메뉴 건너뛰기




Volumn 19, Issue 7, 2011, Pages 874-885

Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

Author keywords

catenin; ADAMTS; Cartilage; MMPs; Osteoarthritis; Sclerostin

Indexed keywords

ADAMTS1 PROTEIN; AGGRECAN; BETA CATENIN; COLLAGEN TYPE 2; INTERLEUKIN 1ALPHA; MATRIX METALLOPROTEINASE; MESSENGER RNA; SCLEROSTIN; TISSUE INHIBITOR OF METALLOPROTEINASE; TUMOR NECROSIS FACTOR ALPHA; WNT PROTEIN;

EID: 79959936613     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2011.04.014     Document Type: Article
Times cited : (165)

References (51)
  • 1
    • 0029591457 scopus 로고
    • Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age
    • Roos H., Adalberth T., Dahlberg L., Lohmander L.S. Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age. Osteoarthritis Cartilage 1995, 3:261-267.
    • (1995) Osteoarthritis Cartilage , vol.3 , pp. 261-267
    • Roos, H.1    Adalberth, T.2    Dahlberg, L.3    Lohmander, L.S.4
  • 2
    • 0017595656 scopus 로고
    • Osteoarthrosis following insufficiency of the cruciate ligaments in man. A clinical study
    • Jacobsen K. Osteoarthrosis following insufficiency of the cruciate ligaments in man. A clinical study. Acta Orthop Scand 1977, 48:520-526.
    • (1977) Acta Orthop Scand , vol.48 , pp. 520-526
    • Jacobsen, K.1
  • 3
    • 60549090080 scopus 로고    scopus 로고
    • Developments in the clinical understanding of osteoarthritis
    • Felson D.T. Developments in the clinical understanding of osteoarthritis. Arthritis Res Ther 2009, 11:203.
    • (2009) Arthritis Res Ther , vol.11 , pp. 203
    • Felson, D.T.1
  • 5
    • 77956163932 scopus 로고    scopus 로고
    • Pharmacotherapy: concepts of pathogenesis and emerging treatments. Novel targets in bone and cartilage
    • Beyer C., Schett G. Pharmacotherapy: concepts of pathogenesis and emerging treatments. Novel targets in bone and cartilage. Best Pract Res Clin Rheumatol 2010, 24:489-496.
    • (2010) Best Pract Res Clin Rheumatol , vol.24 , pp. 489-496
    • Beyer, C.1    Schett, G.2
  • 6
    • 77951073232 scopus 로고    scopus 로고
    • To seek shelter from the WNT in osteoarthritis? WNT-signaling as a target for osteoarthritis therapy
    • Blom A.B., van Lent P.L., van der Kraan P.M., van den Berg W.B. To seek shelter from the WNT in osteoarthritis? WNT-signaling as a target for osteoarthritis therapy. Curr Drug Targets 2010, 11:620-629.
    • (2010) Curr Drug Targets , vol.11 , pp. 620-629
    • Blom, A.B.1    van Lent, P.L.2    van der Kraan, P.M.3    van den Berg, W.B.4
  • 8
    • 58149087220 scopus 로고    scopus 로고
    • Regulation of osteoarthritis development by Wnt-beta-catenin signaling through the endochondral ossification process
    • Kawaguchi H. Regulation of osteoarthritis development by Wnt-beta-catenin signaling through the endochondral ossification process. J Bone Miner Res 2009, 24:8-11.
    • (2009) J Bone Miner Res , vol.24 , pp. 8-11
    • Kawaguchi, H.1
  • 10
    • 39749171039 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration
    • Yuasa T., Otani T., Koike T., Iwamoto M., Enomoto-Iwamoto M. Wnt/beta-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration. Lab Invest 2008, 88:264-274.
    • (2008) Lab Invest , vol.88 , pp. 264-274
    • Yuasa, T.1    Otani, T.2    Koike, T.3    Iwamoto, M.4    Enomoto-Iwamoto, M.5
  • 11
    • 59649095502 scopus 로고    scopus 로고
    • Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1
    • Blom A.B., Brockbank S.M., van Lent P.L., van Beuningen H.M., Geurts J., Takahashi N., et al. Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1. Arthritis Rheum 2009, 60:501-512.
