytochemistry 55 403-409.
124. Owan I, Burr DB, Turner CH, Qiu J, Tu Y, Onyia JE & Duncan RL 1997 Mechanotransduction in bone: osteoblasts are more responsive to fluid forces than mechanical strain. American Journal of Physiology 273 C810-C815.
125. Palokangas H, Mulari M & Vaananen HK 1997 Endocytic pathway from the basal plasma membrane to the ruffled border membrane in bone-resorbing osteoclasts. Journal of Cell Science 110 1767-1780.
126. Petersen DN, Tkalcevic GT, Mansolf AL, Rivera-Gonzalez R & Brown TA 2000 Identification of osteoblast/osteocyte factor 45 (OF45), a bonespecific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes. Journal of Biological Chemistry 275 36172-36180.
127. Petersson IF, Boegard T, Svensson B, Heinegard D & Saxne T 1998 Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint. British Journal of Rheumatology 37 46-50.
128. Pirotte S, Lamour V, Lambert V, Alvarez Gonzalez ML, Ormenese S, Noel A, Mottet D, Castronovo V & Bellahcene A 2011 Dentin matrix protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation. Blood 117 2515-2526.
129. Power J, Poole KE, van Bezooijen R, Doube M, Caballero-Alias AM, Lowik C, Papapoulos S, Reeve J & Loveridge N 2010 Sclerostin and the regulation of bone formation: effects in hip osteoarthritis and femoral neck fracture. Journal of Bone Mineral Research 25 1867-1876.
130. Prasad M, Butler WT & Qin C 2010 Dentin sialophosphoprotein in biomineralization. Connective Tissue Research 51 404-417.
131. Qin C, Brunn JC, Cadena E, Ridall A, Tsujigiwa H,Nagatsuka H,Nagai N& Butler WT 2002 The expression of dentin sialophosphoprotein gene in bone. Journal of Dental Research 81 392-394.
132. Qin C, Brunn JC, Cook RG, Orkiszewski RS, Malone JP, Veis A & Butler WT 2003 Identification and characterization of processed fragments and cleavage sites. Journal of Biological Chemistry 278 34700-34708.
133. Qin C, Baba O & Butler WT 2004 Post-translational modifications of sibling proteins and their roles in osteogenesis and dentinogenesis. Critical Reviews in Oral Biology and Medicine 15 126-136.
134. Qin C, D'Souza R & Feng JQ 2007 Dentin matrix protein 1 (DMP1): new and important roles for biomineralization and phosphate homeostasis. Journal of Dental Research 86 1134-1141.
135. Raynal C, Delmas PD & Chenu C 1996 Bone sialoprotein stimulates in vitro bone resorption. Endocrinology 137 2347-2354.
136. Rittling SR, Matsumoto HN, McKee MD, Nanci A, An XR, Novick KE, Kowalski AJ, Noda M & Denhardt DT 1998 Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro. Journal of Bone and Mineral Research 13 1101-1111.
137. Roberts S, Narisawa S, Harmey D, Millan JL & Farquharson C 2007 Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization. Journal of Bone and Mineral Research 22 617-627.
138. Roberts SJ, Owen HC & Farquharson C 2008 Identification of a novel splice variant of the haloacid dehalogenase: PHOSPHO1. Biochemical and Biophysical Research Communications 371 872-876.
139. Ross FP, Chappel J, Alvarez JI, Sander D, Butler WT, Farach-Carson MC, Mintz KA, Robey PG, Teitelbaum SL & Cheresh DA 1993 Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption. Journal of Biological Chemistry 268 9901-9907.
140. Rowe PS 2004 The wrickkened pathways of FGF23, MEPE and PHEX. Critical Reviews in Oral Biology and Medicine 15 264-281.
141. Rowe PS 2012 The chicken or the egg: PHEX, FGF23 and SIBLINGs unscrambled. Cell Biochemistry and Function.
142. Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ & Oudet CL 2000 MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. Genomics 67 54-68.
143. Rowe PS, Kumagai Y, Gutierrez G, Garrett IR, Blacher R, Rosen D, Cundy J, Navvab S, Chen D, Drezner MK et al. 2004 MEPE has the properties of an osteoblastic phosphatonin and minhibin. Bone 34 303-319.
144. Rowe PS, Matsumoto N, Jo OD, Shih RN, Oconnor J, Roudier MP, Bain S, Liu S, Harrison J & Yanagawa N 2006 Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin. Bone 39 773-786.
145. Saito T, Arsenault AL, Yamauchi M, Kuboki Y & Crenshaw MA 1997 Mineral induction by immobilized phosphoproteins. Bone 21 305-311.
