Mechanotransduction in bone: Osteoblasts are more responsive to fluid forces than mechanical strain

American Journal of Physiology - Cell Physiology

Volumn 273, Issue 3 42-3, 1997, Pages

  Owan, Ichiro ^a   Burr, David B ^a   Turner, Charles H ^a   Qiu, Jinya ^a   Tu, Yuan ^b   Onyia, Jude E ^b   Duncan, Randall L ^a,c  

^a INDIANA UNIVERSITY MEDICAL CENTER   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Osteopontin

Indexed keywords

CHLORIDE; CYCLIC AMP; MESSENGER RNA; OSTEOPONTIN; PURINERGIC RECEPTOR STIMULATING AGENT;

ANIMAL CELL; ARTICLE; EXTRACELLULAR FLUID; FLOW; MECHANICAL STRESS; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0030846047     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1997.273.3.c810     Document Type: Article

References (45)

1. Buckley, M. J., A. J. Banes, L. G. Levin, B. E. Sumpio, M. Sato, R. Jordan, J. Gilbert, G. W. Link, and R. Tran Son Tay. Osteoblasts increase their rate of division and align in response to cyclic, mechanical tension, in vitro. Bone Miner. 4: 225-236, 1988.
2. Burr, D. B., C. Milgrom, D. Fyhrie, M. R. Forwood, M. Nyska, A. Finestone, S. Hoshaw, E. Saiag, and A. Simkin. In vivo measurement of human tibial strains during vigorous activity. Bone 18: 405-410, 1996.
3. Cann, C. E., and R. R. Adachi. Bone resorption and mineral excretion in rats during spaceflight. Am. J. Physiol. 244 (Regulatory Integrative Comp. Physiol. 13): R327-R331, 1983.
4. Chen, J., K. Singh, B. B. Mukherjee, and J. Sodek. Developmental expression of osteopontin (OPN) mRNA in rat tissues: evidence for a role for OPN in bone formation and resorption. Matrix 13: 113-123, 1993.
5. Duncan, R. L., and C. H. Turner. Mechanotransduction and the functional response of bone to mechanical strain. Calcif. Tissue Int. 57: 344-358, 1995.
6. Frost, H. M. Bone Biodynamics. Boston, MA: Little and Brown, 1964.
7. Frost, H. M. A determinant of bone architecture. The minimum effective strain. Clin. Orthop. 200: 198-225, 1983.
8. Gere, J. M., and S. P. Timoshenko. Mechanics of Materials (3rd ed.). Boston, MA: PWS-Kent, 1990, p. 775.
9. Gong, J. K., J. S. Arnold, and S. H. Cohn. Composition of trabecular and cortical bone. Anat. Rec. 149: 325-332, 1964.
10. Harter, L. V., K. A. Hruska, and R. L. Duncan. Human osteoblast-like cells respond to mechanical strain with increased bone matrix protein production independent of hormonal regulation. Endocrinology 136: 528-535, 1995.
11. Hung, C. T., F. D. Allen, S. R. Pollack, and C. T. Brighton. What is the role of the convective current density in the real-time calcium response of cultured bone cells to fluid flow. J. Biomech. 29: 1403-1409, 1996.
12. Johnson, D. L., T. N. McAllister, and J. A. Frangos. Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts. Am. J. Physiol. 271 (Endocrinol. Metab. 34): E205-E208, 1996.
13. Klein-Nulend, J., A. Van Der Plas, C. M. Semeins, N. E. Ajubi, J. A. Frangos, P. J. Nijweide, and E. H. Burger. Sensitivity of osteocytes to biomechanical stress in vitro. FASEB J. 9: 441-445, 1995.
14. Kubota, T., M. Yamauchi, J. Onozaki, S. Sato, Y. Suzuki, and J. Sodek. Influence of an intermittent compressive force on matrix protein expression by ROS 17/2.8 cells, with selective stimulation of osteopontin. Arch. Oral Biol. 38: 23-30, 1993.
15. McKee, M. D., and A. Nanci. Osteopontin at mineralized tissue interfaces in bone, teeth and osseointegrated implants: ultrastructural distribution and implications for mineralized tissue formation, turnover and repair. Microsc. Res. Tech. 33: 141-164, 1996.
16. 3 integrin stimulates immediate cell signals in the osteoclast. J. Biol. Chem. 226: 20369-20374, 1991.
17. Morey, E. R., and D. J. Baylink. Inhibition of bone formation during spaceflight. Science 201: 1138-1141, 1978.
18. 2 release: a new experimental method. Calcif. Tissue Int. 47: 35-39, 1990.
19. Nunamaker, D. M., D. M. Butterweck, and M. T. Provost. Fatigue fractures in thoroughbred racehorses: relationships with age, peak bone strain and training. J. Orthop. Res. 8: 604-611, 1990.
20. Otter, M. W., V. R. Palmieri, and G. V. B. Cochran. Transcortical streaming potentials are generated by circulatory pressure gradients in living canine tibia. J. Orthop. Res. 8: 119-126, 1990.