    • (2009) Arthritis Rheum , vol.60 , pp. 501-512
    • Blom, A.B.1    Brockbank, S.M.2    van Lent, P.L.3    van Beuningen, H.M.4    Geurts, J.5    Takahashi, N.6
  • 12
    • 58149097603 scopus 로고    scopus 로고
    • Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice
    • Zhu M., Tang D., Wu Q., Hao S., Chen M., Xie C., et al. Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice. J Bone Miner Res 2009, 23:10.
    • (2009) J Bone Miner Res , vol.23 , pp. 10
    • Zhu, M.1    Tang, D.2    Wu, Q.3    Hao, S.4    Chen, M.5    Xie, C.6
  • 13
    • 69949135234 scopus 로고    scopus 로고
    • Opposite relationships between circulating Dkk-1 and cartilage breakdown in patients with rheumatoid arthritis and knee osteoarthritis
    • Voorzanger-Rousselot N., Ben-Tabassi N.C., Garnero P. Opposite relationships between circulating Dkk-1 and cartilage breakdown in patients with rheumatoid arthritis and knee osteoarthritis. Ann Rheum Dis 2009, 68:1513-1514.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1513-1514
    • Voorzanger-Rousselot, N.1    Ben-Tabassi, N.C.2    Garnero, P.3
  • 14
    • 37149029397 scopus 로고    scopus 로고
    • Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice
    • Lories R.J., Peeters J., Bakker A., Tylzanowski P., Derese I., Schrooten J., et al. Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum 2007, 56:4095-4103.
    • (2007) Arthritis Rheum , vol.56 , pp. 4095-4103
    • Lories, R.J.1    Peeters, J.2    Bakker, A.3    Tylzanowski, P.4    Derese, I.5    Schrooten, J.6
  • 15
    • 47249108982 scopus 로고    scopus 로고
    • Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction
    • Zhu M., Chen M., Zuscik M., Wu Q., Wang Y.J., Rosier R.N., et al. Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction. Arthritis Rheum 2008, 58:2053-2064.
    • (2008) Arthritis Rheum , vol.58 , pp. 2053-2064
    • Zhu, M.1    Chen, M.2    Zuscik, M.3    Wu, Q.4    Wang, Y.J.5    Rosier, R.N.6
  • 16
    • 67349125148 scopus 로고    scopus 로고
    • Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint
    • Weng L.H., Wang C.J., Ko J.Y., Sun Y.C., Su Y.S., Wang F.S. Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint. Osteoarthritis Cartilage 2009, 17:919-929.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 919-929
    • Weng, L.H.1    Wang, C.J.2    Ko, J.Y.3    Sun, Y.C.4    Su, Y.S.5    Wang, F.S.6
  • 17
    • 77951725798 scopus 로고    scopus 로고
    • Control of Dickkopf-1 ameliorates chondrocyte apoptosis, cartilage destruction and subchondral bone deterioration in osteoarthritic knee
    • Weng L.H., Wang C.J., Ko J.Y., Sun Y.C., Wang F.S. Control of Dickkopf-1 ameliorates chondrocyte apoptosis, cartilage destruction and subchondral bone deterioration in osteoarthritic knee. Arthritis Rheum 2010, 62:1393-1402.
    • (2010) Arthritis Rheum , vol.62 , pp. 1393-1402
    • Weng, L.H.1    Wang, C.J.2    Ko, J.Y.3    Sun, Y.C.4    Wang, F.S.5
  • 19
    • 22844445934 scopus 로고    scopus 로고
    • SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
    • Semenov M., Tamai K., He X. SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J Biol Chem 2005, 280:26770-26775.
    • (2005) J Biol Chem , vol.280 , pp. 26770-26775
    • Semenov, M.1    Tamai, K.2    He, X.3
  • 20
    • 12144286871 scopus 로고    scopus 로고
    • Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist
    • van Bezooijen R.L., Roelen B.A., Visser A., van der Wee-Pals L., de Wilt E., Karperien M., et al. Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. J Exp Med 2004, 199:805-814.
    • (2004) J Exp Med , vol.199 , pp. 805-814
    • van Bezooijen, R.L.1    Roelen, B.A.2    Visser, A.3    van der Wee-Pals, L.4    de Wilt, E.5    Karperien, M.6
  • 21
    • 44449099165 scopus 로고    scopus 로고
    • Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
    • Li X., Ominsky M.S., Niu Q.T., Sun N., Daugherty B., D'Agostin D., et al. Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res 2008, 23:860-869.
