Intrinsic mineralization defect in Hyp mouse osteoblasts

American Journal of Physiology - Endocrinology and Metabolism

Volumn 275, Issue 4 38-4, 1998, Pages

  Xiao, Z S ^a   Crenshaw, M ^b   Guo, R ^a   Nesbitt, T ^a   Drezner, M K ^a   Quarles, L D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Osteocalcin; Osteomalacia; X linked phosphaturia

Indexed keywords

ANIMAL CELL; ARTICLE; EXTRACELLULAR MATRIX; GENE MUTATION; HYPOPHOSPHATEMIA; MINERALIZATION; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOMALACIA; PHOSPHATURIA; PRIORITY JOURNAL;

EID: 0031796266     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.275.4.e700     Document Type: Article

References (35)

1. Anonymous. A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. Nat. Genet. 11: 130-136, 1995.
2. Beck, L., Y. Soumounou, J. Martel, G. Krishnamurthy, C. Gauthier, C. G. Goodyer, and H. S. Tenehouse. Pex/PEX. tissue distribution and evidence for a deletion in the 3′ region of the Pex gene in X-linked hypophosphatemic mice. J. Clin. Invest. 99: 1200-1209, 1997.
3. Carpenter, T. O., K. C. Moltx, B. Ellis, M. Andrioli, T. L. McCarthy, M. Centrella, D. Bryan, and C. M. Gundberg. Osteocalcin production in primary osteoblast cultures derived from normal and Hyp mice. Endocrinology 139: 35-43, 1998.
4. Chung, C. H., E. E. Golub, E. Forbes, T. Tokuoka, and I. M. Shapiro. Mechanism of action of β-glycerophosphate on bone cell mineralization. Calcif. Tissue Int. 51: 305-311, 1992.
5. Creemers, L. B., D. C. Jansen, A. van Veen-Reurings, T. van den Bos, and V. Everts. Microassay for the assessment of low levels of hydroxyproline. Biotechniques 22: 656-658, 1997.
6. Delvin, E. E., P. Richard, M. Debarats, B. Ecarot-Charrier, and F. H. Glorieux. Cultured osteoblasts from normal and hypophosphatemic mice: calcitriol receptors and biological response to the hormone. Bone 11: 87-94, 1990.
7. Dixon, P. H., C. Wooding, P. Christie, M. Grieff, D. Schlessinger, M. P. Whyte, and R. V. Thakkar. Mutations of the PEX regulatory and C-terminal regions cause X-linked hypophosphatemia (Abstract). J. Bone Miner. Res. 12: S128, 1997.
8. Domann, R., and J. Martinez. Alternative to cloning cylinders for isolation of adherent cell clones. Biotechniques 18: 594-595, 1995.
9. Du, L., M. Desbarats, J. Viel, F. H. Glorieux, C. Cawthorn, and B. Ecarot. cDNA cloning of the murine Pex gene implicated in X-linked hypophosphatemia and evidence for expression in bone. Genomics 36: 22-28, 1996.
10. Ecarot, B., F. H. Glorieux, M. Desbarats, R. Travers, and L. Labelle. Defective bone formation by Hyp mouse bone cells transplanted into normal mice: evidence in favor of an intrinsic osteoblast defect. J. Bone Miner. Res. 7: 215-220, 1992.
11. Ecarot-Charrier, B., F. H. Glorieux, M. V. D. Rest, and G. Pereira. Osteoblasts isolated from mouse calvaria initiate matrix mineralization in culture. J. Cell Biol. 96: 639-643, 1983.
12. Grieff, M., S. Mumm, P. Waeltz, R. Mazzarella, M. P. Whyte, R. V. Thakkar, and D. Schlessinger. Expression and cloning of the human X-linked hypophosphatemia gene cDNA. Biochem. Biophys. Res. Commun. 231: 635-639, 1997.
13. Gundberg, C., M. E. Clough, and T. O. Carpenter. Development and validation of a radioimmunoassay for mouse osteocalcin: paradoxical response in the Hyp mouse. Endocrinology 130: 1909-1915, 1992.
14. Guo, R., and L. D. Quarles. Cloning and sequencing of human PEX from a bone cDNA library: evidence for its developmental stage-specific regulation in osteoblasts. J. Bone Miner. Res. 12: 1009-1017, 1997.
15. Holm, I. A., X. Huang, and L. M. Kunkel. Mutational analysis of the PEX gene in patients with X-linked hypophosphatemic rickets. Am. J. Hum. Genet. 60: 790-797, 1997.