146. Sanchez C, Deberg MA, Bellahcene A, Castronovo V, Msika P, Delcour JP, Crielaard JM & Henrotin YE 2008 Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone. Arthritis and Rheumatism 58 442-455.
147. Shirley DG, Faria NJ, Unwin RJ & Dobbie H 2010 Direct micropuncture evidence that matrix extracellular phosphoglycoprotein inhibits proximal tubular phosphate reabsorption. Nephrology, Dialysis, Transplantation 25 3191-3195.
148. Siggelkow H, Schmidt E, Hennies B & Hufner M 2004 Evidence of downregulation of matrix extracellular phosphoglycoprotein during terminal differentiation in human osteoblasts. Bone 35 570-576.
149. Sitara D, Razzaque MS, Hesse M, Yoganathan S, Taguchi T, Erben RG, Juppner H & Lanske B 2004 Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biology 23 421-432.
150. Sodek J, Chen J, Nagata T, Kasugai S, Todescan R Jr, Li IW & Kim RH 1995 Regulation of osteopontin expression in osteoblasts. Annals of the New York Academy of Sciences 760 223-241.
151. Sodek J, Ganss B & McKee MD 2000 Osteopontin. Critical Reviews in Oral Biology and Medicine 11 279-303.
152. Sprowson AP, McCaskie AW & Birch MA 2008 ASARM-truncated MEPE and AC-100 enhance osteogenesis by promoting osteoprogenitor adhesion. Journal of Orthopaedic Research 26 1256-1262.
153. Sreenath T, Thyagarajan T, Hall B, Longenecker G, D'Souza R, Hong S, Wright JT, MacDougall M, Sauk J & Kulkarni AB 2003 Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III. Journal of Biological Chemistry 278 24874-24880.
154. Stewart AJ, Roberts SJ, Seawright E, Davey MG, Fleming RH & Farquharson C 2006 The presence of PHOSPHO1 in matrix vesicles and its developmental expression prior to skeletal mineralization. Bone 39 1000-1007.
155. Stubbs JT III, Mintz KP, Eanes ED, Torchia DA & Fisher LW 1997 Characterization of native and recombinant bone sialoprotein: delineation of the mineral-binding and cell adhesion domains and structural analysis of the RGD domain. Journal of Bone and Mineral Research 12 1210-1222.
156. Sun Y, Prasad M, Gao T, Wang X, Zhu Q, D'Souza R, Feng JQ & Qin C 2010 Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis. Journal of Biological Chemistry 285 31713-31722.
157. Sun Y, Chen L, Ma S, Zhou J, Zhang H, Feng JQ & Qin C 2011 Roles of DMP1 processing in osteogenesis, dentinogenesis and chondrogenesis. Cells, Tissues, Organs 194 199-204.
158. Suzuki K, Zhu B, Rittling SR, Denhardt DT, Goldberg HA, McCulloch CA & Sodek J 2002 Colocalization of intracellular osteopontin with CD44 is associated with migration, cell fusion, and resorption in osteoclasts. Journal of Bone and Mineral Research 17 1486-1497.
159. Suzuki S, Sreenath T, Haruyama N, Honeycutt C, Terse A, Cho A, Kohler T, Muller R, Goldberg M & Kulkarni AB 2009 Dentin sialoprotein and dentin phosphoprotein have distinct roles in dentin mineralization. Matrix Biology 28 221-229.
160. Tartaix PH, Doulaverakis M, George A, Fisher LW, Butler WT, Qin C, Salih E, Tan M, Fujimoto Y, Spevak L et al. 2004 In vitro effects of dentin matrix protein-1 on hydroxyapatite formation provide insights into in vivo functions. Journal of Biological Chemistry 279 18115-18120.
161. Terai K, Takano-Yamamoto T, Ohba Y, Hiura K, Sugimoto M, Sato M, Kawahata H, Inaguma N, Kitamura Y & Nomura S 1999 Role of osteopontin in bone remodeling caused by mechanical stress. Journal of Bone and Mineral Research 14 839-849.
162. Terkeltaub R, Rosenbach M, Fong F & Goding J 1994 Causal link between nucleotide pyrophosphohydrolase overactivity and increased intracellular inorganic pyrophosphate generation demonstrated by transfection of cultured fibroblasts and osteoblasts with plasma cell membrane glycoprotein-1. Relevance to calcium pyrophosphate dihydrate deposition disease. Arthritis and Rheumatism 37 934-941.
163. Toyosawa S, Shintani S, Fujiwara T, Ooshima T, Sato A, Ijuhin N & Komori T 2001 Dentin matrix protein 1 is predominantly expressed in chicken and rat osteocytes but not in osteoblasts. Journal of Bone and Mineral Research 16 2017-2026.