    • (2008) J Bone Miner Res , vol.23 , pp. 860-869
    • Li, X.1    Ominsky, M.S.2    Niu, Q.T.3    Sun, N.4    Daugherty, B.5    D'Agostin, D.6
  • 22
    • 41949089764 scopus 로고    scopus 로고
    • Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    • Robling A.G., Niziolek P.J., Baldridge L.A., Condon K.W., Allen M.R., Alam I., et al. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem 2008, 283:5866-5875.
    • (2008) J Biol Chem , vol.283 , pp. 5866-5875
    • Robling, A.G.1    Niziolek, P.J.2    Baldridge, L.A.3    Condon, K.W.4    Allen, M.R.5    Alam, I.6
  • 23
    • 78649723963 scopus 로고    scopus 로고
    • Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression
    • Heiland G.R., Zwerina K., Baum W., Kireva T., Distler J.H., Grisanti M., et al. Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression. Ann Rheum Dis 2010, 69:2152-2159.
    • (2010) Ann Rheum Dis , vol.69 , pp. 2152-2159
    • Heiland, G.R.1    Zwerina, K.2    Baum, W.3    Kireva, T.4    Distler, J.H.5    Grisanti, M.6
  • 24
    • 79959924300 scopus 로고    scopus 로고
    • The Proinflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts
    • Vincent C., Findlay D.M., Welldon K.J., Wijenayaka A.R., Zheng T.S., Haynes D.R., et al. The Proinflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts. J Bone Miner Res 2009, 17:17.
    • (2009) J Bone Miner Res , vol.17 , pp. 17
    • Vincent, C.1    Findlay, D.M.2    Welldon, K.J.3    Wijenayaka, A.R.4    Zheng, T.S.5    Haynes, D.R.6
  • 25
    • 77955174372 scopus 로고    scopus 로고
    • Sclerostin and the regulation of bone formation: effects in hip osteoarthritis and femoral neck fracture
    • Power J., Poole K.E., van Bezooijen R., Doube M., Caballero-Alias A.M., Lowik C., et al. Sclerostin and the regulation of bone formation: effects in hip osteoarthritis and femoral neck fracture. J Bone Miner Res 2010, 25:1867-1876.
    • (2010) J Bone Miner Res , vol.25 , pp. 1867-1876
    • Power, J.1    Poole, K.E.2    van Bezooijen, R.3    Doube, M.4    Caballero-Alias, A.M.5    Lowik, C.6
  • 26
    • 70350558488 scopus 로고    scopus 로고
    • Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis
    • Appel H., Ruiz-Heiland G., Listing J., Zwerina J., Herrmann M., Mueller R., et al. Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis. Arthritis Rheum 2009, 60:3257-3262.
    • (2009) Arthritis Rheum , vol.60 , pp. 3257-3262
    • Appel, H.1    Ruiz-Heiland, G.2    Listing, J.3    Zwerina, J.4    Herrmann, M.5    Mueller, R.6
  • 29
    • 0028350226 scopus 로고
    • The effects of intraarticular hyaluronan on cartilage and subchondral bone changes in an ovine model of early osteoarthritis
    • Armstrong S., Read R., Ghosh P. The effects of intraarticular hyaluronan on cartilage and subchondral bone changes in an ovine model of early osteoarthritis. J Rheumatol 1994, 21:680-688.
    • (1994) J Rheumatol , vol.21 , pp. 680-688
    • Armstrong, S.1    Read, R.2    Ghosh, P.3
  • 30
    • 77956907233 scopus 로고    scopus 로고
    • The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in sheep and goats
    • Little C.B., Smith M.M., Cake M.A., Read R.A., Murphy M.J., Barry F.P. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in sheep and goats. Osteoarthritis Cartilage 2010, 18(Suppl 3):S80-S92.
    • (2010) Osteoarthritis Cartilage , vol.18 , Issue.SUPPL 3
    • Little, C.B.1    Smith, M.M.2    Cake, M.A.3    Read, R.A.4    Murphy, M.J.5    Barry, F.P.6
  • 31
    • 34249897267 scopus 로고    scopus 로고
    • Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promoters cartilage repair
    • Little C., Meeker C., Golub S., Lawlor K., Farmer P., Smith S., et al. Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promoters cartilage repair. J Clin Invest 2007, 117:1627.