16. Hruska, K. A., L. Rifas, S.-L. Cheng, A. Gupta, L. Halstead, and L. Avioli. X-linked hypophosphatemic rickets and the murine Hyp homologue. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol. 37): F357-F362, 1995.
17. Kumar, R. Phosphatonin - a new phosphaturetic hormone? (Lessons from tumor-induced osteomalacia and X-linked hypophosphataemia). Nephrol. Dial. Transplant. 12: 11-13, 1997.
18. Lajeunesse, D., R. A. Meyer, and L. Hamel. Direct demonstration of a humorally mediated inhibition of renal phosphate transport in the Hyp mouse. Kidney Int. 50: 1531-1538, 1996.
19. Meyer, R. A., M. H. Meyer, and R. W. Gray. Parabiosis suggests a humoral factor is involved in X-linked hypophosphatemia in mice. J. Bone Miner. Res. 4: 493-500, 1989.
20. Nesbitt, T., T. M. Coffman, R. Griffiths, and M. K. Drezner. Cross-transplantation of kidneys in normal and Hyp mice: evidence that the Hyp mouse phenotype is unrelated to an intrinsic renal defect. J. Clin. Invest. 89: 1453-1459, 1992.
21. Nesbitt, T., M. J. Econs, J. K. Byun, J. Martel, H. S. Tenehouse, and M. K. Drezner. Phosphate transport in immortalized cell cultures from the renal proximal tubule of normal and Hyp mice: evidence that the HYP gene locus product is an external factor. J. Bone Miner. Res. 10: 1327-1333, 1995.
22. Owen, T. A., M. Aronow, V. Shalhoub, L. M. Barone, L. Wilming, M. S. Tassinari, M. B. Kennedy, S. Pockwinse, J. B. Lian, and G. S. Stein. Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J. Cell. Physiol. 143: 420-430, 1990.
23. Quarles, L. D., S. R. Siddhanti, and S. Medda. Developmental regulation of osteocalcin expression in MC3T3-E1 osteoblasts: minimal role of the proximal E-Box cis-acting promoter elements. J. Cell. Biochem. 65: 11-24, 1997.
24. Quarles, L. D., D. A. Yohay, L. W. Lever, R. Caton, and R. J. Wenstrup. Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: an in vitro model of osteoblast development. J. Bone Miner. Res. 7: 683-692, 1992.
25. Rifas, L., S. L. Cheng, L. Halstead, A. Gupta, K. A. Hruska, and L. Avioli. Skeletal casein kinase activity defect in the HYP mouse. Calcif. Tissue Int. 61: 256-259, 1997.
26. Rifas, L., L. L. Dawson, L. Halstead, M. Roberts, and L. Avioli. Phosphate transport in osteoblasts from normal and X-linked hypophosphatemic mice. Calcif. Tissue Int. 54: 505-510, 1994.
27. Saito, T., M. Yamauchi, and M. A. Crenshaw. Apatite induction by insoluble dentin collagen. J. Bone Min. Res. 13: 265-270, 1998.
28. 412 with a similar catalytic mechanism and a distinct substrate binding mechanism compared with neutral endopeptidase-24.11. Biochem. J. 315: 863-867, 1996.
29. Sokal, R. R., and F. J. Rohol. Biometry: The Principles and Practice of Statistics in Biological Research (2nd ed.). San Francisco, CA: Freeman, 1981.
30. Stanford, C. M., E. D. Jacobson, E. D. Eanes, L. A. Lembke, and R. J. Midura. Rapidly forming apatitic mineral in an osteoblast cell line (UMR 106-01 BSP). J. Biol. Chem. 270: 9420-9428, 1995.
31. Strom, T. M., F. Francis, B. Lorenz, A. Boddrich, M. J. Econs, H. Lehrach, and T. Meitinger. Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia. Hum. Mol. Genet. 6: 165-171, 1997.
32. 3 in the hypophosphatemic mouse. J. Bone Miner. Res. 11: 1234-1240, 1996.
33. Turner, A. J., and K. Tanzawa. Mammalian membrane metallopeptidases - NEP, ECE, KELL, and PEX. FASEB J. 11: 355-364, 1997.
34. 3. Bone 13: 209-215, 1992.
35. Yanagisawa, M., H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Mitsui, Y. Yazaki, K. Goto, and T. Masaki. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411-415, 1988.