164. Tsuchiya S, Simmer JP, Hu JC, Richardson AS, Yamakoshi F & Yamakoshi Y 2011 Astacin proteases cleave dentin sialophosphoprotein (Dspp) to generate dentin phosphoprotein (Dpp). Journal of Bone and Mineral Research 26 220-228.
165. Tye CE, Rattray KR, Warner KJ, Gordon JA, Sodek J, Hunter GK & Goldberg HA 2003 Delineation of the hydroxyapatite-nucleating domains of bone sialoprotein. Journal of Biological Chemistry 278 7949-7955.
166. Valverde P, Zhang J, Fix A, Zhu J, Ma W, Tu Q & Chen J 2008 Overexpression of bone sialoprotein leads to an uncoupling of bone formation and bone resorption in mice. Journal of Bone and Mineral Research 23 1775-1788.
167. Verdelis K, Ling Y, Sreenath T, Haruyama N, MacDougall M, van der Meulen MC, Lukashova L, Spevak L, Kulkarni AB & Boskey AL 2008 DSPP effects on in vivo bone mineralization. Bone 43 983-990.
168. Wada T, McKee MD, Steitz S & Giachelli CM 1999 Calcification of vascular smooth muscle cell cultures: inhibition by osteopontin. Circulation Research 84 166-178.
169. Wang J, Zhou HY, Salih E, Xu L, Wunderlich L, Gu X, Hofstaetter JG, Torres M & Glimcher MJ 2006 Site-specific in vivo calcification and osteogenesis stimulated by bone sialoprotein. Calcified Tissue International 79 179-189.
170. Wu LN, Genge BR, Kang MW, Arsenault AL & Wuthier RE 2002 Changes in phospholipid extractability and composition accompany mineralization of chicken growth plate cartilage matrix vesicles. Journal of Biological Chemistry 277 5126-5133.
171. Wu H, Teng PN, Jayaraman T, Onishi S, Li J, Bannon L, Huang H, Close J & Sfeir C 2011 Dentin matrix protein 1 (DMP1) signals via cell surface integrin. Journal of Biological Chemistry 286 29462-29469.
172. Xiao ZS, Crenshaw M, Guo R, Nesbitt T, Drezner MK & Quarles LD 1998 Intrinsic mineralization defect in Hyp mouse osteoblasts. American Journal of Physiology 275 E700-E708.
173. Yadav MC, Simao AM, Narisawa S, Huesa C, McKee MD, Farquharson C & Millan JL 2011 Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification. Journal of Bone and Mineral Research 26 286-297.
174. Yamakoshi Y, Hu JC, Fukae M, Zhang H & Simmer JP 2005 Dentin glycoprotein: the protein in the middle of the dentin sialophosphoprotein chimera. Journal of Biological Chemistry 280 17472-17479.
175. Ye L, Mishina Y, Chen D, Huang H, Dallas SL, Dallas MR, Sivakumar P, Kunieda T, Tsutsui TW, Boskey A et al. 2005 Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype. Journal of Biological Chemistry 280 6197-6203.
176. You J, Reilly GC, Zhen X, Yellowley CE, Chen Q, Donahue HJ & Jacobs CR 2001 Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. Journal of Biological Chemistry 276 13365-13371.
177. Zelzer E, McLean W, Ng YS, Fukai N, Reginato AM, Lovejoy S, D'Amore PA & Olsen BR 2002 Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development 129 1893-1904.
178. Zhang X, Zhao J, Li C, Gao S, Qiu C, Liu P, Wu G, Qiang B, Lo WH & Shen Y 2001 DSPP mutation in dentinogenesis imperfecta Shields type II. Nature Genetics 27 151-152.
179. Zhang GX, Mizuno M, Tsuji K & Tamura M 2004 Regulation of mRNA expression of matrix extracellular phosphoglycoprotein (MEPE)/osteoblast/ osteocyte factor 45 (OF45) by fibroblast growth factor 2 in cultures of rat bone marrow-derived osteoblastic cells. Endocrine 24 15-24.
180. Zhang B, Sun Y, Chen L, Guan C, Guo L & Qin C 2010 Expression and distribution of SIBLING proteins in the predentin/dentin and mandible of hyp mice. Oral Diseases 16 453-464.
181. Zohar R, Lee W, Arora P, Cheifetz S, McCulloch C & Sodek J 1997 Single cell analysis of intracellular osteopontin in osteogenic cultures of fetal rat calvarial cells. Journal of Cellular Physiology 170 88-100.