    • (2007) J Clin Invest , vol.117 , pp. 1627
    • Little, C.1    Meeker, C.2    Golub, S.3    Lawlor, K.4    Farmer, P.5    Smith, S.6
  • 32
    • 34548566958 scopus 로고    scopus 로고
    • The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse
    • Glasson S.S., Blanchet T.J., Morris E.A. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage 2007, 15:1061-1069.
    • (2007) Osteoarthritis Cartilage , vol.15 , pp. 1061-1069
    • Glasson, S.S.1    Blanchet, T.J.2    Morris, E.A.3
  • 33
    • 73249137617 scopus 로고    scopus 로고
    • Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development
    • Little C.B., Barai A., Burkhardt D., Smith S.M., Fosang A.J., Werb Z., et al. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum 2009, 60:3723-3733.
    • (2009) Arthritis Rheum , vol.60 , pp. 3723-3733
    • Little, C.B.1    Barai, A.2    Burkhardt, D.3    Smith, S.M.4    Fosang, A.J.5    Werb, Z.6
  • 34
    • 34548453145 scopus 로고    scopus 로고
    • Dynamic biomechanics correlate with histopathology in human tibial cartilage: a preliminary study
    • Young A.A., Appleyard R.C., Smith M.M., Melrose J., Little C.B. Dynamic biomechanics correlate with histopathology in human tibial cartilage: a preliminary study. Clin Orthop Relat Res 2007, 462:212-220.
    • (2007) Clin Orthop Relat Res , vol.462 , pp. 212-220
    • Young, A.A.1    Appleyard, R.C.2    Smith, M.M.3    Melrose, J.4    Little, C.B.5
  • 35
    • 0030688870 scopus 로고    scopus 로고
    • Histomorphological and immunohistochemical evaluation of joint changes in a model of osteoarthritis induced by lateral meniscectomy in sheep
    • Little C., Smith S., Ghosh P., Bellenger C. Histomorphological and immunohistochemical evaluation of joint changes in a model of osteoarthritis induced by lateral meniscectomy in sheep. J Rheumatol 1997, 24:2199-2209.
    • (1997) J Rheumatol , vol.24 , pp. 2199-2209
    • Little, C.1    Smith, S.2    Ghosh, P.3    Bellenger, C.4
  • 37
    • 42449148641 scopus 로고    scopus 로고
    • Modulation of aggrecan and ADAMTS expression in ovine tendinopathy induced by altered strain
    • Smith M.M., Sakurai G., Smith S.M., Young A.A., Melrose J., Stewart C.M., et al. Modulation of aggrecan and ADAMTS expression in ovine tendinopathy induced by altered strain. Arthritis Rheum 2008, 58:1055-1066.
    • (2008) Arthritis Rheum , vol.58 , pp. 1055-1066
    • Smith, M.M.1    Sakurai, G.2    Smith, S.M.3    Young, A.A.4    Melrose, J.5    Stewart, C.M.6
  • 38
    • 0033775615 scopus 로고    scopus 로고
    • Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays
    • Bustin S.A. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 2000, 25:169-193.
    • (2000) J Mol Endocrinol , vol.25 , pp. 169-193
    • Bustin, S.A.1
  • 39
    • 0036668567 scopus 로고    scopus 로고
    • Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems
    • Bustin S.A. Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. J Mol Endocrinol 2002, 29:23-39.
    • (2002) J Mol Endocrinol , vol.29 , pp. 23-39
    • Bustin, S.A.1
  • 40
    • 43949145269 scopus 로고    scopus 로고
    • Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis
    • Dell'accio F., De Bari C., Eltawil N.M., Vanhummelen P., Pitzalis C. Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis. Arthritis Rheum 2008, 58:1410-1421.
    • (2008) Arthritis Rheum , vol.58 , pp. 1410-1421
    • Dell'accio, F.1    De Bari, C.2    Eltawil, N.M.3    Vanhummelen, P.4    Pitzalis, C.5
  • 42
    • 53849125461 scopus 로고    scopus 로고
    • Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis
    • Corr M. Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis. Nat Clin Pract Rheumatol 2008, 4:550-556.