21. Patterson-Buckendahl, P. E., R. E. Grindeland, R. B. Martin, C. E. Cann, and S. B. Arnaud. Osteocalcin as an indicator of bone metabolism during spaceflight. Physiologist 28, Suppl. 6: S227-S228, 1985.
22. Prandtl, L., and O. G. Tietjens. Applied Hydro- and Aeromechanics. New York: McGraw-Hill, 1934.
23. Raab-Cullen, D. M., M. P. Akhter, D. B. Kimmel, and R. R. Recker. Periosteal bone formation stimulated by externally induced bending strains. J. Bone Miner. Res. 9: 1143-1152, 1994.
24. Rambaut, P. C., and R. S. Johnston. Prolonged weightlessness and calcium loss in man. Acta Astronaut. 6: 1113-1122, 1979.
25. 2 and inositol trisphosphate levels in osteoblasts. Am. J. Physiol. 261 (Cell Physiol. 30): C428-C432, 1991.
26. Reich, K. M., C. V. Gay, and J. A. Frangos. Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production. J. Cell. Physiol. 143: 100-104, 1990.
27. Resnick, N., T. Collins, W. Atkinson, D. T. Bonthron, C. F. Dewey, Jr., and M. A. Gimbrone, Jr. Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element. Proc. Natl. Acad. Sci. USA 90: 7908-7910, 1993.
28. Resnick, N., and M. A. Gimbrone, Jr. Hemodynamic forces are complex regulators of endothelial gene expression. FASEB J. 9: 874-882, 1995.
29. Rubin, C. T., and L. E. Lanyon. Regulation of bone formation by applied dynamic loads. J. Bone Joint Surg. Am. 66A: 397-402, 1984.
30. Rubin, C. T., and L. E. Lanyon. Dynamic strain similarity in vertebrates: an alternative to allometric limb bone scaling. J. Theor. Biol. 107: 321-327, 1984.
31. Schaffer, J. L., C. D. Toma, M. C. Meazinni, J. L. Gray, and L. C. Gerstenfeld. Mechanical stimulation of osteopontin gene expression and its relationship to microfilament structure. In: Biological Mechanisms of Tooth Movement and Craniofacial Adaptation, edited by Z. Davidovitch. Boston, MA: Harvard Society for Advancement of Orthodontics. In press.
32. Sessions, N. D., B. P. Halloran, D. D. Bikle, T. J. Wronski, C. M. Cone, and E. R. Morey-Holton. Bone response to normal weight bearing after a period of skeletal unloading. Am. J. Physiol. 257 (Endocrinol. Metab. 20): E606-E610, 1989.
33. Simmons, D. J., J. E. Russell, F. Winter, P. Tran Van, A. Vignery, R. Baron, G. D. Rosenberg, and W. V. Walker. Effect of spaceflight on the non-weight-bearing bones of rat skeleton. Am. J. Physiol. 244 (Regulatory Integrative Comp. Physiol. 13): R319-R326, 1983.
34. 2 mediated. Biochim. Biophys. Acta 627: 91-100, 1980.
35. Turner, C. H., M. R. Forwood, and M. W. Otter. Mechanotransduction in bone: do bone cells act as sensors of fluid flow? FASEB J. 8: 875-878, 1994.
36. Turner, C. H., M. R. Forwood, J.-Y. Rho, and T. Yoshikawa. Mechanical loading thresholds for lamellar and woven bone formation. J. Bone Miner. Res. 9: 87-97, 1994.
37. Turner, C. H., I. Owan, and Y. Takano. Mechanotransduction in bone: role of strain rate. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E438-E442, 1995.
38. Turner, C. H., I. Owan, Y. Tu, J. E. Onyia, and R. L. Duncan. Regulation of osteoblast gene expression by mechanical strains and fluid forces (Abstract). FASEB J. 11: A287, 1997.
39. Vico, L., D. Chappard, C. Alexandre, S. Palle, P. Minaire, G. Riffat, B. Morukov, and S. Rakhmanov. Effects of a 120 day period of bed-rest on bone mass and bone cell activities in man: attempts at countermeasure. Bone Miner. 2: 383-394, 1987.
40. Uhthoff, H. K., and Z. F. G. Jaworski. Bone loss in response to long term immobilization. J. Bone Joint Surg. Br. 60B: 420-429, 1978.
41. Weinbaum, S., S. C. Cowin, and Y. Zeng. A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. J. Biomech. 27: 339-360, 1994.
42. Weinreb, M., G. A. Rodan, and D. D. Thompson. Immobilization-related bone loss in rat is increased by calcium deficiency. Calcif. Tissue Int. 48: 93-100, 1991.
43. Whedon, G. D., and R. P. Heaney. Effects of physical inactivity, paralysis and weightlessness on bone growth. In: Bone, edited by B. K. Hall. Boca Raton, FL: CRC, 1993, vol. 7.
44. Wronski, T. J., and E. R. Morey. Inhibition of cortical and trabecular bone formation in the long bones of immobilized monkeys. Clin. Orthop. Rel. Res. 181: 269-276, 1983.
45. Yeh, C.-K., and G. A. Rodan. Tensile forces enhance prostaglandin E synthesis in osteoblastic cells grown on collagen ribbons. Calcif. Tissue Int. 36: S67-S71, 1984.