    • (2008) Nat Clin Pract Rheumatol , vol.4 , pp. 550-556
    • Corr, M.1
  • 43
    • 70949101564 scopus 로고    scopus 로고
    • Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo
    • e7930
    • Choi H.Y., Dieckmann M., Herz J., Niemeier A. Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo. PLoS ONE 2009, 4. e7930.
    • (2009) PLoS ONE , vol.4
    • Choi, H.Y.1    Dieckmann, M.2    Herz, J.3    Niemeier, A.4
  • 44
    • 33845444007 scopus 로고    scopus 로고
    • IL-1beta and BMPs-interactive players of cartilage matrix degradation and regeneration
    • discussion 56
    • Aigner T., Soeder S., Haag J. IL-1beta and BMPs-interactive players of cartilage matrix degradation and regeneration. Eur Cell Mater 2006, 12:49-56. discussion 56.
    • (2006) Eur Cell Mater , vol.12 , pp. 49-56
    • Aigner, T.1    Soeder, S.2    Haag, J.3
  • 45
    • 0036500653 scopus 로고    scopus 로고
    • The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death
    • Grotewold L., Ruther U. The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death. EMBO J 2002, 21:966-975.
    • (2002) EMBO J , vol.21 , pp. 966-975
    • Grotewold, L.1    Ruther, U.2
  • 46
    • 22244474640 scopus 로고    scopus 로고
    • Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease
    • Loots G.G., Kneissel M., Keller H., Baptist M., Chang J., Collette N.M., et al. Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Res 2005, 15:928-935.
    • (2005) Genome Res , vol.15 , pp. 928-935
    • Loots, G.G.1    Kneissel, M.2    Keller, H.3    Baptist, M.4    Chang, J.5    Collette, N.M.6
  • 47
    • 33746852996 scopus 로고    scopus 로고
    • Opposing roles of WNT-5A and WNT-11 in interleukin-1beta regulation of type II collagen expression in articular chondrocytes
    • Ryu J.H., Chun J.S. Opposing roles of WNT-5A and WNT-11 in interleukin-1beta regulation of type II collagen expression in articular chondrocytes. J Biol Chem 2006, 281:22039-22047.
    • (2006) J Biol Chem , vol.281 , pp. 22039-22047
    • Ryu, J.H.1    Chun, J.S.2
  • 48
    • 12344252610 scopus 로고    scopus 로고
    • Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage
    • Kobayashi M., Squires G.R., Mousa A., Tanzer M., Zukor D.J., Antoniou J., et al. Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage. Arthritis Rheum 2005, 52:128-135.
    • (2005) Arthritis Rheum , vol.52 , pp. 128-135
    • Kobayashi, M.1    Squires, G.R.2    Mousa, A.3    Tanzer, M.4    Zukor, D.J.5    Antoniou, J.6
  • 49
    • 70349934212 scopus 로고    scopus 로고
    • Sclerostin mediates bone response to mechanical unloading via antagonizing Wnt/beta-catenin signaling
    • Lin C., Jiang X., Dai Z., Guo X., Weng T., Wang J., et al. Sclerostin mediates bone response to mechanical unloading via antagonizing Wnt/beta-catenin signaling. J Bone Miner Res 2009, 24:1651-1661.
    • (2009) J Bone Miner Res , vol.24 , pp. 1651-1661
    • Lin, C.1    Jiang, X.2    Dai, Z.3    Guo, X.4    Weng, T.5    Wang, J.6
  • 50
    • 65549152230 scopus 로고    scopus 로고
    • Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis
    • Li X., Ominsky M.S., Warmington K.S., Morony S., Gong J., Cao J., et al. Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J Bone Miner Res 2009, 24:578-588.
    • (2009) J Bone Miner Res , vol.24 , pp. 578-588
    • Li, X.1    Ominsky, M.S.2    Warmington, K.S.3    Morony, S.4    Gong, J.5    Cao, J.6
  • 51
    • 58049204438 scopus 로고    scopus 로고
    • Potential new drug targets for osteoporosis
    • Deal C. Potential new drug targets for osteoporosis. Nat Clin Pract Rheumatol 2009, 5:20-27.
    • (2009) Nat Clin Pract Rheumatol , vol.5 , pp. 20-27
    • Deal, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.